{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:57:19Z","timestamp":1760043439765,"version":"3.41.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["contraceptionjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contraception"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.contraception.2015.08.017","type":"journal-article","created":{"date-parts":[[2015,9,12]],"date-time":"2015-09-12T04:19:32Z","timestamp":1442031572000},"page":"133-138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prediction of nomegestrol acetate pharmacokinetics in healthy female adolescents and adults by whole-body physiology-based pharmacokinetic modelling and clinical validation"],"prefix":"10.1016","volume":"93","author":[{"given":"Teun M.","family":"Post","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireille","family":"Gerrits","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kerbusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rik","family":"de Greef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.contraception.2015.08.017_bb0005","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.2165\/11208180-000000000-00000","article-title":"Nomegestrol acetate\/estradiol: in oral contraception","volume":"72","author":"Yang","year":"2012","journal-title":"Drugs"},{"key":"10.1016\/j.contraception.2015.08.017_bb0010","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3109\/13625187.2011.614029","article-title":"Efficacy and tolerability of a monophasic combined oral contraceptive containing nomegestrol acetate and 17beta-oestradiol in a 24\/4 regimen, in comparison to an oral contraceptive containing ethinylestradiol and drospirenone in a 21\/7 regimen","volume":"16","author":"Mansour","year":"2011","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"10.1016\/j.contraception.2015.08.017_bb0015","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1097\/AOG.0b013e318250c3a0","article-title":"Efficacy, safety, and tolerability of a monophasic oral contraceptive containing nomegestrol acetate and 17beta-estradiol: a randomized controlled trial","volume":"119","author":"Westhoff","year":"2012","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.contraception.2015.08.017_bb0020","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/S0022-3565(24)37149-6","article-title":"Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism","volume":"283","author":"Paine","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.contraception.2015.08.017_bb0025","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1208\/ps040104","article-title":"Protein binding predictions in infants","volume":"4","author":"McNamara","year":"2002","journal-title":"AAPS PharmSci"},{"key":"10.1016\/j.contraception.2015.08.017_bb0030","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1056\/NEJMra035092","article-title":"Developmental pharmacology \u2014 drug disposition, action, and therapy in infants and children","volume":"349","author":"Kearns","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.contraception.2015.08.017_bb0035","doi-asserted-by":"crossref","first-page":"683","DOI":"10.2165\/00003088-200645070-00004","article-title":"A mechanistic approach for the scaling of clearance in children","volume":"45","author":"Edginton","year":"2006","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.contraception.2015.08.017_bb0040","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1517\/17425255.2014.888058","article-title":"The successes and failures of physiologically based pharmacokinetic modeling: there is room for improvement","volume":"10","author":"Poggesi","year":"2014","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/j.contraception.2015.08.017_bb0045","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1208\/s12248-013-9555-6","article-title":"Physiologically based pharmacokinetic models in the prediction of oral drug exposure over the entire pediatric age range-sotalol as a model drug","volume":"16","author":"Khalil","year":"2014","journal-title":"AAPS J"},{"key":"10.1016\/j.contraception.2015.08.017_bb0050","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.contraception.2012.07.001","article-title":"Pharmacokinetic profile of nomegestrol acetate and 17beta-estradiol after multiple and single dosing in healthy women","volume":"87","author":"Gerrits","year":"2013","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2015.08.017_bb0055","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s10928-007-9053-5","article-title":"Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs","volume":"34","author":"Willmann","year":"2007","journal-title":"J Pharmacokinet Pharmacodyn"},{"key":"10.1016\/j.contraception.2015.08.017_bb0060","series-title":"Clinical Growth Charts","article-title":"National Center for Health Statistics","author":"Centers for Disease and Protection","year":"2000"},{"key":"10.1016\/j.contraception.2015.08.017_bb0065","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.2165\/00003088-200645100-00005","article-title":"Development and evaluation of a generic physiologically based pharmacokinetic model for children","volume":"45","author":"Edginton","year":"2006","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.contraception.2015.08.017_bb0070","doi-asserted-by":"crossref","first-page":"e1257","DOI":"10.1542\/peds.2014-2300","article-title":"Contraception for adolescents","volume":"134","author":"Ott","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.contraception.2015.08.017_bb0075","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF02850355","article-title":"Application of physiology-based pharmacokinetic and pharmacodynamic modeling to individualized target-controlled propofol infusions","volume":"23","author":"Edginton","year":"2006","journal-title":"Adv Ther"},{"key":"10.1016\/j.contraception.2015.08.017_bb0080","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2253-5-4","article-title":"Human physiologically based pharmacokinetic model for propofol","volume":"5","author":"Levitt","year":"2005","journal-title":"BMC Anesthesiol"}],"container-title":["Contraception"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010782415005740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010782415005740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T16:01:26Z","timestamp":1748620886000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010782415005740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0010782415005740"],"URL":"https:\/\/doi.org\/10.1016\/j.contraception.2015.08.017","relation":{},"ISSN":["0010-7824"],"issn-type":[{"type":"print","value":"0010-7824"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prediction of nomegestrol acetate pharmacokinetics in healthy female adolescents and adults by whole-body physiology-based pharmacokinetic modelling and clinical validation","name":"articletitle","label":"Article Title"},{"value":"Contraception","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.contraception.2015.08.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}