{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:39:55Z","timestamp":1791203995727,"version":"4.2.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Australian Research Council Future Fellowship","award":["FT130100589"],"award-info":[{"award-number":["FT130100589"]}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1050504"],"award-info":[{"award-number":["1050504"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1066779"],"award-info":[{"award-number":["1066779"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Neurobiology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.conb.2014.08.006","type":"journal-article","created":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T22:15:30Z","timestamp":1410992130000},"page":"44-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":147,"special_numbering":"C","title":["Reconciling abnormalities of brain network structure and function in schizophrenia"],"prefix":"10.1016","volume":"30","author":[{"given":"Alex","family":"Fornito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward T","family":"Bullmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.conb.2014.08.006_bib0005","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0920-9964(97)00140-0","article-title":"The disconnection hypothesis","volume":"30","author":"Friston","year":"1998","journal-title":"Schizophr Res"},{"key":"10.1016\/j.conb.2014.08.006_bib0010","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0920-9964(97)00114-X","article-title":"The dysplastic net hypothesis: an integration of developmental and dysconnectivity theories of schizophrenia","volume":"28","author":"Bullmore","year":"1997","journal-title":"Schizophr Res"},{"key":"10.1016\/j.conb.2014.08.006_bib0015","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.biopsych.2005.10.005","article-title":"Synaptic plasticity and dysconnection in schizophrenia","volume":"59","author":"Stephan","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.conb.2014.08.006_sbref0020","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1016\/j.neuroimage.2011.12.090","article-title":"Schizophrenia, neuroimaging and connectomics","volume":"62","author":"Fornito","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.conb.2014.08.006_sbref0025","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.neubiorev.2010.11.004","article-title":"Dysconnectivity in schizophrenia: where are we now?","volume":"35","author":"Pettersson-Yeo","year":"2011","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.conb.2014.08.006_sbref0030","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s11065-014-9248-7","article-title":"Brain networks in schizophrenia","volume":"24","author":"van den Heuvel","year":"2014","journal-title":"Neuropsychol Rev"},{"key":"10.1016\/j.conb.2014.08.006_bib0035","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.neuron.2006.08.012","article-title":"Principles of diffusion tensor imaging and its applications to basic neuroscience research","volume":"51","author":"Mori","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2014.08.006_bib0040","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/hbm.460020107","article-title":"Functional and effective connectivity in neuroimaging: a synthesis","volume":"2","author":"Friston","year":"1994","journal-title":"Hum Brain Mapping"},{"key":"10.1016\/j.conb.2014.08.006_bib0045","doi-asserted-by":"crossref","first-page":"12788","DOI":"10.1073\/pnas.1204185109","article-title":"Competitive and cooperative dynamics of large-scale brain functional networks supporting recollection","volume":"109","author":"Fornito","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.conb.2014.08.006_bib0050","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biopsych.2011.02.019","article-title":"General and specific functional connectivity disturbances in first-episode schizophrenia during cognitive control performance","volume":"70","author":"Fornito","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.conb.2014.08.006_bib0055","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nrn2201","article-title":"Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging","volume":"8","author":"Fox","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.conb.2014.08.006_bib0060","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/YCO.0b013e328337d78d","article-title":"What can spontaneous fluctuations of the blood oxygenation-level-dependent signal tell us about psychiatric disorders?","volume":"23","author":"Fornito","year":"2010","journal-title":"Curr Opin Psychiatry"},{"key":"10.1016\/j.conb.2014.08.006_bib0065","doi-asserted-by":"crossref","first-page":"10240","DOI":"10.1073\/pnas.0701519104","article-title":"Network structure of cerebral cortex shapes functional connectivity on multiple time scales","volume":"104","author":"Honey","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.conb.2014.08.006_bib0070","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1471-2202-10-55","article-title":"Symbiotic relationship between brain structure and dynamics","volume":"10","author":"Rubinov","year":"2009","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.conb.2014.08.006_bib0075","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1109\/TMI.2008.2012113","article-title":"A DTI-derived measure of cortico-cortical connectivity","volume":"28","author":"Zalesky","year":"2009","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.conb.2014.08.006_bib0080","doi-asserted-by":"crossref","first-page":"9477","DOI":"10.1523\/JNEUROSCI.0333-10.2010","article-title":"Functional connectivity and brain networks in schizophrenia","volume":"30","author":"Lynall","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2014.08.006_bib0085","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.neuroimage.2010.06.041","article-title":"Network-based statistic: identifying differences in brain networks","volume":"53","author":"Zalesky","year":"2010","journal-title":"NeuroImage"},{"key":"10.1016\/j.conb.2014.08.006_sbref0090","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1001\/jamapsychiatry.2013.1976","article-title":"Functional dysconnectivity of corticostriatal circuitry as a risk phenotype for psychosis","volume":"70","author":"Fornito","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.conb.2014.08.006_bib0095","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1073\/pnas.0809141106","article-title":"Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia","volume":"106","author":"Whitfield-Gabrieli","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.conb.2014.08.006_bib0100","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.biopsych.2010.09.050","article-title":"Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory\/verbal hallucinations in patients with schizophrenia","volume":"69","author":"Hoffman","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.conb.2014.08.006_sbref0105","article-title":"Altered striatal functional connectivity in subjects with an at-risk mental state for psychosis","author":"Dandash","year":"2013","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.conb.2014.08.006_sbref0110","article-title":"Characterizing thalamo-cortical disturbances in schizophrenia and bipolar illness","author":"Anticevic","year":"2013","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.conb.2014.08.006_sbref0115","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.biopsych.2010.03.035","article-title":"Brain connectivity is not only lower but different in schizophrenia: a combined anatomical and functional approach","volume":"68","author":"Skudlarski","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.conb.2014.08.006_sbref0120","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.biopsych.2010.08.022","article-title":"Disrupted axonal fiber connectivity in schizophrenia","volume":"69","author":"Zalesky","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.conb.2014.08.006_bib0125","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1152\/jn.90777.2008","article-title":"The global signal and observed anticorrelated resting state brain networks","volume":"101","author":"Fox","year":"2009","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.conb.2014.08.006_bib0130","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.neuroimage.2003.11.025","article-title":"Resting fluctuations in arterial carbon dioxide induce significant low frequency variations in BOLD signal","volume":"21","author":"Wise","year":"2004","journal-title":"NeuroImage"},{"key":"10.1016\/j.conb.2014.08.006_bib0135","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.neuroimage.2006.02.048","article-title":"Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI","volume":"31","author":"Birn","year":"2006","journal-title":"NeuroImage"},{"key":"10.1016\/j.conb.2014.08.006_bib0140","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1152\/jn.00783.2009","article-title":"Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimization","volume":"103","author":"Van Dijk","year":"2010","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.conb.2014.08.006_bib0145","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.neuroimage.2008.09.036","article-title":"The impact of global signal regression on resting state correlations: are anti-correlated networks introduced?","volume":"44","author":"Murphy","year":"2009","journal-title":"NeuroImage"},{"key":"10.1016\/j.conb.2014.08.006_sbref0150","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1089\/brain.2012.0080","article-title":"Trouble at rest: how correlation patterns and group differences become distorted after global signal regression","volume":"2","author":"Saad","year":"2012","journal-title":"Brain Connect"},{"key":"10.1016\/j.conb.2014.08.006_sbref0155","doi-asserted-by":"crossref","first-page":"7438","DOI":"10.1073\/pnas.1405289111","article-title":"Altered global brain signal in schizophrenia","volume":"111","author":"Yang","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.conb.2014.08.006_bib0160","doi-asserted-by":"crossref","DOI":"10.1089\/brain.2014.0244","article-title":"Save the global: global signal connectivity as a tool for studying clinical populations with fMRI","author":"Hahamy","year":"2014","journal-title":"Brain Connect"},{"key":"10.1016\/j.conb.2014.08.006_sbref0165","article-title":"White matter integrity, fiber count, and other fallacies: the dos and donts of diffusion MRI","author":"Jones","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.conb.2014.08.006_bib0170","doi-asserted-by":"crossref","first-page":"19066","DOI":"10.1073\/pnas.1110024108","article-title":"Increased functional connectivity indicates the severity of cognitive impairment in multiple sclerosis","volume":"108","author":"Hawellek","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.conb.2014.08.006_bib0175","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1093\/brain\/awq058","article-title":"Resting state networks change in clinically isolated syndrome","volume":"133","author":"Roosendaal","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.conb.2014.08.006_bib0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/857807","article-title":"The contribution of resting state networks to the study of cortical reorganization in MS","volume":"2013","author":"Sacco","year":"2013","journal-title":"Multiple Sclerosis Int"},{"key":"10.1016\/j.conb.2014.08.006_sbref0185","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1212\/WNL.0b013e31826d5eea","article-title":"Visual resting-state network in relapsing-remitting MS with and without previous optic neuritis","volume":"79","author":"Gallo","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.conb.2014.08.006_bib0190","doi-asserted-by":"crossref","first-page":"e101198","DOI":"10.1371\/journal.pone.0101198","article-title":"Altered inter-subregion connectivity of the default mode network in relapsing remitting multiple sclerosis: a functional and structural connectivity study","volume":"9","author":"Zhou","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.conb.2014.08.006_sbref0195","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1212\/WNL.0b013e31826d602e","article-title":"Functional plasticity in MS: friend or foe?","volume":"79","author":"Schoonheim","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.conb.2014.08.006_bib0200","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1196\/annals.1379.009","article-title":"Functional MRI studies of associative encoding in normal aging, mild cognitive impairment, and Alzheimer's disease","volume":"1097","author":"Sperling","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.conb.2014.08.006_bib0205","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/mds.25864","article-title":"The cognitive burden in Huntington's disease: pathology, phenotype, and mechanisms of compensation","volume":"29","author":"Papoutsi","year":"2014","journal-title":"Mov Disord"},{"key":"10.1016\/j.conb.2014.08.006_bib0210","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S1364-6613(00)01769-1","article-title":"Aging cognition: from neuromodulation to representation","volume":"5","author":"Li","year":"2001","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.conb.2014.08.006_bib0215","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1001\/archpsyc.1987.01800190080012","article-title":"Implications of normal brain development for the pathogenesis of schizophrenia","volume":"44","author":"Weinberger","year":"1987","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.conb.2014.08.006_sbref0220","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.tics.2013.09.012","article-title":"Network hubs in the human brain","volume":"17","author":"van den Heuvel","year":"2013","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.conb.2014.08.006_bib0225","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1523\/JNEUROSCI.5062-08.2009","article-title":"Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease","volume":"29","author":"Buckner","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2014.08.006_bib0230","doi-asserted-by":"crossref","first-page":"e1000157","DOI":"10.1371\/journal.pbio.1000157","article-title":"Development of large-scale functional brain networks in children","volume":"7","author":"Supekar","year":"2009","journal-title":"PLoS Biol"},{"key":"10.1016\/j.conb.2014.08.006_bib0235","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3389\/fnsys.2010.00147","article-title":"Disrupted modularity and local connectivity of brain functional networks in childhood-onset schizophrenia","volume":"4","author":"Alexander-Bloch","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"10.1016\/j.conb.2014.08.006_bib0240","doi-asserted-by":"crossref","first-page":"15915","DOI":"10.1523\/JNEUROSCI.2874-10.2010","article-title":"Aberrant frontal and temporal complex network structure in schizophrenia: a graph theoretical analysis","volume":"30","author":"van den Heuvel","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2014.08.006_bib0245","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1093\/cercor\/bhs227","article-title":"The development of hub architecture in the human functional brain network","volume":"23","author":"Hwang","year":"2013","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.conb.2014.08.006_sbref0250","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1073\/pnas.1315529111","article-title":"Resting-brain functional connectivity predicted by analytic measures of network communication","volume":"111","author":"Go\u00f1i","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.conb.2014.08.006_sbref0255","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1001\/jamapsychiatry.2013.1328","article-title":"Abnormal rich club organization and functional brain dynamics in schizophrenia","volume":"70","author":"van den Heuvel","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.conb.2014.08.006_bib0260","doi-asserted-by":"crossref","first-page":"e1000408","DOI":"10.1371\/journal.pcbi.1000408","article-title":"Modeling the impact of lesions in the human brain","volume":"5","author":"Alstott","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.conb.2014.08.006_bib0265","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2174\/157015912803217305","article-title":"Brain connectivity studies in schizophrenia: unravelling the effects of antipsychotics","volume":"10","author":"Nejad","year":"2012","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.conb.2014.08.006_bib0270","article-title":"Amygdala connectivity differs among chronic, early course, and individuals at risk for developing schizophrenia","author":"Anticevic","year":"2013","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.conb.2014.08.006_bib0275","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/j.neuroimage.2011.10.018","article-title":"Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion","volume":"59","author":"Power","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.conb.2014.08.006_sbref0280","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.neuroimage.2013.04.087","article-title":"Graph analysis of the human connectome: promise, progress, and pitfalls","volume":"80","author":"Fornito","year":"2013","journal-title":"NeuroImage"}],"container-title":["Current Opinion in Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959438814001688?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959438814001688?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T12:39:05Z","timestamp":1760704745000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959438814001688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":56,"alternative-id":["S0959438814001688"],"URL":"https:\/\/doi.org\/10.1016\/j.conb.2014.08.006","relation":{},"ISSN":["0959-4388"],"issn-type":[{"value":"0959-4388","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reconciling abnormalities of brain network structure and function in schizophrenia","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.conb.2014.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}