{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:49:12Z","timestamp":1788385752387,"version":"build-2803163510"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS118786"],"award-info":[{"award-number":["R01 NS118786"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS046072"],"award-info":[{"award-number":["R01 NS046072"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS081248"],"award-info":[{"award-number":["R01 NS081248"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["F31 AG084197"],"award-info":[{"award-number":["F31 AG084197"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG067713"],"award-info":[{"award-number":["R01 AG067713"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Neurobiology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.conb.2024.102961","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:10:23Z","timestamp":1743552623000},"page":"102961","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["CaMKII mechanisms that promote pathological LTP impairments"],"prefix":"10.1016","volume":"92","author":[{"given":"Matthew E.","family":"Larsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Rumian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidia","family":"Quillinan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0893-2200","authenticated-orcid":false,"given":"K. Ulrich","family":"Bayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.conb.2024.102961_sref1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41586-023-06465-y","article-title":"LTP induction by structural rather than enzymatic functions of CaMKII","volume":"621","author":"Tullis","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.conb.2024.102961_bib2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1126\/science.1378648","article-title":"Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice","volume":"257","author":"Silva","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.conb.2024.102961_bib3","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1126\/science.279.5352.870","article-title":"Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning","volume":"279","author":"Giese","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.conb.2024.102961_bib4","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.neuron.2019.05.033","article-title":"CaM kinase: still inspiring at 40","volume":"103","author":"Bayer","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.conb.2024.102961_bib5","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41583-022-00624-2","article-title":"CaMKII: a central molecular organizer of synaptic plasticity, learning and memory","volume":"23","author":"Yasuda","year":"2022","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.conb.2024.102961_bib6","article-title":"A revised view of the role of CaMKII in learing and memory","author":"Bayer","year":"2024","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.conb.2024.102961_bib7","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/emboj.2011.482","article-title":"CaMKII binding to GluN2B is critical during memory consolidation","volume":"31","author":"Halt","year":"2012","journal-title":"EMBO J"},{"key":"10.1016\/j.conb.2024.102961_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.ade5892","article-title":"Decreased nitrosylation of CaMKII causes aging-associated impairments in memory and synaptic plasticity in mice","volume":"16","author":"Rumian","year":"2023","journal-title":"Sci Signal"},{"key":"10.1016\/j.conb.2024.102961_sref9","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1016\/j.celrep.2018.05.036","article-title":"CaMKII metaplasticity drives abeta oligomer-mediated synaptotoxicity","volume":"23","author":"Opazo","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.conb.2024.102961_sref10","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.celrep.2019.03.041","article-title":"Simultaneous live imaging of multiple endogenous proteins reveals a mechanism for Alzheimer\u2019s-related plasticity impairment","volume":"27","author":"Cook","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.conb.2024.102961_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104368","article-title":"Abeta-induced synaptic impairments require CaMKII activity that is stimulated by indirect signaling events","volume":"25","author":"Brown","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.conb.2024.102961_bib12","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer's disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.conb.2024.102961_bib13","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nm1782","article-title":"Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory","volume":"14","author":"Shankar","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.conb.2024.102961_bib14","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/416535a","article-title":"Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo","volume":"416","author":"Walsh","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.conb.2024.102961_bib15","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrn3983","article-title":"A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome","volume":"16","author":"Wiseman","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.conb.2024.102961_bib16","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3233\/JAD-160836","article-title":"Down syndrome, partial trisomy 21, and absence of alzheimer's disease: the role of APP","volume":"56","author":"Doran","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.conb.2024.102961_bib17","doi-asserted-by":"crossref","first-page":"5736","DOI":"10.1038\/s41598-021-85062-3","article-title":"Genetic dissection of down syndrome-associated alterations in APP\/amyloid-beta biology using mouse models","volume":"11","author":"Tosh","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.conb.2024.102961_bib18","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1179\/016164108X323771","article-title":"Expression of amyloid precursor protein after rat traumatic brain injury","volume":"31","author":"Itoh","year":"2009","journal-title":"Neurol Res"},{"key":"10.1016\/j.conb.2024.102961_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2019.101730","article-title":"Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer's disease pathology","volume":"185","author":"Wu","year":"2020","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.conb.2024.102961_bib20","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1089\/neu.1998.15.993","article-title":"Experimental brain injury induces expression of amyloid precursor protein, which may be related to neuronal loss in the hippocampus","volume":"15","author":"Murakami","year":"1998","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.conb.2024.102961_bib21","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s12975-019-00755-2","article-title":"From stroke to dementia: a comprehensive review exposing tight interactions between stroke and amyloid-beta formation","volume":"11","author":"Goulay","year":"2020","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.conb.2024.102961_bib22","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1007\/s12975-021-00921-5","article-title":"Is cerebral amyloid-beta deposition related to post-stroke cognitive impairment?","volume":"12","author":"Ouyang","year":"2021","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.conb.2024.102961_bib23","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/0271678X231159597","article-title":"Targeting BACE1-mediated production of amyloid beta improves hippocampal synaptic function in an experimental model of ischemic stroke","volume":"43","author":"Basak","year":"2023","journal-title":"J Cerebr Blood Flow Metabol"},{"key":"10.1016\/j.conb.2024.102961_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.636653","article-title":"Brain ischemia as a prelude to alzheimer's disease","volume":"13","author":"Pluta","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.conb.2024.102961_bib25","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.3233\/JAD-150299","article-title":"Dysregulation of amyloid-beta protein precursor, beta-secretase, presenilin 1 and 2 genes in the rat selectively vulnerable CA1 subfield of Hippocampus following transient global brain ischemia","volume":"47","author":"Kocki","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.conb.2024.102961_bib26","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3233\/JAD-2007-12406","article-title":"Cerebral ischemia and Alzheimer's disease: the expression of amyloid-beta and apolipoprotein E in human hippocampus","volume":"12","author":"Qi","year":"2007","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.conb.2024.102961_sref27","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.celrep.2017.01.011","article-title":"Autonomous CaMKII activity as a drug target for histological and functional neuroprotection after resuscitation from cardiac arrest","volume":"18","author":"Deng","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.conb.2024.102961_bib28","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.celrep.2014.01.005","article-title":"Autonomous CaMKII mediates both LTP and LTD using a mechanism for differential substrate site selection","volume":"6","author":"Coultrap","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.conb.2024.102961_bib29","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.celrep.2017.05.068","article-title":"DAPK1 mediates LTD by making CaMKII\/GluN2B binding LTP specific","volume":"19","author":"Goodell","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.conb.2024.102961_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe2300","article-title":"CaMKII holoenzyme mechanisms that govern the LTP versus LTD decision","volume":"7","author":"Cook","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.conb.2024.102961_sref31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104693","article-title":"Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory in mice and is neuroprotective in pigs","volume":"299","author":"Rumian","year":"2023","journal-title":"J Biol Chem"},{"key":"10.1016\/j.conb.2024.102961_sref32","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113982","article-title":"Studying CaMKII: tools and standards","volume":"43","author":"Brown","year":"2024","journal-title":"Cell Rep"},{"key":"10.1016\/j.conb.2024.102961_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102299","article-title":"CaMKII T286 phosphorylation has distinct essential functions in three forms of long-term plasticity","volume":"298","author":"Cook","year":"2022","journal-title":"J Biol Chem"},{"key":"10.1016\/j.conb.2024.102961_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114866","article-title":"LTP expression mediated by autonomous activity of GluN2B-bound CaMKII","volume":"43","author":"Rumian","year":"2024","journal-title":"Cell Rep"},{"key":"10.1016\/j.conb.2024.102961_bib35","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1096\/fj.14-250407","article-title":"Autonomous CaMKII requires further stimulation by Ca2+\/calmodulin for enhancing synaptic strength","volume":"28","author":"Barcomb","year":"2014","journal-title":"Faseb J"},{"key":"10.1016\/j.conb.2024.102961_bib36","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/35081080","article-title":"Interaction with the NMDA receptor locks CaMKII in an active conformation","volume":"411","author":"Bayer","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.conb.2024.102961_bib37","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/nn.3178","article-title":"Alzheimer amyloid-beta oligomer bound to postsynaptic prion protein activates Fyn to impair neurons","volume":"15","author":"Um","year":"2012","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.conb.2024.102961_bib38","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nn1503","article-title":"Regulation of NMDA receptor trafficking by amyloid-beta","volume":"8","author":"Snyder","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.conb.2024.102961_bib39","doi-asserted-by":"crossref","first-page":"23798","DOI":"10.1074\/jbc.M001471200","article-title":"Mechanism and regulation of calcium\/calmodulin-dependent protein kinase II targeting to the NR2B subunit of the N-methyl-D-aspartate receptor","volume":"275","author":"Strack","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.conb.2024.102961_bib40","doi-asserted-by":"crossref","first-page":"31272","DOI":"10.1074\/jbc.M111.233668","article-title":"Nucleotides and phosphorylation bi-directionally modulate Ca2+\/calmodulin-dependent protein kinase II (CaMKII) binding to the N-methyl-D-aspartate (NMDA) receptor subunit GluN2B","volume":"286","author":"O'Leary","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.conb.2024.102961_bib41","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.nbd.2013.06.014","article-title":"Transient focal cerebral ischemia induces long-term cognitive function deficit in an experimental ischemic stroke model","volume":"59","author":"Li","year":"2013","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.conb.2024.102961_bib42","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1111\/ejn.12683","article-title":"Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation","volume":"40","author":"Orfila","year":"2014","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.conb.2024.102961_bib43","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/jcbfm.1989.86","article-title":"Ischemic flow threshold for extracellular glutamate increase in cat cortex","volume":"9","author":"Shimada","year":"1989","journal-title":"J Cerebr Blood Flow Metabol"},{"key":"10.1016\/j.conb.2024.102961_bib44","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/35002090","article-title":"Glutamate release in severe brain ischaemia is mainly by reversed uptake","volume":"403","author":"Rossi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.conb.2024.102961_bib45","article-title":"Oxygen\/glucose-deprivation causes long-term impairment of synaptic CaMKII movement","author":"Buonarati","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.conb.2024.102961_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celrep.2019.11.076","article-title":"CaMKII versus DAPK1 binding to GluN2B in ischemic neuronal cell death after resuscitation from cardiac arrest","volume":"30","author":"Buonarati","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.conb.2024.102961_bib47","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1089\/neu.2006.0188","article-title":"Phosphorylation of calcium calmodulin-dependent protein kinase II following lateral fluid percussion brain injury in rats","volume":"24","author":"Folkerts","year":"2007","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.conb.2024.102961_bib48","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1111\/j.1471-4159.2006.03971.x","article-title":"Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome","volume":"98","author":"Siarey","year":"2006","journal-title":"J Neurochem"},{"issue":"Suppl 1","key":"10.1016\/j.conb.2024.102961_bib49","first-page":"S333","article-title":"Cerebral blood flow, cerebral blood volume, and cerebrovascular reactivity after severe head injury","volume":"9","author":"Bouma","year":"1992","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.conb.2024.102961_bib50","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3390\/neurolint16010006","article-title":"Post-traumatic cerebral infarction: a narrative review of pathophysiology, diagnosis, and treatment","volume":"16","author":"Poblete","year":"2024","journal-title":"Neurol Int"},{"key":"10.1016\/j.conb.2024.102961_bib51","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3233\/JAD-220159","article-title":"Traumatic brain injury and risk of alzheimer's disease and related dementias in the population","volume":"88","author":"Mielke","year":"2022","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.conb.2024.102961_bib52","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41582-018-0132-6","article-title":"Dementia in Down syndrome: unique insights for Alzheimer disease research","volume":"15","author":"Lott","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.conb.2024.102961_bib53","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.18632\/aging.102677","article-title":"Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein","volume":"12","author":"Gomez","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.conb.2024.102961_bib54","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.26991","article-title":"LTP and memory impairment caused by extracellular Abeta and Tau oligomers is APP-dependent","volume":"6","author":"Puzzo","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.conb.2024.102961_bib55","doi-asserted-by":"crossref","first-page":"11947","DOI":"10.1523\/JNEUROSCI.2009-17.2017","article-title":"Human brain-derived abeta oligomers bind to synapses and disrupt synaptic activity in a manner that requires APP","volume":"37","author":"Wang","year":"2017","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2024.102961_bib56","doi-asserted-by":"crossref","first-page":"9170","DOI":"10.1523\/JNEUROSCI.1250-11.2011","article-title":"Role of the CaMKII\/NMDA receptor complex in the maintenance of synaptic strength","volume":"31","author":"Sanhueza","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2024.102961_bib57","doi-asserted-by":"crossref","first-page":"16082","DOI":"10.1074\/jbc.M116.734822","article-title":"The CaMKII\/GluN2B protein interaction maintains synaptic strength","volume":"291","author":"Barcomb","year":"2016","journal-title":"J Biol Chem"},{"key":"10.1016\/j.conb.2024.102961_bib58","doi-asserted-by":"crossref","first-page":"9741","DOI":"10.1523\/JNEUROSCI.0681-17.2017","article-title":"Increased GSNOR expression during aging impairs cognitive function and decreases S-nitrosation of CaMKIIalpha","volume":"37","author":"Zhang","year":"2017","journal-title":"J Neurosci"},{"key":"10.1016\/j.conb.2024.102961_bib59","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.ajhg.2017.10.003","article-title":"De novo mutations in protein kinase genes CAMK2A and CAMK2B cause intellectual disability","volume":"101","author":"Kury","year":"2017","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.conb.2024.102961_bib60","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nature12975","article-title":"A polygenic burden of rare disruptive mutations in schizophrenia","volume":"506","author":"Purcell","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.conb.2024.102961_bib61","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1756-6606-1-6","article-title":"Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders","volume":"1","author":"Yamasaki","year":"2008","journal-title":"Mol Brain"}],"container-title":["Current Opinion in Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959438824001235?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959438824001235?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T18:08:59Z","timestamp":1778782139000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959438824001235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":61,"alternative-id":["S0959438824001235"],"URL":"https:\/\/doi.org\/10.1016\/j.conb.2024.102961","relation":{},"ISSN":["0959-4388"],"issn-type":[{"value":"0959-4388","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CaMKII mechanisms that promote pathological LTP impairments","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.conb.2024.102961","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102961"}}