{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:55:40Z","timestamp":1790787340113,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007458","name":"German Multiple Sclerosis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007458","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials Communications"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.conctc.2025.101583","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T08:23:29Z","timestamp":1764923009000},"page":"101583","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Effectiveness of hippotherapy on balance performance, neurophysiological parameters and clinical symptoms of multiple sclerosis: Study protocol of a randomized controlled multicenter study (MS-HIPPO II - Movement in Balance)"],"prefix":"10.1016","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4960-0458","authenticated-orcid":false,"given":"Isabel","family":"Stolz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7851-7961","authenticated-orcid":false,"given":"Leonard","family":"Braunsmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franca","family":"Rosiny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Poehlau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Abel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Anneken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Drache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0432-1498","authenticated-orcid":false,"given":"Kristel","family":"Knaepen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.conctc.2025.101583_bib1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/JES.0b013e3181f44fab","article-title":"Physical activity and irreversible disability in multiple sclerosis","volume":"38","author":"Motl","year":"2010","journal-title":"Exerc. Sport Sci. Rev."},{"key":"10.1016\/j.conctc.2025.101583_bib2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2165\/00007256-200838020-00001","article-title":"Exercise and brain health--implications for multiple sclerosis: part 1--neuronal growth factors","volume":"38","author":"White","year":"2008","journal-title":"Sports Med."},{"key":"10.1016\/j.conctc.2025.101583_bib3","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S1474-4422(17)30281-8","article-title":"Exercise in patients with multiple sclerosis","volume":"16","author":"Motl","year":"2017","journal-title":"Lancet Neurol."},{"issue":"Suppl 3","key":"10.1016\/j.conctc.2025.101583_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/sms.12581","article-title":"Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases","volume":"25","author":"Pedersen","year":"2015","journal-title":"Scand. J. Med. Sci. Sports"},{"issue":"Suppl 1","key":"10.1016\/j.conctc.2025.101583_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1600-0838.2006.00520.x","article-title":"Evidence for prescribing exercise as therapy in chronic disease","volume":"16","author":"Pedersen","year":"2006","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"10.1016\/j.conctc.2025.101583_bib6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s11910-019-1002-3","article-title":"Exercise as medicine in multiple sclerosis-time for a paradigm shift: preventive, symptomatic, and disease-modifying aspects and perspectives","volume":"19","author":"Dalgas","year":"2019","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.conctc.2025.101583_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph182413245","article-title":"Exercise training for multiple sclerosis: a narrative review of history, benefits, safety, guidelines, and promotion","volume":"18","author":"Learmonth","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.conctc.2025.101583_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2021.102948","article-title":"Effects of hippotherapy on postural balance, functional mobility, self-perceived fatigue, and quality of life in people with relapsing-remitting multiple sclerosis: secondary results of an exploratory clinical trial","volume":"52","author":"Moraes","year":"2021","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.conctc.2025.101583_bib11","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1177\/1352458517721354","article-title":"Hippotherapy for patients with multiple sclerosis: a multicenter randomized controlled trial (MS-HIPPO)","volume":"24","author":"Verm\u00f6hlen","year":"2018","journal-title":"Mult. Scler."},{"key":"10.1016\/j.conctc.2025.101583_bib12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.30574\/ijsra.2021.4.1.0185","article-title":"Hippotherapy in multiple sclerosis: a review focusing on motor function","volume":"4","author":"Moutaftsis","year":"2021","journal-title":"Int. J. Sci. Res. Arch."},{"key":"10.1016\/j.conctc.2025.101583_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2021.103161","article-title":"Effectiveness of equine-assisted therapies for improving health outcomes in people with multiple sclerosis: a systematic review and meta-analysis","volume":"55","author":"Su\u00e1rez-Iglesias","year":"2021","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.conctc.2025.101583_bib14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.conctc.2016.02.001","article-title":"Study of the effectiveness of hippotherapy on the symptoms of multiple sclerosis - outline of a randomised controlled multicenter study (MS-HIPPO)","volume":"3","author":"Wollenweber","year":"2016","journal-title":"Contemp. Clin. Trials Commun."},{"key":"10.1016\/j.conctc.2025.101583_bib18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2340\/1650197719952736","article-title":"The balance scale: reliability assessment with elderly residents and patients with an acute stroke","volume":"27","author":"Berg","year":"1995","journal-title":"Scand. J. Rehabil. Med."},{"key":"10.1016\/j.conctc.2025.101583_bib19","first-page":"40","article-title":"Assessment: berg balance scale. A revealing test for balance","volume":"11\u201312","author":"Schaedler","year":"2007","journal-title":"Physiopraxis"},{"key":"10.1016\/j.conctc.2025.101583_bib20","first-page":"56","article-title":"Physical characterization of the posturomed therapy device as a measuring instrument--presentation of a method for quantifying balance capacity","volume":"49","author":"Mueller","year":"2004","journal-title":"Biomed. Eng."},{"key":"10.1016\/j.conctc.2025.101583_bib21","series-title":"It Also Features a Clean and Simple USB Interface, Requiring Only One 15 Ft Cable for Both Data Transfer and Power","article-title":"AMTI AccuSway-Optimized (ACS-O) the AccuGait-Optimized (ACG-O) is AMTI's portable solution for quantifying human gait and balance. The ACG-o\u2019s innovative, patented design is accurate, economical, and easy-to-use on any flat surface","year":"2013"},{"key":"10.1016\/j.conctc.2025.101583_bib22","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.gaitpost.2014.03.191","article-title":"Reliability of center of pressure measures within and between sessions in individuals post-stroke and healthy controls","volume":"40","author":"Gray","year":"2014","journal-title":"Gait Posture"},{"key":"10.1016\/j.conctc.2025.101583_bib23","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1186\/s12883-023-03464-4","article-title":"The effect of fatigue on postural control in individuals with multiple sclerosis: a systematic review","volume":"23","author":"Sedaghati","year":"2023","journal-title":"BMC Neurol."},{"key":"10.1016\/j.conctc.2025.101583_bib24","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1177\/17474930231205207","article-title":"Standardized measurement of balance and mobility post-stroke: consensus-Based core recommendations from the third stroke recovery and rehabilitation roundtable","volume":"19","author":"van Criekinge","year":"2024","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.conctc.2025.101583_bib25","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.gaitpost.2010.09.012","article-title":"The test-retest reliability of centre of pressure measures in bipedal static task conditions--a systematic review of the literature","volume":"32","author":"Ruhe","year":"2010","journal-title":"Gait Posture"},{"key":"10.1016\/j.conctc.2025.101583_bib26","author":"Products"},{"issue":"10","key":"10.1016\/j.conctc.2025.101583_bib40","doi-asserted-by":"crossref","first-page":"e1121","DOI":"10.1001\/archneur.1989.00520460115022","article-title":"The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus","volume":"46","author":"Krupp","year":"1989","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.conctc.2025.101583_bib27","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1055\/s-0030-1262924","article-title":"Assessment: fatigue severity scale \u2013 use for exhaustion","volume":"3","author":"Pfeffer","year":"2010","journal-title":"Ergopraxis"},{"key":"10.1016\/j.conctc.2025.101583_bib28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF02260859","article-title":"A health-related quality of life measure for multiple sclerosis","volume":"4","author":"Vickrey","year":"1995","journal-title":"Qual. Life Res."},{"key":"10.1016\/j.conctc.2025.101583_bib29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(83)90088-X","article-title":"Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale","volume":"16","author":"Carlsson","year":"1983","journal-title":"Pain"},{"key":"10.1016\/j.conctc.2025.101583_bib30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/JNN.0b013e31820b5f9f","article-title":"Clinical measurement of limb spasticity in adults: state of the science","volume":"43","author":"Bhimani","year":"2011","journal-title":"J. Neurosci. Nurs."},{"key":"10.1016\/j.conctc.2025.101583_bib31","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1007\/s11136-007-9259-4","article-title":"Psychometric properties of the WHODASII in rehabilitation patients","volume":"16","author":"P\u00f6sl","year":"2007","journal-title":"Qual. Life Res."},{"key":"10.1016\/j.conctc.2025.101583_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph19052738","article-title":"Measuring equine-assisted therapy: validation and confirmatory factor analysis of an ICF-based standardized assessment-tool","volume":"19","author":"Stolz","year":"2022","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.conctc.2025.101583_bib41","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"key":"10.1016\/j.conctc.2025.101583_bib33","author":"Faul"},{"key":"10.1016\/j.conctc.2025.101583_bib34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.21315\/mjms2021.28.2.2","article-title":"A step-by-step process on sample size determination for medical research","volume":"28","author":"Bujang","year":"2021","journal-title":"Malays. J. Med. Sci."},{"key":"10.1016\/j.conctc.2025.101583_bib35","series-title":"Python Reference Manual","author":"Van Rossum","year":"1995"},{"key":"10.1016\/j.conctc.2025.101583_bib36","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.apmr.2016.09.128","article-title":"Minimal clinically important difference of berg balance scale in people with multiple sclerosis","volume":"98","author":"Gervasoni","year":"2017","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.conctc.2025.101583_bib37","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3109\/09638288.2015.1044622","article-title":"Responsiveness of selected outcome measures of participation restriction and quality of life in patients with multiple sclerosis","volume":"38","author":"Taheri","year":"2016","journal-title":"Disabil. Rehabil."},{"key":"10.1016\/j.conctc.2025.101583_bib38","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4103\/2229-3485.83221","article-title":"Intention-to-treat concept: a review","volume":"2","author":"Gupta","year":"2011","journal-title":"Perspect. Clin. Res."},{"key":"10.1016\/j.conctc.2025.101583_bib39","unstructured":"Federal Institute for Drugs and Medical Devices, German SAE Report Form, 2018 \u200bhttps:\/\/www.bfarm.de\/SharedDocs\/Formulare\/EN\/MedicalDevices\/report_form_clinical_trials_SAE.html."}],"container-title":["Contemporary Clinical Trials Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451865425001577?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451865425001577?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:17:33Z","timestamp":1773937053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451865425001577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":36,"alternative-id":["S2451865425001577"],"URL":"https:\/\/doi.org\/10.1016\/j.conctc.2025.101583","relation":{},"ISSN":["2451-8654"],"issn-type":[{"value":"2451-8654","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness of hippotherapy on balance performance, neurophysiological parameters and clinical symptoms of multiple sclerosis: Study protocol of a randomized controlled multicenter study (MS-HIPPO II - Movement in Balance)","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.conctc.2025.101583","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101583"}}