{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:32:55Z","timestamp":1793151175256,"version":"4.5.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020374","name":"Ministry of AYUSH, Government of India","doi-asserted-by":"publisher","award":["S-12011\/5\/2018-SCHEME(COE)"],"award-info":[{"award-number":["S-12011\/5\/2018-SCHEME(COE)"]}],"id":[{"id":"10.13039\/100020374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.compbiolchem.2026.109357","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:43:35Z","timestamp":1787701415000},"page":"109357","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Phytochemical profiling and mechanistic insights into the anxiolytic potential of Sphaeranthus indicus Linn.: A network pharmacology, molecular docking and simulation approach"],"prefix":"10.1016","volume":"125","author":[{"given":"Sumedh","family":"Joshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Koulgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Aher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manali","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Ghildiyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanuja Manoj","family":"Nesari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109357_bib1","doi-asserted-by":"crossref","DOI":"10.1093\/pcp\/pcr165","article-title":"KNApSAcK family databases: integrated metabolite-plant species databases for multifaceted plant research","volume":"53","author":"Afendi","year":"2012","journal-title":"Plant. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109357_bib2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4103\/0253-7613.27021","article-title":"Pharmacological evaluation of the extracts of Sphaeranthus indicus flowers on anxiolytic activity in mice","volume":"38","author":"Ambavade","year":"2006","journal-title":"Indian. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109357_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Gene Ontol. Consort. Nat. Genet."},{"key":"10.1016\/j.compbiolchem.2026.109357_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110702","article-title":"An update on \u03b2-sitosterol: a potential herbal nutraceutical for diabetic management","volume":"131","author":"Babu","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109357_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.31887\/DCNS.2015.17.3\/bbandelow","article-title":"Epidemiology of anxiety disorders in the 21st century","volume":"17","author":"Bandelow","year":"2015","journal-title":"Dialog.-. Clin. Neurosci."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109357_bib6","first-page":"139","article-title":"Systemic review of medicinal plants used for the treatment of anxiety","volume":"11","author":"Banu","year":"2024","journal-title":"Eur. J. Pharm. Med. Res."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109357_bib7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B Stat. Methodol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109357_bib8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109357_bib9","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/jcc.21287","article-title":"CHARMM: the biomolecular simulation program","volume":"30","author":"Brooks","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.compbiolchem.2026.109357_bib10","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1021\/acs.jcim.3c01153","article-title":"AmberTools","volume":"63","author":"Case","year":"2023","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.compbiolchem.2026.109357_bib11","doi-asserted-by":"crossref","first-page":"7835","DOI":"10.1021\/acs.jcim.5c01063","article-title":"Recent Developments in Amber Biomolecular Simulations","volume":"65","author":"Case","year":"2025","journal-title":"J. Chem. Inf. Model."},{"issue":"24","key":"10.1016\/j.compbiolchem.2026.109357_bib12","first-page":"10729","article-title":"Crystal structures of human acetylcholinesterase in complex with inhibitor and transition-state analogs","volume":"55","author":"Cheung","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.compbiolchem.2026.109357_bib13","series-title":"StatPearls [Internet]","article-title":"Selective serotonin reuptake inhibitors","author":"Chu","year":"2023"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109357_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd2760","article-title":"Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders","volume":"8","author":"Conn","year":"2009","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.compbiolchem.2026.109357_bib15","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.neuroscience.2011.10.045","article-title":"Distribution of dopamine D2-like receptors in the rat amygdala and their role in unconditioned anxiety","volume":"201","author":"de la Mora","year":"2012","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109357_bib16","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.pneurobio.2009.10.010","article-title":"Role of dopamine receptor mechanisms in the amygdaloid modulation of fear and anxiety: structural and functional analysis","volume":"90","author":"de la Mora","year":"2010","journal-title":"Prog. Neurobiol."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109357_bib17","first-page":"133","article-title":"Generalized anxiety disorder and panic disorder in adults: diagnosis and management","volume":"106","author":"DeGeorge","year":"2022","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.compbiolchem.2026.109357_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.608520","article-title":"Dopaminergic system alteration in anxiety and compulsive disorders: a systematic review of neuroimaging studies","volume":"14","author":"Dong","year":"2020","journal-title":"Front. Neurosci."},{"issue":"18","key":"10.1016\/j.compbiolchem.2026.109357_bib19","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.2174\/138161210791293051","article-title":"Using functional neuroimaging to investigate the mechanisms of action of selective serotonin reuptake inhibitors (SSRIs)","volume":"16","author":"E. Murphy","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.compbiolchem.2026.109357_bib20","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109357_bib21","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3390\/neurolint13030038","article-title":"Selective serotonin reuptake inhibitors and adverse effects: a narrative review","volume":"13","author":"Edinoff","year":"2021","journal-title":"Neurol. Int."},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.109357_bib22","first-page":"307","article-title":"Psychotropic activity of Sphaeranthus indicus Linn. in experimental animals","volume":"1","author":"Galani","year":"2009","journal-title":"Pharmacogn. Res."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109357_bib23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4103\/0974-7788.64412","article-title":"Effect of hydroalcoholic extract of Sphaeranthus indicus against experimentally induced anxiety, depression and convulsions in rodents","volume":"1","author":"Galani","year":"2010","journal-title":"Int. J. Ayurveda Res."},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109357_bib24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.4103\/0974-7788.76790","article-title":"Sphaeranthus indicus Linn.: a phytopharmacological review","volume":"1","author":"Galani","year":"2010","journal-title":"Int. J. Ayurveda Res."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109357_bib25","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/10253890.2010.521602","article-title":"Eugenol as an anti-stress agent: modulation of hypothalamic\u2013pituitary\u2013adrenal axis and brain monoaminergic systems in a rat model of stress","volume":"14","author":"Garabadu","year":"2011","journal-title":"Stress"},{"key":"10.1016\/j.compbiolchem.2026.109357_bib26","series-title":"Computational Methods in Medicinal Chemistry, Pharmacology, and Toxicology","first-page":"153","article-title":"Computational techniques for enhancing PK\/PD modeling and simulation and ADMET prediction","author":"Ghani","year":"2025"},{"key":"10.1016\/j.compbiolchem.2026.109357_bib27","first-page":"37","article-title":"The Study on Sphaeranthus Indicus","volume":"11","author":"Girase","year":"2024"},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109357_bib28","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cbpa.2011.02.021","article-title":"The role of computational methods in the identification of bioactive compounds","volume":"15","author":"Glick","year":"2011","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"7","key":"10.1016\/j.compbiolchem.2026.109357_bib29","doi-asserted-by":"crossref","first-page":"632","DOI":"10.2174\/092986607781483831","article-title":"ParDOCK: an all atom energy based Monte Carlo docking protocol for protein-ligand complexes","volume":"14","author":"Gupta","year":"2007","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.compbiolchem.2026.109357_bib30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1201\/9781003256830-8","article-title":"An Overview of Traditional Uses and Pharmacological Profile of Sphaeranthus indicus","author":"Gupta","year":"2023","journal-title":"Aquat. Med. Plants"},{"key":"10.1016\/j.compbiolchem.2026.109357_bib31","series-title":"The Phytochemical Dictionary: A Handbook of Bioactive Compounds from Plants","author":"Harborne","year":"1999"},{"issue":"11","key":"10.1016\/j.compbiolchem.2026.109357_bib32","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio.118","article-title":"Network pharmacology: the next paradigm in drug discovery","volume":"4","author":"Hopkins","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.compbiolchem.2026.109357_bib33","article-title":"DisGeNet: a disease-centric interaction database among diseases and various associated genes","volume":"2025","author":"Hu","year":"2025","journal-title":"Database (Oxf. )"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109357_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"S1","key":"10.1016\/j.compbiolchem.2026.109357_bib35","doi-asserted-by":"crossref","first-page":"71","DOI":"10.31024\/ajpp.2019.5.s1.10","article-title":"Sphaeranthus indicus enhances memory and protects against amnesia in rodent models","volume":"5","author":"Jain","year":"2019","journal-title":"Asian J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109357_bib36","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s43045-023-00315-3","article-title":"Epidemiology of anxiety disorders: global burden and sociodemographic associations","volume":"30","author":"Javaid","year":"2023","journal-title":"Middle East. Curr. Psychiatry"},{"key":"10.1016\/j.compbiolchem.2026.109357_bib37","article-title":"Anxiolytic efficacy of Sphaeranthus indicus Linn Ghana Vati in Generalized Anxiety Disorder: A randomized, placebo-controlled trial","volume":"10","author":"Joshi","year":"2025","journal-title":"Brain Behav. Immun. Integr."},{"key":"10.1016\/j.compbiolchem.2026.109357_bib38","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.abst.2026.03.001","article-title":"Experimental evaluation of anxiolytic and anti-amnestic activities of aqueous and hydroalcoholic extracts of Sphaeranthus indicus L. (Mundi) in Swiss albino mice","volume":"8","author":"Joshi","year":"2026","journal-title":"Advances in Biomarker Sciences and Technology"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109357_bib39","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"Goto S. KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109357_bib40","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1038\/s41598-018-22631-z","article-title":"IMPPAT: A curated database of Indian Medicinal Plants, Phytochemistry And Therapeutics","volume":"8","author":"Karthikeyan","year":"2018","journal-title":"Sci. Rep."},{"issue":"D1","key":"10.1016\/j.compbiolchem.2026.109357_bib41","doi-asserted-by":"crossref","first-page":"D1516","DOI":"10.1093\/nar\/gkae1059","article-title":"PubChem 2025 update","volume":"53","author":"Kim","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109357_bib42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13321-018-0285-8","article-title":"P2Rank: machine learning based tool for rapid and accurate prediction of ligand binding sites from protein structure","volume":"10","author":"Kriv\u00e1k","year":"2018","journal-title":"J. Chemin.-."},{"issue":"W1","key":"10.1016\/j.compbiolchem.2026.109357_bib43","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109357_bib44","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1021\/acs.jctc.5b00935","article-title":"CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM\/OpenMM Simulations using the CHARMM36 Additive Force Field","volume":"12","author":"Lee","year":"2016","journal-title":"J. Chem. Theory Comput."},{"issue":"D1","key":"10.1016\/j.compbiolchem.2026.109357_bib45","doi-asserted-by":"crossref","first-page":"D1633","DOI":"10.1093\/nar\/gkae1075","article-title":"BindingDB in 2024: a FAIR knowledgebase of protein-small molecule binding data","volume":"53","author":"Liu","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109357_bib46","first-page":"229","article-title":"Pharmacotherapy for anxiety disorders: from first-line options to treatment resistance","volume":"19","author":"Melaragno","year":"2021","journal-title":"Focus. (Am. Psychiatr. Publ. )"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109357_bib47","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/npp.2016.146","article-title":"Inflammation in fear- and anxiety-based disorders: PTSD, GAD, and beyond","volume":"42","author":"Michopoulos","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"18","key":"10.1016\/j.compbiolchem.2026.109357_bib48","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.2174\/138161210791293051","article-title":"Using functional neuroimaging to investigate the mechanisms of action of selective serotonin reuptake inhibitors (SSRIs)","volume":"16","author":"Murphy","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.compbiolchem.2026.109357_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/2497354","article-title":"Pharmacological properties and health benefits of eugenol: a comprehensive review","volume":"2021","author":"Nisar","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109357_bib50","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/pro.3978","article-title":"The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions","volume":"30","author":"Oughtred","year":"2021","journal-title":"Protein Sci."},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.109357_bib51","article-title":"\u03b2-sitosterol reduces anxiety and synergizes with established anxiolytic drugs in mice","volume":"2","author":"Panayotis","year":"2021","journal-title":"Cell. Rep. Med."},{"issue":"13","key":"10.1016\/j.compbiolchem.2026.109357_bib52","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera--a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"issue":"28","key":"10.1016\/j.compbiolchem.2026.109357_bib53","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.2174\/0929867325666180226102358","article-title":"RAS in the central nervous system: potential role in neuropsychiatric disorders","volume":"25","author":"Rocha","year":"2018","journal-title":"Curr. Med. Chem."},{"issue":"W1","key":"10.1016\/j.compbiolchem.2026.109357_bib54","doi-asserted-by":"crossref","first-page":"W463","DOI":"10.1093\/nar\/gkaf361","article-title":"PLIP 2025: introducing protein\u2013protein interactions to the protein\u2013ligand interaction profiler","volume":"53","author":"Schake","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.compbiolchem.2026.109357_bib55","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.compbiolchem.2026.109357_bib56","doi-asserted-by":"crossref","first-page":"203","DOI":"10.61554\/ijnrph.v2i2.2024.129","article-title":"Anxiolytics: An In-Depth Review of Contemporary and Emerging Treatment Approaches","author":"Singhal","year":"2024","journal-title":"Int. J. Newgen Res. Pharm. & Healthc."},{"key":"10.1016\/j.compbiolchem.2026.109357_bib57","doi-asserted-by":"crossref","DOI":"10.1590\/1519-6984.251219","article-title":"Eugenol and its liposome-based nano carrier reduce anxiety by inhibiting glyoxalase-1 expression in mice","volume":"83","author":"Siyal","year":"2023","journal-title":"Braz. J. Biol."},{"issue":"10","key":"10.1016\/j.compbiolchem.2026.109357_bib58","first-page":"942","article-title":"Anxiety disorders: a review of diagnosis, pathophysiology, and treatment","volume":"328","author":"Szuhany","year":"2022","journal-title":"JAMA"},{"issue":"15","key":"10.1016\/j.compbiolchem.2026.109357_bib59","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1016\/j.bmc.2005.04.081","article-title":"Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity","volume":"13","author":"Tao","year":"2005","journal-title":"Bioorg. Med. Chem."},{"issue":"D1","key":"10.1016\/j.compbiolchem.2026.109357_bib60","doi-asserted-by":"crossref","first-page":"D325","DOI":"10.1093\/nar\/gkaa1113","article-title":"The Gene Ontology resource: enriching a GOld mine","volume":"49","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109357_bib61","first-page":"44","article-title":"Phytochemical and Pharmacological Potential of Sphaeranthus Indicus Linn","volume":"4","author":"Tiwari","year":"2024"},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109357_bib62","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109357_bib63","doi-asserted-by":"crossref","first-page":"9799","DOI":"10.1038\/s41598-024-58877-z","article-title":"Network pharmacology combined with molecular docking and experimental verification to elucidate the effect of flavan-3-ols and aromatic resin on anxiety","volume":"14","author":"Vikhar Danish Ahmad","year":"2024","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.compbiolchem.2026.109357_bib64","first-page":"1451","article-title":"[Review on anxiolytic effect of natural small-molecule phenols]","volume":"52","author":"Wang","year":"2017","journal-title":"Yao Xue Xue Bao"},{"key":"10.1016\/j.compbiolchem.2026.109357_bib65","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"10.1016\/j.compbiolchem.2026.109357_bib66","first-page":"591","article-title":"The modulatory role of dopamine in anxiety-like behavior","volume":"18","author":"Zarrindast","year":"2015","journal-title":"Arch. Iran. Med."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109357_bib67","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13321-025-00963-z","article-title":"Fifteen years of ChEMBL and its role in cheminformatics and drug discovery","volume":"17","author":"Zdrazil","year":"2025","journal-title":"J. Chemin.-."},{"issue":"7","key":"10.1016\/j.compbiolchem.2026.109357_bib68","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3390\/md14070123","article-title":"Structural features and potent antidepressant effects of total sterols and \u03b2-sitosterol from Sargassum horneri in mice","volume":"14","author":"Zhao","year":"2016","journal-title":"Mar. Drugs"}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126004846?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126004846?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:44:20Z","timestamp":1793148260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927126004846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":68,"alternative-id":["S1476927126004846"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109357","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phytochemical profiling and mechanistic insights into the anxiolytic potential of Sphaeranthus indicus Linn.: A network pharmacology, molecular docking and simulation approach","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109357","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109357"}}