{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:08:16Z","timestamp":1773194896681,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Comprehensive Psychiatry"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1016\/j.comppsych.2003.12.008","type":"journal-article","created":{"date-parts":[[2004,3,3]],"date-time":"2004-03-03T05:17:38Z","timestamp":1078291058000},"page":"114-120","source":"Crossref","is-referenced-by-count":25,"title":["Patterns of axis II comorbidity in early-onset versus late-onset panic disorder in Japan"],"prefix":"10.1016","volume":"45","author":[{"given":"Toshiya","family":"Iketani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Kiriike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray B","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouji","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomitsu","family":"Minamikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Shidao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.comppsych.2003.12.008_BIB1","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1136\/jmg.31.12.944","article-title":"Genetic epidemiology of early onset breast cancer","volume":"31","author":"Eccles","year":"1994","journal-title":"J Med Genet"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB2","first-page":"65","article-title":"Causes of Alzheimer\u2019s disease","volume":"162","author":"Munoz","year":"2000","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB3","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/1097-0142(20010801)92:3<479::AID-CNCR1346>3.0.CO;2-G","article-title":"Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history","volume":"92","author":"Teraoka","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB4","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/ajmg.1608","article-title":"Multiple-threshold models for genetic influences on age of onset for Alzheimer disease","volume":"105","author":"Pedersen","year":"2001","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB5","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1001\/archpsyc.1986.01800110071009","article-title":"Recurrent and nonrecurrent depression","volume":"43","author":"Bland","year":"1986","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0165-0327(88)90018-3","article-title":"Depressive disorders in childhood, III","volume":"15","author":"Kovacs","year":"1988","journal-title":"J Affect Disord"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0165-0327(88)90024-9","article-title":"Early-onset of major depression in parents and their children","volume":"15","author":"Weissman","year":"1988","journal-title":"J Affect Disord"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB8","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1600-0447.1990.tb01399.x","article-title":"Schizophrenia","volume":"82","author":"Pulver","year":"1990","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0165-0327(88)90023-7","article-title":"A family study of bipolar I disorder in adolescence","volume":"15","author":"Strober","year":"1988","journal-title":"J Affect Disord"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB10","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1001\/archpsyc.1992.01820090031005","article-title":"Risks of affective illness in first-degree relatives of bipolar I old-order Amish probands","volume":"49","author":"Paulus","year":"1992","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB11","first-page":"147","article-title":"Age of onset of major subtypes of obsessive-compulsive disorders","volume":"4","author":"Minichiello","year":"1990","journal-title":"J Affect Disord"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0165-1781(92)90075-E","article-title":"Psychiatric disorders in the families of patients with obsessive-compulsive disorder","volume":"42","author":"Bellodi","year":"1992","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB13","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1159\/000258793","article-title":"Panikattacken mit fr\u00fchen und sp\u00e4tem Beginn","volume":"3","author":"Wittchen","year":"1993","journal-title":"Verhaltenstherapie"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB14","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1176\/ajp.152.9.1362","article-title":"Age at onset of panic disorder","volume":"152","author":"Battaglia","year":"1995","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1001\/archpsyc.1997.01830150097014","article-title":"Familial aggregation and phenomenology of \u2018early\u2019-onset (at or before age 20 years) panic disorder","volume":"54","author":"Goldstein","year":"1997","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0165-0327(98)00148-7","article-title":"Differential clinical features of early-onset panic disorder","volume":"54","author":"Segui","year":"1999","journal-title":"J Affect Disord"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB17","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1176\/ajp.155.5.590","article-title":"Anticipation of age at onset in panic disorder","volume":"155","author":"Battaglia","year":"1998","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB18","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1056\/NEJM198911023211801","article-title":"Suicidal ideation and suicide attempts in panic disorder and panic attacks","volume":"321","author":"Weissman","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0010-440X(91)90047-G","article-title":"Predictors of serious suicide attempts among patients with panic disorder","volume":"32","author":"Noyes","year":"1991","journal-title":"Compr Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB20","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1176\/ajp.149.5.680","article-title":"Suicidal ideation and suicidal attempts among patients with panic disorder","volume":"149","author":"Friedman","year":"1992","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB21","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1001\/archpsyc.1993.01820140070008","article-title":"Suicide attempts in patients with panic disorder","volume":"50","author":"Lepine","year":"1993","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0165-1781(94)90036-1","article-title":"Prevalence of personality disorders among patients with anxiety disorders","volume":"51","author":"Sanderson","year":"1993","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB23","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1600-0447.1994.tb08090.x","article-title":"DSM-III-R axis-I and II disorders in agoraphobic patients with and without panic disorder","volume":"89","author":"Hoffart","year":"1994","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB24","series-title":"Challenges in Clinical Practice","first-page":"113","article-title":"Maximizing treatment outcome for panic disorder","author":"Otto","year":"1996"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB25","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1600-0447.1998.tb10052.x","article-title":"Prevalence, pattern and role of personality disorders in panic disorder patients with and without comorbid (lifetime) major depression","volume":"98","author":"Langs","year":"1998","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB26","first-page":"1245","article-title":"Clinical features of the patients with eating disorders and panic disorder","volume":"42","author":"Iketani","year":"2000","journal-title":"Clin Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB27","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/da.10050","article-title":"Personality disorder comorbidity in panic disorder patients with or without current major depression","volume":"13","author":"Iketani","year":"2002","journal-title":"Depression Anxiety"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0165-0327(94)90131-7","article-title":"Predictors of short-term treatment response in 66 patients with panic disorder","volume":"30","author":"Black","year":"1994","journal-title":"J Affect Disord"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB29","first-page":"1309","article-title":"Patterns of personality disorder comorbidity in early-onset versus late-onset major depression","volume":"153","author":"Fava","year":"1996","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0165-0327(95)00022-F","article-title":"Suicidal behavior in patients with panic disorder","volume":"34","author":"Warshaw","year":"1995","journal-title":"J Affect Disord"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB31","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0022-3956(91)90015-3","article-title":"Further evidence of an association between behavioral inhibition and anxiety disorders","volume":"25","author":"Rosenbaum","year":"1991","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB32","series-title":"Structured Clinical Interview for DSM-III-R Patients Edition (SCID-P, Version 1.0)","author":"Spitzer","year":"1990"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB33","series-title":"The Structured Clinical Interview for DSM-III-R Personality Disorders","author":"Spitzer","year":"1987"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB34","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1001\/archpsyc.1990.01810180011002","article-title":"Age at onset of selected mental diseases in five community populations","volume":"47","author":"Burke","year":"1990","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB35","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/0010-440X(81)90002-X","article-title":"Age of onset of phobic disorders","volume":"22","author":"Sheehan","year":"1981","journal-title":"Compr Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB36","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/archpsyc.1965.01720310065008","article-title":"A self-rating depression scale","volume":"12","author":"Zung","year":"1965","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB37","series-title":"Manual for the State-Trait Anxiety Inventory (STAI Form Y)","author":"Spielberger","year":"1970"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB38","first-page":"673","article-title":"A study on a Self-Rating Depression Scale","volume":"75","author":"Fukuda","year":"1973","journal-title":"Psychiatr Neurol Jpn"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB39","first-page":"107","article-title":"Development and validation of the Japanese version of the State-Trait Anxiety Inventory","volume":"22","author":"Nakazato","year":"1982","journal-title":"Shinshin Igaku"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB40","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1001\/archpsyc.1984.01790230015002","article-title":"Major depression in patients with agoraphobia and panic disorder","volume":"41","author":"Breier","year":"1984","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB41","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1521\/pedi.1994.8.4.333","article-title":"State and personality in agoraphobic patients","volume":"8","author":"Hoffart","year":"1994","journal-title":"J Personal Disord"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB42","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1176\/ajp.138.12.1601","article-title":"Personality trait and disorder in depression","volume":"138","author":"Charney","year":"1981","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1192\/bjp.166.1.87","article-title":"Long-term effects of behavioral treatment for panic disorder with agoraphobia","volume":"166","author":"Fava","year":"1995","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB44","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1001\/archpsyc.1990.01810210013002","article-title":"Panic disorder, comorbidity, and suicide attempts","volume":"47","author":"Johnson","year":"1990","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB45","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1176\/ajp.148.9.1195","article-title":"Panic disorder and suicidal ideation and behavior","volume":"148","author":"Beck","year":"1991","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB46","series-title":"Suicide Over the Life Cycle","first-page":"155","article-title":"Personality and suicide","author":"Goldsmith","year":"1990"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB47","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1176\/ajp.150.6.928","article-title":"Diagnostic comorbidity in persons with suicidal ideation and behavior","volume":"150","author":"Rudd","year":"1993","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB48","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1176\/ajp.150.6.935","article-title":"Mental disorders and comorbidity in suicide","volume":"150","author":"Henriksson","year":"1993","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB49","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0165-0327(96)00023-7","article-title":"Suicidal behavior in patients with major depression and comorbid personality disorders","volume":"39","author":"Corbitt","year":"1996","journal-title":"J Affect Disord"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB50","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/milmed\/164.2.103","article-title":"Comorbid affective disorders and personality traits in alcohol abuse inpatients at an Air Force Medical Center","volume":"164","author":"Bourgeois","year":"1999","journal-title":"Mil Med"},{"key":"10.1016\/j.comppsych.2003.12.008_BIB51","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1521\/pedi.15.5.416.19201","article-title":"Substance abuse in borderline personality disorder","volume":"15","author":"Van den Bosch","year":"2001","journal-title":"J Personal Disord"}],"container-title":["Comprehensive Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010440X03002220?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010440X03002220?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T16:53:52Z","timestamp":1550163232000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010440X03002220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S0010440X03002220"],"URL":"https:\/\/doi.org\/10.1016\/j.comppsych.2003.12.008","relation":{},"ISSN":["0010-440X"],"issn-type":[{"value":"0010-440X","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}