{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:47:46Z","timestamp":1791978466437,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T00:00:00Z","timestamp":1596931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comprehensive Psychiatry"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.comppsych.2020.152199","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T21:18:51Z","timestamp":1597180731000},"page":"152199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["The serotonin transporter gene polymorphism (SLC6A4) and risk for psychiatric morbidity and comorbidity in the Baltimore ECA follow-up study"],"prefix":"10.1016","volume":"102","author":[{"given":"Ruben","family":"Miozzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Eaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"O.","family":"Joseph Bienvenu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Samuels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Nestadt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.comppsych.2020.152199_bb0005","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1073\/pnas.90.6.2542","article-title":"Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization","volume":"90","author":"Ramamoorthy","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.comppsych.2020.152199_bb0010","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1046\/j.1471-4159.1996.66062621.x","article-title":"Allelic variation of human serotonin transporter gene expression","volume":"66","author":"Heils","year":"1996","journal-title":"J Neurochem"},{"issue":"5292","key":"10.1016\/j.comppsych.2020.152199_bb0015","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1126\/science.274.5292.1527","article-title":"Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region","volume":"274","author":"Lesch","year":"1996","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.comppsych.2020.152199_bb0020","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0006-3223(99)00171-7","article-title":"A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity","volume":"47","author":"Heinz","year":"2000","journal-title":"Biol Psychiatry"},{"issue":"3","key":"10.1016\/j.comppsych.2020.152199_bb0025","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1176\/appi.ajp.161.3.525","article-title":"Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype","volume":"161","author":"van Dyck","year":"2004","journal-title":"Am J Psychiatry"},{"issue":"7","key":"10.1016\/j.comppsych.2020.152199_bb0030","first-page":"646","article-title":"A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II","volume":"8","author":"Anguelova","year":"2003","journal-title":"Suicidal Behav Mol Psychiatry"},{"issue":"6","key":"10.1016\/j.comppsych.2020.152199_bb0035","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/sj.mp.4001328","article-title":"A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders","volume":"8","author":"Anguelova","year":"2003","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.comppsych.2020.152199_bb0040","first-page":"19","article-title":"Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapy","volume":"5","author":"Kenna","year":"2012","journal-title":"Pharmgenom Pers Med"},{"issue":"5631","key":"10.1016\/j.comppsych.2020.152199_bb0045","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1126\/science.1083968","article-title":"Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene","volume":"301","author":"Caspi","year":"2003","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.comppsych.2020.152199_bb0050","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1001\/archpsyc.65.5.513","article-title":"Population-based study of first onset and chronicity in major depressive disorder","volume":"65","author":"Eaton","year":"2008","journal-title":"Arch Gen Psychiatry"},{"issue":"11","key":"10.1016\/j.comppsych.2020.152199_bb0055","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1001\/archpsyc.1997.01830230023003","article-title":"Natural history of diagnostic interview schedule\/DSM-IV major depression. The Baltimore epidemiologic catchment area follow-up","volume":"54","author":"Eaton","year":"1997","journal-title":"Arch Gen Psychiatry"},{"issue":"6","key":"10.1016\/j.comppsych.2020.152199_bb0060","first-page":"453","article-title":"A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders","volume":"1","author":"Collier","year":"1996","journal-title":"Mol Psychiatry"},{"issue":"1","key":"10.1016\/j.comppsych.2020.152199_bb0065","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/(SICI)1096-8628(19980207)81:1<58::AID-AJMG11>3.0.CO;2-V","article-title":"Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders","volume":"81","author":"Furlong","year":"1998","journal-title":"Am J Med Genet"},{"issue":"3","key":"10.1016\/j.comppsych.2020.152199_bb0070","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s004390050823","article-title":"Variability in the serotonin transporter gene and increased risk for major depression with melancholia","volume":"103","author":"Guti\u00e9rrez","year":"1998","journal-title":"Hum Genet"},{"issue":"4","key":"10.1016\/j.comppsych.2020.152199_bb0075","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1472-8206.2007.00501.x","article-title":"Increased risk for major depression associated with the short allele of the serotonin transporter promoter region (5-HTTLPR-S) and the CYP2C9*3 allele","volume":"21","author":"Dorado","year":"2007","journal-title":"Fundam Clin Pharmacol"},{"issue":"5","key":"10.1016\/j.comppsych.2020.152199_bb0080","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1001\/archpsyc.62.5.529","article-title":"The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication","volume":"62","author":"Kendler","year":"2005","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"10.1016\/j.comppsych.2020.152199_bb0085","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/YPG.0b013e328335112b","article-title":"Association between major depressive disorder and a functional polymorphism of the 5-hydroxytryptamine (serotonin) transporter gene: a meta-analysis","volume":"20","author":"Kiyohara","year":"2010","journal-title":"Psychiatr Genet"},{"issue":"6","key":"10.1016\/j.comppsych.2020.152199_bb0090","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/ajmg.b.30534","article-title":"Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample","volume":"144B","author":"Chorbov","year":"2007","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"2","key":"10.1016\/j.comppsych.2020.152199_bb0095","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0304-3940(01)01704-9","article-title":"Serotonin-2A-receptor and -transporter polymorphisms: lack of association in patients with major depression","volume":"303","author":"Minov","year":"2001","journal-title":"Neurosci Lett"},{"issue":"4","key":"10.1016\/j.comppsych.2020.152199_bb0100","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/sj.mp.4000536","article-title":"Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways","volume":"4","author":"Frisch","year":"1999","journal-title":"Mol Psychiatry"},{"issue":"7","key":"10.1016\/j.comppsych.2020.152199_bb0105","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0006-3223(98)00112-7","article-title":"Functional polymorphism in the serotonin transporter promoter at the SLC6A4 locus and mood disorders","volume":"44","author":"Ohara","year":"1998","journal-title":"Biol Psychiatry"},{"issue":"1","key":"10.1016\/j.comppsych.2020.152199_bb0110","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/mp.2017.44","article-title":"Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression","volume":"23","author":"Culverhouse","year":"2018","journal-title":"Mol Psychiatry"},{"issue":"5","key":"10.1016\/j.comppsych.2020.152199_bb0115","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1176\/appi.ajp.2018.18070881","article-title":"No support for historical candidate gene or candidate gene-by-interaction hypotheses for major depression across multiple large samples","volume":"176","author":"Border","year":"2019","journal-title":"Am J Psychiatry"},{"issue":"3","key":"10.1016\/j.comppsych.2020.152199_bb0120","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/eat.20811","article-title":"The 5-HTTLPR polymorphism and eating disorders: a meta-analysis","volume":"44","author":"Calati","year":"2011","journal-title":"Int J Eat Disord"},{"issue":"3","key":"10.1016\/j.comppsych.2020.152199_bb0125","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/da.20064","article-title":"Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder","volume":"21","author":"Lee","year":"2005","journal-title":"Depress Anxiety"},{"issue":"1","key":"10.1016\/j.comppsych.2020.152199_bb0130","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/ajmg.b.30132","article-title":"Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence","volume":"133B","author":"Feinn","year":"2005","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"6","key":"10.1016\/j.comppsych.2020.152199_bb0135","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/ajmg.b.30699","article-title":"Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review","volume":"147B","author":"Bloch","year":"2008","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"5","key":"10.1016\/j.comppsych.2020.152199_bb0140","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/sj.mp.4000550","article-title":"Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder","volume":"4","author":"Bengel","year":"1999","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.comppsych.2020.152199_bb0145","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1192\/bjp.173.6.501","article-title":"Onset and recovery from panic disorder in the Baltimore epidemiologic catchment area follow-up","volume":"173","author":"Eaton","year":"1998","journal-title":"Br J Psychiatry"},{"issue":"4","key":"10.1016\/j.comppsych.2020.152199_bb0150","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1001\/archpsyc.1981.01780290015001","article-title":"National Institute of Mental Health diagnostic interview schedule. Its history, characteristics, and validity","volume":"38","author":"Robins","year":"1981","journal-title":"Arch Gen Psychiatry"},{"issue":"4","key":"10.1016\/j.comppsych.2020.152199_bb0155","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1017\/S0033291700005031","article-title":"Brief report on the clinical reappraisal of the diagnostic interview schedule carried out at the Johns Hopkins site of the epidemiological catchment area program of the NIMH","volume":"15","author":"Folstein","year":"1985","journal-title":"Psychol Med"},{"key":"10.1016\/j.comppsych.2020.152199_bb0160","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1192\/bjp.180.6.536","article-title":"Prevalence and correlates of personality disorders in a community sample","volume":"180","author":"Samuels","year":"2002","journal-title":"Br J Psychiatry"},{"issue":"3","key":"10.1016\/j.comppsych.2020.152199_bb0165","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1176\/ps.2007.58.3.373","article-title":"Psychiatrists\u2019 ascertained treatment needs for mental disorders in a population-based sample","volume":"58","author":"Messias","year":"2007","journal-title":"Psychiatr Serv"},{"issue":"9","key":"10.1016\/j.comppsych.2020.152199_bb0170","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.jpsychires.2011.03.003","article-title":"Association between a serotonin transporter promoter polymorphism (5HTTLPR) and personality disorder traits in a community sample","volume":"45","author":"Blom","year":"2011","journal-title":"J Psychiatr Res"},{"issue":"6","key":"10.1016\/j.comppsych.2020.152199_bb0175","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1001\/archpsyc.1990.01810180089012","article-title":"SCAN. Schedules for clinical assessment in neuropsychiatry","volume":"47","author":"Wing","year":"1990","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.comppsych.2020.152199_bb0180","series-title":"Schedules for clinical assessment in neuropsychiatry version 2.0","author":"World Health Organization","year":"1993"},{"key":"10.1016\/j.comppsych.2020.152199_bb0185","series-title":"Diagnostic and statistical manual of mental disorders third edition, revised","author":"American Psychiatric Association","year":"1987"},{"issue":"2","key":"10.1016\/j.comppsych.2020.152199_bb0190","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/mp.2008.79","article-title":"Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR)","volume":"15","author":"Strug","year":"2010","journal-title":"Mol Psychiatry"},{"issue":"1","key":"10.1016\/j.comppsych.2020.152199_bb0195","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neulet.2010.08.042","article-title":"Panic disorder and serotonergic genes (SLC6A4, HTR1A and HTR2A): association and interaction with childhood trauma and parenting","volume":"485","author":"Blaya","year":"2010","journal-title":"Neurosci Lett"},{"issue":"1","key":"10.1016\/j.comppsych.2020.152199_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.npp.1300880","article-title":"Serotonin function in panic disorder: important, but why?","volume":"31","author":"Maron","year":"2006","journal-title":"Neuropsychopharmacology."},{"issue":"12","key":"10.1016\/j.comppsych.2020.152199_bb0205","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/jcpp.13079","article-title":"Serotonin system genes and obsessive-compulsive trait dimensions in a population-based, pediatric sample: a genetic association study","volume":"60","author":"Sinopoli","year":"2019","journal-title":"J Child Psychol Psychiatry"},{"issue":"3","key":"10.1016\/j.comppsych.2020.152199_bb0210","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/ajmg.b.32407","article-title":"Disorder-specific genetic factors in obsessive-compulsive disorder: a comprehensive meta-analysis","volume":"171B","author":"Taylor","year":"2016","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"10","key":"10.1016\/j.comppsych.2020.152199_bb0215","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1001\/archpsyc.56.10.921","article-title":"The structure of common mental disorders","volume":"56","author":"Krueger","year":"1999","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"10.1016\/j.comppsych.2020.152199_bb0220","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1001\/archgenpsychiatry.2010.188","article-title":"A dimensional-spectrum model of psychopathology: progress and opportunities","volume":"68","author":"Krueger","year":"2011","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.comppsych.2020.152199_bb0225","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2045-5380-2-13","article-title":"How research on the meta-structure of psychopathology aids in understanding biological correlates of mood and anxiety disorders","volume":"2","author":"Ofrat","year":"2012","journal-title":"Biol Mood Anxiety Disord"},{"issue":"5","key":"10.1016\/j.comppsych.2020.152199_bb0230","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.biopsych.2009.04.030","article-title":"Accurate, large-scale genotyping of 5HTTLPR and flanking single nucleotide polymorphisms in an association study of depression, anxiety, and personality measures","volume":"66","author":"Wray","year":"2009","journal-title":"Biol Psychiatry"}],"container-title":["Comprehensive Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010440X20300419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010440X20300419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T18:36:36Z","timestamp":1757874996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010440X20300419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":46,"alternative-id":["S0010440X20300419"],"URL":"https:\/\/doi.org\/10.1016\/j.comppsych.2020.152199","relation":{},"ISSN":["0010-440X"],"issn-type":[{"value":"0010-440X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The serotonin transporter gene polymorphism (SLC6A4) and risk for psychiatric morbidity and comorbidity in the Baltimore ECA follow-up study","name":"articletitle","label":"Article Title"},{"value":"Comprehensive Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.comppsych.2020.152199","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"152199"}}