{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:17:16Z","timestamp":1762521436086,"version":"build-2065373602"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials Communications"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.conctc.2022.101019","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T05:28:16Z","timestamp":1666934896000},"page":"101019","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Exploratory, multicenter, open-label study to evaluate the effects of linaclotide in patients with chronic constipation with an insufficient response to magnesium oxide: A study protocol"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5150-7942","authenticated-orcid":false,"given":"Tsutomu","family":"Yoshihara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaomi","family":"Kessoku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Takatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Misawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8379-4704","authenticated-orcid":false,"given":"Keiichi","family":"Ashikari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Fuyuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Ohkubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1815-4396","authenticated-orcid":false,"given":"Takuma","family":"Higurashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michihiro","family":"Iwaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Kurihashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Machiko","family":"Nakatogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0696-9659","authenticated-orcid":false,"given":"Koji","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izuru","family":"Terada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.conctc.2022.101019_bib1","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1053\/j.gastro.2019.12.034","article-title":"Mechanisms, evaluation, and management of chronic constipation","volume":"158","author":"Bharucha","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.conctc.2022.101019_bib2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12876-015-0366-3","article-title":"Chronic constipation in the elderly: a primer for the gastroenterologist","volume":"15","author":"De Giorgio","year":"2015","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.conctc.2022.101019_bib3","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1007\/s10620-011-1639-5","article-title":"Impact of chronic constipation on health-related quality of life, work productivity, and healthcare resource use: an analysis of the National Health and Wellness Survey, Dig","volume":"56","author":"Sun","year":"2011","journal-title":"Dis. Sci."},{"key":"10.1016\/j.conctc.2022.101019_bib4","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1365-2036.2006.03238.x","article-title":"Chronic constipation: a survey of the patient perspective","volume":"25","author":"Johanson","year":"2007","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.conctc.2022.101019_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s13730-018-0359-5","article-title":"Severe hypermagnesemia induced by magnesium oxide ingestion: a case series","volume":"8","author":"Yamaguchi","year":"2019","journal-title":"CEN Case Rep"},{"key":"10.1016\/j.conctc.2022.101019_bib6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2982.2009.01465.x","article-title":"Linaclotide - a secretagogue and antihyperalgesic agent - what next?","volume":"22","author":"Bharucha","year":"2010","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.conctc.2022.101019_bib7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1056\/NEJMoa1010863","article-title":"Two randomized trials of linaclotide for chronic constipation","volume":"365","author":"Lembo","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.conctc.2022.101019_bib8","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S2468-1253(18)30123-7","article-title":"Safety and efficacy of elobixibat for chronic constipation: results from a randomised, double-blind, placebo-controlled, phase 3 trial and an open-label, single-arm, phase 3 trial","volume":"3","author":"Nakajima","year":"2018","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.conctc.2022.101019_bib9","article-title":"Normative values for colonic transit time and patient assessment of constipation in adults with functional constipation: systematic review with meta-analysis","volume":"11","author":"Miller","year":"2017","journal-title":"Clin. Med. Insights Gastroenterol."},{"key":"10.1016\/j.conctc.2022.101019_bib10","doi-asserted-by":"crossref","first-page":"P1393","DOI":"10.1053\/j.gastro.2016.02.031","article-title":"Bowel disorders","volume":"150","author":"Mearin","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.conctc.2022.101019_bib11","article-title":"High-dose linaclotide is effective and safe in patients with chronic constipation: a phase III randomized, double-blind, placebo-controlled study with a long-term open-label extension study in Japan","volume":"31","author":"Fukudo","year":"2019","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.conctc.2022.101019_bib12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/ajg.2017.230","article-title":"Low-dose linaclotide (72 \u03bcg) for chronic idiopathic constipation: a 12-week, randomized, double-blind, placebo-controlled trial","volume":"113","author":"Schoenfeld","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.conctc.2022.101019_bib13","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cgh.2012.02.029","article-title":"Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis","volume":"10","author":"Lovell","year":"2012","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.conctc.2022.101019_bib14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.5694\/mja18.00241","article-title":"Chronic idiopathic constipation in adults: epidemiology, pathophysiology, diagnosis and clinical management","volume":"209","author":"Black","year":"2018","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.conctc.2022.101019_bib15","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ajg.2015.67","article-title":"The spectrum of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation: US survey assessing symptoms, care seeking, and disease burden","volume":"110","author":"Heidelbaugh","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.conctc.2022.101019_bib16","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1097\/MCG.0000000000001473","article-title":"Treatment satisfaction with current medications for chronic constipation: an internet survey of Japanese patients","volume":"56","author":"Hayashi","year":"2022","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.conctc.2022.101019_bib17","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1111\/jgh.15295","article-title":"Impact of chronic constipation on health-related quality of life and work productivity in Japan","volume":"36","author":"Tomita","year":"2021","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.conctc.2022.101019_bib18","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s12325-018-0733-x","article-title":"Better understanding and recognition of the disconnects, experiences, and needs of patients with irritable bowel syndrome with constipation (BURDEN IBS-C) study: results of an online questionnaire","volume":"35","author":"Quigley","year":"2018","journal-title":"Adv. Ther."},{"key":"10.1016\/j.conctc.2022.101019_bib19","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1007\/s12325-017-0633-5","article-title":"The better understanding and recognition of the disconnects, experiences, and needs of patients with chronic idiopathic constipation (BURDEN-CIC) study: results of an online questionnaire","volume":"34","author":"Harris","year":"2017","journal-title":"Adv. Ther."},{"key":"10.1016\/j.conctc.2022.101019_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13336","article-title":"Different perception of chronic constipation between patients and gastroenterologists","author":"Bellini","year":"2018","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.conctc.2022.101019_bib21","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s00595-015-1179-2","article-title":"The translation and validation of the Japanese version of the patient assessment of constipation quality of life scale","volume":"46","author":"Tsunoda","year":"2016","journal-title":"Surg. Today"},{"key":"10.1016\/j.conctc.2022.101019_bib22","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00535-013-0825-y","article-title":"Validity and reliability of the Japanese version of the patient Assessment of constipation quality of life questionnaire","volume":"49","author":"Nomura","year":"2014","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.conctc.2022.101019_bib23","article-title":"Efficacy, long-term safety, and impact on quality of life of elobixibat in more severe constipation: post hoc analyses of two phase 3 trials in Japan","volume":"31","author":"Nakajima","year":"2019","journal-title":"Neuro Gastroenterol. Motil."}],"container-title":["Contemporary Clinical Trials Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451865422001363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451865422001363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:09:22Z","timestamp":1762520962000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451865422001363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":23,"alternative-id":["S2451865422001363"],"URL":"https:\/\/doi.org\/10.1016\/j.conctc.2022.101019","relation":{},"ISSN":["2451-8654"],"issn-type":[{"type":"print","value":"2451-8654"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploratory, multicenter, open-label study to evaluate the effects of linaclotide in patients with chronic constipation with an insufficient response to magnesium oxide: A study protocol","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.conctc.2022.101019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101019"}}