{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:06:59Z","timestamp":1790762819397,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["2019009"],"award-info":[{"award-number":["2019009"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20240813150201003"],"award-info":[{"award-number":["JCYJ20240813150201003"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20230807110259002"],"award-info":[{"award-number":["JCYJ20230807110259002"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ202205300150417038"],"award-info":[{"award-number":["JCYJ202205300150417038"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005088","name":"Beijing Municipal Health Commission","doi-asserted-by":"publisher","award":["PXM2020_026275_000002"],"award-info":[{"award-number":["PXM2020_026275_000002"]}],"id":[{"id":"10.13039\/501100005088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005088","name":"Beijing Municipal Health Commission","doi-asserted-by":"publisher","award":["BMHC-2019-9"],"award-info":[{"award-number":["BMHC-2019-9"]}],"id":[{"id":"10.13039\/501100005088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005088","name":"Beijing Municipal Health Commission","doi-asserted-by":"publisher","award":["BMHC-2018-4"],"award-info":[{"award-number":["BMHC-2018-4"]}],"id":[{"id":"10.13039\/501100005088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005088","name":"Beijing Municipal Health Commission","doi-asserted-by":"publisher","award":["BMHC-2021-6"],"award-info":[{"award-number":["BMHC-2021-6"]}],"id":[{"id":"10.13039\/501100005088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100029157","name":"Charlotte Martin Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100029157","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001702","name":"AO Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900583"],"award-info":[{"award-number":["31900583"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960395"],"award-info":[{"award-number":["81960395"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20162"],"award-info":[{"award-number":["U22A20162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102604"],"award-info":[{"award-number":["82102604"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071351"],"award-info":[{"award-number":["32071351"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.compbiolchem.2026.109422","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:46:40Z","timestamp":1789688800000},"page":"109422","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Network toxicology, transcriptomics, immune infiltration, and machine learning-based construction of an environmental endocrine disruptor exposure-associated predictive model for osteonecrosis of the femoral head"],"prefix":"10.1016","volume":"126","author":[{"given":"Jiaxiang","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huisheng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiudong","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhikai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manman","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.compbiolchem.2026.109422_bib1","first-page":"1131","article-title":"Para-nonylphenol impairs osteogenic differentiation of rat bone marrow mesenchymal stem cells by influencing the osteoblasts mineralization","volume":"15","author":"Abnosi","year":"2012","journal-title":"Iran. J. Basic. Med. Sci."},{"issue":"9","key":"10.1016\/j.compbiolchem.2026.109422_bib2","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1093\/emboj\/20.9.2254","article-title":"TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation","volume":"20","author":"Alliston","year":"2001","journal-title":"EMBO J."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109422_bib3","first-page":"850","article-title":"Expression of microRNA\u201127a in a rat model of osteonecrosis of the femoral head and its association with TGF\u2011\u03b2\/Smad7 signalling in osteoblasts","volume":"43","author":"Bai","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.compbiolchem.2026.109422_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.130013","article-title":"Occurrence, potential ecological risks, and degradation of endocrine disrupter, nonylphenol, from the aqueous environment","volume":"275","author":"Bhandari","year":"2021","journal-title":"Chemosphere"},{"issue":"10s1","key":"10.1016\/j.compbiolchem.2026.109422_bib5","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1016\/j.arth.2025.06.002","article-title":"Epidemiology, management, and systematic review of surgical trends for patients who have osteonecrosis of the femoral head","volume":"40","author":"Buddhiraju","year":"2025","journal-title":"J. Arthroplast."},{"key":"10.1016\/j.compbiolchem.2026.109422_bib6","first-page":"28","article-title":"Evolutionary course of the femoral head osteonecrosis: histopathological - radiologic characteristics and clinical staging systems","volume":"32","author":"Chen","year":"2022","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.compbiolchem.2026.109422_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9915877","article-title":"Extracorporeal shockwave therapy modulates the expressions of proinflammatory cytokines IL33 and IL17A, and their receptors ST2 and IL17RA, within the articular cartilage in early avascular necrosis of the femoral head in a rat model","volume":"2021","author":"Cheng","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.compbiolchem.2026.109422_bib8","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ecoenv.2019.06.009","article-title":"Occurrence, fate and toxic effects of the industrial endocrine disrupter, nonylphenol, on plants - a review","volume":"181","author":"de Bruin","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109422_bib9","first-page":"671","article-title":"Involvement of endothelial PECAM-1\/CD31 in angiogenesis","volume":"151","author":"DeLisser","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.compbiolchem.2026.109422_bib10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mrgentox.2014.07.003","article-title":"DNA damage in organs of female and male mice exposed to nonylphenol, as a single agent or in combination with ionizing irradiation: a comet assay study","volume":"772","author":"Dobrzy\u0144ska","year":"2014","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109422_bib11","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/s13287-022-03027-3","article-title":"C\/EBP\u03b1 regulates the fate of bone marrow mesenchymal stem cells and steroid-induced avascular necrosis of the femoral head by targeting the PPAR\u03b3 signalling pathway","volume":"13","author":"Duan","year":"2022","journal-title":"Stem Cell. Res. & Ther."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109422_bib12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s13018-020-01688-5","article-title":"MiR-596 inhibits osteoblastic differentiation and cell proliferation by targeting Smad3 in steroid-induced osteonecrosis of femoral head","volume":"15","author":"Fu","year":"2020","journal-title":"J. Orthop. Surg. Res."},{"issue":"11","key":"10.1016\/j.compbiolchem.2026.109422_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10112236","article-title":"Endocrine disrupting compounds (Nonylphenol and Bisphenol A)-sources, harmfulness and laccase-assisted degradation in the aquatic environment","volume":"10","author":"Ga\u0142\u0105zka","year":"2022","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109422_bib14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3892\/ijmm_00000444","article-title":"Expression profile of matrix metalloproteinase-2 and -9 and their endogenous tissue inhibitors in osteonecrotic femoral heads","volume":"26","author":"Gr\u00e4ssel","year":"2010","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.compbiolchem.2026.109422_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.777697","article-title":"Steroid-induced osteonecrosis of the femoral head: novel insight into the roles of bone endothelial cells in pathogenesis and treatment","volume":"9","author":"Huang","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109422_bib16","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1038\/s41467-024-48255-8","article-title":"Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow","volume":"15","author":"Huang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.compbiolchem.2026.109422_bib17","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ecoenv.2018.05.065","article-title":"A network biology-based approach to evaluating the effect of environmental contaminants on human interactome and diseases","volume":"160","author":"Iida","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"9","key":"10.1016\/j.compbiolchem.2026.109422_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24098263","article-title":"Endocrine disruptor-induced bone damage due to hormone dysregulation: a review","volume":"24","author":"Iwobi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109422_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/toxics10020099","article-title":"Nonylphenol polyethoxylates enhance adipose deposition in developmentally exposed zebrafish","volume":"10","author":"Kassotis","year":"2022","journal-title":"Toxics"},{"issue":"3-5","key":"10.1016\/j.compbiolchem.2026.109422_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jsbmb.2009.02.007","article-title":"Glucocorticoids in osteonecrosis of the femoral head: a new understanding of the mechanisms of action","volume":"114","author":"Kerachian","year":"2009","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.compbiolchem.2026.109422_bib21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.freeradbiomed.2025.08.033","article-title":"Epimedin B attenuates ovariectomy-induced bone loss by suppressing osteoclastogenesis through decreasing ROS production and targeting ESR1","volume":"240","author":"Lai","year":"2025","journal-title":"Free. Radic. Biol. & Med."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109422_bib22","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s12891-023-06342-9","article-title":"Decreased serum MMP-9 levels in patients with nontraumatic osteonecrosis of the femoral head","volume":"24","author":"Li","year":"2023","journal-title":"BMC Musculoskelet. Disord."},{"issue":"7","key":"10.1016\/j.compbiolchem.2026.109422_bib23","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/jbmr.4823","article-title":"Low miR-182-5p expressing extracellular vesicles derived from human bone marrow stromal cells of subjects with steroid-induced osteonecrosis of the femoral head aggravate disease progression","volume":"38","author":"Li","year":"2023","journal-title":"J. Bone Mineral. Res. Off. J. Am. Soc. Bone Mineral. Res."},{"issue":"8","key":"10.1016\/j.compbiolchem.2026.109422_bib24","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.2174\/1570159X18666201119160347","article-title":"The investigation into neurotoxicity mechanisms of nonylphenol: a narrative review","volume":"19","author":"Lotfi","year":"2021","journal-title":"Curr. Neuropharmacol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109422_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-026-03862-5","article-title":"Bisphenol a exposure and major depressive disorder: an integrative analysis combining network toxicology, molecular docking, genetic epidemiology, and transcriptomic validation","volume":"16","author":"Lu","year":"2026","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.compbiolchem.2026.109422_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109762","article-title":"Chronic exposure to nonylphenol induces oxidative stress and liver damage in male zebrafish (Danio rerio): mechanistic insight into cellular energy sensors, lipid accumulation and immune modulation","volume":"351","author":"Mukherjee","year":"2022","journal-title":"Chem. Biol. Interact."},{"issue":"10s1","key":"10.1016\/j.compbiolchem.2026.109422_bib27","doi-asserted-by":"crossref","first-page":"S146","DOI":"10.1016\/j.arth.2025.05.043","article-title":"Increasing prevalence and risk factors for multifocal osteonecrosis in patients who have corticosteroid-associated osteonecrosis of the femoral head: a 15-year multicenter study","volume":"40","author":"Otaka","year":"2025","journal-title":"J. Arthroplast."},{"issue":"7","key":"10.1016\/j.compbiolchem.2026.109422_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22780","article-title":"The mechanism of cytotoxicity of 4-nonylphenol in a human hepatic cell line involves ER-stress, apoptosis, and mitochondrial dysfunction","volume":"35","author":"Paolella","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109422_bib29","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/CS20140714","article-title":"PECAM-1 isoforms, eNOS and endoglin axis in regulation of angiogenesis","volume":"129","author":"Park","year":"2015","journal-title":"Clin. Sci."},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109422_bib30","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1302\/2058-5241.4.180036","article-title":"Osteonecrosis of the femoral head: pathophysiology and current concepts of treatment","volume":"4","author":"Petek","year":"2019","journal-title":"EFORT Open. Rev."},{"key":"10.1016\/j.compbiolchem.2026.109422_bib31","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.envint.2013.10.006","article-title":"Environmental concentration of nonylphenol alters the development of urogenital and visceral organs in avian model","volume":"62","author":"Roig","year":"2014","journal-title":"Environ. Int."},{"issue":"2-3","key":"10.1016\/j.compbiolchem.2026.109422_bib32","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.tox.2011.10.014","article-title":"4-nonylphenol triggers apoptosis and affects 17-\u03b2-estradiol receptors in calvarial osteoblasts","volume":"290","author":"Sabbieti","year":"2011","journal-title":"Toxicology"},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109422_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12030664","article-title":"Unraveling the role of endothelial dysfunction in osteonecrosis of the femoral head: a pathway to new therapies","volume":"12","author":"Shao","year":"2024","journal-title":"Biomedicines"},{"issue":"7","key":"10.1016\/j.compbiolchem.2026.109422_bib34","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.envint.2008.01.004","article-title":"Nonylphenol in the environment: a critical review on occurrence, fate, toxicity and treatment in wastewaters","volume":"34","author":"Soares","year":"2008","journal-title":"Environ. Int."},{"key":"10.1016\/j.compbiolchem.2026.109422_bib35","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ebiom.2016.06.040","article-title":"PPARG post-translational modifications regulate bone formation and bone resorption","volume":"10","author":"Stechschulte","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.compbiolchem.2026.109422_bib36","article-title":"Nuciferine ameliorates steroid-induced osteonecrosis of the femoral head by inhibiting BMSCs ferroptosis via HIF-1\u03b1","volume":"155","author":"Sun","year":"2026","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.109422_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2021.101495","article-title":"Endocrine disrupting chemicals and bone","volume":"35","author":"Turan","year":"2021","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.compbiolchem.2026.109422_bib38","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.gene.2018.05.091","article-title":"The pathogenesis of steroid-induced osteonecrosis of the femoral head: a systematic review of the literature","volume":"671","author":"Wang","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.compbiolchem.2026.109422_bib39","article-title":"Roburic acid inhibits glucocorticoid-induced osteonecrosis of the femoral head associated osteoclast activity via targeting PTP1B","volume":"153","author":"Wang","year":"2026","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.compbiolchem.2026.109422_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1064245","article-title":"The role of immune cells in modulating chronic inflammation and osteonecrosis","volume":"13","author":"Zheng","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109422_bib41","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41413-025-00477-2","article-title":"Advances in the mechanism for steroid-induced osteonecrosis of the femoral head","volume":"14","author":"Zhou","year":"2026","journal-title":"Bone Res."},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109422_bib42","doi-asserted-by":"crossref","first-page":"283","DOI":"10.5603\/EP.a2018.0031","article-title":"Th17 and IL-17 exhibit higher levels in osteonecrosis of the femoral head and have a positive correlation with severity of pain","volume":"69","author":"Zou","year":"2018","journal-title":"Endokrynol. Pol."}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126005499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126005499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:51:12Z","timestamp":1790761872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927126005499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":42,"alternative-id":["S1476927126005499"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109422","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Network toxicology, transcriptomics, immune infiltration, and machine learning-based construction of an environmental endocrine disruptor exposure-associated predictive model for osteonecrosis of the femoral head","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109422","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109422"}}