{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T10:52:23Z","timestamp":1774349543633,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials Communications"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.conctc.2026.101619","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:22:32Z","timestamp":1771658552000},"page":"101619","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Effectiveness of transoral robotic surgery of the base of the tongue vs. conservative treatment for obstructive sleep apnea, a RCT, the RAPID study protocol"],"prefix":"10.1016","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5091-1058","authenticated-orcid":false,"given":"A.G.L.","family":"Toppenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2664-2728","authenticated-orcid":false,"given":"J.","family":"van der Maten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.J.","family":"Schuiling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.L.","family":"Lodder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0812-5786","authenticated-orcid":false,"given":"L.Q.","family":"Schwandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9328","key":"10.1016\/j.conctc.2026.101619_bib1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0140-6736(02)09464-3","article-title":"Obstructive sleep apnoea","volume":"360","author":"Malhotra","year":"2002","journal-title":"Lancet."},{"issue":"1","key":"10.1016\/j.conctc.2026.101619_bib2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s10072-021-05765-3","article-title":"The effect of obstructive sleep apnea on the increased risk of cardiovascular disease: a systematic review and meta-analysis","volume":"43","author":"Salari","year":"2022","journal-title":"Neurol. Sci."},{"issue":"9918","key":"10.1016\/j.conctc.2026.101619_bib3","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0140-6736(13)60734-5","article-title":"Adult obstructive sleep apnoea","volume":"383","author":"Jordan","year":"2014","journal-title":"Lancet."},{"issue":"5","key":"10.1016\/j.conctc.2026.101619_bib4","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1183\/09031936.00099710","article-title":"Non-CPAP therapies in obstructive sleep apnoea","volume":"37","author":"Randerath","year":"2011","journal-title":"Eur. Respir. J."},{"issue":"7-8","key":"10.1016\/j.conctc.2026.101619_bib5","first-page":"649","article-title":"Current challenges in the diagnosis and treatment of obstructive sleep apnea syndrome in the elderly","volume":"130","author":"Iannella","year":"2020","journal-title":"Pol. Arch. Intern. Med."},{"key":"10.1016\/j.conctc.2026.101619_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6459276","article-title":"Friedman Score in relation to compliance and treatment response in nonsevere obstructive sleep apnea","volume":"2020","author":"Berg","year":"2020","journal-title":"Int J Otolaryngol"},{"issue":"4","key":"10.1016\/j.conctc.2026.101619_bib7","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1007\/s11325-021-02323-1","article-title":"Association between obstructive sleep apnea and health-related quality of life in untreated adults: a systematic review","volume":"25","author":"Pauletto","year":"2021","journal-title":"Sleep Breath."},{"issue":"4","key":"10.1016\/j.conctc.2026.101619_bib8","first-page":"291","article-title":"[Adherence to CPAP three months after starting therapy in 1078 patients with Obstructive Sleep Apnea (OSA)]","volume":"102","author":"Koehler","year":"2023","journal-title":"Laryngo-Rhino-Otol."},{"issue":"12","key":"10.1016\/j.conctc.2026.101619_bib9","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/jhh.2015.15","article-title":"Obstructive sleep apnea, hypertension and cardiovascular diseases","volume":"29","author":"Gonzaga","year":"2015","journal-title":"J. Hum. Hypertens."},{"issue":"5","key":"10.1016\/j.conctc.2026.101619_bib10","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/joor.13290","article-title":"Dropout and adherence of obstructive sleep apnoea patients to mandibular advancement device therapy: a systematic review of randomised controlled trials with meta-analysis and meta-regression","volume":"49","author":"Bortolotti","year":"2022","journal-title":"J. Oral Rehabil."},{"issue":"3","key":"10.1016\/j.conctc.2026.101619_bib11","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s00405-024-09102-0","article-title":"Patient centered outcomes of transoral robotic surgery for obstructive sleep apnea: a retrospective analysis","volume":"282","author":"Toppenberg","year":"2025","journal-title":"Eur. Arch. Otorhinolaryngol."},{"issue":"3","key":"10.1016\/j.conctc.2026.101619_bib12","article-title":"Quality of life and sleep outcomes in obstructive sleep apnoea following transoral robotic surgery: a meta-analysis","volume":"50","author":"Gupta","year":"2025","journal-title":"Clin. Otolaryngol."},{"issue":"1","key":"10.1016\/j.conctc.2026.101619_bib13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000284352","article-title":"Transoral robotic tongue base resection in obstructive sleep apnoea-hypopnoea syndrome: a preliminary report","volume":"72","author":"Vicini","year":"2010","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"10.1016\/j.conctc.2026.101619_bib14","unstructured":"Richtlijnen OSA bij volwassenen: Richtlijnen Database; [Available from: richtlijnendatabase.nl\/richtlijn\/osa_bij_volwassenen\/drug-induced_sleep_endoscopy_dise_bij_osa.html."},{"issue":"10","key":"10.1016\/j.conctc.2026.101619_bib15","first-page":"835","article-title":"An instrument to measure functional status outcomes for disorders of excessive sleepiness","volume":"20","author":"Weaver","year":"1997","journal-title":"Sleep"},{"issue":"6","key":"10.1016\/j.conctc.2026.101619_bib16","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/sleep\/30.6.711","article-title":"Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioning","volume":"30","author":"Weaver","year":"2007","journal-title":"Sleep"},{"key":"10.1016\/j.conctc.2026.101619_bib17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.sleep.2023.07.008","article-title":"Epworth sleepiness scale: a meta-analytic study on the internal consistency","volume":"109","author":"Goncalves","year":"2023","journal-title":"Sleep Med."},{"issue":"7","key":"10.1016\/j.conctc.2026.101619_bib18","first-page":"870","article-title":"The development and validation of a dysphagia-specific quality-of-life questionnaire for patients with head and neck cancer: the M. D. Anderson dysphagia inventory","volume":"127","author":"Chen","year":"2001","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.conctc.2026.101619_bib19","article-title":"The measurement and valuation of health status using the EQ-5D: a European perspective","year":"2003","journal-title":"Richard Brooks RR, Frank Charro"},{"issue":"2","key":"10.1016\/j.conctc.2026.101619_bib20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00455-001-0109-1","article-title":"The SWAL-QOL and SWAL-CARE outcomes tool for oropharyngeal dysphagia in adults: III. Documentation of reliability and validity","volume":"17","author":"McHorney","year":"2002","journal-title":"Dysphagia"},{"issue":"2","key":"10.1016\/j.conctc.2026.101619_bib21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/sleep\/19.2.156","article-title":"The efficacy of surgical modifications of the upper airway in adults with obstructive sleep apnea syndrome","volume":"19","author":"Sher","year":"1996","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/j.conctc.2026.101619_bib22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1056\/NEJMoa1308659","article-title":"Upper-airway stimulation for obstructive sleep apnea","volume":"370","author":"Strollo","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.conctc.2026.101619_bib23","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A new method for measuring daytime sleepiness: the Epworth sleepiness scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"issue":"8","key":"10.1016\/j.conctc.2026.101619_bib24","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00405-011-1633-8","article-title":"Drug-induced sleep endoscopy: the VOTE classification","volume":"268","author":"Kezirian","year":"2011","journal-title":"Eur. Arch. Otorhinolaryngol."},{"issue":"1","key":"10.1016\/j.conctc.2026.101619_bib25","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2869.2012.01041.x","article-title":"Holland Sleep Disorders Questionnaire: a new sleep disorders questionnaire based on the International Classification of Sleep Disorders-2","volume":"22","author":"Kerkhof","year":"2013","journal-title":"J. Sleep Res."},{"issue":"12","key":"10.1016\/j.conctc.2026.101619_bib26","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1001\/jama.2020.14265","article-title":"Effect of multilevel upper airway surgery vs medical management on the Apnea-Hypopnea index and patient-reported daytime sleepiness among patients with moderate or severe obstructive sleep Apnea: the SAMS randomized clinical trial","volume":"324","author":"MacKay","year":"2020","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.conctc.2026.101619_bib27","article-title":"OSA upper airways surgery: a targeted approach","volume":"57","author":"De Vito","year":"2021","journal-title":"Medicina (Kaunas)"},{"issue":"4","key":"10.1016\/j.conctc.2026.101619_bib28","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1007\/s11325-021-02528-4","article-title":"Effectiveness of drug-induced sleep endoscopy in improving outcomes of barbed pharyngoplasty for obstructive sleep apnea surgery: a prospective randomized trial","volume":"26","author":"Iannella","year":"2022","journal-title":"Sleep Breath."},{"issue":"9","key":"10.1016\/j.conctc.2026.101619_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11092375","article-title":"Quality of life and excessive daytime sleepiness in adults with obstructive sleep apnea who are treated with multilevel surgery or adherent to continuous positive airway pressure","volume":"11","author":"Iannella","year":"2022","journal-title":"J. Clin. Med."}],"container-title":["Contemporary Clinical Trials Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451865426000268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451865426000268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:25:31Z","timestamp":1774340731000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451865426000268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":29,"alternative-id":["S2451865426000268"],"URL":"https:\/\/doi.org\/10.1016\/j.conctc.2026.101619","relation":{},"ISSN":["2451-8654"],"issn-type":[{"value":"2451-8654","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness of transoral robotic surgery of the base of the tongue vs. conservative treatment for obstructive sleep apnea, a RCT, the RAPID study protocol","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.conctc.2026.101619","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101619"}}