{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:58:36Z","timestamp":1791302316638,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Neurobiology"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.conb.2010.08.014","type":"journal-article","created":{"date-parts":[[2010,9,13]],"date-time":"2010-09-13T06:38:43Z","timestamp":1284359923000},"page":"182-188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"title":["The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases"],"prefix":"10.1016","volume":"21","author":[{"given":"Vafa","family":"Bayat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Jaiswal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo J","family":"Bellen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.conb.2010.08.014_bib0005","series-title":"The Fly Neuromuscular Junction: Structure and Function","year":"2006"},{"key":"10.1016\/j.conb.2010.08.014_bib0010","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.conb.2007.01.001","article-title":"Synaptic development: insights from Drosophila","volume":"17","author":"Collins","year":"2007","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.conb.2010.08.014_bib0015","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1242\/dev.005686","article-title":"Transgenesis upgrades for Drosophila melanogaster","volume":"134","author":"Venken","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.conb.2010.08.014_bib0020","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nrn2839","article-title":"100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future","volume":"11","author":"Bellen","year":"2010","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.conb.2010.08.014_bib0025","doi-asserted-by":"crossref","DOI":"10.3791\/1109","article-title":"Electrophysiological methods for recording synaptic potentials from the NMJ of Drosophila larvae","author":"Imlach","year":"2009","journal-title":"J Vis Exp"},{"key":"10.1016\/j.conb.2010.08.014_bib0030","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/978-1-59745-178-9_26","article-title":"FM 1-43 labeling of synaptic vesicle pools at the Drosophila neuromuscular junction","volume":"440","author":"Verstreken","year":"2008","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.conb.2010.08.014_bib0035","series-title":"Drosophila Protocols","first-page":"175","article-title":"The neuromuscular junction","author":"Bellen","year":"2000"},{"key":"10.1016\/j.conb.2010.08.014_bib0040","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.cell.2009.06.033","article-title":"A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis","volume":"138","author":"Yao","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.conb.2010.08.014_bib0045","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","author":"Brand","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.conb.2010.08.014_bib0050","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.tins.2007.04.003","article-title":"Wnts: up-and-coming at the synapse","volume":"30","author":"Speese","year":"2007","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.conb.2010.08.014_bib0055","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/neu.20165","article-title":"Morphogens and synaptogenesis in Drosophila","volume":"64","author":"Marques","year":"2005","journal-title":"J Neurobiol"},{"key":"10.1016\/j.conb.2010.08.014_bib0060","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.neuron.2005.08.010","article-title":"LIM Kinase1 controls synaptic stability downstream of the type II BMP receptor","volume":"47","author":"Eaton","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2010.08.014_bib0065","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.tins.2004.01.004","article-title":"Orchestrating development and function: retrograde BMP signaling in the Drosophila nervous system","volume":"27","author":"Keshishian","year":"2004","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.conb.2010.08.014_bib0070","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nrg2680","article-title":"Genetics of motor neuron disorders: new insights into pathogenic mechanisms","volume":"10","author":"Dion","year":"2009","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.conb.2010.08.014_bib0075","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1212\/WNL.55.1.89","article-title":"Clinical and pathologic findings in hereditary spastic paraparesis with spastin mutation","volume":"55","author":"White","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.conb.2010.08.014_bib0080","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.cub.2006.02.058","article-title":"Altered synaptic development and active zone spacing in endocytosis mutants","volume":"16","author":"Dickman","year":"2006","journal-title":"Curr Biol"},{"key":"10.1016\/j.conb.2010.08.014_bib0085","doi-asserted-by":"crossref","first-page":"e429","DOI":"10.1371\/journal.pbio.0020429","article-title":"Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function","volume":"2","author":"Sherwood","year":"2004","journal-title":"PLoS Biol"},{"key":"10.1016\/j.conb.2010.08.014_bib0090","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nature06482","article-title":"Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin","volume":"451","author":"Roll-Mecak","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.conb.2010.08.014_bib0095","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ydbio.2009.03.019","article-title":"Drosophila Atlastin regulates the stability of muscle microtubules and is required for synapse development","volume":"330","author":"Lee","year":"2009","journal-title":"Dev Biol"},{"key":"10.1016\/j.conb.2010.08.014_bib0100","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nn1841","article-title":"Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules","volume":"10","author":"Wang","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.conb.2010.08.014_bib0105","doi-asserted-by":"crossref","first-page":"8060","DOI":"10.1074\/jbc.M610314200","article-title":"NIPA1(SPG6), the basis for autosomal dominant form of hereditary spastic paraplegia, encodes a functional Mg2+ transporter","volume":"282","author":"Goytain","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.conb.2010.08.014_bib0110","doi-asserted-by":"crossref","first-page":"20470","DOI":"10.1074\/jbc.271.34.20470","article-title":"Kinetics of interaction of Rab5 and Rab7 with nucleotides and magnesium ions","volume":"271","author":"Simon","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.conb.2010.08.014_bib0115","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1093\/hmg\/ddp324","article-title":"The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling","volume":"18","author":"Tsang","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.conb.2010.08.014_bib0275","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.neuron.2010.04.011","article-title":"Retrograde BMP signaling controls synaptic growth at the NMJ by regulating trio expression in motor neurons","volume":"66","author":"Ball","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2010.08.014_bib0125","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ydbio.2010.03.012","article-title":"Activin signaling functions upstream of Gbb to regulate synaptic growth at the Drosophila neuromuscular junction","volume":"342","author":"Ellis","year":"2010","journal-title":"Dev Biol"},{"key":"10.1016\/j.conb.2010.08.014_bib0130","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1097-2765(00)80400-1","article-title":"Microtubule binding to Smads may regulate TGF beta activity","volume":"5","author":"Dong","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/j.conb.2010.08.014_bib0135","doi-asserted-by":"crossref","first-page":"29076","DOI":"10.1074\/jbc.M604959200","article-title":"Transgenic mice expressing dominant-negative activin receptor IB in forebrain neurons reveal novel functions of activin at glutamatergic synapses","volume":"281","author":"Muller","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.conb.2010.08.014_bib0140","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/mus.880070310","article-title":"The motor end-plate fine structure and ultrastructural localization of acetylcholine receptors in amyotrophic lateral sclerosis","volume":"7","author":"Tsujihata","year":"1984","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.conb.2010.08.014_bib0145","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0896-6273(02)00769-9","article-title":"Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner","volume":"35","author":"Pennetta","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2010.08.014_bib0150","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0896-6273(02)00589-5","article-title":"wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila","volume":"33","author":"Aberle","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2010.08.014_bib0155","doi-asserted-by":"crossref","first-page":"e2334","DOI":"10.1371\/journal.pone.0002334","article-title":"A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism","volume":"3","author":"Ratnaparkhi","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.conb.2010.08.014_bib0160","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.neuron.2008.12.028","article-title":"A presynaptic homeostatic signaling system composed of the Eph receptor, ephexin, Cdc42, and CaV2.1 calcium channels","volume":"61","author":"Frank","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2010.08.014_bib0165","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.cell.2008.04.039","article-title":"The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors","volume":"133","author":"Tsuda","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.conb.2010.08.014_bib0170","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00401-007-0337-z","article-title":"Phosphorylated Smad2\/3 immunoreactivity in sporadic and familial amyotrophic lateral sclerosis and its mouse model","volume":"115","author":"Nakamura","year":"2008","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.conb.2010.08.014_bib0175","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1212\/01.wnl.0000233830.85206.1e","article-title":"SMN1 gene, but not SMN2, is a risk factor for sporadic ALS","volume":"67","author":"Corcia","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.conb.2010.08.014_bib0180","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00401-002-0566-0","article-title":"Motoneuron death in normal and spinal muscular atrophy-affected human fetuses","volume":"104","author":"Fidzianska","year":"2002","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.conb.2010.08.014_bib0185_1","doi-asserted-by":"crossref","first-page":"e3209","DOI":"10.1371\/journal.pone.0003209","article-title":"Modeling spinal muscular atrophy in Drosophila","volume":"3","author":"Chang","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.conb.2010.08.014_bib0190","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1523\/JNEUROSCI.4434-08.2009","article-title":"Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice","volume":"29","author":"Kong","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2010.08.014_bib0195","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.mcp.2010.04.006","article-title":"The genetics of multiple sclerosis: an update","volume":"24","author":"Hoffjan","year":"2010","journal-title":"Mol Cell Probes"},{"key":"10.1016\/j.conb.2010.08.014_bib0200","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1083\/jcb.200911126","article-title":"The novel endosomal membrane protein Ema interacts with the class C Vps-HOPS complex to promote endosomal maturation","volume":"188","author":"Kim","year":"2010","journal-title":"J Cell Biol"},{"key":"10.1016\/j.conb.2010.08.014_bib0205","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1083\/jcb.200412001","article-title":"Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer","volume":"170","author":"Dermaut","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1016\/j.conb.2010.08.014_bib0210","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10048-008-0164-y","article-title":"Familial risks for amyotrophic lateral sclerosis and autoimmune diseases","volume":"10","author":"Hemminki","year":"2009","journal-title":"Neurogenetics"},{"key":"10.1016\/j.conb.2010.08.014_bib0215","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/BF00294462","article-title":"Detection of two transforming growth factor-beta-related morphogens, bone morphogenetic proteins-4 and -5, in RNA of multiple sclerosis and Creutzfeldt-Jakob disease lesions","volume":"90","author":"Deininger","year":"1995","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.conb.2010.08.014_bib0220","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/jnr.21462","article-title":"Bone morphogenetic proteins 4, 6, and 7 are up-regulated in mouse spinal cord during experimental autoimmune encephalomyelitis","volume":"86","author":"Ara","year":"2008","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.conb.2010.08.014_bib0225","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0896-6273(02)01014-0","article-title":"Unrestricted synaptic growth in spinster\u2014a late endosomal protein implicated in TGF-beta-mediated synaptic growth regulation","volume":"36","author":"Sweeney","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2010.08.014_bib0230","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/sj.gene.6363910","article-title":"A genome screen for linkage in Australian sibling-pairs with multiple sclerosis","volume":"3","author":"Ban","year":"2002","journal-title":"Genes Immun"},{"key":"10.1016\/j.conb.2010.08.014_bib0235","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/ajmg.b.30620","article-title":"A first stage genome-wide screen for regions shared identical-by-descent in Hutterite families with multiple sclerosis","volume":"147B","author":"Dyment","year":"2008","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.conb.2010.08.014_bib0240","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.neuro.31.061307.090711","article-title":"Role of axonal transport in neurodegenerative diseases","volume":"31","author":"De Vos","year":"2008","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.conb.2010.08.014_bib0245","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1755-5949.2010.00134.x","article-title":"Dopamine and glutamate in Huntington's disease: a balancing act","volume":"16","author":"Andre","year":"2010","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.conb.2010.08.014_bib0250","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1073\/pnas.0437967100","article-title":"Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease","volume":"100","author":"Holbert","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.conb.2010.08.014_bib0255_1","doi-asserted-by":"crossref","first-page":"8138","DOI":"10.1523\/JNEUROSCI.0256-10.2010","article-title":"dCIP4 (Drosophila Cdc42-interacting protein 4) restrains synaptic growth by inhibiting the secretion of the retrograde Glass bottom boat signal","volume":"30","author":"Nahm","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2010.08.014_bib0280","doi-asserted-by":"crossref","unstructured":"Battaglia G, Cannella M, Riozzi B, Orobello S, Maat-Schieman ML, Aronica E, Busceti CL, Ciarmiello A, Alberti S, Amico E et al.: Early defect of transforming growth factor beta-1 formation in Huntington's disease. J Cell Mol Med 2010 (in press).","DOI":"10.1016\/j.nurt.2009.09.025"},{"key":"10.1016\/j.conb.2010.08.014_bib0265","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev.neuro.28.061604.135632","article-title":"Axon retraction and degeneration in development and disease","volume":"28","author":"Luo","year":"2005","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.conb.2010.08.014_bib0270","doi-asserted-by":"crossref","first-page":"9599","DOI":"10.1523\/JNEUROSCI.2589-08.2008","article-title":"Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1","volume":"28","author":"Feng","year":"2008","journal-title":"J Neurosci"}],"container-title":["Current Opinion in Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959438810001340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959438810001340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T12:29:33Z","timestamp":1760704173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959438810001340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0959438810001340"],"URL":"https:\/\/doi.org\/10.1016\/j.conb.2010.08.014","relation":{},"ISSN":["0959-4388"],"issn-type":[{"value":"0959-4388","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.conb.2010.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}