{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T03:33:51Z","timestamp":1781148831584,"version":"3.54.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Biotechnology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.copbio.2016.11.011","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T04:17:13Z","timestamp":1481257033000},"page":"69-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Dietary and enteral interventions for Crohn's disease"],"prefix":"10.1016","volume":"44","author":[{"given":"Takayuki","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Shimoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moeko","family":"Kuriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.copbio.2016.11.011_bib0235","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/MOG.0000000000000178","article-title":"Nutritional therapy in inflammatory bowel disease","volume":"31","author":"Sarbagili-Shabat","year":"2015","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.copbio.2016.11.011_bib0240","doi-asserted-by":"crossref","first-page":"628157","DOI":"10.1155\/2015\/628157","article-title":"Intestinal permeability in inflammatory bowel disease: pathogenesis, clinical evaluation, and therapy of leaky gut","volume":"2015","author":"Michielan","year":"2015","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.copbio.2016.11.011_sbref0245","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3390\/ijms17040578","article-title":"Modulating composition and metabolic activity of the gut microbiota in IBD patients","volume":"17","author":"Matija\u0161i\u0107","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.copbio.2016.11.011_bib0250","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s13105-015-0395-y","article-title":"An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases","volume":"71","author":"Lorente-Cebri\u00e1n","year":"2015","journal-title":"J Physiol Biochem"},{"key":"10.1016\/j.copbio.2016.11.011_bib0255","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.clnu.2015.01.012","article-title":"The role of immunomodulators on intestinal barrier homeostasis in experimental models","volume":"34","author":"Andrade","year":"2015","journal-title":"Clin Nutr"},{"key":"10.1016\/j.copbio.2016.11.011_bib0260","first-page":"62","article-title":"Interrelationships between glutamine and citrulline metabolism","volume":"19","author":"Marini","year":"2016","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.copbio.2016.11.011_bib0265","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1365-2036.2009.04035.x","article-title":"Review article: diet and inflammatory bowel disease\u2014epidemiology and treatment","volume":"30","author":"Yamamoto","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.copbio.2016.11.011_bib0270","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/MOG.0b013e32835b9a40","article-title":"Nutrition and diet in inflammatory bowel disease","volume":"29","author":"Yamamoto","year":"2013","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.copbio.2016.11.011_sbref0275","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bpg.2016.02.002","article-title":"Probiotics and prebiotics in Crohn's disease therapies","volume":"30","author":"Lichtenstein","year":"2016","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.copbio.2016.11.011_bib0280","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-230X-4-5","article-title":"Lactobacillus GG in inducing and maintaining remission of Crohn's disease","volume":"4","author":"Schultz","year":"2004","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.copbio.2016.11.011_bib0285","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1017\/S0022029903006034","article-title":"Immunomodulatory consequences of oral administration of Lactobacillus rhamnosus strain GG in healthy volunteers","volume":"70","author":"Schultz","year":"2003","journal-title":"J Dairy Res"},{"key":"10.1016\/j.copbio.2016.11.011_bib0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12328-013-0440-8","article-title":"Probiotic treatments for induction and maintenance of remission in inflammatory bowel diseases: a meta-analysis of randomized controlled trials","volume":"7","author":"Fujiya","year":"2014","journal-title":"Clin J Gastroenterol"},{"key":"10.1016\/j.copbio.2016.11.011_bib0295","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/01.MIB.0000437495.30052.be","article-title":"Effect of probiotics on inducing remission and maintaining therapy in ulcerative colitis, Crohn's disease, and pouchitis: meta-analysis of randomized controlled trials","volume":"20","author":"Shen","year":"2014","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.copbio.2016.11.011_bib0300","first-page":"473","article-title":"Systematic review of randomized controlled trials of probiotics, prebiotics, and synbiotics in inflammatory bowel disease","volume":"7","author":"Ghouri","year":"2014","journal-title":"Clin Exp Gastroenterol"},{"key":"10.1016\/j.copbio.2016.11.011_bib0305","first-page":"CD006634","article-title":"Probiotics for induction of remission in Crohn's disease","volume":"3","author":"Butterworth","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.copbio.2016.11.011_bib0310","first-page":"CD004826","article-title":"Probiotics for maintenance of remission in Crohn's disease","volume":"4","author":"Rolfe","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"issue":"Suppl. 2","key":"10.1016\/j.copbio.2016.11.011_bib0315","doi-asserted-by":"crossref","first-page":"830S","DOI":"10.1093\/jn\/137.3.830S","article-title":"Prebiotics: the concept revisited","volume":"137","author":"Roberfroid","year":"2007","journal-title":"J Nutr"},{"key":"10.1016\/j.copbio.2016.11.011_bib0320","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/1574-6941.12186","article-title":"Prebiotic stimulation of human colonic butyrate-producing bacteria and bifidobacteria, in vitro","volume":"87","author":"Scott","year":"2014","journal-title":"FEMS Microbiol Ecol"},{"key":"10.1016\/j.copbio.2016.11.011_bib0325","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/gut.2005.074971","article-title":"Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease","volume":"55","author":"Lindsay","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.copbio.2016.11.011_bib0330","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1471-230X-7-36","article-title":"Effect of oral lactulose on clinical and immunohistochemical parameters in patients with inflammatory bowel disease: a pilot study","volume":"7","author":"Hafer","year":"2007","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.copbio.2016.11.011_bib0335","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1136\/gutjnl-2011-300413","article-title":"Effect of oligofructose-enriched inulin (OF-IN) on bacterial composition and disease activity of patients with Crohn's disease: results from a double-blinded randomised controlled trial","volume":"61","author":"Joossens","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.copbio.2016.11.011_bib0340","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1136\/gut.2010.232025","article-title":"Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease","volume":"60","author":"Benjamin","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.copbio.2016.11.011_bib0345","first-page":"60","article-title":"Dietary factors in the modulation of inflammatory bowel disease activity","volume":"9","author":"Shah","year":"2007","journal-title":"MedGenMed"},{"key":"10.1016\/j.copbio.2016.11.011_sbref0350","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.nut.2015.08.025","article-title":"Specific carbohydrate diet for pediatric inflammatory bowel disease in clinical practice within an academic IBD center","volume":"32","author":"Obih","year":"2016","journal-title":"Nutrition"},{"key":"10.1016\/j.copbio.2016.11.011_sbref0355","first-page":"CD006320","article-title":"Omega 3 fatty acids (fish oil) for maintenance of remission in Crohn's disease","volume":"2","author":"Lev-Tzion","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.copbio.2016.11.011_bib0360","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1001\/jama.299.14.1690","article-title":"Omega-3 free fatty acids for the maintenance of remission in Crohn disease: the EPIC Randomized Controlled Trials","volume":"299","author":"Feagan","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.copbio.2016.11.011_bib0365","first-page":"78","article-title":"Double-blind randomized controlled trial of glutamine-enriched polymeric diet in the treatment of active Crohn's disease","volume":"30","author":"Akobeng","year":"2000","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.copbio.2016.11.011_bib0370","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/sj.ejcn.1602243","article-title":"Glutamine-enriched total parenteral nutrition in patients with inflammatory bowel disease","volume":"59","author":"Ockenga","year":"2005","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.copbio.2016.11.011_sbref0375","first-page":"CD007348","article-title":"Glutamine for induction of remission in Crohn's disease","volume":"2","author":"Akobeng","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.copbio.2016.11.011_bib0380","first-page":"CD000542","article-title":"Enteral nutritional therapy for induction of remission in Crohn's disease","volume":"1","author":"Zachos","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.copbio.2016.11.011_bib0385","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1365-2036.2007.03431.x","article-title":"Meta-analysis: enteral nutrition in active Crohn's disease in children","volume":"26","author":"Dziechciarz","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.copbio.2016.11.011_bib0390","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0016-5085(90)90002-I","article-title":"Clinical, biological, and endoscopic picture of attacks of Crohn's disease. Evolution on prednisolone. Groupe d\u2019Etude Th\u00e9rapeutique des Affections Inflammatoires Digestives","volume":"98","author":"Modigliani","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.copbio.2016.11.011_bib0395","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/01.MIB.0000161307.58327.96","article-title":"Impact of elemental diet on mucosal inflammation in patients with active Crohn's disease: cytokine production and endoscopic and histological findings","volume":"11","author":"Yamamoto","year":"2005","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.copbio.2016.11.011_bib0400","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.cgh.2006.03.010","article-title":"Polymeric diet alone versus corticosteroids in the treatment of active pediatric Crohn's disease: a randomized controlled open-label trial","volume":"4","author":"Borrelli","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.copbio.2016.11.011_bib0405","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.dld.2005.10.005","article-title":"Short- and long-term therapeutic efficacy of nutritional therapy and corticosteroids in paediatric Crohn's disease","volume":"38","author":"Berni Canani","year":"2006","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.copbio.2016.11.011_bib0410","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1590-8658(00)80353-9","article-title":"Oral nutritional supplementation is effective in the maintenance of remission in Crohn's disease","volume":"32","author":"Verma","year":"2000","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.copbio.2016.11.011_bib0415","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/003655201300051199","article-title":"Does adjuvant nutritional support diminish steroid dependency in Crohn disease?","volume":"36","author":"Verma","year":"2001","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.copbio.2016.11.011_bib0420","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1111\/j.1365-2036.2006.03120.x","article-title":"Effectiveness of an \u2018half elemental diet\u2019 as maintenance therapy for Crohn's disease: a randomized-controlled trial","volume":"24","author":"Takagi","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.copbio.2016.11.011_bib0425","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1002\/ibd.20238","article-title":"Impacts of long-term enteral nutrition on clinical and endoscopic disease activities and mucosal cytokines during remission in patients with Crohn's disease: a prospective study","volume":"13","author":"Yamamoto","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.copbio.2016.11.011_bib0430","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1365-2036.2006.03158.x","article-title":"Impact of long-term enteral nutrition on clinical and endoscopic recurrence after resection for Crohn's disease: a prospective, non-randomized, parallel, controlled study","volume":"25","author":"Yamamoto","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.copbio.2016.11.011_bib0435","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00535-009-0136-5","article-title":"Prospective clinical trial: enteral nutrition during maintenance infliximab in Crohn's disease","volume":"45","author":"Yamamoto","year":"2010","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.copbio.2016.11.011_bib0440","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.dld.2012.03.007","article-title":"Nutritional therapy versus 6-mercaptopurine as maintenance therapy in patients with Crohn's disease","volume":"44","author":"Hanai","year":"2012","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.copbio.2016.11.011_bib0445","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00384-012-1587-3","article-title":"Enteral nutrition to suppress postoperative Crohn's disease recurrence: a five-year prospective cohort study","volume":"28","author":"Yamamoto","year":"2013","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.copbio.2016.11.011_sbref0450","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00384-015-2348-x","article-title":"Enteral nutrition for maintaining remission in patients with quiescent Crohn's disease: current status and future perspectives","volume":"31","author":"Nakahigashi","year":"2016","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.copbio.2016.11.011_bib0455","first-page":"CD005984","article-title":"Enteral nutrition for maintenance of remission in Crohn's disease","volume":"3","author":"Akobeng","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.copbio.2016.11.011_bib0460","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MEG.0b013e32832c788c","article-title":"Enteral nutrition for the maintenance of remission in Crohn's disease: a systematic review","volume":"22","author":"Yamamoto","year":"2010","journal-title":"Eur J Gastroenterol Hepatol"}],"container-title":["Current Opinion in Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958166916302671?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958166916302671?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T08:57:27Z","timestamp":1760691447000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0958166916302671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":46,"alternative-id":["S0958166916302671"],"URL":"https:\/\/doi.org\/10.1016\/j.copbio.2016.11.011","relation":{},"ISSN":["0958-1669"],"issn-type":[{"value":"0958-1669","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary and enteral interventions for Crohn's disease","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.copbio.2016.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}