{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:36:10Z","timestamp":1777905370048,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comprehensive Psychiatry"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.comppsych.2016.05.006","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T21:00:28Z","timestamp":1462914028000},"page":"216-224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Correlation between the level of microRNA expression in peripheral blood mononuclear cells and symptomatology in patients with generalized anxiety disorder"],"prefix":"10.1016","volume":"69","author":[{"given":"Sheng-dong","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-yang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-ming","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-jun","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-min","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-shuai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai-fang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.comppsych.2016.05.006_bb0005","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.euroneuro.2011.07.018","article-title":"The size and burden of mental disorders and other disorders of the brain in Europe 2010","volume":"21","author":"Wittchen","year":"2011","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0010","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.genhosppsych.2007.12.006","article-title":"Anxiety disorders and comorbid medical illness","volume":"30","author":"Roy-Byrne","year":"2008","journal-title":"Gen Hosp Psychiatry"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0015","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/hup.2397","article-title":"Health literacy and the pharmacological treatment of anxiety disorders: a systematic review","volume":"29","author":"Palazzo","year":"2014","journal-title":"Hum Psychopharmacol"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0020","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00109-004-0603-7","article-title":"Regulatory polymorphisms underlying complex disease traits","volume":"83","author":"Knight","year":"2005","journal-title":"J Mol Med"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0025","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.2174\/138161212803530781","article-title":"Genetics of anxiety disorders - status quo and quo vadis","volume":"18","author":"Domschke","year":"2012","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0030","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrg2936","article-title":"Gene silencing by microRNAs: contributions of translational repression and mRNA decay","volume":"12","author":"Huntzinger","year":"2011","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0035","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature07242","article-title":"The impact of microRNAs on protein output","volume":"455","author":"Baek","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0040","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg2843","article-title":"The widespread regulation of microRNA biogenesis, function and decay","volume":"11","author":"Krol","year":"2010","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0045","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1038\/npp.2008.131","article-title":"Evidence for selective microRNAs and their effectors as common long-term targets for the actions of mood stabilizers","volume":"34","author":"Zhou","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0050","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s12017-009-8070-5","article-title":"MicroRNAs in mental health: from biological underpinnings to potential therapies","volume":"11","author":"Hunsberger","year":"2009","journal-title":"Neuromolecular Med"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0055","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.stem.2010.02.017","article-title":"Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation","volume":"6","author":"Liu","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0060","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s11910-008-0031-0","article-title":"MicroRNAs in brain function and disease","volume":"8","author":"Kuss","year":"2008","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0065","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neulet.2012.03.062","article-title":"MicroRNAs miR-144\/144* and miR-16 in peripheral blood are potential biomarkers for naturalistic stress in healthy Japanese medical students","volume":"516","author":"Katsuura","year":"2012","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0070","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jpsychires.2014.03.008","article-title":"A preliminary analysis of association between the down-regulation of microRNA-181b expression and symptomatology improvement in schizophrenia patients before and after antipsychotic treatment","volume":"54","author":"Song","year":"2014","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpsychires.2014.08.007","article-title":"Differential expression of microRNA in peripheral blood mononuclear cells as specific biomarker for major depressive disorder patients","author":"Fan","year":"2014","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0080","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nrn2639","article-title":"Effects of stress throughout the lifespan on the brain, behaviour and cognition","volume":"10","author":"Lupien","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0085","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12031-009-9252-1","article-title":"Changes in brain MicroRNAs contribute to cholinergic stress reactions","volume":"40","author":"Meerson","year":"2010","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0090","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1111\/j.1460-9568.2008.06218.x","article-title":"Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor","volume":"27","author":"Uchida","year":"2008","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0095","doi-asserted-by":"crossref","first-page":"14191","DOI":"10.1523\/JNEUROSCI.1673-11.2011","article-title":"MicroRNA as repressors of stress-induced anxiety: the case of amygdalar miR-34","volume":"31","author":"Haramati","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0100","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00429-011-0376-z","article-title":"Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target","volume":"218","author":"Shaltiel","year":"2013","journal-title":"Brain Struct Funct"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0105","doi-asserted-by":"crossref","first-page":"e1003517","DOI":"10.1371\/journal.pcbi.1003517","article-title":"Long non-coding RNA and alternative splicing modulations in Parkinson's leukocytes identified by RNA sequencing","volume":"10","author":"Soreq","year":"2014","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0110","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.pnpbp.2004.01.009","article-title":"Lymphocytes as a neural probe: potential for studying psychiatric disorders","volume":"28","author":"Gladkevich","year":"2004","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0115","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.psychres.2009.03.009","article-title":"Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders","volume":"175","author":"Marazziti","year":"2010","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0120","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jpsychires.2010.04.028","article-title":"MicroRNA-134 plasma levels before and after treatment for bipolar mania","volume":"45","author":"Rong","year":"2011","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0125","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jns.2013.10.002","article-title":"Circulating miR-125b as a biomarker of Alzheimer's disease","volume":"336","author":"Tan","year":"2014","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0130","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamilton","year":"1959","journal-title":"Br J Med Psychol"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0135","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nnano.2011.147","article-title":"Nanopore-based detection of circulating microRNAs in lung cancer patients","volume":"6","author":"Wang","year":"2011","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0140","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/cns.12019","article-title":"Circulating microRNAs as potential risk biomarkers for hematoma enlargement after intracerebral hemorrhage","volume":"18","author":"Zheng","year":"2012","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0145","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0150","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0155","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nature04367","article-title":"A brain-specific microRNA regulates dendritic spine development","volume":"439","author":"Schratt","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0160","doi-asserted-by":"crossref","first-page":"16426","DOI":"10.1073\/pnas.0508448102","article-title":"A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis","volume":"102","author":"Vo","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0165","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1007\/s12035-012-8374-6","article-title":"Big effects of small RNAs: a review of microRNAs in anxiety","volume":"47","author":"Malan-Muller","year":"2013","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0170","doi-asserted-by":"crossref","first-page":"e75960","DOI":"10.1371\/journal.pone.0075960","article-title":"Chronic academic stress increases a group of microRNAs in peripheral blood","volume":"8","author":"Honda","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0175","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.neuron.2014.05.042","article-title":"MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity","volume":"83","author":"Issler","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0180","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3892\/ijmm.2013.1424","article-title":"Serum microRNA expression levels can predict lymph node metastasis in patients with early-stage cervical squamous cell carcinoma","volume":"32","author":"Chen","year":"2013","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0185","doi-asserted-by":"crossref","first-page":"e73786","DOI":"10.1371\/journal.pone.0073786","article-title":"Cell-specific post-transcriptional regulation of gamma-synuclein gene by micro-RNAs","volume":"8","author":"Surgucheva","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0190","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1177\/0194599812442490","article-title":"Integrative analysis in oral squamous cell carcinoma reveals DNA copy number-associated miRNAs dysregulating target genes","volume":"147","author":"Serrano","year":"2012","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0195","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1002\/jcb.24786","article-title":"Regulatory roles of miRNA in the human neural stem cell transformation to glioma stem cells","volume":"115","author":"Liu","year":"2014","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0200","doi-asserted-by":"crossref","first-page":"13899","DOI":"10.1074\/jbc.M111.301275","article-title":"Combined analysis of microRNome and 3'-UTRome reveals a species-specific regulation of progesterone receptor expression in the endometrium of rhesus monkey","volume":"287","author":"Liu","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0205","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature11890","article-title":"\u2018See-saw\u2019 expression of microRNA-198 and FSTL1 from a single transcript in wound healing","volume":"495","author":"Sundaram","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0210","first-page":"269","article-title":"MicroRNA-663 induction upon oxidative stress in cultured human fibroblasts depends on the chronological age of the donor","volume":"15","author":"Waaijer","year":"2014","journal-title":"Biogerontology"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0215","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/jcp.21834","article-title":"Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts","volume":"221","author":"Maes","year":"2009","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0220","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1474-9726.2010.00549.x","article-title":"miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging","volume":"9","author":"Hackl","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0225","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.molonc.2011.08.004","article-title":"Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue","volume":"5","author":"Borgan","year":"2011","journal-title":"Mol Oncol"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0230","first-page":"641","article-title":"Bioinformatiics analysis of differently expressed microRNAs in anxiety disiorder","volume":"32","author":"Fan","year":"2015","journal-title":"Chin J Med Genet"},{"key":"10.1016\/j.comppsych.2016.05.006_bb0235","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1093\/hmg\/ddu170","article-title":"Competing targets of microRNA-608 affect anxiety and hypertension","volume":"23","author":"Hanin","year":"2014","journal-title":"Hum Mol Genet"}],"container-title":["Comprehensive Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010440X15302066?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010440X15302066?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T10:03:27Z","timestamp":1567850607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010440X15302066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":47,"alternative-id":["S0010440X15302066"],"URL":"https:\/\/doi.org\/10.1016\/j.comppsych.2016.05.006","relation":{},"ISSN":["0010-440X"],"issn-type":[{"value":"0010-440X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Correlation between the level of microRNA expression in peripheral blood mononuclear cells and symptomatology in patients with generalized anxiety disorder","name":"articletitle","label":"Article Title"},{"value":"Comprehensive Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.comppsych.2016.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}