{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:23:31Z","timestamp":1760783011282},"reference-count":56,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contraception"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.contraception.2007.09.014","type":"journal-article","created":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T13:26:23Z","timestamp":1201872383000},"page":"214-222","source":"Crossref","is-referenced-by-count":12,"title":["Synthesis and assessment of fertility-regulating potential of 2-(2\u2033-chloroacetamidobenzyl)-3-(3\u2032-indolyl) quinoline in adult rats as a male contraceptive agent"],"prefix":"10.1016","volume":"77","author":[{"given":"Sujit K.","family":"Bhowal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanchita","family":"Lala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhijit","family":"Hazra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyankar","family":"Paira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukdeb","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirup B.","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smritinath","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.contraception.2007.09.014_bib1","series-title":"Fertility control","first-page":"281","article-title":"Status of male contraception: hormonal approach","author":"Paulsen","year":"1994"},{"key":"10.1016\/j.contraception.2007.09.014_bib2","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1021\/jm00228a008","article-title":"1-Halobenzyl-1H-indazole \u20133-carboxylic acids. A new class of antispermatogenic agents","volume":"19","author":"Corsi","year":"1976","journal-title":"J Med Chem"},{"key":"10.1016\/j.contraception.2007.09.014_bib3","first-page":"110","article-title":"Lonidamine and related compounds","volume":"21","author":"Silvestrini","year":"1984","journal-title":"Prog Med Chem"},{"key":"10.1016\/j.contraception.2007.09.014_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00236345","article-title":"Morphological, histochemical and biochemical studies on germ cell mitochondria of normal rats","volume":"196","author":"De Martino","year":"1979","journal-title":"Cell Tissue Res"},{"issue":"Suppl 2","key":"10.1016\/j.contraception.2007.09.014_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000238043","article-title":"Effects of AF1312TS and lonidamine on mammalian testis. A morphological study","volume":"27","author":"De Martino","year":"1981","journal-title":"Chemotherapy"},{"key":"10.1016\/j.contraception.2007.09.014_bib6","first-page":"2037","article-title":"The cytoskeleton as a target of the antineoplastic drug lonidamine","volume":"12","author":"Malcorni","year":"1992","journal-title":"Anticancer Res"},{"key":"10.1016\/j.contraception.2007.09.014_bib7","doi-asserted-by":"crossref","first-page":"21040","DOI":"10.1074\/jbc.273.33.21040","article-title":"Testin secreted by Sertoli cells is associated with the cell surface, and its expression correlates with the disruption of Sertoli-germ cell junctions but not the inter-Sertoli tight junctions","volume":"273","author":"Grima","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.contraception.2007.09.014_bib8","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1095\/biolreprod65.2.449","article-title":"Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis","volume":"65","author":"Cheng","year":"2001","journal-title":"Biol Reprod"},{"key":"10.1016\/j.contraception.2007.09.014_bib9","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1095\/biolreprod64.5.1500","article-title":"Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4\u2032-dichlorobenzyl)- indazole-3-carbohydrazide","volume":"64","author":"Grima","year":"2001","journal-title":"Biol Reprod"},{"key":"10.1016\/j.contraception.2007.09.014_bib10","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/j.1939-4640.1997.tb01949.x","article-title":"Antifertility potential of ornidazole analogues in rats","volume":"18","author":"Cooper","year":"1997","journal-title":"J Androl"},{"key":"10.1016\/j.contraception.2007.09.014_bib11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1530\/reprod\/118.1.127","article-title":"Effect of ornidazole on fertility of male rats: inhibition of a glycolysis-related motility pattern and zona binding required for fertilization in vitro","volume":"118","author":"Bone","year":"2000","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.contraception.2007.09.014_bib12","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/0041-008X(88)90188-3","article-title":"The effect of ornidazole on fertility and epididymal sperm function in rats","volume":"92","author":"McClain","year":"1988","journal-title":"Toxicol Appl Pharma"},{"key":"10.1016\/j.contraception.2007.09.014_bib13","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/0041-008X(88)90187-1","article-title":"Reproduction studies in rats treated with ornidazole","volume":"92","author":"McClain","year":"1988","journal-title":"Toxicol Appl Pharma"},{"key":"10.1016\/j.contraception.2007.09.014_bib14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1530\/jrf.0.1000551","article-title":"Induction of reversible infertility in male rats by oral ornidazole and its effects on sperm motility and epididymal secretions","volume":"100","author":"Oberlander","year":"1994","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.contraception.2007.09.014_bib15","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1530\/jrf.0.1030257","article-title":"The effects of the male antifertility agent ornidazole on sperm function in vitro and in the female genital tract","volume":"103","author":"Yeung","year":"1995","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.contraception.2007.09.014_bib16","series-title":"Cellular and molecular events in spermiogenesis, WHO","first-page":"285","author":"Docampo","year":"1990"},{"key":"10.1016\/j.contraception.2007.09.014_bib17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/jac\/43.3.359","article-title":"Indolylquinoline derivatives are cytotoxic to Leishmania donovani promastigotes and amastigotes in vitro and are effective in treating murine visceral leishmaniasis","volume":"43","author":"Chakrabarty","year":"1999","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.contraception.2007.09.014_bib18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/bbrc.1996.5874","article-title":"Dual inhibition of DNA topoisomerases of Leishmania donovani by novel indolylquinolines","volume":"230","author":"Ray","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.contraception.2007.09.014_bib19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0040-8166(95)80016-6","article-title":"Building a testis","volume":"27","author":"Russell","year":"1995","journal-title":"Tissue Cell"},{"key":"10.1016\/j.contraception.2007.09.014_bib20","doi-asserted-by":"crossref","first-page":"10803","DOI":"10.1016\/S0040-4020(01)89272-3","article-title":"Synthesis of indolylquinolines under Friedel\u2013Crafts reaction conditions","volume":"50","author":"Mahato","year":"1994","journal-title":"Tetrahedron"},{"key":"10.1016\/j.contraception.2007.09.014_bib21","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0015-0282(16)44606-6","article-title":"The improved ten micrometer chamber for rapid sperm count and motility evaluation","volume":"33","author":"Makler","year":"1980","journal-title":"Fertil Steril"},{"key":"10.1016\/j.contraception.2007.09.014_bib22","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1749-6632.1952.tb26576.x","article-title":"Definition of the stages of cycle of the seminiferous epithelium in the rat","volume":"55","author":"Leblond","year":"1952","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.contraception.2007.09.014_bib23","first-page":"238","article-title":"Estimation of nuclear population from microtome sections","volume":"94","author":"Abercombie","year":"1946","journal-title":"Anatom Rec"},{"key":"10.1016\/j.contraception.2007.09.014_bib24","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1042\/bj0890114","article-title":"The preparation of 131I labeled human growth hormone of high specific activity","volume":"89","author":"Greenwood","year":"1963","journal-title":"Biochemistry"},{"key":"10.1016\/j.contraception.2007.09.014_bib25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0010-7824(98)00095-X","article-title":"Assessment of the antifertility effect of phaseolinone, an antileishmanial agent, in male rats","volume":"58","author":"Chakraborty","year":"1998","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2007.09.014_bib26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1017\/S0967199400002240","article-title":"Fertility of mammalian spermatozoa: its development and relativity","volume":"2","author":"Yanagimachi","year":"1994","journal-title":"Zygote"},{"key":"10.1016\/j.contraception.2007.09.014_bib27","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1095\/biolreprod52.2.226","article-title":"Regulation of epididymal epithelial cell function","volume":"52","author":"Robaire","year":"1995","journal-title":"Biol Reprod"},{"key":"10.1016\/j.contraception.2007.09.014_bib28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/jemt.10312","article-title":"Contribution of epididymal secretory proteins for spermatozoa maturation","volume":"61","author":"Dacheux","year":"2003","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.contraception.2007.09.014_bib29","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.anireprosci.2004.05.011","article-title":"Post-testicular sperm environment and fertility","volume":"82-83","author":"Gatti","year":"2004","journal-title":"Anim Reprod Sci"},{"key":"10.1016\/j.contraception.2007.09.014_bib30","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1095\/biolreprod52.5.1012","article-title":"Protein synthesis and secretion by the rat caput epididymis in vivo: influence of the luminal micro-environment","volume":"52","author":"Turner","year":"1995","journal-title":"Biol Reprod"},{"key":"10.1016\/j.contraception.2007.09.014_bib31","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1095\/biolreprod66.5.1219","article-title":"Comparison, characterization, and identification of protease and protease inhibitors in epididymal fluids of domestic animals. Matrix metalloproteinases are major fluid gelatinase","volume":"66","author":"Metayer","year":"2002","journal-title":"Biol Repod"},{"key":"10.1016\/j.contraception.2007.09.014_bib32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1530\/ror.0.0050075","article-title":"Functional processing of fertilin; evidence for a critical role proteolysis in sperm maturation and activation","volume":"5","author":"Blobel","year":"2000","journal-title":"Rev Reprod"},{"key":"10.1016\/j.contraception.2007.09.014_bib33","series-title":"The physiology of reproduction","first-page":"1063","article-title":"Anatomy, vasculature, enervation and fluids of the male reproductive tract","author":"Setchel","year":"1994"},{"key":"10.1016\/j.contraception.2007.09.014_bib34","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1210\/endo-76-1-80","article-title":"Duration of the cycles of the epithelium of normal, hypophysectomized and hypophysectomized hormone treated albino rats","volume":"76","author":"Clearmont","year":"1965","journal-title":"Endocrinology"},{"key":"10.1016\/j.contraception.2007.09.014_bib35","first-page":"1027","article-title":"Hormonal protection from procarbazine-induced testicular damage is selective for survival and recovery of stem spermatogonia","volume":"54","author":"Meitrich","year":"1994","journal-title":"Can Res"},{"key":"10.1016\/j.contraception.2007.09.014_bib36","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1095\/biolreprod50.2.271","article-title":"Testosterone effect on spermatogenesis in the gonadotropin-releasing hormone immunized rat","volume":"50","author":"McLachlan","year":"1994","journal-title":"Biol Reprod"},{"key":"10.1016\/j.contraception.2007.09.014_bib37","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1095\/biolreprod55.4.895","article-title":"Testerone withdrawal promotes stage specific detachment of round spermatid from the rat seminiferous epithelium","volume":"55","author":"O'Donnel","year":"1996","journal-title":"Biol Repord"},{"key":"10.1016\/j.contraception.2007.09.014_bib38","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1095\/biolreprod51.5.945","article-title":"Effects of testosterone on spermatogenic cell populations in the adult rat","volume":"51","author":"McLachlan","year":"1994","journal-title":"Biol Reprod"},{"key":"10.1016\/j.contraception.2007.09.014_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/joe.0.1480001","article-title":"The endocrine regulation of spermatogenesis: independent roles for testosterone and FSH","volume":"148","author":"McLachlan","year":"1996","journal-title":"J Endocrinol"},{"key":"10.1016\/j.contraception.2007.09.014_bib40","series-title":"The physiology of reproduction","first-page":"1509","article-title":"Pituitary and hypothalamus: perspective and overview","author":"Everett","year":"1994"},{"key":"10.1016\/j.contraception.2007.09.014_bib41","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF00221647","article-title":"Focal disruption of spermatogenesis in testis of adult rats after a single administration of human chorionic gonadotrophin","volume":"257","author":"Kerr","year":"1989","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.contraception.2007.09.014_bib42","series-title":"Reproduction and development","first-page":"625","article-title":"Toxicity of spermatogenesis and its detection","author":"Sharpe","year":"1994"},{"key":"10.1016\/j.contraception.2007.09.014_bib43","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1439-0272.1995.tb01097.x","article-title":"Evolution of somatic germ cell populations after busulfan treatment in utero or neonatal cryptorchidism in the rat","volume":"27","author":"Boujrad","year":"1995","journal-title":"Andrologia"},{"key":"10.1016\/j.contraception.2007.09.014_bib44","first-page":"345","article-title":"The endocrine control of spermatogenesis","volume":"14","author":"McLachlan","year":"2000","journal-title":"Bevillier Clin Endo"},{"key":"10.1016\/j.contraception.2007.09.014_bib45","first-page":"102","article-title":"Basement membrane regulation of Sertoli cells","volume":"15","author":"Dyn","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.contraception.2007.09.014_bib46","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1073\/pnas.82.1.114","article-title":"Testicular peritubular cells secrete a protein under androgen control that modulate Sertoli cells functions","volume":"82","author":"Skinner","year":"1985","journal-title":"Proc Nat Acad Sci U S A"},{"key":"10.1016\/j.contraception.2007.09.014_bib47","first-page":"887","article-title":"The cytology of testis","volume":"vol. 1","author":"De Krester","year":"1988"},{"key":"10.1016\/j.contraception.2007.09.014_bib48","series-title":"The Sertoli cells","first-page":"933","author":"Bardin","year":"1988"},{"key":"10.1016\/j.contraception.2007.09.014_bib49","series-title":"The Sertoli cells","first-page":"195","article-title":"Protein secretion by Sertoli cells","author":"Griswold","year":"1993"},{"key":"10.1016\/j.contraception.2007.09.014_bib50","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1210\/endo-122-3-787","article-title":"Evidence from Sertoli cell-depleted rats indicates that spermatid in adults depends on the number of Sertoli cells produced during perinatal development","volume":"122","author":"Orth","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.contraception.2007.09.014_bib51","series-title":"The Physiology of Reproduction","first-page":"1363","article-title":"Regulation of spermatogenesis","author":"Sharpe","year":"1994"},{"key":"10.1016\/j.contraception.2007.09.014_bib52","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1095\/biolreprod49.5.1122","article-title":"Junction-related Sertoli cell cytoskeleton in testosterone-treated hypophysectomized rats","volume":"49","author":"Muffy","year":"1993","journal-title":"Biol Reprod"},{"key":"10.1016\/j.contraception.2007.09.014_bib53","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1095\/biolreprod.104.035717","article-title":"The helix-loop-helix inhibitor of differentiation (ID) proteins induce post-mitotic terminally differentiated Sertoli cell to re-enter the cell cycle and Proliferate","volume":"72","author":"Chaudhury","year":"2005","journal-title":"Biol Reprod"},{"key":"10.1016\/j.contraception.2007.09.014_bib54","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/1074-5521(95)90098-5","article-title":"Charged with meaning: the structure and mechanism of phosphoprotein phosphatases","volume":"2","author":"Taylor","year":"1995","journal-title":"Chem Biol"},{"key":"10.1016\/j.contraception.2007.09.014_bib55","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0002-9343(85)90013-0","article-title":"Laboratory tests and diagnostic procedures in evaluation of liver disease","volume":"79","author":"Chopra","year":"1985","journal-title":"Am J Med"},{"key":"10.1016\/j.contraception.2007.09.014_bib56","series-title":"Harper's review of biochemistry","first-page":"166","article-title":"Metabolism of carbohydrate","author":"Mayes","year":"1985"}],"container-title":["Contraception"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010782407004325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010782407004325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T21:37:33Z","timestamp":1708551453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010782407004325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0010782407004325"],"URL":"https:\/\/doi.org\/10.1016\/j.contraception.2007.09.014","relation":{},"ISSN":["0010-7824"],"issn-type":[{"value":"0010-7824","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}