{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:22:57Z","timestamp":1792264977883,"version":"4.4.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-15-IDEX-02"],"award-info":[{"award-number":["ANR-15-IDEX-02"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-CE16-0009-01"],"award-info":[{"award-number":["ANR-18-CE16-0009-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-CE16-0022-03"],"award-info":[{"award-number":["ANR-18-CE16-0022-03"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-CE13-0029-04"],"award-info":[{"award-number":["ANR-18-CE13-0029-04"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["834317"],"award-info":[{"award-number":["834317"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Association Huntington France"},{"DOI":"10.13039\/501100002915","name":"FRM","doi-asserted-by":"publisher","award":["FDT201904008035"],"award-info":[{"award-number":["FDT201904008035"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Neurobiology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.conb.2020.04.001","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T23:47:23Z","timestamp":1589240843000},"page":"122-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"special_numbering":"C","title":["Traffic signaling: new functions of huntingtin and axonal transport in neurological disease"],"prefix":"10.1016","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-1064","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Vitet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Saudou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.conb.2020.04.001_sbref0005","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1093\/hmg\/ddy442","article-title":"Tau\/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport","volume":"28","author":"Butler","year":"2019","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.conb.2020.04.001_sbref0010","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1523\/JNEUROSCI.2305-16.2016","article-title":"Tau isoforms imbalance impairs the axonal transport of the amyloid precursor protein in human neurons","volume":"37","author":"Lacovich","year":"2017","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2020.04.001_bib0015","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.neuron.2016.02.003","article-title":"The biology of huntingtin","volume":"89","author":"Saudou","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2020.04.001_bib0020","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0896-6273(03)00594-4","article-title":"Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila","volume":"40","author":"Gunawardena","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2020.04.001_bib0025","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","article-title":"Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules","volume":"118","author":"Gauthier","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.conb.2020.04.001_bib0030","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1523\/JNEUROSCI.1870-13.2014","article-title":"The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation","volume":"34","author":"Wong","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2020.04.001_bib0035","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00005072-199902000-00006","article-title":"Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease","volume":"58","author":"Sapp","year":"1999","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.conb.2020.04.001_bib0040","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/B978-0-444-63233-3.00017-8","article-title":"Huntington disease","volume":"147","author":"Ghosh","year":"2018","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.conb.2020.04.001_bib0045","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s13311-019-00782-9","article-title":"Cell-Autonomous and non-cell-autonomous pathogenic mechanisms in huntington\u2019s disease: insights from in vitro and in vivo models","volume":"16","author":"Creus-Muncunill","year":"2019","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.conb.2020.04.001_sbref0050","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature25502","article-title":"The cryo-electron microscopy structure of huntingtin","volume":"555","author":"Guo","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.conb.2020.04.001_bib0055","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1093\/hmg\/6.13.2205","article-title":"Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin","volume":"6","author":"Engelender","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.conb.2020.04.001_bib0060","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1523\/JNEUROSCI.18-04-01261.1998","article-title":"Interaction of huntingtin-associated protein with dynactin P150Glued","volume":"18","author":"Li","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2020.04.001_bib0065","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1074\/jbc.M509806200","article-title":"Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons","volume":"281","author":"McGuire","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.conb.2020.04.001_bib0070","doi-asserted-by":"crossref","first-page":"10045","DOI":"10.1073\/pnas.0610628104","article-title":"Huntingtin facilitates dynein\/dynactin-mediated vesicle transport","volume":"104","author":"Caviston","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.conb.2020.04.001_bib0075","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1038\/emboj.2008.133","article-title":"Huntingtin phosphorylation acts as a molecular switch for anterograde\/retrograde transport in neurons","volume":"27","author":"Colin","year":"2008","journal-title":"EMBO J"},{"key":"10.1016\/j.conb.2020.04.001_bib0080","doi-asserted-by":"crossref","first-page":"13662","DOI":"10.1523\/JNEUROSCI.4144-08.2008","article-title":"Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin","volume":"28","author":"Her","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2020.04.001_bib0085","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1093\/hmg\/ddv415","article-title":"Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo","volume":"24","author":"White","year":"2015","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.conb.2020.04.001_bib0090","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neuron.2009.12.007","article-title":"Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin","volume":"65","author":"Twelvetrees","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2020.04.001_bib0095","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1091\/mbc.e10-03-0233","article-title":"Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes","volume":"22","author":"Caviston","year":"2011","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.conb.2020.04.001_bib0100","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.1523\/JNEUROSCI.2033-12.2013","article-title":"Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites","volume":"33","author":"Liot","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2020.04.001_bib0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060162","article-title":"Huntingtin\u2019s function in axonal transport is conserved in Drosophila melanogaster","volume":"8","author":"Zala","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.conb.2020.04.001_bib0110","doi-asserted-by":"crossref","first-page":"13142","DOI":"10.1074\/jbc.M110.114561","article-title":"A role for huntington disease protein in dendritic RNA granules","volume":"285","author":"Savas","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.conb.2020.04.001_bib0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099341","article-title":"Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells","volume":"9","author":"Drouet","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.conb.2020.04.001_sbref0120","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.celrep.2017.12.013","article-title":"Reconstituting corticostriatal network on-a-chip reveals the contribution of the presynaptic compartment to Huntington\u2019s disease","volume":"22","author":"Virlogeux","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.conb.2020.04.001_sbref0125","doi-asserted-by":"crossref","first-page":"E5655","DOI":"10.1073\/pnas.1603020113","article-title":"TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington\u2019s disease","volume":"113","author":"Zhao","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.conb.2020.04.001_bib0130","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/nm.3514","article-title":"Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington\u2019s disease","volume":"20","author":"Wang","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.conb.2020.04.001_bib0135","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1523\/JNEUROSCI.3920-03.2004","article-title":"Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor","volume":"24","author":"Baquet","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2020.04.001_bib0140","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/39885","article-title":"Anterograde transport of brain-derived neurotrophic factor and its role in the brain","volume":"389","author":"Altar","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.conb.2020.04.001_bib0145","doi-asserted-by":"crossref","first-page":"217","DOI":"10.5607\/en.2018.27.3.217","article-title":"Cortical axonal secretion of BDNF in the striatum is disrupted in the mutant-huntingtin knock-in mouse model of Huntington\u2019s disease","volume":"27","author":"Park","year":"2018","journal-title":"Exp Neurobiol"},{"key":"10.1016\/j.conb.2020.04.001_bib0150","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1172\/JCI27607","article-title":"Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase","volume":"116","author":"Borrell-Pages","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.conb.2020.04.001_bib0155","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/hmg\/ddi165","article-title":"Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo","volume":"14","author":"Warby","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.conb.2020.04.001_sbref0160","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201910889","article-title":"Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice","volume":"12","author":"Ehinger","year":"2020","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.conb.2020.04.001_bib0165","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.0953-816X.2003.03131.x","article-title":"The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin","volume":"19","author":"Rangone","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.conb.2020.04.001_bib0170","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1523\/JNEUROSCI.3706-05.2006","article-title":"Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421","volume":"26","author":"Pardo","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2020.04.001_bib0175","doi-asserted-by":"crossref","first-page":"14318","DOI":"10.1523\/JNEUROSCI.1589-10.2010","article-title":"Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A","volume":"30","author":"Metzler","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2020.04.001_bib0180","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S1534-5807(02)00188-0","article-title":"The IGF-1\/Akt pathway is neuroprotective in Huntington\u2019s disease and involves Huntingtin phosphorylation by Akt","volume":"2","author":"Humbert","year":"2002","journal-title":"Dev Cell"},{"key":"10.1016\/j.conb.2020.04.001_bib0185","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1093\/hmg\/ddn281","article-title":"Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons","volume":"17","author":"Zala","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.conb.2020.04.001_bib0190","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1756-6606-2-33","article-title":"Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington\u2019s disease","volume":"2","author":"Pineda","year":"2009","journal-title":"Mol Brain"},{"key":"10.1016\/j.conb.2020.04.001_bib0195","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1172\/JCI80339","article-title":"Serine 421 regulates mutant huntingtin toxicity and clearance in mice","volume":"126","author":"Kratter","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.conb.2020.04.001_bib0200","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.conb.2004.05.002","article-title":"A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease","volume":"14","author":"Cruz","year":"2004","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.conb.2020.04.001_bib0205","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1021\/acs.jproteome.6b00991","article-title":"Post-translational modifications (PTMs), identified on endogenous huntingtin, cluster within proteolytic domains between HEAT repeats","volume":"16","author":"Ratovitski","year":"2017","journal-title":"J Proteome Res"},{"key":"10.1016\/j.conb.2020.04.001_bib0210","doi-asserted-by":"crossref","first-page":"8608","DOI":"10.1523\/JNEUROSCI.5110-12.2013","article-title":"Huntingtin mediates anxiety\/depression-related behaviors and hippocampal neurogenesis","volume":"33","author":"Ben M\u2019Barek","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2020.04.001_bib0215","series-title":"Huntingtin-mediated axonal transport requires arginine methylation by PRMT6","author":"Migazzi","year":"2020"},{"key":"10.1016\/j.conb.2020.04.001_bib0220","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.cell.2012.12.029","article-title":"Vesicular glycolysis provides on-board energy for fast axonal transport","volume":"152","author":"Zala","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.conb.2020.04.001_sbref0225","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13233","article-title":"Self-propelling vesicles define glycolysis as the minimal energy machinery al transport","volume":"7","author":"Hinckelmann","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.conb.2020.04.001_bib0230","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2005.12.027","article-title":"The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression","volume":"49","author":"Chang","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2020.04.001_bib0235","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.nbd.2011.11.002","article-title":"Modification of Mecp2 dosage alters axonal transport through the Huntingtin\/Hap1 pathway","volume":"45","author":"Roux","year":"2012","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.conb.2020.04.001_bib0240","article-title":"Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease","volume":"7","author":"Fang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.conb.2020.04.001_bib0245","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrn.2017.29","article-title":"Not just amyloid: physiological functions of the amyloid precursor protein family","volume":"18","author":"Muller","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.conb.2020.04.001_bib0250","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.tips.2016.01.005","article-title":"APP receptor? To be or not to be","volume":"37","author":"Deyts","year":"2016","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.conb.2020.04.001_bib0255","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nn.4188","article-title":"Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway","volume":"19","author":"Das","year":"2016","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.conb.2020.04.001_bib0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1326-9-1","article-title":"Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase","volume":"9","author":"Buggia-Prevot","year":"2014","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.conb.2020.04.001_bib0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018754","article-title":"Amyloid precursor protein is trafficked and secreted via synaptic vesicles","volume":"6","author":"Groemer","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.conb.2020.04.001_bib0270","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.09743","article-title":"APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses","volume":"4","author":"Fanutza","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.conb.2020.04.001_bib0275","doi-asserted-by":"crossref","first-page":"16018","DOI":"10.1523\/JNEUROSCI.2009-15.2015","article-title":"The APP intracellular domain is required for normal synaptic morphology, synaptic plasticity, and hippocampus-dependent behavior","volume":"35","author":"Klevanski","year":"2015","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2020.04.001_bib0280","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1038\/sj.emboj.7600824","article-title":"Homo- and heterodimerization of APP family members promotes intercellular adhesion","volume":"24","author":"Soba","year":"2005","journal-title":"EMBO J"},{"key":"10.1016\/j.conb.2020.04.001_bib0285","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neurobiolaging.2018.03.033","article-title":"Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport","volume":"68","author":"Adalbert","year":"2018","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.conb.2020.04.001_bib0290","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00401-018-1847-6","article-title":"Evidence for altered dendritic spine compartmentalization in Alzheimer's disease and functional effects in a mouse model","volume":"135","author":"Androuin","year":"2018","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.conb.2020.04.001_bib0295","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40478-015-0230-2","article-title":"Intracellular amyloid beta oligomers impair organelle transport and induce dendritic spine loss in primary neurons","volume":"3","author":"Umeda","year":"2015","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.conb.2020.04.001_sbref0300","doi-asserted-by":"crossref","first-page":"7976","DOI":"10.1523\/JNEUROSCI.0674-19.2019","article-title":"p110\u03b4 PI3-kinase inhibition perturbs APP and TNF\u03b1 trafficking, reduces plaque burden, dampens neuroinflammation, and prevents cognitive decline in an Alzheimer\u2019s disease mouse model","volume":"39","author":"Mart\u00ednez-M\u00e1rmol","year":"2019","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2020.04.001_bib0305","article-title":"Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of Huntingtin","author":"Bruyere","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.conb.2020.04.001_bib0310","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1083\/jcb.201302078","article-title":"JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors","volume":"202","author":"Fu","year":"2013","journal-title":"J Cell Biol"},{"key":"10.1016\/j.conb.2020.04.001_bib0315","doi-asserted-by":"crossref","first-page":"7036","DOI":"10.18632\/aging.102235","article-title":"Enhancing the retrograde axonal transport by curcumin promotes autophagic flux in N2a\/APP695swe cells","volume":"11","author":"Liang","year":"2019","journal-title":"Aging (Albany NY)"}],"container-title":["Current Opinion in Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959438820300799?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959438820300799?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T12:58:14Z","timestamp":1760705894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959438820300799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":63,"alternative-id":["S0959438820300799"],"URL":"https:\/\/doi.org\/10.1016\/j.conb.2020.04.001","relation":{},"ISSN":["0959-4388"],"issn-type":[{"value":"0959-4388","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Traffic signaling: new functions of huntingtin and axonal transport in neurological disease","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.conb.2020.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}