{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:15:35Z","timestamp":1762521335099,"version":"build-2065373602"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014421","name":"EA Pharma Co., Ltd.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014421","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004820","name":"Mochida Pharmaceutical Co Ltd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004820","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007418","name":"EA Pharma Co Ltd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials Communications"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.conctc.2022.100958","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T12:45:42Z","timestamp":1656333942000},"page":"100958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Rationale and design of a multicenter, single-group, open-label trial aiming at investigating the effectiveness of elobixibat for loss of defecation desire in patients with chronic constipation"],"prefix":"10.1016","volume":"28","author":[{"given":"Atsushi","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5587-1386","authenticated-orcid":false,"given":"Takaomi","family":"Kessoku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michihiro","family":"Iwaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7240-4851","authenticated-orcid":false,"given":"Takashi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5150-7942","authenticated-orcid":false,"given":"Tsutomu","family":"Yoshihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Misawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanji","family":"Ohkuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Fuyuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Higurashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Hosono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Yoneda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Kurihashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3145-0314","authenticated-orcid":false,"given":"Machiko","family":"Nakatogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayao","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Taguri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Oyamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Ariyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noritoshi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.conctc.2022.100958_bib1","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/j.1742-1241.2010.02397.x","article-title":"Systematic review and meta analysis: polyethylene glycol in adults with non-organic constipation","volume":"64","author":"Belsey","year":"2010","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.conctc.2022.100958_bib2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2036.2007.03376.x","article-title":"The burden of constipation on quality of life: results of a multinational survey","volume":"26","author":"Wald","year":"2007","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.conctc.2022.100958_bib3","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/ajg.2013.137","article-title":"Impact of persistent constipation on health-related quality of life and mortality in older community-dwelling women","volume":"108","author":"Koloski","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.conctc.2022.100958_bib4","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.amjmed.2011.03.026","article-title":"Constipation and risk of cardiovascular disease among postmenopausal women","volume":"124","author":"Salmoirago-Blotcher","year":"2011","journal-title":"Am. J. Med."},{"key":"10.1016\/j.conctc.2022.100958_bib5","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.atherosclerosis.2018.12.021","article-title":"Constipation and risk of death and cardiovascular events","volume":"281","author":"Sumida","year":"2019","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.conctc.2022.100958_bib6","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-037080","article-title":"Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort study","volume":"10","author":"Sundb\u00f8ll","year":"2020","journal-title":"BMJ Open"},{"key":"10.1016\/j.conctc.2022.100958_bib7","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/ajg.2010.40","article-title":"Impact of functional gastrointestinal disorders on survival in the community","volume":"105","author":"Chang","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.conctc.2022.100958_bib8","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000230","article-title":"Difference in DD between patients with and without chronic constipation: a large-scale Internet survey","volume":"11","author":"Ohkubo","year":"2020","journal-title":"Clin. Transl. Gastroenterol."},{"key":"10.1016\/j.conctc.2022.100958_bib9","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1177\/1756283X14528269","article-title":"Elobixibat and its potential role in chronic idiopathic constipation","volume":"7","author":"Acosta","year":"2014","journal-title":"Ther. Adv. Gastroenterol."},{"key":"10.1016\/j.conctc.2022.100958_bib10","doi-asserted-by":"crossref","first-page":"G443","DOI":"10.1152\/ajpgi.00194.2001","article-title":"The proximal colonic motor response to rectal mechanical and chemical stimulation","volume":"282","author":"Bampton","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.conctc.2022.100958_bib11","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1136\/gut.30.3.383","article-title":"Effect of bile acid on anorectal function in man","volume":"30","author":"Edwards","year":"1989","journal-title":"Gut"},{"key":"10.1016\/j.conctc.2022.100958_bib12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2105\/AJPH.94.3.361","article-title":"TREND Group, Improving the reporting quality of nonrandomized evaluations of behavioral and public health interventions: the TREND statement","volume":"94","author":"Des Jarlais","year":"2004","journal-title":"Am. J. Publ. Health"},{"key":"10.1016\/j.conctc.2022.100958_bib13","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S2468-1253(18)30123-7","article-title":"Safety and efficacy of elobixibat for chronic constipation: results from a randomised, double-blind, placebo-controlled, phase 3 trial and an open-label, single-arm, phase 3 trial","volume":"3","author":"Nakajima","year":"2018","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.conctc.2022.100958_bib14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.5056\/jnm18194","article-title":"A randomized double-blind placebo-controlled trial on the effect of magnesium oxide in patients with chronic constipation","volume":"25","author":"Mori","year":"2019","journal-title":"J. Neurogastroenterol. Motil."},{"key":"10.1016\/j.conctc.2022.100958_bib15","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.cgh.2014.08.026","article-title":"Lubiprostone increases spontaneous bowel movement frequency and quality of life in patients with chronic idiopathic constipation","volume":"13","author":"Fukudo","year":"2015","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.conctc.2022.100958_bib16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1056\/NEJMoa1010863","article-title":"Two randomized trials of linaclotide for chronic constipation","volume":"365","author":"Lembo","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.conctc.2022.100958_bib17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.14309\/ajg.0000000000000479","article-title":"Poststroke constipation is associated with impaired rectal sensation","volume":"115","author":"Cheng","year":"2020","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.conctc.2022.100958_bib18","doi-asserted-by":"crossref","first-page":"758","DOI":"10.14309\/ajg.0000000000001039","article-title":"Clinical impact of rectal hyposensitivity: a cross-sectional study of 2,876 patients with refractory functional constipation","volume":"116","author":"Vollebregt","year":"2021","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.conctc.2022.100958_bib19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1055\/s-2007-965016","article-title":"Effects of herbal medicine Dai-Kenchu-to on anorectal function in children with severe constipation","volume":"17","author":"Iwai","year":"2007","journal-title":"Eur. J. Pediatr. Surg."},{"key":"10.1016\/j.conctc.2022.100958_bib20","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1111\/apt.12264","article-title":"Randomised clinical trial: the effects of daikenchuto, TU-100, on gastrointestinal and colonic transit, anorectal and bowel function in female patients with functional constipation","volume":"37","author":"Iturrino","year":"2013","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.conctc.2022.100958_bib21","article-title":"Lubiprostone does not influence visceral pain thresholds in patients with irritable bowel syndrome","volume":"23","author":"Whitehead","year":"2011","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.conctc.2022.100958_bib22","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1007\/s10350-005-0087-8","article-title":"Impaired proximal colonic motor response to rectal mechanical and chemical stimulation in obstructed defecation","volume":"48","author":"Dinning","year":"2005","journal-title":"Dis. Colon Rectum"},{"key":"10.1016\/j.conctc.2022.100958_bib23","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/apt.15950","article-title":"The benefit of elobixibat in chronic constipation is associated with faecal deoxycholic acid but not effects of altered microbiota","volume":"52","author":"Misawa","year":"2020","journal-title":"Aliment. Pharmacol. Ther."}],"container-title":["Contemporary Clinical Trials Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451865422000758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451865422000758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:07:24Z","timestamp":1762520844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451865422000758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":23,"alternative-id":["S2451865422000758"],"URL":"https:\/\/doi.org\/10.1016\/j.conctc.2022.100958","relation":{},"ISSN":["2451-8654"],"issn-type":[{"type":"print","value":"2451-8654"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rationale and design of a multicenter, single-group, open-label trial aiming at investigating the effectiveness of elobixibat for loss of defecation desire in patients with chronic constipation","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.conctc.2022.100958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100958"}}