{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:33:12Z","timestamp":1793151192691,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.compbiolchem.2026.109297","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:24:06Z","timestamp":1785770646000},"page":"109297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A machine learning-derived aging-related gene signature for diagnosing HCV cirrhosis: Insights into immune microenvironment and therapeutic targets"],"prefix":"10.1016","volume":"125","author":[{"given":"Yueping","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijing","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoye","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.compbiolchem.2026.109297_bib1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jhep.2013.09.006","article-title":"Expression of HLA-G by mast cells is associated with hepatitis C virus-induced liver fibrosis","volume":"60","author":"Amiot","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.compbiolchem.2026.109297_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"gene Ontol. Consort. Nat. Genet."},{"key":"10.1016\/j.compbiolchem.2026.109297_bib3","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3390\/cells8040376","article-title":"Hepatitis C virus infection: host\u2013virus interaction and mechanisms of viral persistence","volume":"8","author":"Chigbu","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.compbiolchem.2026.109297_bib4","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nature13193","article-title":"The role of senescent cells in ageing","volume":"509","author":"van Deursen","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.compbiolchem.2026.109297_bib5","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/nature04078","article-title":"Evasion of intracellular host defence by hepatitis C virus","volume":"436","author":"Gale","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.compbiolchem.2026.109297_bib6","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1093\/infdis\/jiw457","article-title":"Direct-acting antiviral-induced hepatitis C virus clearance does not completely restore the altered cytokine and chemokine milieu in patients with chronic hepatitis C","volume":"214","author":"Hengst","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.compbiolchem.2026.109297_bib7","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S2468-1253(25)00068-8","article-title":"A 2024 global report on national policies, programmes, and progress towards hepatitis C elimination: findings from 33 hepatitis elimination profiles","volume":"10","author":"Hiebert-Suwondo","year":"2025","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.compbiolchem.2026.109297_bib8","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.4254\/wjh.v9.i36.1305","article-title":"Molecular basis of hepatocellular carcinoma induced by hepatitis C virus infection","volume":"9","author":"Irshad","year":"2017","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.compbiolchem.2026.109297_bib9","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0140-6736(22)01468-4","article-title":"Hepatitis B","volume":"401","author":"Jeng","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.compbiolchem.2026.109297_bib10","doi-asserted-by":"crossref","first-page":"D672","DOI":"10.1093\/nar\/gkae909","article-title":"KEGG: biological systems database as a model of the real world","volume":"53","author":"Kanehisa","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109297_bib11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.compbiolchem.2026.109297_bib12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf"},{"key":"10.1016\/j.compbiolchem.2026.109297_bib13","article-title":"The role of enhanced expression of Cx43 in patients with ulcerative colitis","volume":"19","author":"Liu","year":"2024","journal-title":"Open. Med. (Wars. Pol. )"},{"key":"10.1016\/j.compbiolchem.2026.109297_bib14","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1038\/s41467-021-22756-2","article-title":"Permutation-based identification of important biomarkers for complex diseases via machine learning models","volume":"12","author":"Mi","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.compbiolchem.2026.109297_bib15","doi-asserted-by":"crossref","unstructured":"Morisco, F., Federico, A., Marignani, M., Lombardo, F.L., Cossiga, V., De Conte, A., Romeo, M., Cipullo, M., Begini, P., Gioli, F., Stroffolini, T., 2024. Liver-related outcomes in patients with HCV compensated liver cirrhosis after SVR: results from 5-years of follow-up. Dig. Liver Dis., Abstracts of the 56th A.I.S.F. - Italian Association for theStudy of the Liver - Annual Meeting 2024Rome, March 14th -15th, 2024 56, S35. https:\/\/doi.org\/10.1016\/j.dld.2024.01.055.","DOI":"10.1016\/j.dld.2024.01.055"},{"key":"10.1016\/j.compbiolchem.2026.109297_bib16","first-page":"3","article-title":"Hepatitis C virus, inflammation, and cellular aging: turning back time","volume":"25","author":"Naggie","year":"2017","journal-title":"Top. Antivir. Med."},{"key":"10.1016\/j.compbiolchem.2026.109297_bib17","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1038\/s41467-025-58568-x","article-title":"Preclinical concept studies showing advantage of an inhaled anti-CTGF\/CCN2 protein for pulmonary fibrosis treatment","volume":"16","author":"Neiens","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.compbiolchem.2026.109297_bib18","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.compbiolchem.2026.109297_bib19","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41596-018-0103-9","article-title":"Pathway enrichment analysis and visualization of omics data using g:profiler, GSEA, cytoscape and enrichmentmap","volume":"14","author":"Reimand","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.compbiolchem.2026.109297_bib20","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.3390\/cancers13092270","article-title":"Molecular crosstalk between the hepatitis C virus and the extracellular matrix in liver fibrogenesis and early carcinogenesis","volume":"13","author":"Reungoat","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.compbiolchem.2026.109297_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.712105","article-title":"Chronic hepatitis C pathogenesis: immune response in the liver microenvironment and peripheral compartment","volume":"11","author":"Rios","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.compbiolchem.2026.109297_bib22","doi-asserted-by":"crossref","first-page":"a037101","DOI":"10.1101\/cshperspect.a037101","article-title":"Control of HCV infection by natural killer cells and macrophages","volume":"10","author":"Rosen","year":"2020","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.compbiolchem.2026.109297_bib23","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s40265-020-01458-x","article-title":"Strategies targeting the innate immune response for the treatment of hepatitis C virus-associated liver fibrosis","volume":"81","author":"Sepulveda-Crespo","year":"2021","journal-title":"Drugs"},{"key":"10.1016\/j.compbiolchem.2026.109297_bib24","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.pharmthera.2017.10.009","article-title":"Direct antiviral agents (DAAs) - a new age in the treatment of hepatitis C virus infection","volume":"183","author":"Spengler","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.compbiolchem.2026.109297_bib25","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S2468-1253(20)30249-1","article-title":"Hepatocellular carcinoma incidence with tenofovir versus entecavir in chronic hepatitis B: a systematic review and meta-analysis","volume":"5","author":"Tseng","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.compbiolchem.2026.109297_bib26","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/s41580-024-00727-x","article-title":"The senescence-associated secretory phenotype and its physiological and pathological implications","volume":"25","author":"Wang","year":"2024","journal-title":"Nat. Rev. Mol. Cell. Biol."}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147692712600424X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147692712600424X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:45:15Z","timestamp":1793148315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147692712600424X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":26,"alternative-id":["S147692712600424X"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109297","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A machine learning-derived aging-related gene signature for diagnosing HCV cirrhosis: Insights into immune microenvironment and therapeutic targets","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109297","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109297"}}