{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:59:46Z","timestamp":1781135986431,"version":"3.54.1"},"reference-count":12,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","contraceptionjournal.org","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contraception"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.contraception.2024.110387","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T16:17:48Z","timestamp":1707495468000},"page":"110387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A nine-month repeat-dose intravaginal ring (Ovaprene) irritation study in sheep"],"prefix":"10.1016","volume":"133","author":[{"given":"Sarah","family":"Davis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Parthun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Friend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.contraception.2024.110387_bib1","first-page":"199","article-title":"Understanding contraceptive failure","volume":"23","author":"Trussell","year":"2009","journal-title":"Best Practice Res\u00a0Clin\u00a0Obstet\u00a0Gynaecol"},{"key":"10.1016\/j.contraception.2024.110387_bib2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1439-0272.1994.tb00757.x","article-title":"Effect of lipid peroxidation on beating frequency of human sperm tail","volume":"26","author":"Hong","year":"1994","journal-title":"Andrologia"},{"key":"10.1016\/j.contraception.2024.110387_bib3","first-page":"685","article-title":"A pilot safety and tolerability study of a nonhormonal vaginal contraceptive ring","volume":"54","author":"Del Priore","year":"2009","journal-title":"J\u00a0Reprod\u00a0Med"},{"key":"10.1016\/j.contraception.2024.110387_bib4","article-title":"Successful postcoital testing of Ovaprene: an investigational non-hormonal monthly vaginal contraceptive","author":"Mauck","year":"2024","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2024.110387_bib5","series-title":"Institute of laboratory animal resources","year":"2011"},{"key":"10.1016\/j.contraception.2024.110387_bib6","first-page":"257","article-title":"Relationship between iron-catalysed lipid peroxidation potential and human sperm function","volume":"98","author":"Aitken","year":"1993","journal-title":"J\u00a0Reproduct\u00a0Fertility"},{"key":"10.1016\/j.contraception.2024.110387_bib7","first-page":"531","article-title":"Peroxidative breakdown of phospholipids in human spermatozoa, spermicidal properties of fatty acid peroxides, and protective action of seminal plasma","volume":"31","author":"Jones","year":"1979","journal-title":"Fertil\u00a0Steril"},{"key":"10.1016\/j.contraception.2024.110387_bib8","first-page":"203","article-title":"Analysis of lipid peroxidation in human spermatozoa using BODIPY C11","volume":"13","author":"Aitken","year":"2007","journal-title":"Molec\u00a0Human Reprod"},{"key":"10.1016\/j.contraception.2024.110387_bib9","first-page":"259","article-title":"In vitro effects of metal ions (Fe2+, Mn2+, Pb2+) on sperm motility and lipid peroxidation in human semen","volume":"62","author":"Huang","year":"2001","journal-title":"J\u00a0Toxicol\u00a0Environ\u00a0Health,\u00a0Part A"},{"key":"10.1016\/j.contraception.2024.110387_bib10","first-page":"1759","article-title":"Animal models and alternatives in vaginal research: a comparative review","volume":"28","author":"McCracken","year":"2021","journal-title":"Reprod\u00a0Sci"},{"key":"10.1016\/j.contraception.2024.110387_bib11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.contraception.2004.02.015","article-title":"Efficacy of nonhormonal vaginal contraceptives from a hydrogel delivery system","volume":"70","author":"Saxena","year":"2004","journal-title":"Contraception"},{"key":"10.1016\/j.contraception.2024.110387_bib12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.contraception.2007.04.006","article-title":"Development of vaginal rings for sustained release of nonhormonal contraceptives and anti-HIV agents","volume":"76","author":"Han","year":"2007","journal-title":"Contraception"}],"container-title":["Contraception"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010782424000337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010782424000337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T16:30:31Z","timestamp":1729096231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010782424000337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":12,"alternative-id":["S0010782424000337"],"URL":"https:\/\/doi.org\/10.1016\/j.contraception.2024.110387","relation":{},"ISSN":["0010-7824"],"issn-type":[{"value":"0010-7824","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A nine-month repeat-dose intravaginal ring (Ovaprene) irritation study in sheep","name":"articletitle","label":"Article Title"},{"value":"Contraception","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.contraception.2024.110387","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Dare Bioscience. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110387"}}