{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T16:34:20Z","timestamp":1792946060178,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016334","name":"Nanjing Medical University Third Clinical College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials Communications"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.conctc.2026.101684","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:15:47Z","timestamp":1789085747000},"page":"101684","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A randomized, double-blind, placebo-controlled trial protocol evaluating preoperative medical oral rinse for reducing postoperative xerostomia and improving recovery in elderly patients undergoing pulmonary surgery"],"prefix":"10.1016","volume":"54","author":[{"given":"Sijun","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.conctc.2026.101684_bib1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jopan.2016.03.009","article-title":"Efficacy of an ice popsicle on thirst management in the immediate postoperative period: a randomized clinical trial","volume":"33","author":"Conchon","year":"2018","journal-title":"J Perianesth Nurs"},{"issue":"3","key":"10.1016\/j.conctc.2026.101684_bib2","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jopan.2022.08.007","article-title":"Evaluation of thirst in the early postoperative period in patients undergoing orthopedic surgery","volume":"38","author":"Seyhan","year":"2023","journal-title":"J Perianesth Nurs"},{"issue":"1","key":"10.1016\/j.conctc.2026.101684_bib3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/acu.2021.0072","article-title":"Intraoperative acupuncture as part of a multimodal analgesic regimen to reduce opioid usage after total knee arthroplasty: a prospective cohort trial","volume":"34","author":"Cheng","year":"2022","journal-title":"Med. Acupunct."},{"issue":"1","key":"10.1016\/j.conctc.2026.101684_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s12871-024-02676-6","article-title":"Exploring thirst incidence and risk factors in patients undergoing general anesthesia after extubation based on ERAS principles: a cross sectional study","volume":"24","author":"Zeng","year":"2024","journal-title":"BMC Anesthesiol."},{"issue":"2","key":"10.1016\/j.conctc.2026.101684_bib5","article-title":"Safety and satisfaction analysis of intravenous and inhalational conscious sedation in a geriatric population undergoing oral surgery","volume":"13","author":"Iglesias-Rodeiro","year":"2025","journal-title":"Healthcare (Basel)"},{"issue":"1","key":"10.1016\/j.conctc.2026.101684_bib6","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1038\/s41598-022-07942-6","article-title":"Anxiolytic effects of chewing gum during preoperative fasting and patient-centered outcome in female patients undergoing elective gynecologic surgery: randomized controlled study","volume":"12","author":"Bang","year":"2022","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.conctc.2026.101684_bib7","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1186\/s12903-024-04386-4","article-title":"The effect of artificial saliva on the control of dry mouth: a semi-experimental study on COVID-19 patients under Non-invasive mechanical ventilation","volume":"24","author":"Sedighi","year":"2024","journal-title":"BMC Oral Health"},{"issue":"6","key":"10.1016\/j.conctc.2026.101684_bib8","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.oooo.2021.08.015","article-title":"Anticholinergic medication: related dry mouth and effects on the salivary glands","volume":"132","author":"Arany","year":"2021","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"issue":"6","key":"10.1016\/j.conctc.2026.101684_bib9","first-page":"2817","article-title":"Alleviation of dry mouth by saliva substitutes improved swallowing ability and clinical nutritional status of post-radiotherapy head and neck cancer patients: a randomized controlled trial","volume":"28","author":"Nuchit","year":"2020","journal-title":"Support. Care Cancer"},{"key":"10.1016\/j.conctc.2026.101684_bib10","article-title":"Salivary gland dysfunction secondary to cancer treatment","volume":"3","author":"Vistoso","year":"2022","journal-title":"Front. Oral Health"},{"issue":"3","key":"10.1016\/j.conctc.2026.101684_bib11","first-page":"135","article-title":"Menopause and oral health: clinical implications and preventive strategies","volume":"15","author":"Shrivastava","year":"2024","journal-title":"J Midlife Health"},{"issue":"4","key":"10.1016\/j.conctc.2026.101684_bib12","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/lary.29998","article-title":"Gustatory function and salivary flow rate in healthy adults","volume":"132","author":"Huang","year":"2022","journal-title":"Laryngoscope"},{"issue":"6","key":"10.1016\/j.conctc.2026.101684_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/cre2.70009","article-title":"Anticholinergic burden and dry mouth problems among older adults (\u2265 50 years) receiving dental Care-A retrospective, cross-sectional analysis","volume":"10","author":"Schoppmeier","year":"2024","journal-title":"Clin. Exp. Dent. Res."},{"issue":"4","key":"10.1016\/j.conctc.2026.101684_bib14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s40266-023-01017-5","article-title":"From drugs to dry mouth: a systematic review exploring oral and psychological health conditions associated with dry mouth in older adults with polypharmacy","volume":"40","author":"Cannon","year":"2023","journal-title":"Drugs Aging"},{"issue":"1","key":"10.1016\/j.conctc.2026.101684_bib15","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1186\/s12903-023-03084-x","article-title":"The effect of gum chewing on xerostomia and salivary flow rate in elderly and medically compromised subjects: a systematic review and meta-analysis","volume":"23","author":"Dodds","year":"2023","journal-title":"BMC Oral Health"},{"issue":"4","key":"10.1016\/j.conctc.2026.101684_bib16","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jopan.2014.06.005","article-title":"Postoperative discomfort after abdominal surgery: an observational study","volume":"30","author":"Robleda","year":"2015","journal-title":"J Perianesth Nurs"},{"issue":"2","key":"10.1016\/j.conctc.2026.101684_bib17","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1001\/jamasurg.2016.4065","article-title":"Postoperative pulmonary complications, early mortality, and hospital stay following noncardiothoracic surgery: a multicenter study by the perioperative research network investigators","volume":"152","author":"Fernandez-Bustamante","year":"2017","journal-title":"JAMA Surg."},{"issue":"4","key":"10.1016\/j.conctc.2026.101684_bib18","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/bja\/aex230","article-title":"Postoperative pulmonary complications, pulmonary and systemic inflammatory responses after lung resection surgery with prolonged one-lung ventilation. Randomized controlled trial comparing intravenous and inhalational anaesthesia","volume":"119","author":"de la Gala","year":"2017","journal-title":"Br. J. Anaesth."},{"issue":"1","key":"10.1016\/j.conctc.2026.101684_bib19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13741-023-00327-x","article-title":"The effect of intraoperative goal-directed fluid therapy combined with enhanced recovery after surgery program on postoperative complications in elderly patients undergoing thoracoscopic pulmonary resection: a prospective randomized controlled study","volume":"12","author":"Ma","year":"2023","journal-title":"Perioper Med (Lond)"},{"issue":"1","key":"10.1016\/j.conctc.2026.101684_bib20","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s43163-025-00976-3","article-title":"Prevalence and impact of xerostomia on quality of life: a clinical-based cross-sectional study in Egypt","volume":"41","author":"Ghalwash","year":"2025","journal-title":"The Egyptian Journal of Otolaryngology"},{"issue":"9","key":"10.1016\/j.conctc.2026.101684_bib21","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s00134-014-3339-z","article-title":"A randomized clinical trial of an intervention to relieve thirst and dry mouth in intensive care unit patients","volume":"40","author":"Puntillo","year":"2014","journal-title":"Intensive Care Med."},{"issue":"2","key":"10.1016\/j.conctc.2026.101684_bib22","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jopan.2021.04.018","article-title":"Effect of spray use on mouth dryness and thirst of patients undergoing major abdominal surgery: a randomized controlled study","volume":"37","author":"Oztas","year":"2022","journal-title":"J Perianesth Nurs"},{"issue":"5","key":"10.1016\/j.conctc.2026.101684_bib23","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jopan.2023.11.014","article-title":"The effect of cold oral applications in the management of postoperative thirst: a systematic review","volume":"39","author":"\u00c7elik","year":"2024","journal-title":"J Perianesth Nurs"},{"issue":"11","key":"10.1016\/j.conctc.2026.101684_bib24","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1007\/s00784-020-03272-x","article-title":"Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication","volume":"24","author":"Vinke","year":"2020","journal-title":"Clin. Oral Invest."},{"key":"10.1016\/j.conctc.2026.101684_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s40814-020-00630-0","article-title":"A randomised controlled pilot trial of two interventions to manage dry mouth in pre-operative elective surgical patients","volume":"6","author":"Morton","year":"2020","journal-title":"Pilot Feasibility Stud."},{"issue":"2","key":"10.1016\/j.conctc.2026.101684_bib26","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.semradonc.2025.02.006","article-title":"Radiation-therapy related salivary dysfunction","volume":"35","author":"Blitzer","year":"2025","journal-title":"Semin. Radiat. Oncol."},{"issue":"7","key":"10.1016\/j.conctc.2026.101684_bib27","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1080\/08927014.2022.2111258","article-title":"Effect of experimental and commercial artificial saliva formulations on the activity and viability of microcosm biofilm and on enamel demineralization for irradiated patients with head and neck cancer (HNC)","volume":"38","author":"da Silva","year":"2022","journal-title":"Biofouling"},{"key":"10.1016\/j.conctc.2026.101684_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2022.104056","article-title":"Prediction of xerostomia in a 75-year-old population: a 25-year longitudinal study","volume":"118","author":"Johansson","year":"2022","journal-title":"J. Dent."},{"issue":"4","key":"10.1016\/j.conctc.2026.101684_bib29","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/ALN.0000000000004159","article-title":"Prophylactic penehyclidine inhalation for prevention of postoperative pulmonary complications in high-risk patients: a double-blind randomized trial","volume":"136","author":"Yan","year":"2022","journal-title":"Anesthesiology"},{"issue":"4","key":"10.1016\/j.conctc.2026.101684_bib30","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1007\/s00464-019-06923-7","article-title":"Long-term health-related quality of life following robot-assisted radical transmediastinal esophagectomy","volume":"34","author":"Sugawara","year":"2020","journal-title":"Surg. Endosc."},{"key":"10.1016\/j.conctc.2026.101684_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.apjon.2025.100655","article-title":"Health-related quality of life and related factors among esophageal cancer survivors after esophagectomy in the 6-month postoperative period: a multicenter cross-sectional study in north China","volume":"12","author":"Meng","year":"2025","journal-title":"Asia Pac. J. Oncol. Nurs."}],"container-title":["Contemporary Clinical Trials Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451865426000918?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451865426000918?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T15:49:41Z","timestamp":1792943381000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451865426000918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":31,"alternative-id":["S2451865426000918"],"URL":"https:\/\/doi.org\/10.1016\/j.conctc.2026.101684","relation":{},"ISSN":["2451-8654"],"issn-type":[{"value":"2451-8654","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A randomized, double-blind, placebo-controlled trial protocol evaluating preoperative medical oral rinse for reducing postoperative xerostomia and improving recovery in elderly patients undergoing pulmonary surgery","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.conctc.2026.101684","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101684"}}