{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T10:49:21Z","timestamp":1781866161674,"version":"3.54.5"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comprehensive Psychiatry"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.comppsych.2015.11.010","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T11:45:41Z","timestamp":1449056741000},"page":"150-155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Brain-derived neurotrophic factor serum levels in heroin-dependent patients after 26weeks of withdrawal"],"prefix":"10.1016","volume":"65","author":[{"given":"Kai","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.comppsych.2015.11.010_bb0005","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1001\/jama.284.13.1689","article-title":"Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation","volume":"284","author":"McLellan","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0010","series-title":"Annual Report on Drug Control in China","author":"National Narcotics Control Commission","year":"2015"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0015","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0733-8627(05)70124-3","article-title":"Withdrawal symptoms","volume":"18","author":"Olmedo","year":"2000","journal-title":"Emerg Med Clin North Am"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0020","first-page":"33","article-title":"Changes in protracted withdrawal symptoms after detoxification","volume":"9","author":"Liu","year":"2000","journal-title":"Chin J Drug Depend"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0025","doi-asserted-by":"crossref","first-page":"5894","DOI":"10.1523\/JNEUROSCI.0740-06.2006","article-title":"Conditioned withdrawal drives heroin consumption and decreases reward sensitivity","volume":"26","author":"Kenny","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0030","article-title":"Cocaine self-administration causes signaling deficits in corticostriatal circuitry that are reversed by BDNF in early withdrawal","author":"McGinty","year":"2014","journal-title":"Brain Res"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0035","doi-asserted-by":"crossref","first-page":"pyu088","DOI":"10.1093\/ijnp\/pyu088","article-title":"Temporal regulation of peripheral BDNF levels during cocaine and morphine withdrawal: comparison with a natural reward","volume":"18","author":"Geoffroy","year":"2014","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0040","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1369-1600.2012.00444.x","article-title":"Serum brain-derived neurotrophic factor levels were reduced during methamphetamine early withdrawal","volume":"19","author":"Chen","year":"2014","journal-title":"Addict Biol"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0045","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/350230a0","article-title":"BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra","volume":"350","author":"Hyman","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0050","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nn1687","article-title":"BDNF-dependent synaptic sensitization in midbrain dopamine neurons after cocaine withdrawal","volume":"9","author":"Pu","year":"2006","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0055","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1126\/science.1168501","article-title":"Ventral tegmental area BDNF induces an opiate-dependent-like reward state in na\u00efve rats","volume":"324","author":"Vargas-Perez","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0060","doi-asserted-by":"crossref","first-page":"10700","DOI":"10.1523\/JNEUROSCI.18-24-10700.1998","article-title":"Differential regulation of neurotrophin and trk receptor mRNAs in catecholaminergic nuclei during chronic opiate treatment and withdrawal","volume":"18","author":"Numan","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0065","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neulet.2014.04.048","article-title":"Increased serum brain-derived neurotrophic factor levels during opiate withdrawal","volume":"571","author":"Zhang","year":"2014","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0070","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.pnpbp.2010.05.025","article-title":"BDNF and GDNF serum levels in alcohol-dependent patients during withdrawal","volume":"34","author":"Heberlein","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0075","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ijdevneu.2005.05.009","article-title":"Neurotrophins in murine viscera: a dynamic pattern from birth to adulthood","volume":"23","author":"Lommatzsch","year":"2005","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0080","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.psyneuen.2008.08.020","article-title":"Changes in plasma levels of BDNF and NGF reveal a gender-selective vulnerability to early adversity in rhesus macaques","volume":"34","author":"Cirulli","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0085","first-page":"107","article-title":"The reliability and validity evaluation of rating scale for protracted withdrawal symptoms of heroin addicts","volume":"18","author":"Shi","year":"2009","journal-title":"Chin J Drug Depend"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0090","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.2466\/pr0.1985.57.3f.1091","article-title":"Reliability, discriminant and predictive validity of the Zung Self-Rating Depression Scale","volume":"57","author":"Gabrys","year":"1985","journal-title":"Psychol Rep"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0095","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1192\/bjp.132.4.381","article-title":"Validity of the Zung Self-rating Depression Scale","volume":"132","author":"Biggs","year":"1978","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0100","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tox.2010.06.009","article-title":"Neurotoxicity of heroin-cocaine combinations in rat cortical neurons","volume":"276","author":"Cunha-Oliveira","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0105","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.biopsych.2009.09.036","article-title":"Neuroplasticity in the mesolimbic system induced by natural reward and subsequent reward abstinence","volume":"67","author":"Pitchers","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0110","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.brainresrev.2008.03.002","article-title":"Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs","volume":"58","author":"Cunha-Oliveira","year":"2008","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0115","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.euroneuro.2012.08.016","article-title":"Brain-derived neurotrophic factor serum levels in cocaine-dependent patients during early abstinence","volume":"23","author":"Corominas-Roso","year":"2013","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0120","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1177\/0269881107078491","article-title":"Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor","volume":"21","author":"Angelucci","year":"2007","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0125","doi-asserted-by":"crossref","first-page":"pyv008","DOI":"10.1093\/ijnp\/pyv008","article-title":"A placebo-controlled trial of dextromethorphan as an adjunct in opioid-dependent patients undergoing methadone maintenance treatment","volume":"18","author":"Lee","year":"2015","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0130","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/ntr\/ntu151","article-title":"Association of smoking, nicotine dependence, and BDNF Val66Met polymorphism with BDNF concentrations in serum","volume":"17","author":"Jamal","year":"2014","journal-title":"Nicotine Tob Res"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0135","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jpsychires.2008.03.014","article-title":"Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6months treatment with sertraline, escitalopram, or venlafaxine","volume":"43","author":"Matrisciano","year":"2009","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0140","doi-asserted-by":"crossref","first-page":"e42676","DOI":"10.1371\/journal.pone.0042676","article-title":"Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder","volume":"7","author":"Yoshida","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0145","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.pnpbp.2007.11.011","article-title":"Stress at work alters serum brain-derived neurotrophic factor (BDNF) levels and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in healthy volunteers: BDNF and MHPG as possible biological markers of mental stress?","volume":"32","author":"Mitoma","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0150","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1177\/0269881111411332","article-title":"Serum levels of BDNF are associated with craving in opiate-dependent patients","volume":"25","author":"Heberlein","year":"2011","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0155","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/ajmg.b.31062","article-title":"Analysis of whole genome biomarker expression in blood and brain","volume":"153","author":"Rollins","year":"2010","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0160","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.biopsych.2005.01.008","article-title":"Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity","volume":"57","author":"Karege","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0165","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/S1461145710000738","article-title":"Blood BDNF concentrations reflect brain-tissue BDNF levels across species","volume":"14","author":"Klein","year":"2011","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0170","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.nlm.2008.07.014","article-title":"BDNF is a novel marker of cognitive function in ageing women: the DR\u2019s EXTRA Study","volume":"90","author":"Komulainen","year":"2008","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0175","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.2337\/db06-0550","article-title":"Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene","volume":"55","author":"Gray","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.comppsych.2015.11.010_bb0180","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00213-012-2643-y","article-title":"Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia","volume":"222","author":"Zhang","year":"2012","journal-title":"Psychopharmacology"}],"container-title":["Comprehensive Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010440X15301139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010440X15301139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T20:45:44Z","timestamp":1718225144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010440X15301139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":36,"alternative-id":["S0010440X15301139"],"URL":"https:\/\/doi.org\/10.1016\/j.comppsych.2015.11.010","relation":{},"ISSN":["0010-440X"],"issn-type":[{"value":"0010-440X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain-derived neurotrophic factor serum levels in heroin-dependent patients after 26weeks of withdrawal","name":"articletitle","label":"Article Title"},{"value":"Comprehensive Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.comppsych.2015.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}