{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:40:55Z","timestamp":1782895255200,"version":"3.54.5"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral and Maxillofacial Surgery Clinics of North America"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.coms.2026.03.005","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T21:35:10Z","timestamp":1776288910000},"page":"433-440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nuances of Perioperative Therapy in Gingivobuccal Cancers"],"prefix":"10.1016","volume":"38","author":[{"given":"Anoop Remesan","family":"Nair","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpaja Kuttassery","family":"Ullattil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnakumar","family":"Thankappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4\u20135","key":"10.1016\/j.coms.2026.03.005_bib1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.oraloncology.2008.05.017","article-title":"Current concepts in management of oral cancer\u2014surgery","volume":"45","author":"Shah","year":"2009","journal-title":"Oral Oncol"},{"issue":"1","key":"10.1016\/j.coms.2026.03.005_bib2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/jomfp.JOMFP_113_17","article-title":"Oral cancer statistics in India on the basis of first report of 29 population-based cancer registries","volume":"22","author":"Sharma","year":"2018","journal-title":"J Oral Maxillofac Pathol"},{"issue":"2","key":"10.1016\/j.coms.2026.03.005_bib3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4103\/0019-509X.25886","article-title":"Oral squamous cell carcinoma: etiology, pathogenesis and prognostic value of genomic alterations","volume":"43","author":"Mehrotra","year":"2006","journal-title":"Indian J Cancer"},{"issue":"4","key":"10.1016\/j.coms.2026.03.005_bib4","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1046\/j.1440-1843.2003.00507.x","article-title":"Smokeless tobacco and health in India and South Asia","volume":"8","author":"Gupta","year":"2003","journal-title":"Respirology"},{"issue":"4","key":"10.1016\/j.coms.2026.03.005_bib5","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/0002-9610(80)90211-1","article-title":"Carcinoma of the cheek mucosa. A retrospective analysis","volume":"140","author":"Bloom","year":"1980","journal-title":"Am J Surg"},{"issue":"5","key":"10.1016\/j.coms.2026.03.005_bib6","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0748-7983(96)92969-8","article-title":"Post-operative radiotherapy in carcinoma of buccal mucosa, a prospective randomized trial","volume":"22","author":"Mishra","year":"1996","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.coms.2026.03.005_bib7","series-title":"AJCC cancer staging manual","year":"2017"},{"issue":"4","key":"10.1016\/j.coms.2026.03.005_bib8","first-page":"1925","article-title":"Need for adjuvant radiotherapy in oral cancer: depth of invasion rather than tumor diameter","volume":"280","author":"Rusterholz","year":"2023","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"20","key":"10.1016\/j.coms.2026.03.005_bib9","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1200\/JCO.18.01921","article-title":"Management of the neck in squamous cell carcinoma of the oral cavity and oropharynx: ASCO Clinical Practice Guideline","volume":"37","author":"Koyfman","year":"2019","journal-title":"J Clin Oncol"},{"issue":"19","key":"10.1016\/j.coms.2026.03.005_bib10","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1056\/NEJMoa032641","article-title":"Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer","volume":"350","author":"Bernier","year":"2004","journal-title":"N Engl J Med"},{"issue":"19","key":"10.1016\/j.coms.2026.03.005_bib11","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa032646","article-title":"Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck","volume":"350","author":"Cooper","year":"2004","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1016\/j.coms.2026.03.005_bib12","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/hed.20279","article-title":"Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501)","volume":"27","author":"Bernier","year":"2005","journal-title":"Head Neck"},{"issue":"12","key":"10.1016\/j.coms.2026.03.005_bib13","first-page":"1105","article-title":"Re-examining post-operative chemoradiotherapy in head and neck cancer: an updated long-term combined analysis of RTOG 9501\/EORTC 22931","volume":"34","author":"Lacas","year":"2023","journal-title":"Ann Oncol"},{"issue":"18","key":"10.1016\/j.coms.2026.03.005_bib14","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1200\/JCO.22.00274","article-title":"For head and neck cancer, it is still cisplatin, but how much, how often, and how tolerable?","volume":"40","author":"Hayes","year":"2022","journal-title":"J Clin Oncol"},{"issue":"18","key":"10.1016\/j.coms.2026.03.005_bib15","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1200\/JCO.21.01293","article-title":"Weekly cisplatin plus radiation for postoperative head and neck cancer (JCOG1008): a multicenter, noninferiority, phase II\/III randomized controlled trial","volume":"40","author":"Kiyota","year":"2022","journal-title":"J Clin Oncol"},{"issue":"11","key":"10.1016\/j.coms.2026.03.005_bib16","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1200\/JCO.2017.74.9457","article-title":"Once-a-Week versus Once-Every-3-Weeks cisplatin chemoradiation for locally advanced head and neck cancer: a phase III randomized noninferiority trial","volume":"36","author":"Noronha","year":"2018","journal-title":"J Clin Oncol"},{"issue":"23","key":"10.1016\/j.coms.2026.03.005_bib17","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1200\/JCO.2013.53.9163","article-title":"Postoperative chemoradiotherapy and cetuximab for high-risk squamous cell carcinoma of the head and neck: Radiation Therapy Oncology Group RTOG-0234","volume":"32","author":"Harari","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.coms.2026.03.005_bib18","first-page":"1","article-title":"Current treatment strategies and risk stratification for oral carcinoma","volume":"42","author":"Kiyota","year":"2022","journal-title":"JCO Educ Book"},{"issue":"2","key":"10.1016\/j.coms.2026.03.005_bib19","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.radonc.2017.06.026","article-title":"Dose-volume correlates of mandibular osteoradionecrosis in oropharynx cancer patients receiving intensity-modulated radiotherapy: results from a case-matched comparison","volume":"124","author":"Mohamed","year":"2017","journal-title":"Radiother Oncol"},{"issue":"3","key":"10.1016\/j.coms.2026.03.005_bib20","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.ijrobp.2011.04.020","article-title":"Treatment planning constraints to avoid xerostomia in head-and-neck radiotherapy: an independent test of QUANTEC criteria using a prospectively collected dataset","volume":"82","author":"Moiseenko","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3 Suppl","key":"10.1016\/j.coms.2026.03.005_bib21","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.ijrobp.2009.07.1754","article-title":"Use of normal tissue complication probability models in the clinic","volume":"76","author":"Marks","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.coms.2026.03.005_bib22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/0284186X.2015.1037864","article-title":"Dose-volume factors correlating with trismus following chemoradiation for head and neck cancer","volume":"55","author":"Rao","year":"2016","journal-title":"Acta Oncol"},{"issue":"10","key":"10.1016\/j.coms.2026.03.005_bib23","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.oraloncology.2014.07.015","article-title":"Neoadjuvant chemotherapy followed by surgery in very locally advanced technically unresectable oral cavity cancers","volume":"50","author":"Patil","year":"2014","journal-title":"Oral Oncol"},{"issue":"2","key":"10.1016\/j.coms.2026.03.005_bib24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/curroncol32020099","article-title":"Compartmentalization of high infratemporal fossa in oral cavity squamous cell carcinomas and its impact on clinical outcome","volume":"32","author":"Mahajan","year":"2025","journal-title":"Curr Oncol"},{"issue":"5","key":"10.1016\/j.coms.2026.03.005_bib25","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s12663-025-02549-6","article-title":"Comparative evaluation of upfront surgery and neoadjuvant chemotherapy followed by surgery in locally advanced oral squamous cell carcinoma","volume":"24","author":"Bera","year":"2025","journal-title":"J Maxillofac Oral Surg"},{"issue":"2","key":"10.1016\/j.coms.2026.03.005_bib26","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/hed.70035","article-title":"Neoadjuvant chemotherapy followed by surgery\u2014a promising strategy to reduce morbidity in locally advanced tongue cancer","volume":"48","author":"Deshpande","year":"2025","journal-title":"Head Neck"},{"issue":"10","key":"10.1016\/j.coms.2026.03.005_bib27","article-title":"Outcomes of neoadjuvant chemotherapy in locally advanced oral cancers: a retrospective analytical study","volume":"16","author":"Baskaran","year":"2024","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.coms.2026.03.005_bib28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1056\/NEJMoa2415434","article-title":"Neoadjuvant and adjuvant pembrolizumab in locally advanced head and neck cancer","volume":"393","author":"Uppaluri","year":"2025","journal-title":"N Engl J Med"},{"issue":"10526","key":"10.1016\/j.coms.2026.03.005_bib29","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0140-6736(25)01850-1","article-title":"Nivolumab added to cisplatin and radiotherapy versus cisplatin and radiotherapy alone after surgery for people with squamous cell carcinoma of the head and neck at a high risk of relapse (GORTEC 2018-01 NIVOPOST-OP): a randomised, open-label, phase 3 trial","volume":"407","author":"Bourhis","year":"2026","journal-title":"Lancet"},{"key":"10.1016\/j.coms.2026.03.005_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2025.103018","article-title":"Comparative review of KEYNOTE-689 and NIVOPOSTOP trials and their impact on perioperative immunotherapy in locally advanced head and neck cancer","volume":"140","author":"Imamura","year":"2025","journal-title":"Cancer Treat Rev"},{"issue":"10","key":"10.1016\/j.coms.2026.03.005_bib31","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1001\/jamaoto.2022.2291","article-title":"Association of neoadjuvant pembrolizumab for oral cavity squamous cell carcinoma with adverse events after surgery in treatment-naive patients","volume":"148","author":"Tang","year":"2022","journal-title":"JAMA Otolaryngol Head Neck Surg"}],"container-title":["Oral and Maxillofacial Surgery Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1042369926000191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1042369926000191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:38:25Z","timestamp":1782891505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1042369926000191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1042369926000191"],"URL":"https:\/\/doi.org\/10.1016\/j.coms.2026.03.005","relation":{},"ISSN":["1042-3699"],"issn-type":[{"value":"1042-3699","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nuances of Perioperative Therapy in Gingivobuccal Cancers","name":"articletitle","label":"Article Title"},{"value":"Oral and Maxillofacial Surgery Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coms.2026.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}