{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T11:53:25Z","timestamp":1772106805450,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contraception"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.contraception.2007.06.011","type":"journal-article","created":{"date-parts":[[2007,9,17]],"date-time":"2007-09-17T12:21:21Z","timestamp":1190031681000},"page":"297-305","source":"Crossref","is-referenced-by-count":11,"title":["Study of low-density lipoprotein receptor regulation by oral (steroid) contraceptives: desogestrel, levonorgestrel and ethinyl estradiol in JEG-3 cell line and placental tissue"],"prefix":"10.1016","volume":"76","author":[{"given":"Gopalakrishnan","family":"Ramakrishnan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Rana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandana","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimai Chand","family":"Chandra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.contraception.2007.06.011_bib1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1161\/hq0202.102318","article-title":"Female hormones and thrombosis","volume":"22","author":"Rosendaal","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.contraception.2007.06.011_bib2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1055\/s-2003-38334","article-title":"Venous and arterial thrombosis during oral contraceptive use: risks and risk factors","volume":"3","author":"Tanis","year":"2003","journal-title":"Semin Vasc Med"},{"key":"10.1016\/j.contraception.2007.06.011_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1783\/0000000052972988","article-title":"Potential impact of oral contraceptive choice on myocardial infarction, mortality and deep vein thrombosis","volume":"31","author":"Martin","year":"2005","journal-title":"J Fam Plann Reprod Health Care"},{"key":"10.1016\/j.contraception.2007.06.011_bib4","series-title":"Contraception science and practice","first-page":"39","article-title":"Complication of oral contraceptions","author":"Drife","year":"1989"},{"key":"10.1016\/j.contraception.2007.06.011_bib5","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1056\/NEJM198109103051104","article-title":"Oral contraceptives and cardiovascular disease","volume":"305","author":"Stadel","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1016\/j.contraception.2007.06.011_bib6","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJM198109173051205","article-title":"Oral contraceptives and cardiovascular disease","volume":"305","author":"Stadel","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1016\/j.contraception.2007.06.011_bib7","first-page":"727","article-title":"Mortality among oral contraceptive users","volume":"2","author":"Royal College of General Practitioners' Oral Contraceptive Study","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.contraception.2007.06.011_bib8","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/0002-8703(81)90231-3","article-title":"Oral contraceptives and cardiovascular disease","volume":"101","author":"Dalen","year":"1981","journal-title":"Am Heart J"},{"key":"10.1016\/j.contraception.2007.06.011_bib9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/bmj.2.5703.203","article-title":"Thromboembolic disease and the steroidal content of oral contraceptives: a report to the Committee on Safety of Drugs","volume":"2","author":"Inman","year":"1970","journal-title":"Br Med J"},{"key":"10.1016\/j.contraception.2007.06.011_bib10","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1136\/bmj.280.6224.1157","article-title":"Progestogens and cardiovascular reactions associated with oral contraceptives and a comparison of the safety of 50- and 30-\u03bcg preparations","volume":"280","author":"Meade","year":"1980","journal-title":"Br Med J"},{"key":"10.1016\/j.contraception.2007.06.011_bib11","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1056\/NEJM198304143081502","article-title":"Effect of estrogen\/progestin potency on lipid\/lipoprotein cholesterol","volume":"308","author":"Wahl","year":"1983","journal-title":"N Engl J Med"},{"key":"10.1016\/j.contraception.2007.06.011_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0010-7824(01)00224-4","article-title":"Effects of two low-dose oral contraceptives containing ethinylestradiol and either desogestrel or levonorgestrel on serum lipids and lipoproteins with particular regard to LDL size","volume":"64","author":"Foulon","year":"2001","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2007.06.011_bib13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0010-7824(01)00269-4","article-title":"The effects of two progestogen-only pills containing either desogestrel (75 \u03bcg\/day) or levonorgestrel (30 \u03bcg\/day) on lipid metabolism","volume":"64","author":"Barkfeldt","year":"2001","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2007.06.011_bib14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0010-7824(01)00236-0","volume":"64","author":"Endrikat","year":"2001","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2007.06.011_bib15","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1365-2796.2006.01643.x","article-title":"The apoB\/apoA-I ratio: a strong, new risk factor for cardiovascular disease and a target for lipid-lowering therapy \u2014 a review of the evidence","volume":"259","author":"Walldius","year":"2006","journal-title":"J Intern Med"},{"key":"10.1016\/j.contraception.2007.06.011_bib16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1161\/01.CIR.85.1.22","article-title":"Decreased HDL2 and HDL3 cholesterol, apo A-I and apo A-II, and increased risk of myocardial infarction","volume":"85","author":"Buring","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.contraception.2007.06.011_bib17","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1161\/CIRCULATIONAHA.104.532499","article-title":"Non-high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in men","volume":"112","author":"Pischon","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.contraception.2007.06.011_bib18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(00)80213-5","article-title":"The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor","volume":"89","author":"Brown","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.contraception.2007.06.011_bib19","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1210\/en.142.4.1525","article-title":"Sterol regulatory element binding protein-1a regulation of the steroidogenic acute regulatory protein gene","volume":"142","author":"Shea-Eaton","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.contraception.2007.06.011_bib20","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1126\/science.2988123","article-title":"The LDL receptor gene: a mosaic of exons shared with different proteins","volume":"228","author":"Sudhof","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.contraception.2007.06.011_bib21","first-page":"133","article-title":"Effects of sex hormones on regulation of ABCG2 expression in the placental cell line BeWo","volume":"9","author":"Satoru","year":"2006","journal-title":"J Pharm Pharm Sci"},{"key":"10.1016\/j.contraception.2007.06.011_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1042\/bj0540050","article-title":"The chemical assay of progesterone","volume":"54","author":"Edgar","year":"1953","journal-title":"Biochem J"},{"key":"10.1016\/j.contraception.2007.06.011_bib23","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0021-9258(18)57334-8","volume":"174","author":"Friedgood","year":"1948","journal-title":"J Biol Chem"},{"key":"10.1016\/j.contraception.2007.06.011_bib24","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1136\/jcp.2003.010520","article-title":"Computer based receptogram approach: an objective way of assessing immunohistochemistry of androgen receptor staining and its correlation with hormonal response in metastatic carcinoma of prostate","volume":"57","author":"Nabi","year":"2004","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.contraception.2007.06.011_bib25","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI103182","article-title":"The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum","volume":"34","author":"Havel","year":"1955","journal-title":"J Clin Invest"},{"key":"10.1016\/j.contraception.2007.06.011_bib26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0003-2697(69)90017-7","article-title":"Study of a new cholesterol agent","volume":"29","author":"Zlatkis","year":"1969","journal-title":"Anal Biochem"},{"key":"10.1016\/j.contraception.2007.06.011_bib27","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein\u2013dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.contraception.2007.06.011_bib28","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.contraception.2007.06.011_bib29","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications","volume":"76","author":"Towbin","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.contraception.2007.06.011_bib30","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1001\/archinte.164.18.1965","article-title":"Risk of venous thromboembolic disease associated with hormonal contraceptives and hormone replacement therapy: a clinical review","volume":"164","author":"Gomes","year":"2004","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.contraception.2007.06.011_bib31","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1001\/jama.292.13.1581","article-title":"Esterified estrogens and conjugated equine estrogens and the risk of venous thrombosis","volume":"292","author":"Smith","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.contraception.2007.06.011_bib32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1055\/s-2003-38332","article-title":"Inherited thrombophilia, pregnancy, and oral contraceptive use: clinical implications","volume":"3","author":"De Stefano","year":"2003","journal-title":"Semin Vasc Med"},{"key":"10.1016\/j.contraception.2007.06.011_bib33","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1056\/NEJMoa003216","article-title":"Oral contraceptives and the risk of myocardial infarction","volume":"345","author":"Tanis","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.contraception.2007.06.011_bib34","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1136\/bmj.318.7198.1579","article-title":"Oral contraceptives and myocardial infarction: results of the MICA case-control study","volume":"318","author":"Dunn","year":"1999","journal-title":"BMJ"},{"key":"10.1016\/j.contraception.2007.06.011_bib35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/bmj.312.7023.83","article-title":"Third generation oral contraceptives and risk of venous thromboembolic disorders: an international case-control study","volume":"312","author":"Spitzer","year":"1996","journal-title":"BMJ"},{"key":"10.1016\/j.contraception.2007.06.011_bib36","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0092-8674(00)81304-5","article-title":"Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment","volume":"85","author":"Sakai","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.contraception.2007.06.011_bib37","doi-asserted-by":"crossref","first-page":"12778","DOI":"10.1074\/jbc.272.19.12778","article-title":"Cleavage site for sterol-regulated protease localized to a Leu-Ser bond in lumenal loop of sterol regulatory element binding protein-2","volume":"272","author":"Duncan","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.contraception.2007.06.011_bib38","doi-asserted-by":"crossref","first-page":"17801","DOI":"10.1074\/jbc.273.28.17801","article-title":"Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning","volume":"273","author":"Duncan","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.contraception.2007.06.011_bib39","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0010-7824(98)00014-6","article-title":"Newer oral contraceptives and the risk of venous thromboembolism","volume":"57","author":"Walker","year":"1998","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2007.06.011_bib40","doi-asserted-by":"crossref","first-page":"1S","DOI":"10.1016\/S0010-7824(98)00030-4","article-title":"Developments in contraception a comprehensive review of Desogen (desogestrel and ethinylestradiol)","volume":"57","author":"Lammers","year":"1998","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2007.06.011_bib41","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1093\/humrep\/17.9.2307","article-title":"Myocardial infarction and third generation oral contraceptives: aggregation of recent studies","volume":"17","author":"Spitzer","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.contraception.2007.06.011_bib42","first-page":"1034","article-title":"Advisory board for the new progestins. Evaluation of a new generation of oral contraceptives","volume":"81","author":"Speroff","year":"1993","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.contraception.2007.06.011_bib43","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/S0140-6736(95)91927-9","article-title":"Effect of different progestagens in low oestrogen oral contraceptives on venous thromboembolic disease","volume":"346","year":"1995","journal-title":"Lancet"}],"container-title":["Contraception"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010782407003411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010782407003411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T14:31:53Z","timestamp":1629729113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010782407003411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0010782407003411"],"URL":"https:\/\/doi.org\/10.1016\/j.contraception.2007.06.011","relation":{},"ISSN":["0010-7824"],"issn-type":[{"value":"0010-7824","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}