{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:32:59Z","timestamp":1793151179377,"version":"4.5.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360063"],"award-info":[{"award-number":["82360063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.compbiolchem.2026.109274","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:30:39Z","timestamp":1785699039000},"page":"109274","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Study on the potential role of KIF23 in doxorubicin-induced cardiomyopathy through multi-omics integration and AI-based screening"],"prefix":"10.1016","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6269-2281","authenticated-orcid":false,"given":"Dabao","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengya","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7398-7846","authenticated-orcid":false,"given":"Shaowu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8107-4064","authenticated-orcid":false,"given":"Richao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuewu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.compbiolchem.2026.109274_bib1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature08460","article-title":"Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1","volume":"462","author":"Barbie","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.compbiolchem.2026.109274_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2024.109203","article-title":"Computational exploration of novel ketoprofen derivatives: molecular dynamics simulations and MM-PBSA calculations for COX-2 inhibition as promising anti-inflammatory drugs","volume":"183","author":"Bettadj","year":"2024","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib3","doi-asserted-by":"crossref","first-page":"14649","DOI":"10.3390\/ijms232314649","article-title":"The innate immune system in cardiovascular diseases and its role in doxorubicin-induced cardiotoxicity","volume":"23","author":"Bhagat","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3390\/jcdd12060207","article-title":"Doxorubicin-induced cardiotoxicity: a comprehensive update","volume":"12","author":"Bhutani","year":"2025","journal-title":"J. Cardiovasc. Dev. Dis."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib5","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1200\/JCO.22.02355","article-title":"Nivolumab and doxorubicin, vinblastine, and dacarbazine in early-stage unfavorable hodgkin lymphoma: final analysis of the randomized german hodgkin study group phase II NIVAHL trial","volume":"41","author":"Br\u00f6ckelmann","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib6","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.1038\/s41467-019-12507-9","article-title":"The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis","volume":"10","author":"Capalbo","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib7","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jhep.2024.08.025","article-title":"Regulation of KIF23 by miR-107 controls replicative tumor cell fitness in mouse and human hepatocellular carcinoma","volume":"82","author":"Castoldi","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib8","article-title":"Enhancing nanomedicine efficacy in KPC pancreatic tumors through ketotifen-mediated tumor microenvironment remodeling","volume":"390","author":"Charalambous","year":"2025","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib9","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1136\/gutjnl-2015-310625","article-title":"The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinoma in association with the wnt\/\u03b2-catenin signalling pathway","volume":"65","author":"Chen","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.compbiolchem.2026.109274_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2025.111043","article-title":"Network toxicology, molecular docking, and molecular dynamics simulations revealed the effects of carbendazim on bone metabolism and identified potential treatment drugs","volume":"197","author":"Chen","year":"2025","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib11","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41419-021-03614-x","article-title":"Regulated cell death pathways in doxorubicin-induced cardiotoxicity","volume":"12","author":"Christidi","year":"2021","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1023\/A:1022627411411","article-title":"Support-vector networks","volume":"20","author":"Cortes","year":"1995","journal-title":"Mach. Learn."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib13","doi-asserted-by":"crossref","first-page":"W357","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib14","doi-asserted-by":"crossref","DOI":"10.1126\/science.adi8577","article-title":"Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes","volume":"390","author":"DeMeo","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.compbiolchem.2026.109274_bib15","article-title":"Endothelial transcription factor EB protects against doxorubicin-induced endothelial toxicity and cardiac dysfunction","author":"Du","year":"2025","journal-title":"Circ. Circ. 124. 71774."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene expression omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization paths for generalized linear models via coordinate descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib18","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00018-023-04922-5","article-title":"Infiltrating macrophages amplify doxorubicin-induced cardiac damage: role of catecholamines","volume":"80","author":"Gambardella","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib19","doi-asserted-by":"crossref","first-page":"D945","DOI":"10.1093\/nar\/gkw1074","article-title":"The ChEMBL database in 2017","volume":"45","author":"Gaulton","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ph18050681","article-title":"Doxorubicin-induced cardiotoxicity and the emerging role of SGLT2 inhibitors: from glycemic control to cardio-oncology","volume":"18","author":"Goje","year":"2025","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.compbiolchem.2026.109274_bib21","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2025.38325","article-title":"Preserved cognitive function after statin administration during cancer treatment with doxorubicin: a secondary analysis of a randomized clinical trial","volume":"8","author":"Grizzard","year":"2025","journal-title":"JAMA Netw. Open."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib22","article-title":"Esterase-responsive mitochondria-targeted hydropersulfide donors mitigate doxorubicin cardiotoxicity while preserving anticancer activity","author":"Gu","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103753","article-title":"5-oxoproline prevents doxorubicin-induced cardiotoxicity and tumor growth","volume":"85","author":"Guo","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib24","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1161\/CIRCULATIONAHA.124.071217","article-title":"Human single-nucleus RNA sequencing identifies CD47 as a therapeutic target for doxorubicin-induced cardiomyopathy","volume":"152","author":"Guo","year":"2025","journal-title":"Circulation"},{"key":"10.1016\/j.compbiolchem.2026.109274_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-78327-w","article-title":"Comparing cefotaxime and ceftriaxone in combating meningitis through nose-to-brain delivery using bio\/chemoinformatics tools","volume":"10","author":"Hathout","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113788","article-title":"Prx5 overexpression protect against doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and inflammation via the TLR4\/NF-\u03baB pathway","volume":"146","author":"Hu","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib27","article-title":"Cardioprotective strategies against doxorubicin-induced cardiotoxicity: A review from standard therapies to emerging mitochondrial transplantation","volume":"189","author":"Ito-Hagiwara","year":"2025","journal-title":"Biomed. Pharmacother. Biomedecine Pharmacother."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118315","article-title":"Cardioprotective strategies against doxorubicin-induced cardiotoxicity: a review from standard therapies to emerging mitochondrial transplantation","volume":"189","author":"Ito-Hagiwara","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib30","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.lungcan.2015.11.018","article-title":"Overexpression of KIF23 predicts clinical outcome in primary lung cancer patients","volume":"92","author":"Kato","year":"2016","journal-title":"Lung Cancer"},{"key":"10.1016\/j.compbiolchem.2026.109274_bib31","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1021\/acs.jcim.2c00044","article-title":"GROMACS in the cloud: a global supercomputer to speed up alchemical drug design","volume":"62","author":"Kutzner","year":"2022","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib32","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib33","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1021\/ci200227u","article-title":"LigPlot+: multiple ligand\u2013protein interaction diagrams for drug discovery","volume":"51","author":"Laskowski","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib34","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","article-title":"The sva package for removing batch effects and other unwanted variation in high-throughput experiments","volume":"28","author":"Leek","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.compbiolchem.2026.109274_bib35","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1016\/j.cell.2023.05.039","article-title":"Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity","volume":"186","author":"Lei","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.compbiolchem.2026.109274_bib36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41514-024-00135-7","article-title":"A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging","volume":"10","author":"Linders","year":"2024","journal-title":"Npj Aging"},{"key":"10.1016\/j.compbiolchem.2026.109274_bib37","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.122.321587","article-title":"Critical role of the cGAS-STING pathway in doxorubicin-induced cardiotoxicity","volume":"132","author":"Luo","year":"2023","journal-title":"Circ. Res."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/jox15010009","article-title":"Cardiotoxicity of chemotherapy: a multi-OMIC perspective","volume":"15","author":"Ma","year":"2025","journal-title":"J. Xenobiotics"},{"key":"10.1016\/j.compbiolchem.2026.109274_bib39","doi-asserted-by":"crossref","first-page":"5320","DOI":"10.1021\/acs.jcim.1c00909","article-title":"Virtual double-system single-box for absolute dissociation free energy calculations in GROMACS","volume":"61","author":"Macchiagodena","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib40","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1186\/s12967-025-06446-x","article-title":"Algorithms and tools for data-driven omics integration to achieve multilayer biological insights: a narrative review","volume":"23","author":"Morabito","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib41","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1161\/CIRCULATIONAHA.124.065473","article-title":"Cardio-oncology: a new clinical frontier and novel platform for cardiovascular investigation","volume":"150","author":"Moslehi","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.compbiolchem.2026.109274_bib42","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s44318-024-00327-7","article-title":"Kinesin-like motor protein KIF23 maintains neural stem and progenitor cell pools in the developing cortex","volume":"44","author":"Naher","year":"2025","journal-title":"EMBO J."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib43","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s40959-025-00349-y","article-title":"Unraveling the genetic blueprint of doxorubicin-induced cardiotoxicity through systems genetics approaches","volume":"11","author":"Orgil","year":"2025","journal-title":"Cardio Oncol."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib44","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1056\/NEJMoa2403394","article-title":"Doxorubicin\u2013trabectedin with trabectedin maintenance in leiomyosarcoma","volume":"391","author":"Pautier","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib45","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3892\/ijmm.2025.5624","article-title":"Alteration of cardiac energetics and mitochondrial function in doxorubicin-induced cardiotoxicity: molecular mechanism and prospective implications (review)","volume":"56","author":"Qing","year":"2025","journal-title":"Int. J. Mol. Med."},{"issue":"25","key":"10.1016\/j.compbiolchem.2026.109274_bib46","first-page":"293","article-title":"Cardiovascular and oncologic considerations in adult hodgkin lymphoma","author":"Raman","year":"2025","journal-title":"JACC CardioOncology State--Art. Rev. JACC CardioOncology S2666-873"},{"key":"10.1016\/j.compbiolchem.2026.109274_bib47","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib48","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1016\/j.csbj.2022.04.018","article-title":"Using molecular dynamics simulations to interrogate T cell receptor non-equilibrium kinetics","volume":"20","author":"Rollins","year":"2022","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib49","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1053\/j.gastro.2023.02.043","article-title":"A therapeutically targetable TAZ-TEAD2 pathway drives the growth of hepatocellular carcinoma via ANLN and KIF23","volume":"164","author":"Saito","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.compbiolchem.2026.109274_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2025.123595","article-title":"SiRNA-mediated knockdown of TOP2B protects hiPSC-derived cardiomyocytes from doxorubicin-induced toxicity","volume":"371","author":"Saroj","year":"2025","journal-title":"Life Sci."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib51","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10822-010-9352-6","article-title":"Ligand docking and binding site analysis with PyMOL and autodock\/vina","volume":"24","author":"Seeliger","year":"2010","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib52","article-title":"Molecular masking of synthetic immunomodulator evokes antitumor immunity with reduced immune tolerance and systemic toxicity by temporal activity recovery and sustained stimulation","volume":"36","author":"Shin","year":"2024","journal-title":"Adv. Mater. Deerfield Beach Fla"},{"key":"10.1016\/j.compbiolchem.2026.109274_bib53","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.compbiolchem.2026.109274_bib54","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib55","article-title":"Colchicine ameliorates dilated cardiomyopathy via SIRT2-mediated suppression of NLRP3 inflammasome activation","volume":"11","author":"Sun","year":"2022","journal-title":"J. Am. Heart Assoc. Cardiovasc. Cerebrovasc. Dis."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2025.102581","article-title":"Immune cell subtype contributions to doxorubicin cardiotoxicity\u2013defining immune targets for translational interventions","volume":"85","author":"Van fraeyenhove","year":"2025","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib57","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41392-025-02326-4","article-title":"Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential","volume":"10","author":"Wang","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102818","article-title":"Targeting autophagy in doxorubicin-induced cardiotoxicity: a comprehensive review of scientific landscapes and therapeutic innovations","volume":"110","author":"Wang","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib59","doi-asserted-by":"crossref","first-page":"W356","DOI":"10.1093\/nar\/gkx374","article-title":"PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib60","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41392-025-02220-z","article-title":"The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications","volume":"10","author":"Wang","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib61","doi-asserted-by":"crossref","first-page":"7434","DOI":"10.3390\/ijms25137434","article-title":"3D-QSAR, scaffold hopping, virtual screening, and molecular dynamics simulations of pyridin-2-one as mIDH1 inhibitors","volume":"25","author":"Wang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib62","article-title":"Cerium oxide doped prussian blue nanoparticles for targeted modulation of the myocardial injury microenvironment and theranostics of doxorubicin-induced cardiomyopathy","volume":"21","author":"Wang","year":"2025","journal-title":"Small"},{"key":"10.1016\/j.compbiolchem.2026.109274_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2026.117745","article-title":"Cellular crosstalk in doxorubicin-induced cardiotoxicity: underlying mechanisms and therapeutic strategies","volume":"247","author":"Wei","year":"2026","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103157","article-title":"Inhibition of METTL3 ameliorates doxorubicin-induced cardiotoxicity through suppression of TFRC-mediated ferroptosis","volume":"72","author":"Wu","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib65","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3923\/ijp.2025.64.77","article-title":"Network pharmacology and molecular docking study on the pharmacological mechanism of verbascoside for the treatment of high-altitude renal disease","volume":"21","author":"Xiao","year":"2025","journal-title":"Int. J. Pharmacol."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib66","article-title":"Sauchinone preserves cardiac function in doxorubicin-induced cardiomyopathy by inhibiting the NLRP3 inflammasome","volume":"140","author":"Xin","year":"2025","journal-title":"Phytomedicine Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib67","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.7150\/ijbs.115489","article-title":"Cardiomyocyte GSDME drives doxorubicin-induced cardiotoxicity by targeting the CCL2-CCR2 axis","volume":"21","author":"Xue","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib68","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13059-020-1950-6","article-title":"Decontamination of ambient RNA in single-cell RNA-seq with DecontX","volume":"21","author":"Yang","year":"2020","journal-title":"Genome Biol."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib69","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics J. Integr. Biol."},{"key":"10.1016\/j.compbiolchem.2026.109274_bib70","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/bioinformatics\/btu684","article-title":"DOSE: an R\/bioconductor package for disease ontology semantic and enrichment analysis","volume":"31","author":"Yu","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.compbiolchem.2026.109274_bib71","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1186\/s12967-025-06490-7","article-title":"Identifying disease progression biomarkers in metabolic associated steatotic liver disease (MASLD) through weighted gene co-expression network analysis and machine learning","volume":"23","author":"Zhang","year":"2025","journal-title":"J. Transl. Med."}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126004019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126004019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:47:13Z","timestamp":1793148433000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927126004019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":71,"alternative-id":["S1476927126004019"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109274","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study on the potential role of KIF23 in doxorubicin-induced cardiomyopathy through multi-omics integration and AI-based screening","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109274","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109274"}}