{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:54:19Z","timestamp":1782284059820,"version":"3.54.5"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/S024093\/1"],"award-info":[{"award-number":["EP\/S024093\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computers in Biology and Medicine"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.compbiomed.2025.110899","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T03:49:41Z","timestamp":1756352981000},"page":"110899","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"PA","title":["Computational model of cardiac cycle driven brain pulsation: a novel tool for brain disease exploration"],"prefix":"10.1016","volume":"197","author":[{"given":"Alice","family":"Collier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe","family":"Haste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Hayman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fargol","family":"Rezayaraghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyson","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Waters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Kurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Jerusalem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.compbiomed.2025.110899_b1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.semcdb.2015.07.001","article-title":"How computational models can help unlock biological systems","volume":"47\u201348","author":"Brodland","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.compbiomed.2025.110899_b2","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.pisc.2016.06.062","article-title":"A review on application of finite element modelling in bone biomechanics","volume":"8","author":"Parashar","year":"2016","journal-title":"Perspect. Sci."},{"issue":"11","key":"10.1016\/j.compbiomed.2025.110899_b3","doi-asserted-by":"crossref","DOI":"10.1115\/1.4065557","article-title":"Effects of fetal position on the loading of the fetal brain during the onset of the second stage of labor","volume":"146","author":"Collier","year":"2024","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.compbiomed.2025.110899_b4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2019.103442","article-title":"Medical imaging based in silico head model for ischaemic stroke simulation","volume":"101","author":"Bing","year":"2020","journal-title":"J. M. B. B. M.","ISSN":"https:\/\/id.crossref.org\/issn\/1751-6161","issn-type":"print"},{"issue":"1","key":"10.1016\/j.compbiomed.2025.110899_b5","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevApplied.12.014058","article-title":"Nonlinear dynamical behavior of the deep white matter during head impact","volume":"12","author":"Abderezaei","year":"2019","journal-title":"Phys. Rev. Appl."},{"issue":"13","key":"10.1016\/j.compbiomed.2025.110899_b6","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevLett.120.138101","article-title":"Mechanistic insights into human brain impact dynamics through modal analysis","volume":"120","author":"Laksari","year":"2018","journal-title":"P. R. L."},{"issue":"9","key":"10.1016\/j.compbiomed.2025.110899_b7","doi-asserted-by":"crossref","DOI":"10.1115\/1.4046503","article-title":"A nonlinear reduced-order model of the corpus callosum under planar coronal excitation","volume":"142","author":"Mojahed","year":"2020","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.compbiomed.2025.110899_b8","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/mrm.1910350516","article-title":"Hemodynamically independent analysis of cerebrospinal fluid and brain motion observed with dynamic phase contrast MRI","volume":"35","author":"Alperin","year":"1996","journal-title":"Magn. Reson. Med."},{"issue":"9","key":"10.1016\/j.compbiomed.2025.110899_b9","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0730-725X(98)00142-8","article-title":"Assessment of the biomechanical state of intracranial tissues by dynamic MRI of cerebrospinal fluid pulsations: a phantom study","volume":"16","author":"Chu","year":"1998","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.compbiomed.2025.110899_b10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2045-8118-8-5","article-title":"The pulsating brain: a review of experimental and clinical studies of intracranial pulsatility","volume":"8","author":"Wagshul","year":"2011","journal-title":"Fluid. Barriers CNS"},{"key":"10.1016\/j.compbiomed.2025.110899_b11","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4050","article-title":"Quantifying cardiac-induced brain tissue expansion using DENSE","volume":"32","author":"Adams","year":"2019","journal-title":"NMR Biomed."},{"key":"10.1016\/j.compbiomed.2025.110899_b12","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1053\/j.sult.2016.01.001","article-title":"Cerebrospinal fluid dynamics and the pathophysiology of hydrocephalus: new concepts","volume":"37","author":"Yamada","year":"2016","journal-title":"Semin. Ultrasound CT MR"},{"key":"10.1016\/j.compbiomed.2025.110899_b13","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/jmri.20684","article-title":"Idiopathic normal pressure hydrocephalus may be a \u201ctwo hit\u201d disease: Benign external hydrocephalus in infancy followed by deep white matter ischemia in late adulthood","volume":"24","author":"Bradley","year":"2006","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.compbiomed.2025.110899_b14","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1016\/j.wneu.2019.05.211","article-title":"Cerebellar tissue strain in chiari malformation with headache","volume":"130","author":"Dawes","year":"2019","journal-title":"World Neurosurg."},{"key":"10.1016\/j.compbiomed.2025.110899_b15","doi-asserted-by":"crossref","DOI":"10.1115\/1.4040227","article-title":"Regional quantification of brain tissue strain using displacement-encoding with stimulated echoes magnetic resonance imaging","volume":"140","author":"Pahlavian","year":"2018","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.compbiomed.2025.110899_b16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3174\/ajnr.A3171","article-title":"MRI evidence of impaired CSF homeostasis in obesity-associated idiopathic intracranial hypertension","volume":"34","author":"Alperin","year":"2013","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.compbiomed.2025.110899_b17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/svn-2016-000035","article-title":"Update on cerebral small vessel disease: a dynamic whole-brain disease","volume":"1","author":"Shi","year":"2016","journal-title":"Stroke Vasc. Neurol."},{"key":"10.1016\/j.compbiomed.2025.110899_b18","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1007\/s00330-020-07054-7","article-title":"MR elastography frequency-dependent and independent parameters demonstrate accelerated decrease of brain stiffness in elder subjects","volume":"30","author":"Lv","year":"2020","journal-title":"Eur. J. Radiol."},{"issue":"3","key":"10.1016\/j.compbiomed.2025.110899_b19","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/mrm.24499","article-title":"In vivo measurement of volumetric strain in the human brain induced by arterial pulsation and harmonic waves","volume":"70","author":"Hirsch","year":"2013","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.compbiomed.2025.110899_b20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3171\/2011.5.PEDS1121","article-title":"Chiari malformation type I and syrinx in children undergoing magnetic resonance imaging","volume":"8","author":"Strahle","year":"2011","journal-title":"J. Neurosurg. Pediatr."},{"key":"10.1016\/j.compbiomed.2025.110899_b21","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3171\/jns.2000.92.6.0920","article-title":"Asymptomatic chiari type I malformations identified on magnetic resonance imaging","volume":"92","author":"Meadows","year":"2000","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.compbiomed.2025.110899_b22","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1097\/00006123-199905000-00042","article-title":"Chiari I malformation redefined: clinical and radiographic findings for 364 symptomatic patients","volume":"44","author":"Milhorat","year":"1999","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.compbiomed.2025.110899_b23","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s11916-002-0056-z","article-title":"Headache and chiari I malformation: clinical presentation, diagnosis, and controversies in management","volume":"6","author":"Taylor","year":"2002","journal-title":"Curr. Pain Headache Rep."},{"issue":"2","key":"10.1016\/j.compbiomed.2025.110899_b24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s11596-018-1877-2","article-title":"Clinical characteristics, imaging findings and surgical outcomes of chiari malformation type I in pediatric and adult patients","volume":"38","author":"Lei","year":"2018","journal-title":"Curr. Med. Sci."},{"key":"10.1016\/j.compbiomed.2025.110899_b25","doi-asserted-by":"crossref","DOI":"10.1016\/j.brain.2024.100100","article-title":"Increased hindbrain motion in chiari I malformation patients measured through 3D amplified MRI (3D aMRI)","volume":"7","author":"Abderezaei","year":"2024","journal-title":"Brain Multiphysics"},{"key":"10.1016\/j.compbiomed.2025.110899_b26","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1148\/radiology.183.2.1561334","article-title":"Chiari I malformations: clinical and radiologic reappraisal","volume":"183","author":"Elster","year":"1992","journal-title":"J. Radiol."},{"key":"10.1016\/j.compbiomed.2025.110899_b27","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1179\/016164111X12962202723805","article-title":"Cerebrospinal fluid hydrodynamics in type I chiari malformation","volume":"33","author":"Shaffer","year":"2011","journal-title":"Neurol. Res."},{"issue":"3","key":"10.1016\/j.compbiomed.2025.110899_b28","first-page":"481","article-title":"Dural sinus occlusion: Evaluation with phase-sensitive gradient-echo MR imaging","volume":"12","author":"Tsuruda","year":"1991","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.compbiomed.2025.110899_b29","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1148\/radiology.185.3.1438741","article-title":"Brain motion: measurement with phase-contrast MR imaging","volume":"185","author":"Enzmann","year":"1992","journal-title":"J. Radiol."},{"key":"10.1016\/j.compbiomed.2025.110899_b30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1006\/jmre.1998.1676","article-title":"DENSE: displacement encoding with stimulated echoes in cardiac functional MRI","volume":"137","author":"Aletras","year":"1999","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.compbiomed.2025.110899_b31","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.media.2008.06.016","article-title":"Motion-guided segmentation for cine DENSE MRI","volume":"13","author":"Spottiswoode","year":"2009","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.compbiomed.2025.110899_b32","doi-asserted-by":"crossref","DOI":"10.1007\/s10439-020-02695-7","article-title":"Regional brain tissue displacement and strain is elevated in subjects with chiari malformation type I compared to healthy controls: A study using DENSE MRI","author":"Nwotchouang","year":"2021","journal-title":"Ann. Biomed. Eng."},{"issue":"1","key":"10.1016\/j.compbiomed.2025.110899_b33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1148\/radiol.2021203036","article-title":"Cerebellar and brainstem displacement measured with DENSE MRI in chiari malformation following posterior fossa decompression surgery","volume":"301","author":"Eppelheimer","year":"2021","journal-title":"Radiology"},{"issue":"8","key":"10.1016\/j.compbiomed.2025.110899_b34","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1118\/1.3157109","article-title":"Tracking brain motion during the cardiac cycle using spiral cine-dense MRI","volume":"36","author":"Zhong","year":"2009","journal-title":"Med. Phys."},{"issue":"4","key":"10.1016\/j.compbiomed.2025.110899_b35","first-page":"546","article-title":"Cerebellar and hindbrain motion in chiari malformation with and without syringomyelia","volume":"24","author":"Leung","year":"2016","journal-title":"J. Neurosurg.: Spine"},{"issue":"6","key":"10.1016\/j.compbiomed.2025.110899_b36","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1002\/mrm.26142","article-title":"Amplified magnetic resonance imaging (aMRI)","volume":"75","author":"Holdsworth","year":"2016","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.compbiomed.2025.110899_b37","unstructured":"H.-Y. Wu, et al., Eulerian video magnification for revealing subtle changes in the world, in: Proceedings of the SIGGRAPH, 2012."},{"key":"10.1016\/j.compbiomed.2025.110899_b38","doi-asserted-by":"crossref","DOI":"10.1002\/mrm.27236","article-title":"Revealing sub-voxel motions of brain tissue using phase-based amplified MRI (aMRI)","author":"Terem","year":"2018","journal-title":"Magn. Reson. Med."},{"issue":"4","key":"10.1016\/j.compbiomed.2025.110899_b39","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1145\/2461912.2461966","article-title":"Phase-based video motion processing","volume":"32","author":"Wadhwa","year":"2013","journal-title":"ACM Trans. Graph."},{"key":"10.1016\/j.compbiomed.2025.110899_b40","first-page":"444","article-title":"The steerable pyramid: A flexible architecture for multi-scale derivative computation","volume":"vol. 3","author":"Simoncelli","year":"1995"},{"issue":"6","key":"10.1016\/j.compbiomed.2025.110899_b41","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.jbiomech.2005.01.034","article-title":"Non-newtonian blood flow in human right coronary arteries: Transient simulations","volume":"39","author":"Johnston","year":"2006","journal-title":"J. Biomech."},{"key":"10.1016\/j.compbiomed.2025.110899_b42","series-title":"Abaqus\/Explicit 2020","author":"Dassault Syst\u00e8mes","year":"2020"},{"key":"10.1016\/j.compbiomed.2025.110899_b43","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1007\/s00330-015-3932-8","article-title":"Cerebrospinal fluid volumetric MRI mapping as a simple measurement for evaluating brain atrophy","volume":"26","author":"De Vis","year":"2016","journal-title":"Eur. Radiol.","ISSN":"https:\/\/id.crossref.org\/issn\/0938-7994","issn-type":"print"},{"key":"10.1016\/j.compbiomed.2025.110899_b44","series-title":"Radiopaedia.Org","article-title":"Chiari 1 malformation","author":"Haouimi","year":"2022"},{"issue":"1","key":"10.1016\/j.compbiomed.2025.110899_b45","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1600-0404.1970.tb05606.x","article-title":"The density of tissues in and about the head","volume":"46","author":"Barber","year":"1970","journal-title":"Acta Neurol. Scand."},{"issue":"1","key":"10.1016\/j.compbiomed.2025.110899_b46","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s10659-016-9606-1","article-title":"Bulging brains","volume":"129","author":"Weickenmeier","year":"2017","journal-title":"J. Elasticity","ISSN":"https:\/\/id.crossref.org\/issn\/1573-2681","issn-type":"print"},{"issue":"3","key":"10.1016\/j.compbiomed.2025.110899_b47","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ijsolstr.2008.09.010","article-title":"The elastic moduli estimation of the solid-water mixture","volume":"46","author":"Yoon","year":"2009","journal-title":"Int. J. Solids Struct.","ISSN":"https:\/\/id.crossref.org\/issn\/0020-7683","issn-type":"print"},{"key":"10.1016\/j.compbiomed.2025.110899_b48","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.apm.2021.01.037","article-title":"Modelling and direct numerical simulation of flow and solute dispersion in the spinal subarachnoid space","volume":"94","author":"Guti\u00e9rrez-Montes","year":"2021","journal-title":"Appl. Math. Model.","ISSN":"https:\/\/id.crossref.org\/issn\/0307-904X","issn-type":"print"},{"issue":"2","key":"10.1016\/j.compbiomed.2025.110899_b49","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s10439-009-9813-z","article-title":"Biomechanical assessment of brain dynamic responses due to blast pressure waves","volume":"38","author":"Chafi","year":"2010","journal-title":"Ann. Biomed. Eng."},{"issue":"2","key":"10.1016\/j.compbiomed.2025.110899_b50","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1115\/1.1554412","article-title":"Axial mechanical properties of fresh human cerebral blood vessels","volume":"125","author":"Monson","year":"2003","journal-title":"J. Biomech. Eng.","ISSN":"https:\/\/id.crossref.org\/issn\/0148-0731","issn-type":"print"},{"issue":"1","key":"10.1016\/j.compbiomed.2025.110899_b51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0021-9290(71)90010-8","article-title":"Dynamic response of human cranial bone","volume":"4","author":"Wood","year":"1971","journal-title":"J. Biomech.","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9290","issn-type":"print"},{"issue":"3","key":"10.1016\/j.compbiomed.2025.110899_b52","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s10237-022-01566-5","article-title":"Systematic review and meta-analysis of the biomechanical properties of the human dura mater applicable in computational human head models","volume":"21","author":"Pearcy","year":"2022","journal-title":"Biomech. Model. Mechanobiol.","ISSN":"https:\/\/id.crossref.org\/issn\/1617-7940","issn-type":"print"},{"issue":"2","key":"10.1016\/j.compbiomed.2025.110899_b53","doi-asserted-by":"crossref","DOI":"10.1115\/1.3005171","article-title":"Three-dimensional computational modeling of subject-specific cerebrospinal fluid flow in the subarachnoid space","volume":"131","author":"Gupta","year":"2008","journal-title":"J. Biomech. Eng."},{"issue":"5","key":"10.1016\/j.compbiomed.2025.110899_b54","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000028659","article-title":"Effects of proteins, blood cells and glucose on the viscosity of cerebrospinal fluid","volume":"28","author":"Bloomfield","year":"1998","journal-title":"Pediatr. Neurosurg."},{"issue":"6","key":"10.1016\/j.compbiomed.2025.110899_b55","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ncl.2008.02.003","article-title":"Management of intracranial hypertension","volume":"26","author":"Rangel-Castillo","year":"2008","journal-title":"Neurol. Clin."},{"issue":"2234","key":"10.1016\/j.compbiomed.2025.110899_b56","doi-asserted-by":"crossref","DOI":"10.1098\/rsta.2021.0325","article-title":"Modelling brain tissue elasticity with the ogden model and an alternative family of constitutive models","volume":"380","author":"Anssari-Benam","year":"2022","journal-title":"Philos. Trans. R. Soc. A: Math. Phys. Eng. Sci."},{"issue":"15","key":"10.1016\/j.compbiomed.2025.110899_b57","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1016\/j.jbiomech.2010.07.002","article-title":"Mechanical difference between white and gray matter in the rat cerebellum measured by scanning force microscopy","volume":"43","author":"Christ","year":"2010","journal-title":"J. Biomech.","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9290","issn-type":"print"},{"key":"10.1016\/j.compbiomed.2025.110899_b58","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.actbio.2023.07.040","article-title":"An atlas of the heterogeneous viscoelastic brain with local power-law attenuation synthesised using prony-series","volume":"169","author":"Morrison","year":"2023","journal-title":"Acta Biomater.","ISSN":"https:\/\/id.crossref.org\/issn\/1742-7061","issn-type":"print"},{"key":"10.1016\/j.compbiomed.2025.110899_b59","doi-asserted-by":"crossref","DOI":"10.1016\/j.brain.2022.100051","article-title":"Anisotropic mechanical properties in the healthy human brain estimated with multi-excitation transversely isotropic MR elastography","volume":"3","author":"Smith","year":"2022","journal-title":"Brain Multiphysics","ISSN":"https:\/\/id.crossref.org\/issn\/2666-5220","issn-type":"print"},{"issue":"3","key":"10.1016\/j.compbiomed.2025.110899_b60","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1136\/svn-2017-000087","article-title":"Blood pressure gradients in cerebral arteries: a clue to pathogenesis of cerebral small vessel disease","volume":"2","author":"Blanco","year":"2017","journal-title":"Stroke Vasc. Neurol."},{"issue":"8","key":"10.1016\/j.compbiomed.2025.110899_b61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1010166","article-title":"Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees","volume":"18","author":"Xue","year":"2022","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.compbiomed.2025.110899_b62","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2023.104503","article-title":"A network-based model of dynamic cerebral autoregulation","volume":"147","author":"Daher","year":"2023","journal-title":"Microvasc. Res."},{"issue":"3","key":"10.1016\/j.compbiomed.2025.110899_b63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1145\/1360612.1360643","article-title":"Skeleton extraction by mesh contraction","volume":"27","author":"Au","year":"2008","journal-title":"ACM Trans. Graph."},{"key":"10.1016\/j.compbiomed.2025.110899_b64","series-title":"Basic Neurochemistry","isbn-type":"print","first-page":"411","article-title":"Regulation of cerebral metabolic rate","author":"Clarke","year":"2012","ISBN":"https:\/\/id.crossref.org\/isbn\/9780123749475"},{"key":"10.1016\/j.compbiomed.2025.110899_b65","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-fluid-122414-034321","article-title":"Cerebrospinal fluid mechanics and its coupling to cerebrovascular dynamics.","volume":"48","author":"Linninger","year":"2016","journal-title":"Annu. Rev. Fluid Mech."},{"key":"10.1016\/j.compbiomed.2025.110899_b66","series-title":"Abaqus 2020 documentation","author":"Dassault Syst\u00e8mes","year":"2020"},{"key":"10.1016\/j.compbiomed.2025.110899_b67","doi-asserted-by":"crossref","DOI":"10.1007\/s12206-016-1230-2","article-title":"A comparative study between partitioned and monolithic methods for the problems with 3D fluid-structure interaction of blood vessels","author":"Ha","year":"2017","journal-title":"J. Mech. Sci. Technol."},{"key":"10.1016\/j.compbiomed.2025.110899_b68","series-title":"Spatio-Temporal Characteristics of Human Brain and Cerebrovasculature Biomechanics Through in Vivo Imaging and Computational Analysis","author":"Abderezaei","year":"2021"},{"key":"10.1016\/j.compbiomed.2025.110899_b69","first-page":"260","article-title":"3D steerable pyramid based on conic filters","volume":"vol. 5266","author":"Delle Luche","year":"2004"},{"issue":"3","key":"10.1016\/j.compbiomed.2025.110899_b70","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1002\/mrm.28797","article-title":"3D amplified MRI (aMRI)","volume":"86","author":"Terem","year":"2021","journal-title":"Magn. Reson. Med."},{"issue":"12","key":"10.1016\/j.compbiomed.2025.110899_b71","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1109\/TMI.2020.3012932","article-title":"Amplified flow imaging (aflow): A novel mri-based tool to unravel the coupled dynamics between the human brain and cerebrovasculature","volume":"39","author":"Abderezaei","year":"2020","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.compbiomed.2025.110899_b72","doi-asserted-by":"crossref","DOI":"10.1016\/j.brain.2021.100022","article-title":"Development, calibration, and testing of 3D amplified MRI (aMRI) for the quantification of intrinsic brain motion","volume":"2","author":"Abderezaei","year":"2021","journal-title":"Brain Multiphysics"},{"key":"10.1016\/j.compbiomed.2025.110899_b73","doi-asserted-by":"crossref","DOI":"10.1016\/j.actbio.2024.10.003","article-title":"Machine learning reveals correlations between brain age and mechanics","author":"Hoppst\u00e4dter","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.compbiomed.2025.110899_b74","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.nicl.2015.12.007","article-title":"Regional brain stiffness changes across the alzheimer\u2019s disease spectrum","volume":"10","author":"Murphy","year":"2015","journal-title":"Neuroimage Clin."},{"issue":"06","key":"10.1016\/j.compbiomed.2025.110899_b75","first-page":"584","article-title":"In vivo measurement of brain tumor elasticity using intraoperative shear wave elastography","volume":"37","author":"Chauvet","year":"2016","journal-title":"Ultraschall Med"},{"key":"10.1016\/j.compbiomed.2025.110899_b76","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.116581","article-title":"Cardiac and respiration-induced brain deformations in humans quantified with high-field MRI","volume":"210","author":"Sloots","year":"2020","journal-title":"NeuroImage","ISSN":"https:\/\/id.crossref.org\/issn\/1053-8119","issn-type":"print"},{"key":"10.1016\/j.compbiomed.2025.110899_b77","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12987-022-00376-2","article-title":"Human intracranial pulsatility during the cardiac cycle: a computational modelling framework","volume":"19","author":"Causemann","year":"2022","journal-title":"Fluids Barriers CNS","ISSN":"https:\/\/id.crossref.org\/issn\/2045-8118","issn-type":"print"},{"issue":"6493","key":"10.1016\/j.compbiomed.2025.110899_b78","article-title":"Feasibility of assessing non-invasive intracranial compliance using FSI simulation-based and MR elastography-based brain stiffness","volume":"14","author":"Gholampour","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiomed.2025.110899_b79","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2025.110047","article-title":"Cerebrospinal fluid flow dynamics in the aqueduct of sylvius for rigid and deformable brain models","volume":"190","author":"Shojaeianforoud","year":"2025","journal-title":"Comput. Biol. Med.","ISSN":"https:\/\/id.crossref.org\/issn\/0010-4825","issn-type":"print"},{"key":"10.1016\/j.compbiomed.2025.110899_b80","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2022.147962","article-title":"Patient-specific computational fluid dynamic simulation of cerebrospinal fluid flow in the intracranial space","volume":"1790","author":"Fillingham","year":"2022","journal-title":"Brain Res.","ISSN":"https:\/\/id.crossref.org\/issn\/0006-8993","issn-type":"print"},{"issue":"23","key":"10.1016\/j.compbiomed.2025.110899_b81","article-title":"In vitro and numerical simulation of blood removal from cerebrospinal fluid: comparison of lumbar drain to neurapheresis therapy.","volume":"17","author":"Khani","year":"2020","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.compbiomed.2025.110899_b82","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jbiomech.2017.10.007","article-title":"Chiari malformation may increase perivascular cerebrospinal fluid flow into the spinal cord: A subject-specific computational modelling study","volume":"65","author":"Lloyd","year":"2017","journal-title":"J. Biomech.","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9290","issn-type":"print"},{"key":"10.1016\/j.compbiomed.2025.110899_b83","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2019.108541","article-title":"Methods to measure, model and manipulate fluid flow in brain","volume":"333","author":"Chatterjee","year":"2020","journal-title":"J. Neurosci. Methods","ISSN":"https:\/\/id.crossref.org\/issn\/0165-0270","issn-type":"print"},{"key":"10.1016\/j.compbiomed.2025.110899_b84","series-title":"Abaqus\/Standard-based quantification of human cardiac mechanical properties","author":"Genet","year":"2016"},{"key":"10.1016\/j.compbiomed.2025.110899_b85","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1007\/s00701-020-04424-4","article-title":"Origin of intracranial pressure pulse waveform","volume":"162","author":"Czosnyka","year":"2020","journal-title":"Acta Neurochir."},{"key":"10.1016\/j.compbiomed.2025.110899_b86","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s00701-015-2465-x","article-title":"Comparison of pulsatile and static pressures within the intracranial and lumbar compartments in patients with chiari malformation type 1: a prospective observational study","volume":"157","author":"Fric1","year":"2015","journal-title":"Acta Neurochir"},{"key":"10.1016\/j.compbiomed.2025.110899_b87","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.3171\/2016.4.JNS152862","article-title":"Comparative observational study on the clinical presentation, intracranial volume measurements, and intracranial pressure scores in patients with either chiari malformation type I or idiopathic intracranial hypertension","volume":"126","author":"Fric1","year":"2017","journal-title":"J. Neurosurg."},{"issue":"2","key":"10.1016\/j.compbiomed.2025.110899_b88","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/jmri.28717","article-title":"Cerebrospinal fluid flow and brain motion in chiari i malformation: past, present, and future","volume":"58","author":"Bhadelia","year":"2023","journal-title":"J. Magn. Reson. Imaging"}],"container-title":["Computers in Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001048252501251X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001048252501251X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:13:42Z","timestamp":1772813622000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001048252501251X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":88,"alternative-id":["S001048252501251X"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiomed.2025.110899","relation":{},"ISSN":["0010-4825"],"issn-type":[{"value":"0010-4825","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Computational model of cardiac cycle driven brain pulsation: a novel tool for brain disease exploration","name":"articletitle","label":"Article Title"},{"value":"Computers in Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiomed.2025.110899","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110899"}}