{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:11:23Z","timestamp":1790644283609,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100001167","name":"Larry L. Hillblom Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001167","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Neurobiology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.conb.2026.103173","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T19:27:40Z","timestamp":1773084460000},"page":"103173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Implications of cellular senescence in Parkinson\u2019s disease: Recent developments and future directions"],"prefix":"10.1016","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1324-4875","authenticated-orcid":false,"given":"Julie K.","family":"Andersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.conb.2026.103173_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41531-020-0117-1","article-title":"Current and projected future economic burden of Parkinson's disease in the U.S","volume":"6","author":"Yang","year":"2020","journal-title":"npj Parkinson's Dis"},{"key":"10.1016\/j.conb.2026.103173_bib2","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and treatment of parkinson disease: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.conb.2026.103173_bib3","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.1111\/febs.12335","article-title":"The hallmarks of Parkinson's disease","volume":"280","author":"Antony","year":"2013","journal-title":"FEBS J"},{"key":"10.1016\/j.conb.2026.103173_sref4","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2024.1334261","article-title":"The hallmarks of aging as a conceptual framework for health and longevity research","volume":"5","author":"Tartiere","year":"2024","journal-title":"Front Aging"},{"key":"10.1016\/j.conb.2026.103173_bib5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/bs.mcb.2022.12.007","article-title":"Assessing microbiota composition in the context of aging","volume":"181","author":"Campos-Iglesias","year":"2024","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.conb.2026.103173_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102141","article-title":"Cellular senescence in brain aging and neurodegeneration","volume":"93","author":"Melo Dos Santos","year":"2024","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.conb.2026.103173_bib7","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1016\/j.cell.2024.05.059","article-title":"Guidelines for minimal information on cellular senescence experimentation in vivo","volume":"187","author":"Ogrodnik","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.conb.2026.103173_bib8","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/s41580-024-00727-x","article-title":"The senescence-associated secretory phenotype and its physiological and pathological implications","volume":"25","author":"Wang","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.conb.2026.103173_bib9","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/s42255-021-00483-8","article-title":"The metabolic roots of senescence: mechanisms and opportunities for intervention","volume":"3","author":"Wiley","year":"2021","journal-title":"Nat Metab"},{"key":"10.1016\/j.conb.2026.103173_sref10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.tcb.2022.04.011","article-title":"The heterogeneity of cellular senescence: insights at the single-cell level","volume":"33","author":"Cohn","year":"2023","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.conb.2026.103173_bib11","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.celrep.2017.12.092","article-title":"Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to Parkinson's Disease","volume":"22","author":"Chinta","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.conb.2026.103173_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/cells10071694","article-title":"Alpha-Synuclein preformed fibrils induce cellular senescence in Parkinson's Disease models","volume":"10","author":"Verma","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.conb.2026.103173_sref13","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.tins.2024.09.006","article-title":"Defining and characterizing neuronal senescence, 'neurescence', as G(X) arrested cells","volume":"47","author":"Hudson","year":"2024","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.conb.2026.103173_bib14","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41593-019-0372-9","article-title":"Senolytic therapy alleviates Abeta-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model","volume":"22","author":"Zhang","year":"2019","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.conb.2026.103173_bib15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s40035-024-00447-4","article-title":"Cellular senescence in Alzheimer's disease: from physiology to pathology","volume":"13","author":"Zhu","year":"2024","journal-title":"Transl Neurodegener"},{"key":"10.1016\/j.conb.2026.103173_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094402","article-title":"Senescent microglia: the key to the ageing brain?","volume":"22","author":"Greenwood","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.conb.2026.103173_bib17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1083\/jcb.201708092","article-title":"Senescence and aging: causes, consequences, and therapeutic avenues","volume":"217","author":"McHugh","year":"2018","journal-title":"J Cell Biol"},{"key":"10.1016\/j.conb.2026.103173_bib18","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41401-023-01153-z","article-title":"Cell senescence induced by toxic interaction between alpha-synuclein and iron precedes nigral dopaminergic neuron loss in a mouse model of Parkinson's disease","volume":"45","author":"Shen","year":"2024","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.conb.2026.103173_bib19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/1877718X251316552","article-title":"Aging, cellular senescence and Parkinson's disease","volume":"15","author":"Ma","year":"2025","journal-title":"J Parkinsons Dis"},{"key":"10.1016\/j.conb.2026.103173_bib20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12979-024-00429-0","article-title":"Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration","volume":"21","author":"Du","year":"2024","journal-title":"Immun Ageing"},{"key":"10.1016\/j.conb.2026.103173_bib21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41420-024-01816-8","article-title":"Glial senescence enhances alpha-synuclein pathology owing to its insufficient clearance caused by autophagy dysfunction","volume":"10","author":"Hong","year":"2024","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.conb.2026.103173_bib22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5607\/en.2015.24.2.103","article-title":"Mitochondrial dysfunction in Parkinson's Disease","volume":"24","author":"Moon","year":"2015","journal-title":"Exp Neurobiol"},{"key":"10.1016\/j.conb.2026.103173_bib23","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.bbagen.2008.02.005","article-title":"Redox imbalance in Parkinson's disease","volume":"1780","author":"Chinta","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.conb.2026.103173_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25084187","article-title":"DNA damage and Parkinson's Disease","volume":"25","author":"Pfeifer","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.conb.2026.103173_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-22400-z","article-title":"Mitochondrial biogenesis, telomere length and cellular senescence in Parkinson's disease and lewy body dementia","volume":"12","author":"Asghar","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.conb.2026.103173_bib26","article-title":"Gut microbiota: a novel therapeutic target for Parkinson's Disease","volume":"13","author":"Zhu","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.conb.2026.103173_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.593026","article-title":"Blood-Brain barrier leakage is increased in Parkinson's Disease","volume":"11","author":"Al-Bachari","year":"2020","journal-title":"Front Physiol"},{"key":"10.1016\/j.conb.2026.103173_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24087435","article-title":"Proteins and transcriptional dysregulation of the brain extracellular matrix in Parkinson's Disease: a systematic review","volume":"24","author":"Rike","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.conb.2026.103173_sref29","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13061400","article-title":"Role of cellular senescence in Parkinson's Disease: potential for disease-modification through senotherapy","volume":"13","author":"Rademacher","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.conb.2026.103173_bib30","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41573-024-01033-z","article-title":"Therapeutic targeting of senescent cells in the CNS","volume":"23","author":"Riessland","year":"2024","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.conb.2026.103173_sref31","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3233\/JAD-231462","article-title":"A need for refined senescence biomarkers and measures of senolytics in the brain","volume":"98","author":"Orr","year":"2024","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.conb.2026.103173_bib32","doi-asserted-by":"crossref","DOI":"10.1186\/1476-4598-8-117","article-title":"Identification of small molecule compounds that inhibit the HIF-1 signaling pathway","volume":"8","author":"Xia","year":"2009","journal-title":"Mol Cancer"},{"key":"10.1016\/j.conb.2026.103173_bib33","doi-asserted-by":"crossref","first-page":"19382","DOI":"10.1039\/D0RA03383A","article-title":"Properties of differentiated SH-SY5Y grown on carbon-based materials","volume":"10","author":"Yoon","year":"2020","journal-title":"RSC Adv"},{"key":"10.1016\/j.conb.2026.103173_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2024.103919","article-title":"Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease","volume":"128","author":"Muwanigwa","year":"2024","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.conb.2026.103173_bib35","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.stem.2019.08.013","article-title":"Loss of SATB1 induces p21-Dependent cellular senescence in post-mitotic dopaminergic neurons","volume":"25","author":"Riessland","year":"2019","journal-title":"Cell Stem Cell"}],"container-title":["Current Opinion in Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959438826000097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959438826000097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T12:22:23Z","timestamp":1779711743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959438826000097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":35,"alternative-id":["S0959438826000097"],"URL":"https:\/\/doi.org\/10.1016\/j.conb.2026.103173","relation":{},"ISSN":["0959-4388"],"issn-type":[{"value":"0959-4388","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Implications of cellular senescence in Parkinson\u2019s disease: Recent developments and future directions","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.conb.2026.103173","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103173"}}