{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:43:36Z","timestamp":1789386216881,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","contraceptionjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contraception"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.contraception.2018.11.002","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T11:55:47Z","timestamp":1542110147000},"page":"77-86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"title":["Medical abortion in the late first trimester: a systematic review"],"prefix":"10.1016","volume":"99","author":[{"given":"Nathalie","family":"Kapp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Eckersberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Lavelanet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Isabel","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.contraception.2018.11.002_bb0005","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/j.1471-0528.2012.03310.x","article-title":"Acceptability of misoprostol-only medical termination of pregnancy compared with vacuum aspiration: an international, multicentre trial","volume":"119","author":"Rodriguez","year":"2012","journal-title":"BJOG"},{"key":"10.1016\/j.contraception.2018.11.002_bb0010","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0002-9378(97)70511-8","article-title":"Safety, efficacy, and acceptability of medical abortion in China, Cuba, and India: a comparative trial of mifepristone-misoprostol versus surgical abortion","volume":"176","author":"Winikoff","year":"1997","journal-title":"Am J Obstet Gynecol"},{"issue":"11","key":"10.1016\/j.contraception.2018.11.002_bb0015","article-title":"Medical methods for first trimester abortion","volume":"9","author":"Kulier","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.contraception.2018.11.002_bb0020","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1363\/psrh.12015","article-title":"Abortion incidence and service availability in the United States, 2014","volume":"49","author":"Jones","year":"2017","journal-title":"Perspect Sex Reprod Health"},{"key":"10.1016\/j.contraception.2018.11.002_bb0025","series-title":"Program of Action: Report of the International Conference on Population and Development, Cairo","year":"1994"},{"key":"10.1016\/j.contraception.2018.11.002_bb0030","series-title":"Safe and unsafe induced abortion - Global and regional levels in 2008, and trends during 1995\u20132008","author":"WHO","year":"2012"},{"key":"10.1016\/j.contraception.2018.11.002_bb0035","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0140-6736(15)00838-7","article-title":"Global, regional, and national levels and trends in maternal mortality between 1990 and 2015, with scenario-based projections to 2030: a systematic analysis by the UN Maternal Mortality Estimation Inter-Agency Group","volume":"387","author":"Alkema","year":"2016","journal-title":"Lancet (Lond Engl)"},{"key":"10.1016\/j.contraception.2018.11.002_bb0040","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1016\/S0140-6736(17)31794-4","article-title":"Global, regional, and subregional classification of abortions by safety, 2010\u201314: estimates from a Bayesian hierarchical model","volume":"390","author":"Ganatra","year":"2017","journal-title":"Lancet (Lond Engl)"},{"key":"10.1016\/j.contraception.2018.11.002_bb0045","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.contraception.2012.06.011","article-title":"First-trimester medical abortion with mifepristone 200 mg and misoprostol: a systematic review","volume":"87","author":"Raymond","year":"2013","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2018.11.002_bb0050","series-title":"Clinical practice handbook for safe abortion","author":"World Health Organization","year":"2014"},{"key":"10.1016\/j.contraception.2018.11.002_bb0055","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.contraception.2015.06.018","article-title":"Outpatient medical abortion is safe and effective through 70 days gestation","volume":"92","author":"Abbas","year":"2015","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2018.11.002_bb0060","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/AOG.0b013e31818d8eb4","article-title":"Two distinct oral routes of misoprostol in mifepristone medical abortion: a randomized controlled trial","volume":"112","author":"Winikoff","year":"2008","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.contraception.2018.11.002_bb0065","first-page":"1","article-title":"Randomised preference trial of medical versus surgical termination of pregnancy less than 14 weeks' gestation (TOPS)","volume":"13","author":"Robson","year":"2009","journal-title":"Health Technol Assess (Winch Eng)"},{"key":"10.1016\/j.contraception.2018.11.002_bb0070","first-page":"101","article-title":"Mifepristone in combination with misoprostol for the termination of pregnancy at 8\u201316 weeks' gestational age: a multicentre randomized controlled trial","volume":"24","author":"Chen","year":"2013","journal-title":"J Reprod Contracept"},{"key":"10.1016\/j.contraception.2018.11.002_bb0075","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ijgo.2010.01.010","article-title":"Anthropometric characteristics and success rates of oral or vaginal misoprostol for pregnancy termination in the first and second trimesters","volume":"109","author":"van Bogaert","year":"2010","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.contraception.2018.11.002_bb0080","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1479-828X.2007.00721.x","article-title":"A randomised trial of two regimens of vaginal misoprostol to manage termination of pregnancy of up to 16 weeks","volume":"47","author":"Khazardoost","year":"2007","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.contraception.2018.11.002_bb0085","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.contraception.2009.12.002","article-title":"Two medical abortion regimens for late first-trimester termination of pregnancy: a prospective randomized trial","volume":"81","author":"Dalenda","year":"2010","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2018.11.002_bb0090","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.contraception.2018.11.002_bb0095","series-title":"Interpreting results and drawing conclusions. Cochrane handbook for systematic reviews of interventions","author":"Schunemann","year":"2009"},{"key":"10.1016\/j.contraception.2018.11.002_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst Rev"},{"key":"10.1016\/j.contraception.2018.11.002_bb0105","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/humrep\/17.1.92","article-title":"A randomized comparison of medical abortion and surgical vacuum aspiration at 10\u201313 weeks gestation","volume":"17","author":"Ashok","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.contraception.2018.11.002_bb0110","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/j.1471-0528.2005.00638.x","article-title":"A randomised controlled trial of mifepristone in combination with misoprostol administered sublingually or vaginally for medical abortion up to 13 weeks of gestation","volume":"112","author":"Hamoda","year":"2005","journal-title":"BJOG"},{"key":"10.1016\/j.contraception.2018.11.002_bb0115","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/0010-7824(96)00044-3","article-title":"Evaluation of the effectiveness of vaginal misoprostol to induce first trimester abortion","volume":"53","author":"Bugalho","year":"1996","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2018.11.002_bb0120","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.contraception.2013.10.018","article-title":"A two-pill sublingual misoprostol outpatient regimen following mifepristone for medical abortion through 70 days' LMP: a prospective comparative open-label trial","volume":"89","author":"Bracken","year":"2014","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2018.11.002_bb0125","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1097\/AOG.0b013e31826c315f","article-title":"Extending outpatient medical abortion services through 70 days of gestational age","volume":"120","author":"Winikoff","year":"2012","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.contraception.2018.11.002_bb0130","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ijgo.2016.02.018","article-title":"Prospective study of home use of mifepristone and misoprostol for medical abortion up to 10weeks of pregnancy in Kazakhstan","volume":"134","author":"Platais","year":"2016","journal-title":"Int J Gynaecol Obstet"}],"container-title":["Contraception"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010782418304864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010782418304864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T20:13:25Z","timestamp":1757880805000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010782418304864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0010782418304864"],"URL":"https:\/\/doi.org\/10.1016\/j.contraception.2018.11.002","relation":{},"ISSN":["0010-7824"],"issn-type":[{"value":"0010-7824","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Medical abortion in the late first trimester: a systematic review","name":"articletitle","label":"Article Title"},{"value":"Contraception","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.contraception.2018.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}