{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:51:20Z","timestamp":1792036280310,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019446","name":"Medical and Health Science and Technology Development Project of Shandong Province","doi-asserted-by":"publisher","award":["202212010053"],"award-info":[{"award-number":["202212010053"]}],"id":[{"id":"10.13039\/501100019446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.compbiolchem.2026.109478","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:25:30Z","timestamp":1791645930000},"page":"109478","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Integrative multi-omics analysis reveals the PFAS-gut microbiome-FN1 axis in chronic kidney disease: From exposome to therapeutic target"],"prefix":"10.1016","volume":"126","author":[{"given":"Dandan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingya","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3338-7187","authenticated-orcid":false,"given":"Bingling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.compbiolchem.2026.109478_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2025.1675458","article-title":"The gut-kidney axis in chronic kidney disease: mechanisms, microbial metabolites, and microbiome-targeted therapeutics","volume":"12","author":"Alobaidi","year":"2025","journal-title":"Front. Med."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib2","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/ki.2010.71","article-title":"Interferon-alpha and -beta in kidney inflammation","volume":"77","author":"Anders","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The protein data bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib4","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib5","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ieam.258","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins","volume":"7","author":"Buck","year":"2011","journal-title":"Integr. Environ. Assess. Manag."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib6","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib7","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1021\/es062686m","article-title":"Serum concentrations of 11 polyfluoroalkyl compounds in the U.S. population: data from NHANES 1999\u20132000","volume":"41","author":"Calafat","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib8","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1136\/gutjnl-2018-316723","article-title":"Human gut microbiome: hopes, threats and promises","volume":"67","author":"Cani","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.compbiolchem.2026.109478_bib9","article-title":"Association of perfluoroalkyl and polyfluoroalkyl substances with kidney function and chronic kidney disease: the Gen3G study","volume":"176","author":"Cardenas","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib10","doi-asserted-by":"crossref","first-page":"D165","DOI":"10.1093\/nar\/gkab1113","article-title":"JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles","volume":"50","author":"Castro-Mondragon","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib11","article-title":"Perfluoroalkyl substances and gut microbiome in children","volume":"171","author":"Chen","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib12","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41591-019-0495-2","article-title":"Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study","volume":"25","author":"Depommier","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1741-7007-9-71","article-title":"Molecular dynamics simulations and drug discovery","volume":"9","author":"Durrant","year":"2011","journal-title":"BMC Biol."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005659","article-title":"OpenMM 7: rapid development of high performance algorithms for molecular dynamics","volume":"13","author":"Eastman","year":"2017","journal-title":"PLOS Comput. Biol."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib15","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib16","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btac757","article-title":"gseapy: a comprehensive package for performing gene set enrichment analysis in Python","volume":"39","author":"Fang","year":"2023","journal-title":"Bioinformatics"},{"key":"10.1016\/j.compbiolchem.2026.109478_bib17","doi-asserted-by":"crossref","first-page":"7256","DOI":"10.1021\/acs.est.3c07961","article-title":"Adopting mechanistic molecular biology approaches in exposome research for causal understanding","volume":"58","author":"Foreman","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib18","article-title":"Integrating multi-omics with environmental data for precision health","volume":"187","author":"Goodrich","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib19","article-title":"The potential mediating role of the gut microbiome and metabolites in the association between PFAS and kidney function in young adults","volume":"183","author":"Hampson","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib20","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1093\/ije\/dyx102","article-title":"Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption","volume":"46","author":"Hartwig","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph21040468","article-title":"Association of combined per- and polyfluoroalkyl substances and metals with chronic kidney disease: NHANES 2013\u20132018","volume":"21","author":"Haruna","year":"2024","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"10.1016\/j.compbiolchem.2026.109478_bib22","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-physiol-022516-034227","article-title":"Mechanisms of renal fibrosis","volume":"80","author":"Humphreys","year":"2018","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib23","first-page":"518","article-title":"Bile acids and farnesoid X receptor in renal pathophysiology","volume":"10","author":"Li","year":"2024","journal-title":"Kidney Dis."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib24","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.kint.2023.01.021","article-title":"Proteomic landscape of the extracellular matrix in the fibrotic kidney","volume":"103","author":"Li","year":"2023","journal-title":"Kidney Int."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib25","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.3390\/nu16203440","article-title":"Akkermansia muciniphila for the prevention of type 2 diabetes and obesity: a meta-analysis of animal studies","volume":"16","author":"Liu","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.compbiolchem.2026.109478_bib26","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nm.3902","article-title":"Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis","volume":"21","author":"Lovisa","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-beta: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib28","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1242\/jcs.00059","article-title":"Fibronectin at a glance","volume":"115","author":"Pankov","year":"2002","journal-title":"J. Cell. Sci."},{"issue":"23","key":"10.1016\/j.compbiolchem.2026.109478_bib29","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1007\/s00018-017-2650-6","article-title":"Periostin in kidney diseases","volume":"74","author":"Prakoura","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1287698","article-title":"Genetic evidence supporting the causal role of gut microbiota in chronic kidney disease and chronic systemic inflammation in CKD: a bilateral two-sample Mendelian randomization study","volume":"14","author":"Ren","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib31","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib32","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.3390\/microorganisms11071772","article-title":"Desulfovibrio in the gut: the enemy within?","volume":"11","author":"Singh","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.compbiolchem.2026.109478_bib33","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.2215\/CJN.04670418","article-title":"Perfluorinated chemicals as emerging environmental threats to kidney health: a scoping review","volume":"13","author":"Stanifer","year":"2018","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib34","article-title":"Perfluorooctanoic acid exposure induces gut microbiome dysbiosis and metabolic alterations in mice","volume":"286","author":"Su","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.compbiolchem.2026.109478_bib35","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.compbiolchem.2026.109478_bib36","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.semnephrol.2023.151408","article-title":"Gut microbiota-targeted interventions in the management of chronic kidney disease","volume":"43","author":"Sumida","year":"2023","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41370-018-0094-1","article-title":"A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects","volume":"29","author":"Sunderland","year":"2019","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib38","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib39","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/diagnostics15010021","article-title":"The gut-kidney axis in chronic kidney diseases","volume":"15","author":"Tsuji","year":"2024","journal-title":"Diagnostics"},{"key":"10.1016\/j.compbiolchem.2026.109478_bib40","article-title":"Associations of per- and polyfluoroalkyl substances and mortality among individuals with chronic kidney disease: a retrospective cohort study","volume":"912","author":"Xie","year":"2024","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib41","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.ajhg.2021.05.014","article-title":"Constrained maximum likelihood-based Mendelian randomization robust to both correlated and uncorrelated pleiotropic effects","volume":"108","author":"Xue","year":"2021","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib42","article-title":"Association between exposure to per- and polyfluoroalkyl substances and kidney function: a population study","volume":"12","author":"Zhang","year":"2025","journal-title":"Front. Med."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib43","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1214\/19-AOS1866","article-title":"Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score","volume":"48","author":"Zhao","year":"2020","journal-title":"Ann. Stat."},{"key":"10.1016\/j.compbiolchem.2026.109478_bib44","article-title":"Causal relationship between gut microbiota and kidney diseases: a two-sample Mendelian randomization study","volume":"14","author":"Zhou","year":"2023","journal-title":"Front. Immunol."}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126006055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126006055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:34:42Z","timestamp":1792035282000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927126006055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":44,"alternative-id":["S1476927126006055"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109478","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative multi-omics analysis reveals the PFAS-gut microbiome-FN1 axis in chronic kidney disease: From exposome to therapeutic target","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109478","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109478"}}