{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:06:21Z","timestamp":1785546381758,"version":"3.56.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.compbiolchem.2026.109212","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T23:26:37Z","timestamp":1782343597000},"page":"109212","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["In silico evaluation of isochlorogenic acid as a potential AbPf2 inhibitor for managing Alternaria pathogenicity"],"prefix":"10.1016","volume":"124","author":[{"given":"Anjali","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhya","family":"Upadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gohar","family":"Taj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109212_bib1","article-title":"Testing the inhibitory effect of tricin against some foodborne bacteria and estimation of its phenol coefficient","volume":"15","author":"Al-Badri","year":"2023","journal-title":"Iraqi J. Mark. Res. Consum. Prot."},{"key":"10.1016\/j.compbiolchem.2026.109212_bib2","first-page":"1023","article-title":"Effect of Alternaria blight on oil content of rapeseed-mustard","volume":"57","author":"Ansari","year":"1988","journal-title":"Curr. Sci."},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109212_bib3","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1076\/1388-0209(200009)3841-AFT284","article-title":"Gallic acid derivatives from Mezoneuronbenthamianum leaves","volume":"38","author":"Binutu","year":"2000","journal-title":"Pharm. Biol."},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109212_bib4","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1128\/EC.00226-14","article-title":"How the necrotrophic fungus Alternaria brassicicola kills plant cells remains an enigma","volume":"14","author":"Cho","year":"2015","journal-title":"Eukaryot. Cell."},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.109212_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127140","article-title":"A pectate lyase-coding gene abundantly expressed during early stages of infection is required for full virulence in Alternaria brassicicola","volume":"10","author":"Cho","year":"2015","journal-title":"PLoS. One"},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109212_bib6","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/tpj.12217","article-title":"Fungal-specific transcription factor AbPf2 activates pathogenicity in Alternaria brassicicola","volume":"75","author":"Cho","year":"2013","journal-title":"Plant. J."},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.109212_bib7","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijantimicag.2005.09.002","article-title":"Antimicrobial activity of flavonoids","volume":"26","author":"Cushnie","year":"2005","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109212_bib8","doi-asserted-by":"crossref","first-page":"577","DOI":"10.54085\/ap.2024.13.1.60","article-title":"silico molecular docking analysis of Cichorium intybus L. phytochemical compounds against two related targets of type 2 diabetes mellitus","volume":"13","author":"Devakrishna","year":"2024","journal-title":"Ann. Phytomed."},{"key":"10.1016\/j.compbiolchem.2026.109212_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcab.2023.102744","article-title":"Advances in green extraction methods, biological properties, and applications of betanin and vitexin: an updated review and bibliometric analysis","volume":"51","author":"de Freitas Marinho","year":"2023","journal-title":"Biocatal. Agric. Biotechnol."},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109212_bib10","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1089\/jmf.2014.3189","article-title":"Functional components of bamboo shavings and bamboo leaf extracts and their antioxidant activities in vitro","volume":"18","author":"Gong","year":"2015","journal-title":"J. Med. Food"},{"issue":"11","key":"10.1016\/j.compbiolchem.2026.109212_bib11","first-page":"860","article-title":"Isochlorogenic acid (ICGA): natural medicine with potentials in pharmaceutical developments","volume":"18","author":"Hao-Nan","year":"2020","journal-title":"Chin. J. Nat. Med."},{"issue":"20","key":"10.1016\/j.compbiolchem.2026.109212_bib12","doi-asserted-by":"crossref","first-page":"974","DOI":"10.6026\/97320630008974","article-title":"Sequence analysis and homology modeling of peroxidase from Medicago sativa","volume":"8","author":"Hooda","year":"2012","journal-title":"Bioinformation"},{"issue":"22","key":"10.1016\/j.compbiolchem.2026.109212_bib13","doi-asserted-by":"crossref","first-page":"7460","DOI":"10.3390\/molecules28227460","article-title":"Isochlorogenic acid glucosides from the Arabian medicinal plant Artemisia sieberi and their antimicrobial activities","volume":"28","author":"Jamal","year":"2023","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109212_bib14","article-title":"Antimicrobial activity of fractions and extract from Gentiana asclepiadea L. underground parts with molecular docking analysis","volume":"61","author":"Jovanovi\u0107","year":"2022","journal-title":"Acta Med. Median."},{"issue":"10","key":"10.1016\/j.compbiolchem.2026.109212_bib15","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1021\/acs.jafc.0c07579","article-title":"Caffeic acid and its derivatives: antimicrobial drugs toward microbial pathogens","volume":"69","author":"Khan","year":"2021","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109212_bib16","first-page":"1110","article-title":"Alternaria blight of oilseed brassicas: a review on management strategies through conventional, non-conventional and biotechnological approaches","volume":"8","author":"Kumar","year":"2016","journal-title":"J. Appl. Nat. Sci."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109212_bib17","article-title":"A review on medicinal properties of orientin","volume":"2016","author":"Lam","year":"2016","journal-title":"Adv. Pharmacol. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109212_bib18","first-page":"283","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109212_bib19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s43450-021-00158-1","article-title":"Simultaneous determination of flavonoids from bamboo leaf extracts using liquid chromatography\u2013tandem mass spectrometry","volume":"31","author":"Li","year":"2021","journal-title":"Rev. Bras. De. Farmacogn."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109212_bib20","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1038\/s41598-021-83598-y","article-title":"Anti-fungal activity of moso bamboo (Phyllostachys pubescens) leaf extract and its development into a botanical fungicide to control pepper phytophthora blight","volume":"11","author":"Liao","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiolchem.2026.109212_bib21","doi-asserted-by":"crossref","first-page":"10844","DOI":"10.1021\/jf303595e","article-title":"Enzymatic acylation of isoorientin and isovitexin from bamboo-leaf extracts with fatty acids and antiradical activity of the acylated derivatives","volume":"60","author":"Ma","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.compbiolchem.2026.109212_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2024.110734","article-title":"Luteolin exhibits antimicrobial actions against Salmonella Typhimurium and Escherichia coli: impairment of cell adhesion, membrane integrity, and energy metabolism","volume":"166","author":"Mahamud","year":"2024","journal-title":"Food Control."},{"issue":"11","key":"10.1016\/j.compbiolchem.2026.109212_bib23","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.13057\/biodiv\/d231104","article-title":"Phytochemical, GC-MS analysis and antioxidant activities of leaf methanolic extract of Lai (Durio kutejensis), the endemic plant of Kalimantan, Indonesia","volume":"23","author":"Manurung","year":"2022","journal-title":"Biodiversitas"},{"key":"10.1016\/j.compbiolchem.2026.109212_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijbiomac.2012.12.027","article-title":"vitro antioxidant activities of polysaccharides extracted from Moso bamboo leaf","volume":"55","author":"Mao","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.compbiolchem.2026.109212_bib25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.pestbp.2017.05.012","article-title":"Chlorogenic acid is a fungicide active against phytopathogenic fungi","volume":"140","author":"Mart\u00ednez","year":"2017","journal-title":"Pestic. Biochem. Physiol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109212_bib26","article-title":"Alternaria blight: a chronic disease in rapeseed-mustard","volume":"1","author":"Meena","year":"2010","journal-title":"Journal of Oilseed Brassica"},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109212_bib27","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1439-0434.2004.00828.x","article-title":"Identification of critical stage for disease development and biocontrol of Alternaria blight of Indian mustard (Brassica juncea)","volume":"152","author":"Meena","year":"2004","journal-title":"J. Phytopathol."},{"key":"10.1016\/j.compbiolchem.2026.109212_bib28","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.indcrop.2015.09.041","article-title":"Simultaneous determination of multi-class bioactive constituents for quality assessment of Garcinia species using UHPLC\u2013QqQLIT\u2013MS\/MS","volume":"77","author":"Pandey","year":"2015","journal-title":"Ind. Crops Prod."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109212_bib29","article-title":"Omicron B.1.1.529 tyrosine phosphatase receptor transition among SARS-CoV-2 heredities: a validation of homology modelling and phylogenetic analysis","volume":"2","author":"Paritala","year":"2022","journal-title":"J. Plant. Bioinforma. Biotechnol."},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.109212_bib30","doi-asserted-by":"crossref","DOI":"10.1099\/jmm.0.001526","article-title":"Evaluation of the antifungal effect of chlorogenic acid against strains of Candida spp. resistant to fluconazole: apoptosis induction and in silico analysis of the possible mechanisms of action","volume":"71","author":"Rocha da Silva","year":"2022","journal-title":"J. Med. Microbiol."},{"issue":"4\u20135","key":"10.1016\/j.compbiolchem.2026.109212_bib31","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1078\/1438-4639-00241","article-title":"Development of a globally harmonized system for hazard communication","volume":"206","author":"Silk","year":"2003","journal-title":"Int. J. Hyg. Environ. Health"},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109212_bib32","first-page":"1207","article-title":"Characterization of Alternaria brassicae causing Alternaria blight of rapeseed mustard (Brassica juncea L.) and its management","volume":"9","author":"Singh","year":"2014","journal-title":"Bioscan"},{"issue":"23","key":"10.1016\/j.compbiolchem.2026.109212_bib33","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.1080\/10408398.2024.2390550","article-title":"A comprehensive review of apigenin, a dietary flavonoid: biological sources, nutraceutical prospects, chemistry, pharmacological insights, and health benefits","volume":"65","author":"Singh","year":"2025","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109212_bib34","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/prot.340170404","article-title":"Recognition of errors in three-dimensional structures of proteins","volume":"17","author":"Sippl","year":"1993","journal-title":"Protein. Struct. Funct. Bioinforma."},{"key":"10.1016\/j.compbiolchem.2026.109212_bib35","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3126\/ajn.v9i1.90918","article-title":"Fungicidal management of Alternaria blight in rapeseed (Brassica rapa L.)","volume":"9","author":"Subedi","year":"2025","journal-title":"Agron. J. Nepal."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109212_bib36","first-page":"213","article-title":"Pathogenesis mechanisms employed by Alternaria species","volume":"6","author":"Taj","year":"2015","journal-title":"J. Oilseed Brassica"},{"issue":"6","key":"10.1016\/j.compbiolchem.2026.109212_bib37","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.3390\/antiox12061239","article-title":"Anti-inflammatory and antioxidant effects of leaves and sheath from bamboo (Phyllostachys edulis J. Houz)","volume":"12","author":"Tundis","year":"2023","journal-title":"Antioxidants"},{"issue":"10","key":"10.1016\/j.compbiolchem.2026.109212_bib38","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.3390\/microorganisms9102041","article-title":"Towards advances in medicinal plant antimicrobial activity: a review study on challenges and future perspectives","volume":"9","author":"Vaou","year":"2021","journal-title":"Microorganisms"},{"issue":"8","key":"10.1016\/j.compbiolchem.2026.109212_bib39","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.3390\/antibiotics11081014","article-title":"Interactions between medicinal plant-derived bioactive compounds: focus on antimicrobial combination effects","volume":"11","author":"Vaou","year":"2022","journal-title":"Antibiotics"},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.109212_bib40","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1110\/ps.0236803","article-title":"Can correct protein models be identified?","volume":"12","author":"Wallner","year":"2003","journal-title":"Protein Sci."},{"issue":"11","key":"10.1016\/j.compbiolchem.2026.109212_bib41","first-page":"860","article-title":"Isochlorogenic acid (ICGA): natural medicine with potentials in pharmaceutical developments","volume":"18","author":"Wang","year":"2020","journal-title":"Chin. J. Nat. Med."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109212_bib42","doi-asserted-by":"crossref","first-page":"W407","DOI":"10.1093\/nar\/gkm290","article-title":"ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins","volume":"35","author":"Wiederstein","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109212_bib43","first-page":"1","article-title":"Medicinal properties of bamboos","volume":"1","author":"Wr\u00f3blewska","year":"2018","journal-title":"Pharmacogn. Med. Plants"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109212_bib44","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3993\/jfbi03201307","article-title":"Biosynthesis of silver nanoparticles by bamboo leaves extract and their antimicrobial activity","volume":"6","author":"Yasin","year":"2013","journal-title":"J. Fiber Bioeng. Inf."}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126003397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126003397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:40:16Z","timestamp":1785541216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927126003397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":44,"alternative-id":["S1476927126003397"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109212","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In silico evaluation of isochlorogenic acid as a potential AbPf2 inhibitor for managing Alternaria pathogenicity","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109212","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109212"}}