{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T15:24:37Z","timestamp":1774538677882,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contraception"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.contraception.2006.03.011","type":"journal-article","created":{"date-parts":[[2006,5,19]],"date-time":"2006-05-19T11:19:02Z","timestamp":1148037542000},"page":"239-244","source":"Crossref","is-referenced-by-count":6,"title":["Pharmacokinetics of chlormadinone acetate following single and multiple oral dosing of chlormadinone acetate (2 mg) and ethinylestradiol (0.03 mg) and elimination and clearance of a single dose of radiolabeled chlormadinone acetate"],"prefix":"10.1016","volume":"74","author":[{"given":"Rolf","family":"Terlinden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz","family":"Uragg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"G\u00f6hler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christa","family":"Kneip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.contraception.2006.03.011_bib1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.5694\/j.1326-5377.2000.tb139325.x","article-title":"Forty years of combined oral contraception: the evolution of a revolution","volume":"173","author":"Fraser","year":"2000","journal-title":"Med J Aust"},{"key":"10.1016\/j.contraception.2006.03.011_bib2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0065-230X(08)60801-5","article-title":"On the epidemiology of oral contraceptives and disease","volume":"49","author":"Prentice","year":"1987","journal-title":"Adv Cancer Res"},{"key":"10.1016\/j.contraception.2006.03.011_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1001\/jama.284.1.72","article-title":"Ischemic stroke risk with oral contraceptives. A meta-analysis","volume":"284","author":"Gillum","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.contraception.2006.03.011_bib4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/jnci\/94.1.32","article-title":"Impact of progestin and estrogen potency in oral contraceptives on ovarian cancer risk","volume":"94","author":"Schildkraut","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.contraception.2006.03.011_bib5","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1001\/jama.284.14.1791","article-title":"Risk of breast cancer with oral contraceptive use in women with a family history of breast cancer","volume":"284","author":"Grabrick","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.contraception.2006.03.011_bib6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0010-7824(98)00008-0","article-title":"Efficacy and safety of the new antiandrogenic oral contraceptive Belara\u00ae","volume":"57","author":"Zahradnik","year":"1998","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2006.03.011_bib7","doi-asserted-by":"crossref","first-page":"751","DOI":"10.2165\/00003495-200464070-00005","article-title":"Ethinylestradiol\/chlormadinone acetate","volume":"64","author":"Curran","year":"2004","journal-title":"Drugs"},{"key":"10.1016\/j.contraception.2006.03.011_bib8","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2165\/00003495-200363050-00003","article-title":"Progestogens with antiandrogenic properties","volume":"63","author":"Raudrant","year":"2003","journal-title":"Drugs"},{"key":"10.1016\/j.contraception.2006.03.011_bib9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000051701","article-title":"Acne resolution rates: results of a single-blind, randomized, controlled, parallel phase III trial with EE\/CMA (Belara) and EE\/LNG (Microgynon)","volume":"203","author":"Worret","year":"2001","journal-title":"Dermatology"},{"key":"10.1016\/j.contraception.2006.03.011_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0010-7824(91)90122-V","article-title":"Group comparison of serum ethynylestradiol, SHBG and CBG levels in 83 women using two low-dose combination oral contraceptives for three months","volume":"43","author":"Dibbelt","year":"1991","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2006.03.011_bib11","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0010-7824(93)90118-Q","article-title":"Pharmacokinetics of cyproterone acetate and ethinylestradiol in 15 women who received a combination oral contraceptive during three treatment cycles","volume":"48","author":"Kuhnz","year":"1993","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2006.03.011_bib12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s002280050098","article-title":"Influence of repeated oral doses of ethinylestradiol on the metabolic deposition of [13C2]-ethinylestradiol in young women","volume":"50","author":"Kuhnz","year":"1996","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.contraception.2006.03.011_bib13","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0010-7824(79)90036-2","article-title":"Investigations of pharmacokinetics of ethinyloestradiol to specific consideration of a possible first-pass effect in women","volume":"19","author":"H\u00fcmpel","year":"1979","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2006.03.011_bib14","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/S0002-9378(89)80010-9","article-title":"Pharmacology of contraceptive steroids: a brief review","volume":"160","author":"Goldzieher","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.contraception.2006.03.011_bib15","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0010-7824(91)90069-R","article-title":"The pharmacokinetics of ethynylestradiol in the presence and absence of gestodene and desogestrel","volume":"43","author":"Orme","year":"1991","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2006.03.011_bib16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1365-2125.1998.00749.x","article-title":"Effect of ritonavir on the pharmacokinetics of ethinyl oestradiol in healthy female volunteers","volume":"46","author":"Ouellet","year":"1998","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.contraception.2006.03.011_bib17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0010-7824(73)90004-8","article-title":"Disappearance of 1\u03b1-3H-chlormadinone acetate from the plasma of women","volume":"7","author":"Dugwekar","year":"1973","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2006.03.011_bib18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2515\/therapie:2003018","article-title":"Etude de la biodisponibilit\u00e9 relative de deux formulatins orales d'ac\u00e9tate de chlormadinone: Lut\u00e9ran\u00ae 5 mg et Lut\u00e9ran\u00ae comprim\u00e9 dos\u00e9 \u00e0 10 mg","volume":"58","author":"Chassard","year":"2003","journal-title":"Therapie"},{"key":"10.1016\/j.contraception.2006.03.011_bib19","first-page":"445","article-title":"Drugs and pharmaceutical sciences","volume":"vol. 15","author":"Gibaldi","year":"1982"},{"key":"10.1016\/j.contraception.2006.03.011_bib20","series-title":"Biopharmazie. Theorie und Praxis der Pharmakokinetik","first-page":"383","author":"Meier","year":"1981"},{"key":"10.1016\/j.contraception.2006.03.011_bib21","series-title":"Clinical pharmacokinetics","author":"Rowland","year":"1995"},{"key":"10.1016\/j.contraception.2006.03.011_bib22","series-title":"Drugs and pharmaceutical sciences","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1201\/b14095-12","volume":"vol. 15","author":"Gibaldi","year":"1982"},{"key":"10.1016\/j.contraception.2006.03.011_bib23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/rpd\/43.1-4.93","article-title":"The dosimetric quantities in the new ICRP recommendations","volume":"43","author":"Drexler","year":"1992","journal-title":"Radiat Prot Dosimetry"},{"key":"10.1016\/j.contraception.2006.03.011_bib24","series-title":"Hormone therapy in breast and prostate cancer","first-page":"325","article-title":"Steroidal antiandrogens","author":"Schr\u00f6der","year":"2002"},{"key":"10.1016\/j.contraception.2006.03.011_bib25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1023\/A:1020072325818","article-title":"Pharmacokinetics and potency of progestins used for hormone replacement therapy and contraception","volume":"3","author":"Stanzyk","year":"2002","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.contraception.2006.03.011_bib26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0010-7824(85)90114-3","article-title":"Pharmacokinetics of ethinyl estradiol: a current view","volume":"32","author":"Newburger","year":"1985","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2006.03.011_bib27","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1016\/0002-9378(90)90550-Q","article-title":"Pharmacokinetics of ethinyl estradiol and mestranol","volume":"163","author":"Goldzieher","year":"1990","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.contraception.2006.03.011_bib28","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1080\/13625180008500407","article-title":"A 1-year pharmacokinetic investigation of a novel oral contraceptive containing drospirenone in healthy female volunteers","volume":"5","author":"Blode","year":"2000","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"10.1016\/j.contraception.2006.03.011_bib29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF01978421","article-title":"A single-dose and 3-month clinical-pharmacokinetic study with a new combination oral contraceptive","volume":"11","author":"Heuner","year":"1995","journal-title":"Adv Contracept"},{"key":"10.1016\/j.contraception.2006.03.011_bib30","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0010-7824(89)90094-2","article-title":"Interaction with the pharmacokinetics of ethinylestradiol and progestogens contained in oral contraceptives","volume":"40","author":"Jung-Hoffmann","year":"1989","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2006.03.011_bib31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/ejc.7.2.79.90","article-title":"A pharmacokinetic study with a low-dose oral contraceptive containing 20 microg ethinylestradiol plus 100 microg levonorgestrel","volume":"7","author":"Endrikat","year":"2002","journal-title":"Eur J Contracept Reprod Health Care"}],"container-title":["Contraception"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010782406000904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010782406000904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T23:21:26Z","timestamp":1586906486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010782406000904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0010782406000904"],"URL":"https:\/\/doi.org\/10.1016\/j.contraception.2006.03.011","relation":{},"ISSN":["0010-7824"],"issn-type":[{"value":"0010-7824","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}