{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:07:18Z","timestamp":1785546438096,"version":"3.56.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011093","name":"University of Phayao","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.compbiolchem.2026.109226","type":"journal-article","created":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T15:04:19Z","timestamp":1783263859000},"page":"109226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Integrative hematological and transcriptomic analysis reveals monocyte alterations and molecular signatures of inflammatory-coagulation crosstalk in long COVID"],"prefix":"10.1016","volume":"124","author":[{"given":"Parin","family":"Kamseng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namngern","family":"Chantaramanee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rittikorn","family":"Sompan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarayot","family":"Rareongjai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.compbiolchem.2026.109226_bib1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nrc2657","article-title":"p21 in cancer: intricate networks and multiple activities","volume":"9","author":"Abbas","year":"2009","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109226_bib2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1056\/NEJMoa2015432","article-title":"Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19","volume":"383","author":"Ackermann","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109226_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10040812","article-title":"Endothelial Dysfunction in COVID-19: A Unifying Mechanism and a Potential Therapeutic Target","volume":"10","author":"Ambrosino","year":"2022","journal-title":"Biomedicines"},{"issue":"6","key":"10.1016\/j.compbiolchem.2026.109226_bib4","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","article-title":"VEGF in Signaling and Disease: Beyond Discovery and Development","volume":"176","author":"Apte","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.compbiolchem.2026.109226_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1254899","article-title":"Immunological profiling in long COVID: overall low grade inflammation and T-lymphocyte senescence and increased monocyte activation correlating with increasing fatigue severity","volume":"14","author":"Berentschot","year":"2023","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.109226_bib6","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.cell.2020.04.026","article-title":"Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19","volume":"181","author":"Blanco-Melo","year":"2020","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.109226_bib7","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41577-021-00536-9","article-title":"Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19","volume":"21","author":"Bonaventura","year":"2021","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109226_bib8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbamcr.2010.01.003","article-title":"The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity","volume":"1803","author":"Brew","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.109226_bib9","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1111\/j.1755-5922.2010.00171.x","article-title":"Plasminogen activator inhibitor-1 (PAI-1): a key factor linking fibrinolysis and age-related subclinical and clinical conditions","volume":"28","author":"Cesari","year":"2010","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.compbiolchem.2026.109226_bib10","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fimmu.2018.00104","article-title":"M. A20\/Tumor Necrosis Factor \u03b1-Induced Protein 3 in Immune Cells Controls Development of Autoinflammation and Autoimmunity: Lessons from Mouse Models","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.compbiolchem.2026.109226_bib11","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/s41587-020-0602-4","article-title":"COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis","volume":"38","author":"Chua","year":"2020","journal-title":"Nat. Biotechnol."},{"issue":"8","key":"10.1016\/j.compbiolchem.2026.109226_bib12","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1073\/pnas.1104491109","article-title":"Protein phosphatase 1 subunit Ppp1r15a\/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells","volume":"109","author":"Clavarino","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"23","key":"10.1016\/j.compbiolchem.2026.109226_bib13","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1182\/blood.2020006000","article-title":"COVID-19 and its implications for thrombosis and anticoagulation","volume":"135","author":"Connors","year":"2020","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.compbiolchem.2026.109226_bib14","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.drudis.2020.06.013","article-title":"COVID-19 and pneumonia: a role for the uPA\/uPAR system","volume":"25","author":"D'Alonzo","year":"2020","journal-title":"Drug. Discov. Today"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109226_bib15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cell.2012.03.003","article-title":"MYC on the path to cancer","volume":"149","author":"Dang","year":"2012","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109226_bib16","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41579-022-00846-2","article-title":"Long COVID: major findings, mechanisms and recommendations","volume":"21","author":"Davis","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109226_bib17","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1038\/s41467-020-17292-4","article-title":"Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia","volume":"11","author":"De Biasi","year":"2020","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109226_bib18","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1055\/s-0033-1334487","article-title":"Three decades of research on plasminogen activator inhibitor-1: a multifaceted serpin","volume":"39","author":"Declerck","year":"2013","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.compbiolchem.2026.109226_bib19","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3389\/fimmu.2020.00827","article-title":"Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)","volume":"11","author":"Diao","year":"2020","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.compbiolchem.2026.109226_bib20","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nrc1209","article-title":"AP-1: a double-edged sword in tumorigenesis","volume":"3","author":"Eferl","year":"2003","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109226_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009220","article-title":"Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses","volume":"17","author":"Feng","year":"2021","journal-title":"PLoS. Pathog."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109226_bib22","doi-asserted-by":"crossref","DOI":"10.1172\/JCI140491","article-title":"Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection","volume":"131","author":"Files","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.compbiolchem.2026.109226_bib23","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1111\/jth.15490","article-title":"Persistent endotheliopathy in the pathogenesis of long COVID syndrome","volume":"19","author":"Fogarty","year":"2021","journal-title":"J. Thromb. Haemost."},{"issue":"9","key":"10.1016\/j.compbiolchem.2026.109226_bib24","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1161\/CIRCRESAHA.116.306853","article-title":"Cross Talk Pathways Between Coagulation and Inflammation","volume":"118","author":"Foley","year":"2016","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109226_bib25","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s43066-021-00144-1","article-title":"Long-term clinical and biochemical residue after COVID-19 recovery","volume":"11","author":"Gameil","year":"2021","journal-title":"Egypt. Liver J."},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109226_bib26","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41569-020-00469-1","article-title":"Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation","volume":"18","author":"Gu","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"issue":"6504","key":"10.1016\/j.compbiolchem.2026.109226_bib27","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1126\/science.abc6027","article-title":"Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients","volume":"369","author":"Hadjadj","year":"2020","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109226_bib28","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12967-022-03346-2","article-title":"Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME\/CFS)","volume":"20","author":"Haffke","year":"2022","journal-title":"J. Transl. Med."},{"issue":"9","key":"10.1016\/j.compbiolchem.2026.109226_bib29","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1097\/CCM.0000000000004458","article-title":"Coagulopathy of Coronavirus Disease 2019","volume":"48","author":"Iba","year":"2020","journal-title":"Crit. Care Med."},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109226_bib30","doi-asserted-by":"crossref","first-page":"208","DOI":"10.2174\/187152809788680994","article-title":"CD44 and its role in inflammation and inflammatory diseases","volume":"8","author":"Johnson","year":"2009","journal-title":"Inflamm. Allergy Drug. Targets"},{"key":"10.1016\/j.compbiolchem.2026.109226_bib31","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fimmu.2015.00182","article-title":"The Role of CD44 in Disease Pathophysiology and Targeted Treatment","volume":"6","author":"Jordan","year":"2015","journal-title":"Front. Immunol."},{"issue":"36","key":"10.1016\/j.compbiolchem.2026.109226_bib32","doi-asserted-by":"crossref","first-page":"22351","DOI":"10.1073\/pnas.2010229117","article-title":"IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome","volume":"117","author":"Kang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.compbiolchem.2026.109226_bib33","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2021-069590","article-title":"Risks of deep vein thrombosis, pulmonary embolism, and bleeding after covid-19: nationwide self-controlled cases series and matched cohort study","volume":"377","author":"Katsoularis","year":"2022","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109226_bib34","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/BCJ20220016","article-title":"A central role for amyloid fibrin microclots in long COVID\/PASC: origins and therapeutic implications","volume":"479","author":"Kell","year":"2022","journal-title":"Biochem. J."},{"key":"10.1016\/j.compbiolchem.2026.109226_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.720109","article-title":"Monocytes and Macrophages in COVID-19","volume":"12","author":"Knoll","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.compbiolchem.2026.109226_bib36","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3389\/fendo.2020.00556","article-title":"Master Regulator Activating Transcription Factor 3 (ATF3) in Metabolic Homeostasis and Cancer","volume":"11","author":"Ku","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"7","key":"10.1016\/j.compbiolchem.2026.109226_bib37","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1055\/s-0040-1709996","article-title":"Coronavirus Disease 2019: The Role of the Fibrinolytic System from Transmission to Organ Injury and Sequelae","volume":"46","author":"Kwaan","year":"2020","journal-title":"Semin. Thromb. Hemost."},{"issue":"7884","key":"10.1016\/j.compbiolchem.2026.109226_bib38","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41586-021-03995-1","article-title":"Virus-induced senescence is a driver and therapeutic target in COVID-19","volume":"599","author":"Lee","year":"2021","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.compbiolchem.2026.109226_bib39","doi-asserted-by":"crossref","first-page":"e438","DOI":"10.1016\/S2352-3026(20)30145-9","article-title":"Coagulation abnormalities and thrombosis in patients with COVID-19","volume":"7","author":"Levi","year":"2020","journal-title":"Lancet Haematol."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109226_bib40","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41590-021-01104-y","article-title":"Pathological sequelae of long-haul COVID","volume":"23","author":"Mehandru","year":"2022","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.compbiolchem.2026.109226_bib41","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","article-title":"Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages","volume":"20","author":"Merad","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109226_bib42","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41591-021-01283-z","article-title":"Post-acute COVID-19 syndrome","volume":"27","author":"Nalbandian","year":"2021","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.109226_bib43","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cytogfr.2015.07.001","article-title":"Leukemia inhibitory factor (LIF)","volume":"26","author":"Nicola","year":"2015","journal-title":"Cytokine Growth Factor. Rev."},{"issue":"8","key":"10.1016\/j.compbiolchem.2026.109226_bib44","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1016\/j.jtha.2023.04.039","article-title":"Thromboinflammation in long COVID-the elusive key to postinfection sequelae?","volume":"21","author":"Nicolai","year":"2023","journal-title":"J. Thromb. Haemost."},{"issue":"9","key":"10.1016\/j.compbiolchem.2026.109226_bib45","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1111\/jth.15016","article-title":"Hypofibrinolytic state and high thrombin generation may play a major role in SARS-COV2 associated thrombosis","volume":"18","author":"Nougier","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.compbiolchem.2026.109226_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1151780","article-title":"Elevated circulating monocytes and monocyte activation in COVID-19 convalescent individuals","volume":"14","author":"Park","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109226_bib47","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s10020-022-00548-8","article-title":"Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanism","volume":"28","author":"Patel","year":"2022","journal-title":"Mol. Med."},{"key":"10.1016\/j.compbiolchem.2026.109226_bib48","doi-asserted-by":"crossref","DOI":"10.1101\/2021.06.25.449905","article-title":"Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) up to 15 Months Post-Infection","volume":"12","author":"Patterson","year":"2021","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109226_bib49","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s41590-021-01113-x","article-title":"Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection","volume":"23","author":"Phetsouphanh","year":"2022","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109226_bib50","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrm1004","article-title":"CD44: from adhesion molecules to signalling regulators","volume":"4","author":"Ponta","year":"2003","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"6","key":"10.1016\/j.compbiolchem.2026.109226_bib51","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/MOH.0000000000000666","article-title":"Mechanisms of immunothrombosis in COVID-19","volume":"28","author":"Portier","year":"2021","journal-title":"Curr. Opin. Hematol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109226_bib52","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12933-021-01359-7","article-title":"Persistent clotting protein pathology in Long COVID\/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin","volume":"20","author":"Pretorius","year":"2021","journal-title":"Cardiovasc. Diabetol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109226_bib53","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12933-022-01579-5","article-title":"Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID\/Post-Acute Sequelae of COVID-19 (PASC)","volume":"21","author":"Pretorius","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"issue":"11","key":"10.1016\/j.compbiolchem.2026.109226_bib54","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1182\/blood.2020008086","article-title":"Postdischarge venous thromboembolism following hospital admission with COVID-19","volume":"136","author":"Roberts","year":"2020","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109226_bib55","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrendo.2016.12","article-title":"BMP signalling in skeletal development, disease and repair","volume":"12","author":"Salazar","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109226_bib56","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrm2821","article-title":"Regulation of cell signalling by uPAR","volume":"11","author":"Smith","year":"2010","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109226_bib57","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1016\/S1473-3099(21)00703-9","article-title":"A clinical case definition of post-COVID-19 condition by a Delphi consensus","volume":"22","author":"Soriano","year":"2022","journal-title":"Lancet Infect. Dis."},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.109226_bib58","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.cell.2022.01.014","article-title":"Multiple early factors anticipate post-acute COVID-19 sequelae","volume":"185","author":"Su","year":"2022","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.compbiolchem.2026.109226_bib59","doi-asserted-by":"crossref","first-page":"a016295","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"7","key":"10.1016\/j.compbiolchem.2026.109226_bib60","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41577-020-0343-0","article-title":"COVID-19: the vasculature unleashed","volume":"20","author":"Teuwen","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109226_bib61","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1111\/jth.15267","article-title":"Prolonged elevation of D-dimer levels in convalescent COVID-19 patients is independent of the acute phase response","volume":"19","author":"Townsend","year":"2021","journal-title":"J. Thromb. Haemost."},{"issue":"10234","key":"10.1016\/j.compbiolchem.2026.109226_bib62","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(20)30937-5","article-title":"Endothelial cell infection and endotheliitis in COVID-19","volume":"395","author":"Varga","year":"2020","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109226_bib63","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1182\/bloodadvances.2020003968","article-title":"Sustained prothrombotic changes in COVID-19 patients 4 months after hospital discharge","volume":"5","author":"von Meijenfeldt","year":"2021","journal-title":"Blood Adv."},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109226_bib64","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41591-022-01689-3","article-title":"Long-term cardiovascular outcomes of COVID-19","volume":"28","author":"Xie","year":"2022","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.109226_bib65","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1002\/jcp.27407","article-title":"Tumor suppressors BTG1 and BTG2: Beyond growth control","volume":"234","author":"Yuniati","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.109226_bib66","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41423-020-0402-2","article-title":"Functional exhaustion of antiviral lymphocytes in COVID-19 patients","volume":"17","author":"Zheng","year":"2020","journal-title":"Cell. Mol. Immunol."},{"issue":"6","key":"10.1016\/j.compbiolchem.2026.109226_bib67","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/nsr\/nwaa041","article-title":"Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients","volume":"7","author":"Zhou","year":"2020","journal-title":"Natl. Sci. Rev."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109226_bib68","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1038\/s41598-020-80010-z","article-title":"Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients","volume":"11","author":"Zuo","year":"2021","journal-title":"Sci. Rep."}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126003531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126003531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:44:56Z","timestamp":1785541496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927126003531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":68,"alternative-id":["S1476927126003531"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109226","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative hematological and transcriptomic analysis reveals monocyte alterations and molecular signatures of inflammatory-coagulation crosstalk in long COVID","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109226","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109226"}}