{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:21:15Z","timestamp":1791656475406,"version":"4.3.4"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":295,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contraception: X"],"published-print":{"date-parts":[[2020]]},"DOI":"10.1016\/j.conx.2020.100046","type":"journal-article","created":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T23:27:49Z","timestamp":1604878069000},"page":"100046","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Drugs used to induce fetal demise prior to abortion: a systematic review"],"prefix":"10.1016","volume":"2","author":[{"given":"Tesfaye H.","family":"Tufa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Prager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella F.","family":"Lavelanet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caron","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.conx.2020.100046_bb0005","doi-asserted-by":"crossref","first-page":"e1152","DOI":"10.1016\/S2214-109X(20)30315-6","article-title":"Unintended pregnancy and abortion by income, region, and the legal status of abortion: estimates from a comprehensive model for 1990\u20132019","volume":"8","author":"Bearak","year":"2020","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.conx.2020.100046_bb0010","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/01.AOG.0000189095.32382.d0","article-title":"Risk factors associated with presenting for abortion in the second trimester","volume":"107","author":"Drey","year":"2006","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.conx.2020.100046_bb0015","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1363\/4521013","article-title":"Who seeks abortions at or after 20 weeks?","volume":"45","author":"Foster","year":"2013","journal-title":"Perspect Sex Reprod Health"},{"key":"10.1016\/j.conx.2020.100046_bb0020","first-page":"1687","article-title":"Denial of abortion because of provider gestational age limits in the United States","volume":"104","author":"Upadhyay","year":"2014","journal-title":"Am J Public Health"},{"key":"10.1016\/j.conx.2020.100046_bb0025","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.contraception.2011.05.016","article-title":"Safety of digoxin for fetal demise before second-trimester abortion by dilation and evacuation","volume":"85","author":"Dean","year":"2012","journal-title":"Contraception"},{"key":"10.1016\/j.conx.2020.100046_bb0030","first-page":"807","article-title":"Update on selective reduction","volume":"25","author":"Evans","year":"2005","journal-title":"Prenat Diagn Publ Affil Int Soc Prenat Diagn"},{"key":"10.1016\/j.conx.2020.100046_bb0035","doi-asserted-by":"crossref","unstructured":"J D, E D, undefined. Induction of fetal demise before abortion. Contraception 2010; 81:462\u201373.","DOI":"10.1016\/j.contraception.2010.01.018"},{"key":"10.1016\/j.conx.2020.100046_bb0040","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.contraception.2012.07.019","article-title":"Transvaginal administration of intraamniotic digoxin prior to dilation and evacuation","volume":"87","author":"Gariepy","year":"2013","journal-title":"Contraception"},{"key":"10.1016\/j.conx.2020.100046_bb0045","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/1471-0528.15640","article-title":"Intra-amniotic digoxin for feticide between 21 and 30 weeks of gestation: a prospective study","volume":"126","author":"Sharvit","year":"2019","journal-title":"BJOG"},{"key":"10.1016\/j.conx.2020.100046_bb0050","doi-asserted-by":"crossref","first-page":"337","DOI":"10.7863\/ultra.33.2.337","article-title":"Potassium chloride\u2013induced fetal demise","volume":"33","author":"Sfakianaki","year":"2014","journal-title":"J Ultrasound Med"},{"key":"10.1016\/j.conx.2020.100046_bb0055","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.contraception.2015.05.002","article-title":"Induction of fetal demise before pregnancy termination: practices of family planning providers","volume":"92","author":"Denny","year":"2015","journal-title":"Contraception"},{"key":"10.1016\/j.conx.2020.100046_bb0060","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0929-6441(09)60128-4","article-title":"Late termination of pregnancy: experience from an east Asian population and report of a novel technique for feticide","volume":"17","author":"Chen","year":"2009","journal-title":"J Med Ultrasound"},{"key":"10.1016\/j.conx.2020.100046_bb0065","doi-asserted-by":"crossref","first-page":"47","DOI":"10.7196\/SAMJ.6006","article-title":"Late termination of pregnancy by intracardiac potassium chloride injection: 5 years\u2019 experience at a tertiary referral Centre","volume":"103","author":"Govender","year":"2013","journal-title":"S Afr Med J"},{"key":"10.1016\/j.conx.2020.100046_bb0070","doi-asserted-by":"crossref","unstructured":"Moher D, Shamseer L, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 2015 Jan 1; 4:1.","DOI":"10.1186\/2046-4053-4-1"},{"key":"10.1016\/j.conx.2020.100046_bb0075","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.conx.2020.100046_bb0080","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.contraception.2018.04.010","article-title":"Outcomes of dilation and evacuation with and without feticide by intra-cardiac potassium chloride injection: a service evaluation","volume":"98","author":"Lohr","year":"2018","journal-title":"Contraception"},{"key":"10.1016\/j.conx.2020.100046_bb0085","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.contraception.2007.10.011","article-title":"Effectiveness and safety of digoxin to induce fetal demise prior to second-trimester abortion","volume":"77","author":"Molaei","year":"2008","journal-title":"Contraception"},{"key":"10.1016\/j.conx.2020.100046_bb0090","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.contraception.2009.08.014","article-title":"A randomized pilot study on the effectiveness and side-effect profiles of two doses of digoxin as fetocide when administered intraamniotically or intrafetally prior to second-trimester surgical abortion","volume":"81","author":"Nucatola","year":"2010","journal-title":"Contraception"},{"key":"10.1016\/j.conx.2020.100046_bb0095","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.contraception.2013.08.005","article-title":"Feasibility, effectiveness and safety of transvaginal digoxin administration prior to dilation and evacuation","volume":"88","author":"Tocce","year":"2013","journal-title":"Contraception"},{"key":"10.1016\/j.conx.2020.100046_bb0100","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1097\/AOG.0000000000001671","article-title":"Intra-fetal compared with intra-amniotic digoxin before dilation and evacuation: a randomized controlled trial","volume":"128","author":"White","year":"2016","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.conx.2020.100046_bb0105","first-page":"139","article-title":"Effect of causing fetal cardiac asystole on second-trimester abortion","volume":"94","author":"Elimian","year":"1999","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.conx.2020.100046_bb0110","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000333815","article-title":"Fetal Intracardiac potassium chloride injection to expedite second-trimester dilation and evacuation","volume":"31","author":"Singh","year":"2012","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.conx.2020.100046_bb0115","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.contraception.2011.01.005","article-title":"Infection and extramural delivery with use of digoxin as a feticidal agent","volume":"85","author":"Steward","year":"2012","journal-title":"Contraception"},{"key":"10.1016\/j.conx.2020.100046_bb0120","unstructured":"WHO | What is Quality of Care and why is it important? https:\/\/www.who.int\/maternal_child_adolescent\/topics\/quality-of care\/definition\/en\/ (accessed September 23, 2020)."}],"container-title":["Contraception: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590151620300290?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590151620300290?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T02:32:50Z","timestamp":1762914770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590151620300290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":24,"alternative-id":["S2590151620300290"],"URL":"https:\/\/doi.org\/10.1016\/j.conx.2020.100046","relation":{},"ISSN":["2590-1516"],"issn-type":[{"value":"2590-1516","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Drugs used to induce fetal demise prior to abortion: a systematic review","name":"articletitle","label":"Article Title"},{"value":"Contraception: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.conx.2020.100046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100046"}}