{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:48:47Z","timestamp":1779144527112,"version":"3.51.4"},"reference-count":21,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contraception"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.contraception.2011.02.010","type":"journal-article","created":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T08:32:13Z","timestamp":1301473933000},"page":"525-532","source":"Crossref","is-referenced-by-count":9,"title":["Mucosal integrity and inflammatory markers in the female lower genital tract as potential screening tools for vaginal microbicides"],"prefix":"10.1016","volume":"84","author":[{"given":"H. Irene","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney A.","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney","family":"Fay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Parry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal A.","family":"Elovitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alka","family":"Shaunik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Barnhart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.contraception.2011.02.010_bb0005","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/095646249300400308","article-title":"A dosing study of nonoxynol-9 and genital irritation","volume":"4","author":"Roddy","year":"1993","journal-title":"Int J STD AIDS"},{"key":"10.1016\/j.contraception.2011.02.010_bb0010","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00042560-199804010-00006","article-title":"Safety study of nonoxynol-9 as a vaginal microbicide: evidence of adverse effects","volume":"17","author":"Stafford","year":"1998","journal-title":"J Acquir Immune Defic Syndr Hum Retrovirol"},{"issue":"32","key":"10.1016\/j.contraception.2011.02.010_bb0015","first-page":"e1","article-title":"Cervicovaginal colposcopic lesions associated with 5 nonoxynol-9 vaginal spermicide formulations","volume":"198","author":"Harwood","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.contraception.2011.02.010_bb0020","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1086\/322047","article-title":"The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission","volume":"184","author":"Fichorova","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.contraception.2011.02.010_bb0025","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1600-0897.2008.00670.x","article-title":"Safety analysis of the diaphragm in combination with lubricant or acidifying microbicide gels: effects on markers of inflammation and innate immunity in cervicovaginal fluid","volume":"61","author":"Anderson","year":"2009","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.contraception.2011.02.010_bb0030","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/QAD.0b013e328013d9b5","article-title":"PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity","volume":"21","author":"Keller","year":"2007","journal-title":"AIDS"},{"key":"10.1016\/j.contraception.2011.02.010_bb0035","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(02)11079-8","article-title":"Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial","volume":"360","author":"Van Damme","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.contraception.2011.02.010_bb0040","series-title":"Manual for the standardization of colposcopy for the evaluation of vaginal products, update 2004","author":"World Health Organization","year":"2004"},{"key":"10.1016\/j.contraception.2011.02.010_bb0045","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/oxfordjournals.humrep.a138048","article-title":"The techniques and complications of out-patient uterine washing in the assessment of endometrial function","volume":"8","author":"Li","year":"1993","journal-title":"Hum Reprod"},{"key":"10.1016\/j.contraception.2011.02.010_bb0050","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1095\/biolreprod.104.029603","article-title":"Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives","volume":"71","author":"Fichorova","year":"2004","journal-title":"Biol Reprod"},{"key":"10.1016\/j.contraception.2011.02.010_bb0055","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1600-0897.2007.00563.x","article-title":"Mucosal innate immunity as a determinant of HIV susceptibility","volume":"59","author":"Iqbal","year":"2008","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.contraception.2011.02.010_bb0060","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.0105-2896.2005.00287.x","article-title":"Innate and adaptive immunity in female genital tract: cellular responses and interactions","volume":"206","author":"Wira","year":"2005","journal-title":"Immunol Rev"},{"key":"10.1016\/j.contraception.2011.02.010_bb0065","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.contraception.2004.08.012","article-title":"The effect of nonoxynol-9 on human endometrium","volume":"71","author":"Jain","year":"2005","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2011.02.010_bb0070","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1289\/ehp.7199","article-title":"Epidemiologic evaluation of measurement data in the presence of detection limits","volume":"112","author":"Lubin","year":"2004","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.contraception.2011.02.010_bb0075","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1086\/513279","article-title":"A comprehensive murine model to evaluate topical vaginal microbicides: mucosal inflammation and susceptibility to genital herpes as surrogate markers of safety","volume":"195","author":"Galen","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.contraception.2011.02.010_bb0080","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1128\/AAC.00588-06","article-title":"Biocompatibility of solid-dosage forms of anti-human immunodeficiency virus type 1 microbicides with the human cervicovaginal mucosa modeled ex vivo","volume":"50","author":"Trifonova","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.contraception.2011.02.010_bb0085","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1021\/ac702628q","article-title":"Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study","volume":"80","author":"Fichorova","year":"2008","journal-title":"Anal Chem"},{"key":"10.1016\/j.contraception.2011.02.010_bb0090","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jviromet.2010.01.018","article-title":"Development of an in vitro dual-chamber model of the female genital tract as a screening tool for epithelial toxicity","volume":"165","author":"Gali","year":"2010","journal-title":"J Virol Methods"},{"key":"10.1016\/j.contraception.2011.02.010_bb0095","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1471-2334-6-90","article-title":"Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission","volume":"6","author":"Cone","year":"2006","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.contraception.2011.02.010_bb0100","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1093\/humrep\/16.6.1151","article-title":"Distribution of a spermicide containing nonoxynol-9 in the vaginal canal and the upper female reproductive tract","volume":"16","author":"Barnhart","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.contraception.2011.02.010_bb0105","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0010-7824(03)00178-1","article-title":"Disruption of the upper female reproductive tract epithelium by nonoxynol-9","volume":"68","author":"Dayal","year":"2003","journal-title":"Contraception"}],"container-title":["Contraception"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001078241100062X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001078241100062X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T14:36:09Z","timestamp":1560090969000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001078241100062X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S001078241100062X"],"URL":"https:\/\/doi.org\/10.1016\/j.contraception.2011.02.010","relation":{},"ISSN":["0010-7824"],"issn-type":[{"value":"0010-7824","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}