{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:14:55Z","timestamp":1762521295957,"version":"build-2065373602"},"reference-count":13,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T00:00:00Z","timestamp":1623456000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials Communications"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.conctc.2021.100806","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T13:53:44Z","timestamp":1623765224000},"page":"100806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Efficacy and safety of preoperative preparation with Lugol's iodine solution in euthyroid patients with Graves\u2019 disease (LIGRADIS Trial): Study protocol for a multicenter randomized trial"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1439-5632","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Mu\u00f1oz de Nova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3787-8285","authenticated-orcid":false,"given":"Guzm\u00e1n","family":"Franch-Arcas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8689-7941","authenticated-orcid":false,"given":"Gina Paola","family":"Mej\u00eda-Abril","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Eugenia","family":"Flores-Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6754-8535","authenticated-orcid":false,"given":"Nuria","family":"Mu\u00f1oz-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2668-8195","authenticated-orcid":false,"given":"Elena","family":"Pintos-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Guadarrama Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"Vald\u00e9s de Anca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1836-0165","authenticated-orcid":false,"given":"Enrique","family":"Mercader-Cidoncha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5906-6600","authenticated-orcid":false,"given":"Aitor","family":"de la Quintana-Basarrate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Osorio-Silla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8684-1393","authenticated-orcid":false,"given":"Susana","family":"Ros-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9157-475X","authenticated-orcid":false,"given":"Lander","family":"Gallego-Otaegui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8735-4148","authenticated-orcid":false,"given":"Elena","family":"Santos-Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concepci\u00f3n","family":"Mart\u00ednez-Nieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Gamborino-Caram\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2800-9173","authenticated-orcid":false,"given":"Mariano","family":"Art\u00e9s-Caselles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4067-5240","authenticated-orcid":false,"given":"Leyre","family":"Lorente-Poch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maitane","family":"Garc\u00eda-Carrillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0718-2797","authenticated-orcid":false,"given":"Pablo","family":"Moreno-Llorente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Mar\u00edn-Velarde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7126-0780","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Ortega-Serrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0424-3136","authenticated-orcid":false,"given":"Juan Manuel","family":"Martos-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Vidal-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Luengo-Pierrard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6831-6739","authenticated-orcid":false,"given":"Jes\u00fas Mar\u00eda","family":"Villar-del-Moral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.conctc.2021.100806_bib1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000490384","article-title":"2018 European thyroid association guideline for the management of graves' hyperthyroidism","volume":"7","author":"Kahaly","year":"2018","journal-title":"Eur. Thyroid J."},{"key":"10.1016\/j.conctc.2021.100806_bib2","first-page":"CD010576","article-title":"Thyroid surgery for Graves \u2019 disease and Graves \u2019 ophthalmopathy","volume":"25","author":"Zw","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.conctc.2021.100806_bib3","first-page":"1955","article-title":"Results of administering iodine to patients having exophtalmic goiter","volume":"80","author":"Plummer","year":"1923","journal-title":"J. Am. Med. Assoc."},{"issue":"4","key":"10.1016\/j.conctc.2021.100806_bib4","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.amjsurg.2016.07.015","article-title":"Randomized trial of a short course of preoperative potassium iodide in patients undergoing thyroidectomy for Graves' disease","volume":"213","author":"Whalen","year":"2017","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.conctc.2021.100806_bib5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.amsu.2016.06.002","article-title":"The effect of preoperative Lugol's iodine on intraoperative bleeding in patients with hyperthyroidism","volume":"9","author":"Yilmaz","year":"2016","journal-title":"Ann. Med. Surg."},{"issue":"6","key":"10.1016\/j.conctc.2021.100806_bib6","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1210\/jc.2007-0229","article-title":"Effect of lugol solution on thyroid gland blood flow and microvessel density in the patients with Graves' disease","volume":"92","author":"Erbil","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.conctc.2021.100806_bib7","first-page":"123","article-title":"Effect of preoperative iodine in patients with Graves' disease controlled with antithyroid drugs and thyroxine","volume":"70","author":"Kaur","year":"1988","journal-title":"Ann. R. Coll. Surg. Engl."},{"issue":"5","key":"10.1016\/j.conctc.2021.100806_bib8","first-page":"334","article-title":"Thyroidectomy: is Lugol's iodine necessary?","volume":"64","author":"Coyle","year":"1982","journal-title":"Ann. R. Coll. Surg. Engl."},{"issue":"1","key":"10.1016\/j.conctc.2021.100806_bib9","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.surg.2017.03.030","article-title":"Impact of potassium iodide on thyroidectomy for Graves' disease: implications for safety and operative difficulty","volume":"163","author":"Randle","year":"2018","journal-title":"Surgery"},{"issue":"6","key":"10.1016\/j.conctc.2021.100806_bib10","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1177\/0194599819829052","article-title":"Effects of preoperative iodine administration on thyroidectomy for hyperthyroidism: a systematic review and meta-analysis","volume":"160","author":"Tsai","year":"2019","journal-title":"Otolaryngol. Head Neck Surg."},{"issue":"10","key":"10.1016\/j.conctc.2021.100806_bib11","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/thy.2016.0229","article-title":"2016 American thyroid association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis","volume":"26","author":"Ross","year":"2016","journal-title":"Thyroid"},{"issue":"1","key":"10.1016\/j.conctc.2021.100806_bib12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/cen.12688","article-title":"2013 European survey of clinical practice patterns in the management of Graves' disease","volume":"84","author":"Bartalena","year":"2016","journal-title":"Clin. Endocrinol."},{"issue":"8","key":"10.1016\/j.conctc.2021.100806_bib13","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1007\/s00268-014-2489-z","article-title":"Novel thyroidectomy difficulty scale correlates with operative times","volume":"38","author":"Schneider","year":"2014","journal-title":"World J. Surg."}],"container-title":["Contemporary Clinical Trials Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451865421001071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451865421001071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:06:28Z","timestamp":1762520788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451865421001071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":13,"alternative-id":["S2451865421001071"],"URL":"https:\/\/doi.org\/10.1016\/j.conctc.2021.100806","relation":{},"ISSN":["2451-8654"],"issn-type":[{"type":"print","value":"2451-8654"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of preoperative preparation with Lugol's iodine solution in euthyroid patients with Graves\u2019 disease (LIGRADIS Trial): Study protocol for a multicenter randomized trial","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.conctc.2021.100806","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100806"}}