{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:02:37Z","timestamp":1789642957002,"version":"4.0.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Neurobiology"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.conb.2008.07.015","type":"journal-article","created":{"date-parts":[[2008,9,17]],"date-time":"2008-09-17T08:03:24Z","timestamp":1221638604000},"page":"245-250","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":213,"title":["L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth"],"prefix":"10.1016","volume":"18","author":[{"given":"Ralf S","family":"Schmid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia F","family":"Maness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.conb.2008.07.015_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nn1827","article-title":"Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration","volume":"10","author":"Maness","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.conb.2008.07.015_bib2","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1523\/JNEUROSCI.22-12-04918.2002","article-title":"The neural cell adhesion molecule L1 potentiates integrin-dependent cell migration to extracellular matrix proteins","volume":"22","author":"Thelen","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2008.07.015_bib3","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1083\/jcb.149.7.1485","article-title":"Plasmin-sensitive dibasic sequences in the third fibronectin-like domain of L1-cell adhesion molecule (CAM) facilitate homomultimerization and concomitant integrin recruitment","volume":"149","author":"Silletti","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1016\/j.conb.2008.07.015_bib4","first-page":"2791","article-title":"Adhesion molecule L1 stimulates neuronal migration through Vav2\u2013Pak1 signaling","volume":"15","author":"Schmid","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.conb.2008.07.015_bib5","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1523\/JNEUROSCI.20-11-04177.2000","article-title":"A MAP kinase signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis","volume":"11","author":"Schmid","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2008.07.015_bib6","doi-asserted-by":"crossref","first-page":"28880","DOI":"10.1074\/jbc.M404075200","article-title":"Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion","volume":"279","author":"Silletti","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.conb.2008.07.015_bib7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.molmed.2007.11.005","article-title":"Organizing the fluid membrane bilayer: diseases linked to spectrin and ankyrin","volume":"14","author":"Bennett","year":"2008","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.conb.2008.07.015_bib8","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1091\/mbc.e06-01-0090","article-title":"MAP kinase pathway-dependent phosphorylation of the L1-CAM ankyrin binding site regulates neuronal growth","volume":"17","author":"Whittard","year":"2006","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.conb.2008.07.015_bib9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1523\/JNEUROSCI.3573-07.2008","article-title":"L1 interaction with ankyrin regulates mediolateral topography in the retinocollicular projection","volume":"28","author":"Buhusi","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2008.07.015_bib10_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cell.2004.10.004","article-title":"Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at Purkinje axon initial segment","volume":"119","author":"Ango","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.conb.2008.07.015_bib11_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.neuron.2004.10.016","article-title":"Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex","volume":"44","author":"Demyanenko","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2008.07.015_bib12","doi-asserted-by":"crossref","first-page":"25024","DOI":"10.1074\/jbc.M303084200","article-title":"Close homolog of L1 is an enhancer of integrin-mediated cell migration","volume":"278","author":"Buhusi","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.conb.2008.07.015_bib13","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1093\/cercor\/bhi041","article-title":"Reelin, integrin and Dab1 interactions during embryonic cerebral cortical development","volume":"15","author":"Schmid","year":"2005","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.conb.2008.07.015_bib14","doi-asserted-by":"crossref","first-page":"13854","DOI":"10.1523\/JNEUROSCI.4494-07.2007","article-title":"Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex","volume":"27","author":"Belvindrah","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2008.07.015_bib15","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1083\/jcb.200104122","article-title":"Overlapping functions of the cell adhesion molecules Nr-CAM and L1 in cerebellar granule cell development","volume":"154","author":"Sakurai","year":"2001","journal-title":"J Cell Biol"},{"key":"10.1016\/j.conb.2008.07.015_bib16","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/sj.emboj.7601939","article-title":"Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha","volume":"27","author":"Ye","year":"2008","journal-title":"EMBO J"},{"key":"10.1016\/j.conb.2008.07.015_bib17","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0896-6273(02)00857-7","article-title":"Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex","volume":"35","author":"Sasaki","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2008.07.015_bib18","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nn2018","article-title":"Semaphorin-3A guides radial migration of cortical neurons during development","volume":"11","author":"Chen","year":"2008","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.conb.2008.07.015_bib19","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/35007001","article-title":"Semaphorin 3A is a chemoattractant for cortical apical dendrites","volume":"404","author":"Polleux","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.conb.2008.07.015_bib20","doi-asserted-by":"crossref","first-page":"13667","DOI":"10.1523\/JNEUROSCI.2888-07.2007","article-title":"Close homolog of L1 and neuropilin 1 mediate guidance of thalamocortical axons at the ventral telencephalon","volume":"27","author":"Wright","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2008.07.015_bib21_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0896-6273(00)00033-7","article-title":"Analysis of the L1-deficient mouse phenotype reveals cross-talk between Sema3A and L1 signaling pathways in axonal guidance [see comments]","volume":"27","author":"Castellani","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2008.07.015_bib22","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1038\/emboj.2008.86","article-title":"FAK\u2013MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse","volume":"27","author":"Bechara","year":"2008","journal-title":"EMBO J"},{"key":"10.1016\/j.conb.2008.07.015_bib23","doi-asserted-by":"crossref","first-page":"6348","DOI":"10.1093\/emboj\/cdf645","article-title":"Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A","volume":"21","author":"Castellani","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.conb.2008.07.015_bib24","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0896-6273(03)00666-4","article-title":"FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies","volume":"40","author":"Beggs","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2008.07.015_bib25","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/nn1317","article-title":"Control of axonal branching and synapse formation by focal adhesion kinase","volume":"7","author":"Rico","year":"2004","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.conb.2008.07.015_bib26","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1083\/jcb.200109059","article-title":"Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis","volume":"157","author":"Niethammer","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.conb.2008.07.015_bib27","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1523\/JNEUROSCI.20-06-02238.2000","article-title":"Neural cell adhesion molecule-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras\u2013mitogen-activated protein kinase pathway","volume":"20","author":"Kolkova","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2008.07.015_bib28_1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0092-8674(03)00435-5","article-title":"The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands","volume":"113","author":"Paratcha","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.conb.2008.07.015_bib29","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.neuron.2005.01.043","article-title":"GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons","volume":"45","author":"Pozas","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2008.07.015_bib30_1","doi-asserted-by":"crossref","first-page":"42971","DOI":"10.1074\/jbc.M511097200","article-title":"Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule","volume":"280","author":"Weinhold","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.conb.2008.07.015_bib31","doi-asserted-by":"crossref","first-page":"6659","DOI":"10.1128\/MCB.00205-07","article-title":"Polysialic acid-directed migration and differentiation of neural precursors are essential for mouse brain development","volume":"27","author":"Angata","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.conb.2008.07.015_bib32","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/nn2008","article-title":"Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity","volume":"10","author":"Di Cristo","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.conb.2008.07.015_bib33","doi-asserted-by":"crossref","first-page":"9372","DOI":"10.1523\/JNEUROSCI.1702-04.2004","article-title":"Polysialylated neural cell adhesion molecule promotes remodeling and formation of hippocampal synapses","volume":"24","author":"Dityatev","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2008.07.015_bib34","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4419-1170-4_19","article-title":"NCAM in neuropsychiatric and neurodegenerative disorders","author":"Brennaman","year":"2008","journal-title":"Neurochem Res"},{"key":"10.1016\/j.conb.2008.07.015_bib35","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1242\/jcs.019729","article-title":"NCAM is ubiquitylated, endocytosed and recycled in neurons","volume":"120","author":"Diestel","year":"2007","journal-title":"J Cell Sci"},{"key":"10.1016\/j.conb.2008.07.015_bib36","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.mcn.2008.01.006","article-title":"Developmental regulation of GABAergic interneuron branching and synaptic development in the prefrontal cortex by soluble neural cell adhesion molecule","volume":"37","author":"Brennaman","year":"2008","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.conb.2008.07.015_bib37","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1083\/jcb.200101099","article-title":"Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins","volume":"155","author":"Mechtersheimer","year":"2001","journal-title":"J Cell Biol"},{"key":"10.1016\/j.conb.2008.07.015_bib38","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1523\/JNEUROSCI.0565-05.2005","article-title":"Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior","volume":"25","author":"Pillai-Nair","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2008.07.015_bib39","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0014-2999(00)00568-9","article-title":"Dysregulation of the neural cell adhesion molecule and neuropsychiatric disorders","volume":"405","author":"Vawter","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.conb.2008.07.015_bib40","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4419-1170-4_20","article-title":"Neural cell adhesion molecule in cancer: expression and mechanisms","author":"Zecchini","year":"2008","journal-title":"Neurochem Res"},{"key":"10.1016\/j.conb.2008.07.015_bib41","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/ijc.21880","article-title":"The adhesion molecule L1 (CD171) promotes melanoma progression","volume":"119","author":"Meier","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1016\/j.conb.2008.07.015_bib42","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/sj.onc.1210769","article-title":"Deregulated Wnt\/beta-catenin program in high-risk neuroblastomas without MYCN amplification","volume":"27","author":"Liu","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.conb.2008.07.015_bib43","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.canlet.2007.11.012","article-title":"Antibodies directed against L1-CAM synergize with Genistein in inhibiting growth and survival pathways in SKOV3ip human ovarian cancer cells","volume":"261","author":"Novak-Hofer","year":"2008","journal-title":"Cancer Lett"},{"key":"10.1016\/j.conb.2008.07.015_bib44","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/hmg\/9.6.879","article-title":"Neural cell recognition molecule L1: relating biological complexity to human disease mutations","volume":"9","author":"Kenwrick","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.conb.2008.07.015_bib45","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/hmg\/ddg165","article-title":"CALL interrupted in a patient with nonspecific mental retardation: gene dosage-dependent alteration of murine brain development and behavior","volume":"12","author":"Frints","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.conb.2008.07.015_bib46","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0006-3223(00)00978-1","article-title":"Neuropathology of bipolar disorder","volume":"48","author":"Vawter","year":"2000","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.conb.2008.07.015_bib47","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/YPG.0b013e328012d850","article-title":"NCAM1 association study of bipolar disorder and schizophrenia: polymorphisms and alternatively spliced isoforms lead to similarities and differences","volume":"17","author":"Atz","year":"2007","journal-title":"Psychiatr Genet"}],"container-title":["Current Opinion in Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959438808000731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959438808000731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T12:26:03Z","timestamp":1760703963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959438808000731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0959438808000731"],"URL":"https:\/\/doi.org\/10.1016\/j.conb.2008.07.015","relation":{},"ISSN":["0959-4388"],"issn-type":[{"value":"0959-4388","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.conb.2008.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}