{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:11:19Z","timestamp":1774451479449,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comprehensive Psychiatry"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.comppsych.2015.04.013","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T13:07:32Z","timestamp":1431349652000},"page":"23-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Examining the levels of BDNF and cortisol in children and adolescent victims of sexual abuse\u2014a preliminary study"],"prefix":"10.1016","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0220-1204","authenticated-orcid":false,"given":"\u015eeref","family":"\u015eim\u015fek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu\u011fba","family":"Y\u00fcksel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130brahim","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem","family":"Uysal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcmeysa","family":"Alaca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.comppsych.2015.04.013_bb0005","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/da.22078","article-title":"Synergistic relationships among stress, depression, and troubled relationships: insights from psychoneuroimmunology","volume":"30","author":"Jaremka","year":"2013","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1751-0759-7-7","article-title":"Psychological stress contributed to the development of low-grade fever in a patient with chronic fatigue syndrome: a case report","volume":"7","author":"Oka","year":"2013","journal-title":"Biopsychosoc Med"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0015","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1188\/13.ONF.E327-E336","article-title":"Development and evaluation of targeted psychological skills training for oncology nurses in managing stressful patient and family encounters","volume":"40","author":"Traeger","year":"2013","journal-title":"Oncol Nurs Forum"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0020","doi-asserted-by":"crossref","first-page":"17180","DOI":"10.1073\/pnas.1121254109","article-title":"Brain on stress: how the social environment gets under the skin","volume":"109","author":"McEwen","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0025","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/00004583-200303000-00006","article-title":"Ten-year research update review: child sexual abuse","volume":"42","author":"Putnam","year":"2003","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0030","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0145-2134(94)90026-4","article-title":"The international epidemiology of child sexual abuse","volume":"18","author":"Finkelhor","year":"1994","journal-title":"Child Abuse Negl"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0035","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bandc.2007.02.007","article-title":"The effects of stress and stress hormones on human cognition: implications for the field of brain and cognition","volume":"65","author":"Lupien","year":"2007","journal-title":"Brain Cogn"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0040","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1300\/J070v10n04_07","article-title":"Exploring the multiplicity of childhood sexual abuse with a focus on polyincestuous contexts of abuse","volume":"10","author":"Crowley","year":"2002","journal-title":"J Child Sex Abus"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0045","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.comppsych.2006.02.008","article-title":"Factors linked to outcomes in sexually abused girls: a regression tree analysis","volume":"47","author":"Hebert","year":"2006","journal-title":"Compr Psychiatry"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0050","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.psych.093008.100321","article-title":"Stress hormone regulation: biological role and translation into therapy","volume":"61","author":"Holsboer","year":"2010","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0055","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/nn.3266","article-title":"Glucocorticoid receptors recruit the CaMKII\u03b1-BDNF-CREB pathways to mediate memory consolidation","volume":"15","author":"Chen","year":"2012","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0060","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/0166-2236(94)90139-2","article-title":"Neurotrophins and brain insults","volume":"17","author":"Lindvall","year":"1994","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0065","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.1460-9568.1992.tb00888.x","article-title":"Regulation of neurotrophin mRNA expression in the rat brain by glucocorticoids","volume":"4","author":"Barbany","year":"1992","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0070","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/0306-4522(93)90584-3","article-title":"Adrenalectomy attenuates kainic acid-elicited increases of messenger RNAs for neurotrophins and their receptors in the rat brain","volume":"54","author":"Barbany","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0075","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1046\/j.1460-9568.2000.00185.x","article-title":"Gluco-and mineralocorticoid receptor-mediated regulation of neurotrophic factor gene expression in the dorsal hippocampus and the neocortex of the rat","volume":"12","author":"Hansson","year":"2000","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0080","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1210\/me.2009-0395","article-title":"Cyclin-dependent kinase 5 modulates the transcriptional activity of the mineralocorticoid receptor and regulates expression of brain-derived neurotrophic factor","volume":"24","author":"Kino","year":"2010","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0085","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1677\/JOE-08-0509","article-title":"Acute or chronic stress induce cell compartment-specific phosphorylation of glucocorticoid receptor and alter its transcriptional activity in Wistar rat brain","volume":"202","author":"Adzic","year":"2009","journal-title":"J Endocrinol"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0090","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/neu.1079","article-title":"Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration","volume":"49","author":"Wellman","year":"2001","journal-title":"J Neurobiol"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0095","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/cne.21071","article-title":"Synapse loss from chronically elevated glucocorticoids: relationship to neuropil volume and cell number in hippocampal area CA3","volume":"498","author":"Tata","year":"2006","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0100","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neuroscience.2012.09.017","article-title":"Are BDNF and glucocorticoid activities calibrated?","volume":"239","author":"Jeanneteau","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0105","doi-asserted-by":"crossref","first-page":"16074","DOI":"10.1073\/pnas.1110444108","article-title":"Glucocorticoids are critical regulators of dendritic spine development and plasticity in vivo","volume":"108","author":"Liston","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0110","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0006-3223(99)00044-X","article-title":"Developmental traumatology part I: biological stress systems","volume":"45","author":"De Bellis","year":"1999","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0115","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1017\/S0954579401003145","article-title":"Diverse patterns of neuroendocrine activity in maltreated children","volume":"13","author":"Cicchetti","year":"2001","journal-title":"Dev Psychopathol"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0120","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0006-3223(01)01310-5","article-title":"Diurnal salivary cortisol in pediatric posttraumatic stress disorder","volume":"51","author":"Carrion","year":"2002","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0125","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.psyneuen.2004.06.004","article-title":"Initial urinary epinephrine and cortisol levels predict acute PTSD symptoms in child trauma victims","volume":"30","author":"Delahanty","year":"2005","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0130","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.biopsych.2006.07.037","article-title":"Salivary cortisol and psychopathology in children bereaved by the September 11, 2001 terror attacks","volume":"61","author":"Pfeffer","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0135","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.psyneuen.2004.03.006","article-title":"Increased adrenocorticotropin suppression following dexamethasone administration in sexually abused adolescents with posttraumatic stress disorder","volume":"29","author":"Duval","year":"2004","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0140","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1046\/j.1440-1819.2001.00787.x","article-title":"Early sexual abuse and low cortisol","volume":"55","author":"King","year":"2001","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0145","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1037\/0033-2909.133.1.25","article-title":"If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans","volume":"133","author":"Miller","year":"2007","journal-title":"Psychol Bull"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0150","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1017\/S0954579409990332","article-title":"Attenuation of cortisol across development for victims of sexual abuse","volume":"22","author":"Trickett","year":"2010","journal-title":"Dev Psychopathol"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0155","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.neubiorev.2005.08.002","article-title":"Psychobiology of persistent antisocial behavior: stress, early vulnerabilities and the attenuation hypothesis","volume":"30","author":"Susman","year":"2006","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0160","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.psyneuen.2008.03.008","article-title":"The link between childhood trauma and depression: insights from HPA axis studies in humans","volume":"33","author":"Heim","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0165","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1152\/physrev.00041.2006","article-title":"Physiology and neurobiology of stress and adaptation: central role of the brain","volume":"87","author":"McEwen","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0170","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neuroscience.2012.04.012","article-title":"Intermittent social defeat stress enhances mesocorticolimbic \u0394FosB\/BDNF co-expression and persistently activates corticotegmental neurons: implication for vulnerability to psychostimulants","volume":"212","author":"Nikulina","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0175","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.physbeh.2012.03.005","article-title":"Contrasting hippocampal and amygdalar expression of genes related to neural plasticity during escape from social aggression","volume":"107","author":"Arendt","year":"2012","journal-title":"Physiol Behav"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0180","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1017\/S1461145707007560","article-title":"Long-term down-regulation of BDNF mRNA in rat hippocampal CA1 subregion correlates with PTSD-like behavioural stress response","volume":"10","author":"Kozlovsky","year":"2007","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0185","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.biopsych.2008.02.023","article-title":"Low plasma brain-derived neurotrophic factor and childhood physical neglect are associated with verbal memory impairment in major depression\u2014a preliminary report","volume":"64","author":"Grassi-Oliveira","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0190","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1399-5618.2007.00478.x","article-title":"Traumatic life events in bipolar disorder: impact on BDNF levels and psychopathology","volume":"9","author":"Kauer-Sant\u2019Anna","year":"2007","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0195","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.pnpbp.2009.04.018","article-title":"BDNF plasma levels in patients suffering from post-traumatic stress disorder","volume":"33","author":"Dell\u2019Osso","year":"2009","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0200","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/NMD.0b013e31827ab268","article-title":"Trauma profile in Egyptian adolescents with first-episode schizophrenia relation to psychopathology and plasma brain-derived neurotrophic factor","volume":"201","author":"Fawzi","year":"2013","journal-title":"J Nerv Ment Dis"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0205","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2174\/187152706778559309","article-title":"Stress and brain atrophy","volume":"5","author":"Bremner","year":"2006","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0210","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bandc.2013.11.012","article-title":"BDNF serum levels in subjects developing or not post-traumatic stress disorder after trauma exposure","volume":"84","author":"Angelucci","year":"2014","journal-title":"Brain Cogn"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0215","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrn3379","article-title":"Neurotrophin regulation of neural circuit development and function","volume":"14","author":"Park","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0220","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.pnpbp.2010.01.010","article-title":"Serum brain-derived neurotrophic factor in patients with trauma psychopathology","volume":"34","author":"Hauck","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.comppsych.2015.04.013_bb0225","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.4088\/JCP.09m05106blu","article-title":"Corticotropin-releasing factor, \u0131nterleukin-6, brain-derived neurotrophic factor, \u0131nsulin-like growth factor-1, and substance P in the cerebrospinal fluid of civilians with posttraumatic stress disorder before and after treatment with paroxetine","volume":"72","author":"Bonne","year":"2011","journal-title":"J Clin Psychiatry"}],"container-title":["Comprehensive Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010440X15000644?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010440X15000644?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T14:22:07Z","timestamp":1537626127000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010440X15000644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":45,"alternative-id":["S0010440X15000644"],"URL":"https:\/\/doi.org\/10.1016\/j.comppsych.2015.04.013","relation":{},"ISSN":["0010-440X"],"issn-type":[{"value":"0010-440X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Examining the levels of BDNF and cortisol in children and adolescent victims of sexual abuse\u2014a preliminary study","name":"articletitle","label":"Article Title"},{"value":"Comprehensive Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.comppsych.2015.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}