{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:05:53Z","timestamp":1790762753486,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.compbiolchem.2026.109400","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:29:15Z","timestamp":1788881355000},"page":"109400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Integrative network toxicology and virtual knockout analysis suggest TSNA-associated molecular features in large cell neuroendocrine carcinoma"],"prefix":"10.1016","volume":"126","author":[{"given":"Zhe","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuzhe","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.compbiolchem.2026.109400_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib2","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1158\/0008-5472.CAN-05-3757","article-title":"Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor","volume":"66","author":"Alvarez","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000788","article-title":"Deciphering diseases and biological targets for environmental chemicals using toxicogenomics networks","volume":"6","author":"Audouze","year":"2010","journal-title":"PLoS. Comput. Biol."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3389\/fimmu.2014.00276","article-title":"Th17 cells in cancer: the ultimate identity crisis","volume":"5","author":"Bailey","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrg2918","article-title":"Network medicine: a network-based approach to human disease","volume":"12","author":"Barab\u00e1si","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nrc1799","article-title":"Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?","volume":"6","author":"Baylin","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib7","article-title":"Dimensionality reduction for visualizing single-cell data using UMAP","author":"Becht","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib8","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1021\/jm100112j","article-title":"A medicinal chemist's guide to molecular interactions","volume":"53","author":"Bissantz","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib9","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/35077225","article-title":"Oncogenic kinase signalling","volume":"411","author":"Blume-Jensen","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib10","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1038\/s41598-017-02317-8","article-title":"E-cigarettes induce toxicological effects that can raise the cancer risk","volume":"7","author":"Canistro","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.immuni.2013.07.012","article-title":"Oncology meets immunology: the cancer-immunity cycle","volume":"39","author":"Chen","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib12","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1021\/ci300367a","article-title":"admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties","volume":"52","author":"Cheng","year":"2012","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib13","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib14","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.15585\/mmwr.mm6745a5","article-title":"Notes from the Field: Use of Electronic Cigarettes and Any Tobacco Product Among Middle and High School Students - United States, 2011-2018","volume":"67","author":"Cullen","year":"2018","journal-title":"MMWR Morb. Mortal. Wkly Rep."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib16","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.bbapap.2009.12.010","article-title":"Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer","volume":"1804","author":"Eck","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib17","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nrc2664","article-title":"Targeting PI3K signalling in cancer: opportunities, challenges and limitations","volume":"9","author":"Engelman","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib18","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/35077213","article-title":"Proliferation, cell cycle and apoptosis in cancer","volume":"411","author":"Evan","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib19","doi-asserted-by":"crossref","first-page":"9046","DOI":"10.3390\/ijerph120809046","article-title":"Tobacco-Specific Nitrosamines in Electronic Cigarettes: Comparison between Liquid and Aerosol Levels","volume":"12","author":"Farsalinos","year":"2015","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib20","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/JTO.0000000000000589","article-title":"Pulmonary Large-Cell Neuroendocrine Carcinoma: From Epidemiology to Therapy","volume":"10","author":"Fasano","year":"2015","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib21","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1126\/science.1749933","article-title":"The energy landscapes and motions of proteins","volume":"254","author":"Frauenfelder","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib22","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nrc3245","article-title":"The immune contexture in human tumours: impact on clinical outcome","volume":"12","author":"Fridman","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib23","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.cell.2017.07.029","article-title":"The PI3K Pathway in Human Disease","volume":"170","author":"Fruman","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib24","doi-asserted-by":"crossref","first-page":"D1100","DOI":"10.1093\/nar\/gkr777","article-title":"ChEMBL: a large-scale bioactivity database for drug discovery","volume":"40","author":"Gaulton","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib25","doi-asserted-by":"crossref","first-page":"8685","DOI":"10.1073\/pnas.0701361104","article-title":"The human disease network","volume":"104","author":"Goh","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/tobaccocontrol-2012-050859","article-title":"Levels of selected carcinogens and toxicants in vapour from electronic cigarettes","volume":"23","author":"Goniewicz","year":"2014","journal-title":"Tob. Control."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib27","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib28","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib29","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.cell.2015.11.015","article-title":"High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities","volume":"163","author":"Hart","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib30","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nrc1190","article-title":"Tobacco carcinogens, their biomarkers and tobacco-induced cancer","volume":"3","author":"Hecht","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib31","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1056\/NEJMra023075","article-title":"Gene silencing in cancer in association with promoter hypermethylation","volume":"349","author":"Herman","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib32","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/35077232","article-title":"Genome maintenance mechanisms for preventing cancer","volume":"411","author":"Hoeijmakers","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib33","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio.118","article-title":"Network pharmacology: the next paradigm in drug discovery","volume":"4","author":"Hopkins","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib34","first-page":"37","article-title":"Molecular dynamics simulations: advances and applications","volume":"8","author":"Hospital","year":"2015","journal-title":"Adv. Appl. Bioinform Chem."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib35","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1021\/acs.chemrestox.1c00417","article-title":"Influence of Nitrite on Formation of Tobacco-Specific Nitrosamines in Electronic Cigarette Liquids and Aerosols","volume":"35","author":"Jin","year":"2022","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib36","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S2213-2600(15)00521-4","article-title":"E-cigarettes and smoking cessation in real-world and clinical settings: a systematic review and meta-analysis","volume":"4","author":"Kalkhoran","year":"2016","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib38","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1126\/science.1069492","article-title":"Systems biology: a brief overview","volume":"295","author":"Kitano","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib39","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib40","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/s41591-018-0096-5","article-title":"Phenotype molding of stromal cells in the lung tumor microenvironment","volume":"24","author":"Lambrechts","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib41","first-page":"E1560","article-title":"E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells","volume":"115","author":"Lee","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib42","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.cell.2010.06.011","article-title":"Cell signaling by receptor tyrosine kinases","volume":"141","author":"Lemmon","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib43","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1056\/NEJMoa040938","article-title":"Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib","volume":"350","author":"Lynch","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib44","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.envpol.2014.10.013","article-title":"Aerosol deposition doses in the human respiratory tree of electronic cigarette smokers","volume":"196","author":"Manigrasso","year":"2015","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib45","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib46","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends Immunol."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib47","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1021\/acs.chemrestox.6b00188","article-title":"Chemical Composition of Aerosol from an E-Cigarette: A Quantitative Comparison with Cigarette Smoke","volume":"29","author":"Margham","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib48","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nrc3090","article-title":"Cyclin D as a therapeutic target in cancer","volume":"11","author":"Musgrove","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib49","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib50","article-title":"scTenifoldKnk: An efficient virtual knockout tool for gene function predictions via single-cell gene regulatory network perturbation","volume":"3","author":"Osorio","year":"2022","journal-title":"Patterns (N. Y)"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib51","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fendo.2015.00025","article-title":"IGF-Binding Protein 2 - Oncogene or Tumor Suppressor?","volume":"6","author":"Pickard","year":"2015","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib52","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkw943","article-title":"DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants","volume":"45","author":"Pi\u00f1ero","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib53","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib54","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrc2590","article-title":"Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?","volume":"9","author":"Schuller","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib55","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10822-010-9352-6","article-title":"Ligand docking and binding site analysis with PyMOL and Autodock\/Vina","volume":"24","author":"Seeliger","year":"2010","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib56","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib57","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1126\/science.aaa8172","article-title":"The future of immune checkpoint therapy","volume":"348","author":"Sharma","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib58","doi-asserted-by":"crossref","first-page":"9644","DOI":"10.1021\/acs.est.6b01741","article-title":"Emissions from Electronic Cigarettes: Key Parameters Affecting the Release of Harmful Chemicals","volume":"50","author":"Sleiman","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib59","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1089\/jamp.2015.1268","article-title":"Predicted Deposition of E-Cigarette Aerosol in the Human Lungs","volume":"29","author":"Sosnowski","year":"2016","journal-title":"J. Aerosol Med. Pulm. Drug. Deliv."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib60","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1021\/tx400410s","article-title":"Systems toxicology: from basic research to risk assessment","volume":"27","author":"Sturla","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib61","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nrc1189","article-title":"Cancer chemoprevention with dietary phytochemicals","volume":"3","author":"Surh","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib62","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biosystems.2014.11.005","article-title":"CytoNCA: a cytoscape plugin for centrality analysis and evaluation of protein interaction networks","volume":"127","author":"Tang","year":"2015","journal-title":"Biosystems"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib63","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41571-019-0266-5","article-title":"The emerging role of epigenetic therapeutics in immuno-oncology","volume":"17","author":"Topper","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib64","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1097\/JTO.0000000000000630","article-title":"The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification","volume":"10","author":"Travis","year":"2015","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib65","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib66","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.cell.2011.02.016","article-title":"Interactome networks and human disease","volume":"144","author":"Vidal","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib67","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkab255","article-title":"ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties","volume":"49","author":"Xiong","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib68","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/35052073","article-title":"Untangling the ErbB signalling network","volume":"2","author":"Yarden","year":"2001","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.compbiolchem.2026.109400_bib69","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1093\/bioinformatics\/btv313","article-title":"DSigDB: drug signatures database for gene set analysis","volume":"31","author":"Yoo","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.compbiolchem.2026.109400_bib70","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nri1806","article-title":"Regulatory T cells, tumour immunity and immunotherapy","volume":"6","author":"Zou","year":"2006","journal-title":"Nat. Rev. Immunol."}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147692712600527X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147692712600527X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:48:33Z","timestamp":1790761713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147692712600527X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":70,"alternative-id":["S147692712600527X"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109400","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative network toxicology and virtual knockout analysis suggest TSNA-associated molecular features in large cell neuroendocrine carcinoma","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109400","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109400"}}