{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:24:11Z","timestamp":1786987451132,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005422","name":"RIGLD","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005422","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials Communications"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.conctc.2023.101201","type":"journal-article","created":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T11:39:43Z","timestamp":1693049983000},"page":"101201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Impact of probiotics on gut microbiota composition and clinical symptoms of coeliac disease patients following gluten-free diet"],"prefix":"10.1016","volume":"35","author":[{"given":"Mona","family":"Soheilian Khorzoghi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2495-1831","authenticated-orcid":false,"given":"Mohammad","family":"Rostami-Nejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2135-7581","authenticated-orcid":false,"given":"Abbas","family":"Yadegar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2782-8970","authenticated-orcid":false,"given":"Hossein","family":"Dabiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azam","family":"Hadadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Rodrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.conctc.2023.101201_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/nu10121824","article-title":"Probiotics in celiac disease","volume":"10","author":"Cristofori","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.conctc.2023.101201_bib2","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1136\/jcp.2005.035345","article-title":"Coeliac disease: an update for pathologists","volume":"59","author":"Dickson","year":"2006","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.conctc.2023.101201_bib3","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.19082\/3883","article-title":"Celiac disease in Iran: a systematic review and meta-analysis","volume":"9","author":"Mohammadibakhsh","year":"2017","journal-title":"Electron. Physician"},{"key":"10.1016\/j.conctc.2023.101201_bib4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1651-2227.2002.tb01635.x","article-title":"Coeliac disease is associated with intrauterine growth and neonatal infections","volume":"91","author":"Sandberg-Bennich","year":"2002","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.conctc.2023.101201_bib5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3109\/08830185.2011.599084","article-title":"Unraveling the ties between celiac disease and intestinal microbiota","volume":"30","author":"Sanz","year":"2011","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.conctc.2023.101201_bib6","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.14309\/ajg.0000000000000749","article-title":"Probiotics for celiac disease: a systematic review and meta-analysis of randomized controlled trials","volume":"115","author":"Seiler","year":"2020","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.conctc.2023.101201_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1590\/s0004-2803.201700000-07","article-title":"Effects of probiotic intake on intestinal bifidobacteria of celiac patients","volume":"54","author":"Martinello","year":"2017","journal-title":"Arq. Gastroenterol."},{"key":"10.1016\/j.conctc.2023.101201_bib8","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1099\/jmm.0.47410-0","article-title":"Imbalance in the composition of the duodenal microbiota of children with coeliac disease","volume":"56","author":"Nadal","year":"2007","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.conctc.2023.101201_bib9","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.biochi.2012.03.025","article-title":"Differences in faecal bacteria populations and faecal bacteria metabolism in healthy adults and celiac disease patients","volume":"94","author":"Nistal","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.conctc.2023.101201_bib10","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.3390\/nu13072146","article-title":"New insights into non-dietary treatment in celiac disease: emerging therapeutic options","volume":"13","author":"Segura","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.conctc.2023.101201_bib11","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/S0140-6736(09)60254-3","article-title":"Coeliac disease","volume":"373","author":"Di Sabatino","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.conctc.2023.101201_bib12","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3390\/gidisord2030029","article-title":"Interventions to increase adherence to a gluten free diet in patients with coeliac disease: a scoping review","volume":"2","author":"Muhammad","year":"2020","journal-title":"Gastrointest. Dis."},{"key":"10.1016\/j.conctc.2023.101201_bib13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/adc.70.3.211","article-title":"Need for follow up in coeliac disease","volume":"70","author":"Bardella","year":"1994","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.conctc.2023.101201_bib14","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/qjmed\/91.12.853","article-title":"Coeliac disease detected by screening is not silent--simply unrecognized","volume":"91","author":"Johnston","year":"1998","journal-title":"QJM: Mon. J. Assoc. Physicians"},{"key":"10.1016\/j.conctc.2023.101201_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gut.39.1.43","article-title":"Factors associated with serum antibodies to reticulin, endomysium, and gliadin in an adult population","volume":"39","author":"McMillan","year":"1996","journal-title":"Gut"},{"key":"10.1016\/j.conctc.2023.101201_bib16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/MCG.0000000000000392","article-title":"Frequency and cause of persistent symptoms in celiac disease patients on a long-term gluten-free diet","volume":"50","author":"Stasi","year":"2016","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.conctc.2023.101201_bib17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.imlet.2008.04.006","article-title":"Adjuvant effect of Lactobacillus casei in a mouse model of gluten sensitivity","volume":"119","author":"D\u2019Arienzo","year":"2008","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.conctc.2023.101201_bib18","first-page":"1933","article-title":"Altered duodenal microbiota composition in celiac disease patients suffering from persistent symptoms on a long-term gluten-free diet","volume":"109","author":"Wacklin","year":"2014","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.conctc.2023.101201_bib19","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.3390\/nu11102375","article-title":"The gut microbiota in celiac disease and probiotics","volume":"11","author":"Chibbar","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.conctc.2023.101201_bib20","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1365-3083.2011.02582.x","article-title":"Immunomodulatory effects of Lactobacillus casei administration in a mouse model of gliadin\u2010sensitive enteropathy","volume":"74","author":"D\u2019arienzo","year":"2011","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.conctc.2023.101201_bib21","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/labinvest.2012.13","article-title":"Gluten induces coeliac-like disease in sensitised mice involving IgA, CD71 and transglutaminase 2 interactions that are prevented by probiotics","volume":"92","author":"Papista","year":"2012","journal-title":"Lab. Invest."},{"key":"10.1016\/j.conctc.2023.101201_bib22","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s10620-015-4020-2","article-title":"Gut microbiota and celiac disease","volume":"61","author":"Marasco","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.conctc.2023.101201_bib23","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1365-2249.2008.03635.x","article-title":"Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture","volume":"152","author":"Lindfors","year":"2008","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.conctc.2023.101201_bib24","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.3390\/nu12092674","article-title":"Probiotics, prebiotics and other dietary supplements for gut microbiota modulation in celiac disease patients","volume":"12","author":"Marasco","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.conctc.2023.101201_bib25","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1080\/19490976.2020.1765946","article-title":"Colonization by Enterobacteriaceae is crucial for acute inflammatory responses in murine small intestine via regulation of corticosterone production","volume":"11","author":"Menezes-Garcia","year":"2020","journal-title":"Gut Microb."},{"key":"10.1016\/j.conctc.2023.101201_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2180-8-232","article-title":"Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease","volume":"8","author":"Collado","year":"2008","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.conctc.2023.101201_bib27","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.3389\/fimmu.2019.03094","article-title":"Environmental exposures and autoimmune diseases: contribution of gut microbiome","author":"Khan","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.conctc.2023.101201_bib28","doi-asserted-by":"crossref","first-page":"660","DOI":"10.3390\/nu8100660","article-title":"Effect of Bifidobacterium breve on the intestinal microbiota of coeliac children on a gluten free diet: a pilot study","volume":"8","author":"Quagliariello","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.conctc.2023.101201_bib29","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1111\/j.1572-0241.2003.07632.x","article-title":"High rate of gastrointestinal symptoms in celiac patients living on a gluten-free diet: controlled study","volume":"98","author":"Midhagen","year":"2003","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.conctc.2023.101201_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-230X-13-75","article-title":"Predictors of persistent symptoms and reduced quality of life in treated coeliac disease patients: a large cross-sectional study","volume":"13","author":"Paarlahti","year":"2013","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.conctc.2023.101201_bib31","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.3748\/wjg.v18.i12.1348","article-title":"Celiac disease: management of persistent symptoms in patients on a gluten-free diet","volume":"18","author":"Dewar","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.conctc.2023.101201_bib32","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1111\/j.1462-2920.2009.01982.x","article-title":"Towards the human intestinal microbiota phylogenetic core","volume":"11","author":"Tap","year":"2009","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.conctc.2023.101201_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2180-11-219","article-title":"Duodenal and faecal microbiota of celiac children: molecular, phenotype and metabolome characterization","volume":"11","author":"Di Cagno","year":"2011","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.conctc.2023.101201_bib34","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/ibd.21830","article-title":"Differences of small intestinal bacteria populations in adults and children with\/without celiac disease: effect of age, gluten diet, and disease","volume":"18","author":"Nistal","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.conctc.2023.101201_bib35","article-title":"Comparison of small gut and whole gut microbiota of first-degree relatives with adult celiac disease patients and controls","volume":"164","author":"Bodkhe","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.conctc.2023.101201_bib36","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1590\/S0004-28032014000200013","article-title":"Lower bifidobacteria counts in adult patients with celiac disease on a gluten-free diet","volume":"51","author":"Golfetto","year":"2014","journal-title":"Arq. Gastroenterol."},{"key":"10.1016\/j.conctc.2023.101201_bib37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/MCG.0b013e31827759ac","article-title":"Exploratory, randomized, double-blind, placebo-controlled study on the effects of Bifidobacterium infantis natren life start strain super strain in active celiac disease","volume":"47","author":"Smecuol","year":"2013","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.conctc.2023.101201_bib38","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1097\/MCG.0000000000001023","article-title":"Clinical and microbiological effect of a multispecies probiotic supplementation in celiac patients with persistent IBS-type symptoms: a randomized, double-blind, placebo-controlled, multicenter trial","volume":"53","author":"Francavilla","year":"2019","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.conctc.2023.101201_bib39","article-title":"Probiotics and the microbiome in celiac disease: a randomised controlled trial","volume":"2016","author":"Harnett","year":"2016","journal-title":"Evid.-based Compl. Altern. Med."},{"key":"10.1016\/j.conctc.2023.101201_bib40","first-page":"1","article-title":"Probiotics, prebiotics and synbiotics: safe options for next-generation therapeutics","author":"Yadav","year":"2022","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.conctc.2023.101201_bib41","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1016\/j.sjbs.2022.02.044","article-title":"Efficacy of probiotics-based interventions as therapy for inflammatory bowel disease: a recent update","volume":"29","author":"Selvamani","year":"2022","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.conctc.2023.101201_bib42","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.clnu.2018.06.931","article-title":"Clinical intervention using Bifidobacterium strains in celiac disease children reveals novel microbial modulators of TNF-\u03b1 and short-chain fatty acids","volume":"38","author":"Primec","year":"2019","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.conctc.2023.101201_bib43","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1017\/S0007114514000609","article-title":"Double-blind, randomised, placebo-controlled intervention trial to evaluate the effects of Bifidobacterium longum CECT 7347 in children with newly diagnosed coeliac disease","volume":"112","author":"Olivares","year":"2014","journal-title":"Br. J. Nutr."},{"issue":"5","key":"10.1016\/j.conctc.2023.101201_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00284-022-02820-w","article-title":"Impact of nutritional profile on gut microbiota diversity in patients with celiac disease","volume":"79","author":"Soheilian-Khorzoghi","year":"2022","journal-title":"Curr. Microbiol."}],"container-title":["Contemporary Clinical Trials Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451865423001473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451865423001473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:08:17Z","timestamp":1762520897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451865423001473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":44,"alternative-id":["S2451865423001473"],"URL":"https:\/\/doi.org\/10.1016\/j.conctc.2023.101201","relation":{},"ISSN":["2451-8654"],"issn-type":[{"value":"2451-8654","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of probiotics on gut microbiota composition and clinical symptoms of coeliac disease patients following gluten-free diet","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.conctc.2023.101201","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101201"}}