{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:39:21Z","timestamp":1792179561909,"version":"4.4.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["contraceptionjournal.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contraception"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.contraception.2016.06.022","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T08:33:18Z","timestamp":1467707598000},"page":"322-329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Maintaining physiological testosterone levels by adding dehydroepiandrosterone to combined oral contraceptives: I. Endocrine effects"],"prefix":"10.1016","volume":"96","author":[{"given":"Herjan J.T.","family":"Coelingh Bennink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Laan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke M.M.","family":"Termeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Appels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelin","family":"Albert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart C.J.M.","family":"Fauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos H.H.","family":"Thijssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik H.W.","family":"van Lunsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.contraception.2016.06.022_bb0005","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0306-4530(93)90060-X","article-title":"Sex steroids, sexual behavior, and selection attention for erotic stimuli in women using oral contraceptives","volume":"18","author":"Alexander","year":"1993","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.contraception.2016.06.022_bb0010","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/jsm.12774","article-title":"Is there a correlation between androgens and sexual desire in women?","volume":"12","author":"W\u00e5hlin-Jacobsen","year":"2015","journal-title":"J Sex Med"},{"issue":"Suppl. 2","key":"10.1016\/j.contraception.2016.06.022_bb0015","first-page":"S82","article-title":"The role of androgens and the menopause in the female sexual response","volume":"10","author":"Davis","year":"1998","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.contraception.2016.06.022_bb0020","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jsbmb.2013.05.006","article-title":"Androgen treatment of postmenopausal women","volume":"142","author":"Davis","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.contraception.2016.06.022_bb0025","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/01.gme.0000179049.08371.c7","article-title":"Efficacy and safety of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial","volume":"13","author":"Davis","year":"2006","journal-title":"Menopause"},{"key":"10.1016\/j.contraception.2016.06.022_bb0030","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12905-015-0270-6","article-title":"Effectiveness of a low dose testosterone undecanoate to improve sexual function in postmenopausal women","volume":"15","author":"Tungmunsakulchai","year":"2015","journal-title":"BMC Womens Health"},{"key":"10.1016\/j.contraception.2016.06.022_bb0035","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/cmt.5.4.357.365","article-title":"Addition of testosterone to estrogen replacement therapy in oophorectomized women: effects on sexuality and well-being","volume":"5","author":"Fl\u00f6ter","year":"2002","journal-title":"Climacteric"},{"key":"10.1016\/j.contraception.2016.06.022_bb0040","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0015-0282(02)02969-2","article-title":"Female androgen insufficiency: the Princeton consensus statement on definition, classification, and assessment","volume":"77","author":"Bachmann","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.contraception.2016.06.022_bb0045","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/j.1743-6109.2007.00584.x","article-title":"Are the Endocrine Society's clinical practice guidelines on androgen therapy in women misguided? A commentary","volume":"4","author":"Traish","year":"2007","journal-title":"J Sex Med"},{"key":"10.1016\/j.contraception.2016.06.022_bb0050","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/S0015-0282(02)02970-9","article-title":"Androgen deficiency in the oophorectomized woman","volume":"77","author":"Shifren","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.contraception.2016.06.022_bb0055","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/01.GME.0000060256.03945.20","article-title":"Transdermal testosterone therapy improves well-being, mood, and sexual function in premenopausal women","volume":"10","author":"Goldstat","year":"2003","journal-title":"Menopause"},{"key":"10.1016\/j.contraception.2016.06.022_bb0060","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00404-013-2969-7","article-title":"Androgen therapy in women: for whom and when","volume":"288","author":"Pluchino","year":"2013","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.contraception.2016.06.022_bb0065","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/B978-0-12-800094-6.00002-9","article-title":"Free testosterone: clinical utility and important analytical aspects of measurement","volume":"63","author":"Shea","year":"2014","journal-title":"Adv Clin Chem"},{"key":"10.1016\/j.contraception.2016.06.022_bb0070","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/humupd\/dmt038","article-title":"The effect of combined oral contraception on testosterone levels in healthy women: a systematic review and meta-analysis","volume":"20","author":"Zimmerman","year":"2014","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.contraception.2016.06.022_bb0075","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1111\/j.1743-6109.2012.02848.x","article-title":"The effects of hormonal contraceptives on female sexuality: a review","volume":"9","author":"Burrows","year":"2012","journal-title":"J Sex Med"},{"key":"10.1016\/j.contraception.2016.06.022_bb0080","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/10532528.2004.10559822","article-title":"Oral contraceptives and libido in women","volume":"15","author":"Davis","year":"2004","journal-title":"Annu Rev Sex Res"},{"key":"10.1016\/j.contraception.2016.06.022_bb0085","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1517\/14656566.2.9.1367","article-title":"Oral contraceptives and mood","volume":"2","author":"Kahn","year":"2001","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.contraception.2016.06.022_bb0090","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0165-0327(01)00356-1","article-title":"To what extent do oral contraceptives influence mood and affect?","volume":"70","author":"Oinonen","year":"2002","journal-title":"J Affect Disord"},{"key":"10.1016\/j.contraception.2016.06.022_bb0095","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3109\/13625187.2012.728643","article-title":"The influence of combined oral contraceptives on female sexual desire: a systematic review","volume":"18","author":"Pastor","year":"2013","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"10.1016\/j.contraception.2016.06.022_bb0100","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1600-0412.2011.01333.x","article-title":"Adverse mood symptoms with oral contraceptives","volume":"91","author":"Poromaa","year":"2012","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.contraception.2016.06.022_bb0105","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/jsm.12392","article-title":"Clitoral vascularization and sexual behavior in young patients treated with drospirenone-ethinyl estradiol or contraceptive vaginal ring: a prospective, randomized, pilot study","volume":"11","author":"Battaglia","year":"2014","journal-title":"J Sex Med"},{"key":"10.1016\/j.contraception.2016.06.022_bb0110","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.psyneuen.2006.12.011","article-title":"Does oral contraceptive-induced reduction in free testosterone adversely affect the sexuality or mood of women?","volume":"32","author":"Graham","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.contraception.2016.06.022_bb0115","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/j.1743-6109.2006.00294.x","article-title":"Comparison of androgens in women with hypoactive sexual desire disorder: those on combined oral contraceptives (COCs) vs. those not on COCs","volume":"3","author":"Warnock","year":"2006","journal-title":"J Sex Med"},{"issue":"Suppl. 4","key":"10.1016\/j.contraception.2016.06.022_bb0120","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/S0015-0282(02)02961-8","article-title":"Sexual effects of androgens in women: some theoretical considerations","volume":"77","author":"Bancroft","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.contraception.2016.06.022_bb0125","first-page":"3208","article-title":"Dehydroepiandrosterone replacement administration: pharmacokinetic and pharmacodynamic studies in healthy elderly subjects","volume":"85","author":"Legrain","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.contraception.2016.06.022_bb0130","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1177\/00912700122012742","article-title":"Effects of oral prasterone (dehydroepiandrosterone) on single-dose pharmacokinetics of oral prednisone and cortisol suppression in normal women","volume":"41","author":"Meno-Tetang","year":"2001","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.contraception.2016.06.022_bb0135","first-page":"1360","article-title":"Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age","volume":"78","author":"Morales","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.contraception.2016.06.022_bb0140","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1210\/jcem.83.6.4850","article-title":"Oral dehydroepiandrosterone for adrenal androgen replacement: pharmacokinetics and peripheral conversion to androgens and estrogens in young healthy females after dexamethasone suppression","volume":"83","author":"Arlt","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.contraception.2016.06.022_bb0145","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.contraception.2014.11.002","article-title":"Restoring testosterone levels by adding dehydroepiandrosterone to a drospirenone containing combined oral contraceptive: I. Endocrine effects","volume":"91","author":"Zimmerman","year":"2015","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2016.06.022_bb0150","article-title":"Maintaining physiological testosterone levels by adding dehydroepiandrosterone to combined oral contraceptives: II. Effects on sexual function","author":"Van Lunsen","year":"2016","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2016.06.022_bb0155","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0022-4731(82)90038-3","article-title":"Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature","volume":"16","author":"S\u00f6derg\u00e5rd","year":"1982","journal-title":"J Steroid Biochem"},{"key":"10.1016\/j.contraception.2016.06.022_bb0160","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1210\/jcem.84.10.6079","article-title":"A critical evaluation of simple methods for the estimation of free testosterone in serum","volume":"84","author":"Vermeulen","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.contraception.2016.06.022_bb0165","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A power primer","volume":"112","author":"Cohen","year":"1992","journal-title":"Psychol Bull"},{"key":"10.1016\/j.contraception.2016.06.022_bb0170","series-title":"Analysis of crossover trials in practical statistics for medical research","author":"Altman","year":"1991"},{"key":"10.1016\/j.contraception.2016.06.022_bb0175","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.cca.2013.12.042","article-title":"Peculiar observations in measuring testosterone in women treated with oral contraceptives supplemented with dehydroepiandrosterone (DHEA)","volume":"430","author":"Heijboer","year":"2014","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.contraception.2016.06.022_bb0180","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1210\/jc.2003-030680","article-title":"Measurement of free testosterone in normal women and women with androgen deficiency: comparison of methods","volume":"89","author":"Miller","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl. 1","key":"10.1016\/j.contraception.2016.06.022_bb0185","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3109\/13697137.2013.801736","article-title":"Androgen therapy in women, beyond libido","volume":"16","author":"Davis","year":"2013","journal-title":"Climacteric"},{"key":"10.1016\/j.contraception.2016.06.022_bb0190","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0140-6736(10)60355-8","article-title":"Primary ovarian insufficiency","volume":"376","author":"De Vos","year":"2010","journal-title":"Lancet"},{"issue":"Suppl. 4","key":"10.1016\/j.contraception.2016.06.022_bb0195","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0015-0282(02)02985-0","article-title":"Androgen production in women","volume":"77","author":"Burger","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.contraception.2016.06.022_bb0200","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.contraception.2012.07.001","article-title":"Pharmacokinetic profile of nomegestrol acetate and 17beta-estradiol after multiple and single dosing in healthy women","volume":"87","author":"Gerrits","year":"2013","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2016.06.022_bb0205","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.contraception.2015.08.017","article-title":"Prediction of nomegestrol acetate pharmacokinetics in healthy female adolescents and adults by whole-body physiology-based pharmacokinetic modelling and clinical validation","volume":"2","author":"Post","year":"2016","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2016.06.022_bb0210","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/13625180902850039","article-title":"Pharmacokinetics of an oral contraceptive containing oestradiol valerate and dienogest","volume":"14","author":"Zeun","year":"2009","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"10.1016\/j.contraception.2016.06.022_bb0215","doi-asserted-by":"crossref","first-page":"949","DOI":"10.2165\/00002512-200320130-00001","article-title":"Pharmacology and therapeutic effects of dehydroepiandrosterone in older subjects","volume":"20","author":"Legrain","year":"2003","journal-title":"Drugs Aging"}],"container-title":["Contraception"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001078241630141X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001078241630141X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T23:54:32Z","timestamp":1748994872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001078241630141X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S001078241630141X"],"URL":"https:\/\/doi.org\/10.1016\/j.contraception.2016.06.022","relation":{},"ISSN":["0010-7824"],"issn-type":[{"value":"0010-7824","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maintaining physiological testosterone levels by adding dehydroepiandrosterone to combined oral contraceptives: I. Endocrine effects","name":"articletitle","label":"Article Title"},{"value":"Contraception","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.contraception.2016.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Pantarhei Bioscience. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}