{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T17:53:18Z","timestamp":1773510798270,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contraception"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.contraception.2007.01.005","type":"journal-article","created":{"date-parts":[[2007,3,29]],"date-time":"2007-03-29T11:16:59Z","timestamp":1175167019000},"page":"S123-S129","source":"Crossref","is-referenced-by-count":41,"special_numbering":"S","title":["Levonorgestrel intrauterine system: bleeding disorders and anticoagulant therapy"],"prefix":"10.1016","volume":"75","author":[{"given":"Rezan A.","family":"Kadir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.contraception.2007.01.005_bib1","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1182\/blood.V69.2.454.454","article-title":"Epidemiological investigation of the prevalence of von Willebrand's disease","volume":"69","author":"Rodeghiero","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.contraception.2007.01.005_bib2","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0022-3476(05)80384-1","article-title":"Prevalence of von Willebrand disease in children: a multiethnic study","volume":"123","author":"Werner","year":"1993","journal-title":"J Pediatr"},{"key":"10.1016\/j.contraception.2007.01.005_bib3","series-title":"Textbook of Hemophilia","first-page":"265","article-title":"von Willebrand disease: epidemiology","author":"Rodeghiero","year":"2005"},{"key":"10.1016\/j.contraception.2007.01.005_bib4","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1182\/blood-2005-09-3879","article-title":"Bleeding in carriers of hemophilia","volume":"108","author":"Plug","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.contraception.2007.01.005_bib5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1046\/j.1365-2516.2000.00447.x","article-title":"Gynaecological and obstetrical morbidity in women with Type I von Willebrand disease: results of a patient survey","volume":"6","author":"Kouides","year":"2000","journal-title":"Hemophilia"},{"key":"10.1016\/j.contraception.2007.01.005_bib6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1046\/j.1365-2516.1999.00342.x","article-title":"von Willebrand disease and bleeding in women","volume":"5","author":"Ragni","year":"1999","journal-title":"Hemophilia"},{"key":"10.1016\/j.contraception.2007.01.005_bib7","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1055\/s-0038-1649813","article-title":"The reproductive health of women with von Willebrand disease unresponsive to DDAVP: results of an international survey. On behalf of the Subcommittee on von Willebrand Factor of the Scientific and Standardization Committee of the ISTH","volume":"74","author":"Foster","year":"1995","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.contraception.2007.01.005_bib8","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1471-0528.1990.tb16249.x","article-title":"Assessment of menstrual blood loss using a pictorial chart","volume":"97","author":"Higham","year":"1990","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.contraception.2007.01.005_bib9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1046\/j.1365-2516.1999.00285.x","article-title":"Assessment of menstrual blood loss and gynaecological problems in patients with inherited bleeding disorders","volume":"5","author":"Kadir","year":"1999","journal-title":"Hemophilia"},{"key":"10.1016\/j.contraception.2007.01.005_bib10","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(97)08248-2","article-title":"Frequency of inherited bleeding disorders in women with menorrhagia","volume":"351","author":"Kadir","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.contraception.2007.01.005_bib11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1365-2516.2005.01108.x","article-title":"More than menorrhagia: a review of the obstetric and gynaecological manifestations of bleeding disorders","volume":"11","author":"James","year":"2005","journal-title":"Hemophilia"},{"key":"10.1016\/j.contraception.2007.01.005_bib12","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1046\/j.1365-2516.2003.00756.x","article-title":"Medical, reproductive and psychosocial experiences of women diagnosed with von Willebrand's disease receiving care in hemophilia treatment centers: a case-control study","volume":"9","author":"Kirtava","year":"2003","journal-title":"Hemophilia"},{"key":"10.1016\/j.contraception.2007.01.005_bib13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/ajh.10327","article-title":"Health status and health-related quality of life associated with von Willebrand disease","volume":"73","author":"Barr","year":"2003","journal-title":"Am J Hematol"},{"key":"10.1016\/j.contraception.2007.01.005_bib14","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1046\/j.1365-2516.1998.00208.x","article-title":"Quality of life during menstruation in patients with inherited bleeding disorders","volume":"4","author":"Kadir","year":"1998","journal-title":"Hemophilia"},{"key":"10.1016\/j.contraception.2007.01.005_bib15","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/0002-9378(90)90031-2","article-title":"Measured menstrual blood loss in women with a bleeding disorder or using oral anticoagulant therapy","volume":"162","author":"van Eijkeren","year":"1990","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.contraception.2007.01.005_bib16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0010-7824(95)00038-C","article-title":"Levonorgestrel intrauterine device in the treatment of menorrhagia in Chinese women: efficacy versus acceptability","volume":"51","author":"Tang","year":"1995","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2007.01.005_bib17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0306-5456(00)00020-6","article-title":"The effectiveness of the levonorgestrel-releasing intrauterine system in menorrhagia: a systematic review","volume":"108","author":"Stewart","year":"2001","journal-title":"BJOG"},{"key":"10.1016\/j.contraception.2007.01.005_bib18","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1111\/j.1471-0528.2004.00305.x","article-title":"The use of levonorgestrel-releasing intrauterine system for treatment of menorrhagia in women with inherited bleeding disorders","volume":"111","author":"Kingman","year":"2004","journal-title":"BJOG"},{"key":"10.1016\/j.contraception.2007.01.005_bib19","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.ajog.2005.05.002","article-title":"The use of the levonorgestrel-releasing intrauterine system in the management of menorrhagia in women with hemostatic disorders","volume":"193","author":"Schaedel","year":"2005","journal-title":"Am J Obstet Gynecol"},{"issue":"Suppl 1","key":"10.1016\/j.contraception.2007.01.005_bib20","first-page":"121","article-title":"Treatment of menorrhagia associated with oral anticoagulation: efficacy of levonorgestrel releasing intrauterine device","volume":"115","author":"Pisoni","year":"2005","journal-title":"Thromb Res"},{"issue":"Suppl 2","key":"10.1016\/j.contraception.2007.01.005_bib21","first-page":"146","article-title":"The efficacy and safety of the levonorgestrel intrauterine device (Mirena) for bleeding disorder-related menorrhagia in an American cohort","volume":"12","author":"Kouides","year":"2006","journal-title":"Hemophilia"},{"issue":"Suppl","key":"10.1016\/j.contraception.2007.01.005_bib22","first-page":"105","article-title":"The effectiveness of the levonorgestrel intrauterine system (LNG IUS) in the treatment of menorrhagia in a district clinic for abnormal uterine bleeding","volume":"105","author":"Mansour","year":"1998","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.contraception.2007.01.005_bib23","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0010-7824(82)90092-0","article-title":"Clinical performance of a new levonorgestrel-releasing intrauterine device: a randomized comparison with a Nova-T-copper device","volume":"25","author":"Nilsson","year":"1982","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2007.01.005_bib24","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/j.1471-0528.1997.tb11542.x","article-title":"The levonorgestrel intrauterine system in the management of menorrhagia","volume":"104","author":"Barrington","year":"1997","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.contraception.2007.01.005_bib25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0015-0282(03)00608-3","article-title":"Comparison of a levonorgestrel-releasing intrauterine device versus expectant management after conservative surgery for symptomatic endometriosis: a pilot study","volume":"80","author":"Vercellini","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.contraception.2007.01.005_bib26","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/j.1471-0528.1991.tb13514.x","article-title":"Haemorrhagic problems in obstetrics and gynaecology in patients with congenital coagulopathies","volume":"98","author":"Greer","year":"1991","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.contraception.2007.01.005_bib27","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1046\/j.1365-2516.1998.00143.x","article-title":"Haemoperitoneum caused by haemorrhagic corpus luteum in a patient with Type 3 von Willebrand's disease","volume":"4","author":"Gomez","year":"1998","journal-title":"Hemophilia"},{"key":"10.1016\/j.contraception.2007.01.005_bib28","first-page":"431","article-title":"Prevention of haemoperitoneum during ovulation by oral contraceptives in women with Type III von Willebrand's disease and afibrinogenemia (case report)","volume":"76","author":"Bottini","year":"1991","journal-title":"Haematologica"},{"key":"10.1016\/j.contraception.2007.01.005_bib29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/humrep\/deh004","article-title":"The evaluation of the effectiveness of an intrauterine-administered progestogen (levonorgestrel) in the symptomatic treatment of endometriosis and in the staging of the disease","volume":"19","author":"Lockhat","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.contraception.2007.01.005_bib30","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1093\/humrep\/deh869","article-title":"Randomized clinical trial of a levonorgestrel-releasing intrauterine system and a depot GnRH analogue for the treatment of chronic pelvic pain in women with endometriosis","volume":"20","author":"Petta","year":"2005","journal-title":"Hum Reprod"},{"issue":"9243","key":"10.1016\/j.contraception.2007.01.005_bib31","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0140-6736(00)03204-9","article-title":"Endometrial protection from tamoxifen-stimulated changes by a levonorgestrel-releasing intrauterine system: a randomised controlled trial","volume":"356","author":"Gardner","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.contraception.2007.01.005_bib32","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0378-5122(03)00163-4","article-title":"Continuous intrauterine compared with cyclic oral progestin administration in perimenopausal HRT","volume":"46","author":"Boon","year":"2003","journal-title":"Maturitas"},{"key":"10.1016\/j.contraception.2007.01.005_bib33","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3109\/00016349709047827","article-title":"Intrauterine administration of levonorgestrel 5 and 10 microg\/24 h in perimenopausal hormone replacement therapy. A randomised clinical study during one year","volume":"76","author":"Wollter-Svensson","year":"1997","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.contraception.2007.01.005_bib34","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1471-0528.2002.01167.x","article-title":"Intrauterine 10 microg and 20 microg levonorgestrel systems in postmenopausal women receiving oral oestrogen replacement therapy: clinical, endometrial and metabolic response","volume":"109","author":"Raudaskoski","year":"2002","journal-title":"BJOG"},{"key":"10.1016\/j.contraception.2007.01.005_bib35","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.ygyno.2003.07.002","article-title":"Nuclear morphometric changes and therapy monitoring in patients with endometrial hyperplasia: a study comparing effects of intrauterine levonorgestrel and systemic medroxyprogesterone","volume":"91","author":"Vereide","year":"2003","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.contraception.2007.01.005_bib36","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1067\/mob.2003.346","article-title":"Treatment of nonatypical and atypical endometrial hyperplasia with a levonorgestrel-releasing intrauterine system","volume":"188","author":"Wilemeersch","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.contraception.2007.01.005_bib37","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1067\/mob.2002.122130","article-title":"Intrauterine progesterone treatment of early endometrial cancer","volume":"186","author":"Montz","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.contraception.2007.01.005_bib38","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0015-0282(02)04913-0","article-title":"Therapeutic effects of the levonorgestrel-releasing intrauterine system in the treatment of idiopathic menorrhagia","volume":"79","author":"Xiao","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.contraception.2007.01.005_bib39","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00004347-198609000-00005","article-title":"Endometrial morphology during long-term use of levonorgestrel-releasing intrauterine devices","volume":"5","author":"Silverberg","year":"1986","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.contraception.2007.01.005_bib40","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1001\/jama.291.12.1456","article-title":"Clinical outcomes and costs with the levonorgestrel-releasing intrauterine system or hysterectomy for treatment of menorrhagia: randomized trial 5-year follow-up","volume":"291","author":"Hurskainen","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.contraception.2007.01.005_bib41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0015-0282(97)81476-8","article-title":"Intracervical and fundal administration of levonorgestrel for contraception: endometrial thickness, patterns of bleeding, and persisting ovarian follicles","volume":"68","author":"Pakarinen","year":"1997","journal-title":"Fertil Steril"},{"key":"10.1016\/j.contraception.2007.01.005_bib42","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1093\/humrep\/13.12.3379","article-title":"The effect of a levonorgestrel-releasing intrauterine system on uterine artery blood flow, hormone concentrations and ovarian cyst formation in fertile women","volume":"13","author":"Jarvela","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.contraception.2007.01.005_bib43","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1046\/j.1469-0705.2002.00805.x","article-title":"Comparison of ovarian cyst formation in women using the levonorgestrel-releasing intrauterine system vs. hysterectomy","volume":"20","author":"Inki","year":"2002","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.contraception.2007.01.005_bib44","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0010-7824(98)00041-9","article-title":"Cardiovascular disease and use of oral and injectable progestogen only contraceptives and combine injectable contraceptives. Results of an international, multicenter, case control study","volume":"57","author":"World Health Organization","year":"1998","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2007.01.005_bib45","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/S0140-6736(99)04394-9","article-title":"Risk of idiopathic venous thromboembolism in users of progestagens alone","volume":"354","author":"Vasilakis","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.contraception.2007.01.005_bib46","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0015-0282(16)49397-0","article-title":"Sustained intrauterine release of levonorgestrel over five years","volume":"45","author":"Nilsson","year":"1986","journal-title":"Fertil Steril"},{"key":"10.1016\/j.contraception.2007.01.005_bib47","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0010-7824(87)80016-1","article-title":"Long-term follow-up of women treated with Norplant\u00ae implants","volume":"35","author":"Diaz","year":"1987","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2007.01.005_bib48","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0010-7824(92)90149-N","article-title":"Pharmacokinetics of levonorgestrel and ethinylestradiol in 9 women who received a low-dose oral contraceptive over a treatment period of 3 months and, after a wash-out phase, a single oral administration of the same contraceptive formulation","volume":"46","author":"Kuhnz","year":"1992","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2007.01.005_bib49","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0010-7824(76)90007-X","article-title":"Plasma levels of d-norgestrel after oral administration","volume":"14","author":"Weiner","year":"1976","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2007.01.005_bib50","series-title":"Medical eligibility criteria for contraceptive use","author":"World Health Organization (WHO)","year":"2004"}],"container-title":["Contraception"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010782407000649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010782407000649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T12:28:57Z","timestamp":1707740937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010782407000649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0010782407000649"],"URL":"https:\/\/doi.org\/10.1016\/j.contraception.2007.01.005","relation":{},"ISSN":["0010-7824"],"issn-type":[{"value":"0010-7824","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}