{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:05:31Z","timestamp":1793214331803,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"The Multiple Sclerosis Society (Scotland)"},{"name":"BMBF (Leukonet)"},{"name":"Deutsche Forschungsgemeinschaft (CMPB, SFB\/TR43)"},{"name":"EU-FP6 (X-ALD and Peroxisomes)"},{"name":"EU-FP7 (NGIDD)"},{"name":"Olivers Army"}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Neurobiology"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.conb.2009.08.003","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T05:25:34Z","timestamp":1253165134000},"page":"498-504","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["The role of CNS glia in preserving axon function"],"prefix":"10.1016","volume":"19","author":[{"given":"Julia M","family":"Edgar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus-Armin","family":"Nave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.conb.2009.08.003_bib1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0006-8993(92)90178-C","article-title":"Fiber composition of the human corpus callosum","volume":"598","author":"Aboitiz","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.conb.2009.08.003_bib2","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1002\/glia.20557","article-title":"Astrocyte glycogen and brain energy metabolism","volume":"55","author":"Brown","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.conb.2009.08.003_bib3","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/(SICI)1098-1136(20000115)29:2<112::AID-GLIA3>3.0.CO;2-Z","article-title":"Unwrapping new layers of complexity in axon\/glial relationships","volume":"29","author":"Witt","year":"2000","journal-title":"Glia"},{"key":"10.1016\/j.conb.2009.08.003_bib4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.immunol.021908.132528","article-title":"Microglial physiology: unique stimuli, specialized responses","volume":"27","author":"Ransohoff","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.conb.2009.08.003_bib5","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S1474-4422(09)70043-2","article-title":"Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis","volume":"8","author":"Trapp","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.conb.2009.08.003_bib6","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1002\/glia.20778","article-title":"Biology and pathology of nonmyelinating Schwann cells","volume":"56","author":"Griffin","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.conb.2009.08.003_bib7","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/glia.20528","article-title":"Activity-dependent regulation of energy metabolism by astrocytes: an update","volume":"55","author":"Pellerin","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.conb.2009.08.003_bib8","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1093\/brain\/awl323","article-title":"Axonal protection in multiple sclerosis\u2014a particular need during remyelination?","volume":"129","author":"Smith","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.conb.2009.08.003_bib9","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nn0507-535","article-title":"ALS: astrocytes move in as deadly neighbors","volume":"10","author":"Julien","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.conb.2009.08.003_bib10","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.neuro.30.051606.094309","article-title":"Axon\u2013glial signaling and the glial support of axon function","volume":"31","author":"Nave","year":"2008","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.conb.2009.08.003_bib11","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/nn1997","article-title":"Microglia: active sensor and versatile effector cells in the normal and pathologic brain","volume":"10","author":"Hanisch","year":"2007","journal-title":"Nat Neurosci"},{"issue":"Pt 11","key":"10.1016\/j.conb.2009.08.003_bib12","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1093\/brain\/123.11.2314","article-title":"Evidence for adaptive functional changes in the cerebral cortex with axonal injury from multiple sclerosis","volume":"123","author":"Reddy","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.conb.2009.08.003_bib13","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.expneurol.2007.07.005","article-title":"White matter inhibitors in CNS axon regeneration failure","volume":"209","author":"Xie","year":"2008","journal-title":"Exp Neurol"},{"key":"10.1016\/j.conb.2009.08.003_bib14","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1469-1809.2007.00412.x","article-title":"Charcot\u2013Marie-Tooth disease: a clinico-genetic confrontation","volume":"72","author":"Barisic","year":"2008","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.conb.2009.08.003_bib15","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/ncpneuro0583","article-title":"Mechanisms of disease: inherited demyelinating neuropathies\u2014from basic to clinical research","volume":"3","author":"Nave","year":"2007","journal-title":"Nat Clin Pract Neurol"},{"key":"10.1016\/j.conb.2009.08.003_bib16","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/glia.20386","article-title":"Schwann cells and the pathogenesis of inherited motor and sensory neuropathies (Charcot\u2013Marie-Tooth disease)","volume":"54","author":"Berger","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.conb.2009.08.003_bib17","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S1474-4422(08)70258-8","article-title":"Hereditary spastic paraplegia: clinical features and pathogenetic mechanisms","volume":"7","author":"Salinas","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.conb.2009.08.003_bib18","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1086\/344206","article-title":"Is the transportation highway the right road for hereditary spastic paraplegia?","volume":"71","author":"Crosby","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.conb.2009.08.003_bib19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/ng0394-257","article-title":"X-linked spastic paraplegia and Pelizaeus-Merzbacher disease are allelic disorders at the proteolipid protein locus","volume":"6","author":"Saugier-Veber","year":"1994","journal-title":"Nat Genet"},{"key":"10.1016\/j.conb.2009.08.003_bib20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0896-6273(01)80046-5","article-title":"Assembly of CNS myelin in the absence of proteolipid protein","volume":"18","author":"Klugmann","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2009.08.003_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.brainres.2008.11.066","article-title":"Effects of osmolality on PLP-null myelin structure: implications re axon damage","volume":"1253","author":"Rosenbluth","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.conb.2009.08.003_bib22","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/glia.20370","article-title":"Subtle myelin defects in PLP-null mice","volume":"54","author":"Rosenbluth","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.conb.2009.08.003_bib23","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1126\/science.280.5369.1610","article-title":"Axonal swellings and degeneration in mice lacking the major proteolipid of myelin","volume":"280","author":"Griffiths","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.conb.2009.08.003_bib24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1083\/jcb.200312012","article-title":"Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia","volume":"166","author":"Edgar","year":"2004","journal-title":"J Cell Biol"},{"key":"10.1016\/j.conb.2009.08.003_bib25","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1083\/jcb.200509174","article-title":"Evolution of a neuroprotective function of central nervous system myelin","volume":"172","author":"Yin","year":"2006","journal-title":"J Cell Biol"},{"key":"10.1016\/j.conb.2009.08.003_bib26","doi-asserted-by":"crossref","first-page":"7068","DOI":"10.1523\/JNEUROSCI.0771-08.2008","article-title":"P0 protein is required for and can induce formation of Schmidt-Lantermann incisures in myelin internodes","volume":"28","author":"Yin","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2009.08.003_bib27","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1523\/JNEUROSCI.20-11-04002.2000","article-title":"The evolution of lipophilin genes from invertebrates to tetrapods: DM-20 cannot replace proteolipid protein in CNS myelin","volume":"20","author":"Stecca","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2009.08.003_bib28","doi-asserted-by":"crossref","first-page":"7717","DOI":"10.1523\/JNEUROSCI.1254-07.2007","article-title":"Proteolipid protein is required for transport of sirtuin 2 into CNS myelin","volume":"27","author":"Werner","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2009.08.003_bib29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.mam.2007.02.001","article-title":"SIRT1 and neuronal diseases","volume":"29","author":"Tang","year":"2008","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.conb.2009.08.003_bib30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11064-006-9127-6","article-title":"Microtubule deacetylases, SirT2 and HDAC6, in the nervous system","volume":"32","author":"Southwood","year":"2007","journal-title":"Neurochem Res"},{"key":"10.1016\/j.conb.2009.08.003_bib31","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/ng1095","article-title":"Disruption of the CNP gene uncouples oligodendroglial functions in axonal support and myelination","volume":"33","author":"Lappe-Siefke","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.conb.2009.08.003_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/glia.20893","article-title":"Early ultrastructural defects of axons and axon\u2013glia junctions in mice lacking expression of Cnp1","author":"Edgar","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.conb.2009.08.003_bib33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/1097-4547(20010115)63:2<151::AID-JNR1007>3.0.CO;2-Y","article-title":"Myelin proteolipid proteins promote the interaction of oligodendrocytes and axons","volume":"63","author":"Yool","year":"2001","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.conb.2009.08.003_bib34","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1093\/brain\/awm236","article-title":"Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?","volume":"130","author":"Marik","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.conb.2009.08.003_bib35","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.mcn.2004.06.006","article-title":"Comparison of myelin, axon, lipid, and immunopathology in the central nervous system of differentially myelin-compromised mutant mice: a morphological and biochemical study","volume":"27","author":"Loers","year":"2004","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.conb.2009.08.003_bib36","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1523\/JNEUROSCI.18-06-01953.1998","article-title":"Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons","volume":"18","author":"Yin","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2009.08.003_bib37","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.expneurol.2005.04.017","article-title":"Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: Neuropathology and behavioral deficits in single- and double-null mice","volume":"195","author":"Pan","year":"2005","journal-title":"Exp Neurol"},{"key":"10.1016\/j.conb.2009.08.003_bib38_1","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1523\/JNEUROSCI.5204-08.2009","article-title":"Axonal protective effects of the myelin-associated glycoprotein","volume":"29","author":"Nguyen","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2009.08.003_bib39","doi-asserted-by":"crossref","first-page":"9741","DOI":"10.1523\/JNEUROSCI.0458-08.2008","article-title":"Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration","volume":"28","author":"Zoller","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2009.08.003_bib40","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11064-008-9668-y","article-title":"A hypothesis about the relationship of myelin-associated glycoprotein's function in myelinated axons to its capacity to inhibit neurite outgrowth","volume":"34","author":"Quarles","year":"2009","journal-title":"Neurochem Res"},{"key":"10.1016\/j.conb.2009.08.003_bib41","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1056\/NEJM199801293380502","article-title":"Axonal transection in the lesions of multiple sclerosis","volume":"338","author":"Trapp","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.conb.2009.08.003_bib42","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/brain\/120.3.393","article-title":"Axonal damage in acute multiple sclerosis lesions","volume":"120","author":"Ferguson","year":"1997","journal-title":"Brain"},{"key":"10.1016\/j.conb.2009.08.003_bib43","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.expneurol.2005.10.033","article-title":"Axon loss is responsible for chronic neurological deficit following inflammatory demyelination in the rat","volume":"197","author":"Papadopoulos","year":"2006","journal-title":"Exp Neurol"},{"key":"10.1016\/j.conb.2009.08.003_bib44","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1093\/brain\/awm219","article-title":"Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsing\u2014remitting experimental autoimmune encephalomyelitis","volume":"130","author":"Rasmussen","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.conb.2009.08.003_bib45","doi-asserted-by":"crossref","first-page":"8206","DOI":"10.1523\/JNEUROSCI.1921-06.2006","article-title":"Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes","volume":"26","author":"Ip","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2009.08.003_bib46","doi-asserted-by":"crossref","first-page":"6832","DOI":"10.1073\/pnas.0812500106","article-title":"Extensive remyelination of the CNS leads to functional recovery","volume":"106","author":"Duncan","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.conb.2009.08.003_bib47","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1093\/brain\/awn080","article-title":"Remyelination protects axons from demyelination-associated axon degeneration","volume":"131","author":"Irvine","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.conb.2009.08.003_bib48","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nrn2480","article-title":"Remyelination in the CNS: from biology to therapy","volume":"9","author":"Franklin","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.conb.2009.08.003_bib49","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/jnen\/59.2.89","article-title":"Adrenomyeloneuropathy: a neuropathologic review featuring its noninflammatory myelopathy","volume":"59","author":"Powers","year":"2000","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.conb.2009.08.003_bib50","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1194\/jlr.M800321-JLR200","article-title":"Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy","volume":"50","author":"Singh","year":"2009","journal-title":"J Lipid Res"},{"key":"10.1016\/j.conb.2009.08.003_bib51","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00401-007-0288-4","article-title":"Lack of adrenoleukodystrophy protein enhances oligodendrocyte disturbance and microglia activation in mice with combined Abcd1\/Mag deficiency","volume":"114","author":"Dumser","year":"2007","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.conb.2009.08.003_bib52_1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/ng2070","article-title":"Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes","volume":"39","author":"Kassmann","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.conb.2009.08.003_bib53","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.expneurol.2003.10.004","article-title":"Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man","volume":"185","author":"Fischer","year":"2004","journal-title":"Exp Neurol"},{"key":"10.1016\/j.conb.2009.08.003_bib54","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1093\/hmg\/ddm226","article-title":"Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content","volume":"16","author":"De Vos","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.conb.2009.08.003_bib55","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.neuro.31.061307.090711","article-title":"Role of axonal transport in neurodegenerative diseases","volume":"31","author":"De Vos","year":"2008","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.conb.2009.08.003_bib56","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.bbadis.2006.01.004","article-title":"Genetics of familial and sporadic amyotrophic lateral sclerosis","volume":"1762","author":"Gros-Louis","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.conb.2009.08.003_bib57","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cell.2009.03.006","article-title":"Rethinking ALS: the FUS about TDP-43","volume":"136","author":"Lagier-Tourenne","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.conb.2009.08.003_bib58","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1523\/JNEUROSCI.21-10-03369.2001","article-title":"Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment","volume":"21","author":"Pramatarova","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2009.08.003_bib59","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1523\/JNEUROSCI.5258-07.2008","article-title":"Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice","volume":"28","author":"Jaarsma","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2009.08.003_bib60","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.stem.2008.09.017","article-title":"Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation","volume":"3","author":"Di Giorgio","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.conb.2009.08.003_bib61","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/nn1885","article-title":"Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model","volume":"10","author":"Di Giorgio","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.conb.2009.08.003_bib62","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1471-4159.2006.03742.x","article-title":"Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis","volume":"97","author":"Vargas","year":"2006","journal-title":"J Neurochem"},{"key":"10.1016\/j.conb.2009.08.003_bib63","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nn1876","article-title":"Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons","volume":"10","author":"Nagai","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.conb.2009.08.003_bib64","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1111\/j.1471-4159.2007.04677.x","article-title":"Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia","volume":"102","author":"Xiao","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.conb.2009.08.003_bib65_1","article-title":"Neuron\u2013glia interactions underlie ALS-like axonal cytoskeletal pathology","author":"King","year":"2009","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.conb.2009.08.003_bib66","doi-asserted-by":"crossref","first-page":"16021","DOI":"10.1073\/pnas.0607423103","article-title":"Wild-type microglia extend survival in PU. 1 knockout mice with familial amyotrophic lateral sclerosis","volume":"103","author":"Beers","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.conb.2009.08.003_bib67","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1123511","article-title":"Onset and progression in inherited ALS determined by motor neurons and microglia","volume":"312","author":"Boillee","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.conb.2009.08.003_bib68_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nn2047","article-title":"Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis","volume":"11","author":"Yamanaka","year":"2008","journal-title":"Nat Neurosci"},{"issue":"12","key":"10.1016\/j.conb.2009.08.003_bib69","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1093\/hmg\/ddp136","article-title":"Astrocytic protection of spinal motor neurons but not cortical neurons against loss of Als2\/alsin function","volume":"18","author":"Jacquier","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.conb.2009.08.003_bib70","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1523\/JNEUROSCI.3887-04.2005","article-title":"Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide","volume":"25","author":"Stagi","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2009.08.003_bib71","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1096\/fj.06-6679fje","article-title":"Unloading kinesin transported cargoes from the tubulin track via the inflammatory c-Jun N-terminal kinase pathway","volume":"20","author":"Stagi","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.conb.2009.08.003_bib72","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1083\/jcb.149.6.1207","article-title":"Tumor necrosis factor induces hyperphosphorylation of kinesin light chain and inhibits kinesin-mediated transport of mitochondria","volume":"149","author":"De Vos","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1016\/j.conb.2009.08.003_bib73","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0301-0082(93)90015-K","article-title":"Myelinated nerve fibres in the CNS","volume":"40","author":"Hildebrand","year":"1993","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.conb.2009.08.003_bib74","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s12031-007-9027-5","article-title":"Gap junctions couple astrocytes and oligodendrocytes","volume":"35","author":"Orthmann-Murphy","year":"2008","journal-title":"J Mol Neurosci"}],"container-title":["Current Opinion in Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959438809001135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959438809001135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T12:28:38Z","timestamp":1760704118000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959438809001135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":74,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0959438809001135"],"URL":"https:\/\/doi.org\/10.1016\/j.conb.2009.08.003","relation":{},"ISSN":["0959-4388"],"issn-type":[{"value":"0959-4388","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of CNS glia in preserving axon function","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.conb.2009.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}