{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:31:02Z","timestamp":1791441062112,"version":"4.3.3"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"am","delay-in-days":295,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Center for Direct Catalytic Conversion of Biomass to Biofuels"},{"name":"U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences","award":["DE-SC0000997"],"award-info":[{"award-number":["DE-SC0000997"]}]},{"name":"U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, Chemical Sciences, Geosciences, and Biosciences Division","award":["DE-FG02-07ER15905"],"award-info":[{"award-number":["DE-FG02-07ER15905"]}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Biotechnology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.copbio.2018.12.008","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T21:24:03Z","timestamp":1548105843000},"page":"202-208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":148,"special_numbering":"C","title":["Linking phenylpropanoid metabolism, lignin deposition, and plant growth inhibition"],"prefix":"10.1016","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8256-4771","authenticated-orcid":false,"given":"Fabiola","family":"Muro-Villanueva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2748-313X","authenticated-orcid":false,"given":"Xiangying","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5195-562X","authenticated-orcid":false,"given":"Clint","family":"Chapple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.copbio.2018.12.008_bib0005","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.copbio.2013.09.008","article-title":"Lignin plays a negative role in the biochemical process for producing lignocellulosic biofuels","volume":"27","author":"Zeng","year":"2014","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.copbio.2018.12.008_sbref0010","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.copbio.2015.10.009","article-title":"Designer lignins: harnessing the plasticity of lignification","volume":"37","author":"Mottiar","year":"2016","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0015","first-page":"139","article-title":"Inhibition of lignin formation by l-\u03b1-amino-\u03b2-phenylpropanoic acid, an inhibitor of phenylalanine ammonia-lyase","volume":"29","author":"Amrhein","year":"1983","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0020","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF01279727","article-title":"The influence of lignification on the development of vascular tissue in Vigna radiata L","volume":"124","author":"Smart","year":"1985","journal-title":"Protoplasma"},{"key":"10.1016\/j.copbio.2018.12.008_bib0025","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cbpa.2015.08.006","article-title":"Genetic manipulation of lignocellulosic biomass for bioenergy","volume":"29","author":"Wang","year":"2015","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0030","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.copbio.2012.11.004","article-title":"Can genetic engineering of lignin deposition be accomplished without an unacceptable yield penalty?","volume":"24","author":"Bonawitz","year":"2013","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0035","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1365-313X.2002.01266.x","article-title":"The Arabidopsis REF8 gene encodes the 3-hydroxylase of phenylpropanoid metabolism","volume":"30","author":"Franke","year":"2002","journal-title":"Plant J"},{"key":"10.1016\/j.copbio.2018.12.008_bib0040","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1105\/tpc.020297","article-title":"Silencing of Hydroxycinnamoyl-Coenzyme A Shikimate\/Quinate Hydroxycinnamoyltransferase affects phenylpropanoid biosynthesis","volume":"16","author":"Hoffmann","year":"2004","journal-title":"Plant Cell"},{"key":"10.1016\/j.copbio.2018.12.008_bib0045","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00425-007-0558-3","article-title":"Both caffeoyl-Coenzyme A 3-O-methyltransferase 1 and caffeic acid O-methyltransferase 1 are involved in redundant functions for lignin, flavonoids and sinapoyl malate biosynthesis in Arabidopsis","volume":"226","author":"Do","year":"2007","journal-title":"Planta"},{"key":"10.1016\/j.copbio.2018.12.008_bib0050","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1365-313X.2009.03996.x","article-title":"Mutations in the cinnamate 4-hydroxylase gene impact metabolism, growth and development in Arabidopsis","volume":"60","author":"Schilmiller","year":"2009","journal-title":"Plant J"},{"key":"10.1016\/j.copbio.2018.12.008_bib0055","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1105\/tpc.107.054148","article-title":"Downregulation of Cinnamoyl-Coenzyme A Reductase in poplar: multiple-level phenotyping reveals effects on cell wall polymer metabolism and structure","volume":"19","author":"Lepl\u00e9","year":"2007","journal-title":"Plant Cell"},{"key":"10.1016\/j.copbio.2018.12.008_bib0060","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/j.1469-8137.2010.03572.x","article-title":"Reduced wood stiffness and strength, and altered stem form, in young antisense 4CL transgenic poplars with reduced lignin contents","volume":"189","author":"Voelker","year":"2011","journal-title":"New Phytol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0065","article-title":"Improving wood properties for wood utilization through multi-omics integration in lignin biosynthesis","volume":"9","author":"Wang","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2018.12.008_bib0070","doi-asserted-by":"crossref","first-page":"16573","DOI":"10.1073\/pnas.0505749102","article-title":"Targeted down-regulation of cytochrome P450 enzymes for forage quality improvement in alfalfa (Medicago sativa L.)","volume":"102","author":"Reddy","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.copbio.2018.12.008_bib0075","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1469-8137.2010.03621.x","article-title":"Selective lignin downregulation leads to constitutive defense response expression in alfalfa (Medicago sativa L.)","volume":"190","author":"Gallego-Giraldo","year":"2011","journal-title":"New Phytol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0080","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1046\/j.1365-313X.1998.00014.x","article-title":"Down-regulation of Cinnamoyl-CoA Reductase induces significant changes of lignin profiles in transgenic tobacco plants","volume":"13","author":"Piquemal","year":"1998","journal-title":"Plant J"},{"key":"10.1016\/j.copbio.2018.12.008_bib0085","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s00425-003-0987-6","article-title":"Down-regulation of the AtCCR1 gene in Arabidopsis thaliana: effects on phenotype, lignins and cell wall degradability","volume":"217","author":"Goujon","year":"2003","journal-title":"Planta"},{"key":"10.1016\/j.copbio.2018.12.008_bib0090","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1104\/pp.110.157370","article-title":"Functional analysis of the Arabidopsis PAL gene family in plant growth, development, and response to environmental stress","volume":"153","author":"Huang","year":"2010","journal-title":"Plant Physiol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0095","first-page":"2409","article-title":"Four isoforms of Arabidopsis 4-coumarate:CoA ligase have overlapping yet distinct roles in phenylpropanoid metabolism","volume":"169","author":"Li","year":"2015","journal-title":"Plant Physiol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0100","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.phytochem.2007.03.022","article-title":"Down-regulation of Hydroxycinnamoyl CoA: Shikimate Hydroxycinnamoyl Transferase in transgenic alfalfa affects lignification, development and forage quality","volume":"68","author":"Shadle","year":"2007","journal-title":"Phytochemistry"},{"key":"10.1016\/j.copbio.2018.12.008_bib0105","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1126\/science.1241602","article-title":"Caffeoyl shikimate esterase (CSE) is an enzyme in the lignin biosynthetic pathway in Arabidopsis","volume":"341","author":"Vanholme","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.copbio.2018.12.008_bib0110","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/tpj.13177","article-title":"An essential role of caffeoyl shikimate esterase in monolignol biosynthesis in Medicago truncatula","volume":"86","author":"Ha","year":"2016","journal-title":"Plant J"},{"key":"10.1016\/j.copbio.2018.12.008_bib0115","first-page":"1413","article-title":"An Arabidopsis mutant defective in the general phenylpropanoid pathway","volume":"4","author":"Chapple","year":"1992","journal-title":"Plant Cell"},{"key":"10.1016\/j.copbio.2018.12.008_bib0120","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1023\/A:1023022825098","article-title":"A new Arabidopsis thaliana mutant deficient in the expression of O-methyltransferase impacts lignins and sinapoyl esters","volume":"51","author":"Goujon","year":"2003","journal-title":"Plant Mol Biol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0125","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1073\/pnas.1100310108","article-title":"Genetic manipulation of lignin reduces recalcitrance and improves ethanol production from switchgrass","volume":"108","author":"Fu","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.copbio.2018.12.008_bib0130","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1104\/pp.112.4.1479","article-title":"Red xylem and higher lignin extractability by down-regulating a Cinnamyl Alcohol Dehydrogenase in poplar","volume":"112","author":"Baucher","year":"1996","journal-title":"Plant Physiol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0135","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1105\/tpc.105.030767","article-title":"CINNAMYL ALCOHOL DEHYDROGENASE-C and -D are the primary genes involved in lignin biosynthesis in the floral stem of Arabidopsis","volume":"17","author":"Sibout","year":"2005","journal-title":"Plant Cell"},{"key":"10.1016\/j.copbio.2018.12.008_sbref0140","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1104\/pp.17.01462","article-title":"Vessel-specific reintroduction of CINNAMOYL-COA REDUCTASE 1 (CCR1) in dwarfed ccr1 mutants restores vessel and xylary fiber integrity and increases biomass","volume":"176","author":"De Meester","year":"2018","journal-title":"Plant Physiol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0145","first-page":"2159","article-title":"Disruption of interfascicular fiber differentiation in an Arabidopsis mutant","volume":"9","author":"Zhong","year":"1997","journal-title":"Plant Cell"},{"key":"10.1016\/j.copbio.2018.12.008_bib0150","first-page":"689","article-title":"Collapsed xylem phenotype of Arabidopsis identifies mutants deficient in cellulose deposition in the secondary cell wall","volume":"9","author":"Turner","year":"1997","journal-title":"Plant Cell"},{"key":"10.1016\/j.copbio.2018.12.008_bib0155","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1046\/j.1365-313x.2001.01021.x","article-title":"Cloning and characterization of irregular xylem4 (irx4): a severely lignin-deficient mutant of Arabidopsis","volume":"26","author":"Jones","year":"2001","journal-title":"Plant J"},{"key":"10.1016\/j.copbio.2018.12.008_bib0160","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1046\/j.1365-313X.2002.01267.x","article-title":"Changes in secondary metabolism and deposition of an unusual lignin in the ref8 mutant of Arabidopsis","volume":"30","author":"Franke","year":"2002","journal-title":"Plant J"},{"key":"10.1016\/j.copbio.2018.12.008_bib0165","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1534\/genetics.107.083881","article-title":"Semidominant mutations in Reduced Epidermal Fluorescence 4 reduce phenylpropanoid content in Arabidopsis","volume":"178","author":"Stout","year":"2008","journal-title":"Genetics"},{"key":"10.1016\/j.copbio.2018.12.008_bib0170","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1105\/tpc.108.061325","article-title":"A battery of transcription factors involved in the regulation of secondary cell wall biosynthesis in Arabidopsis","volume":"20","author":"Zhong","year":"2008","journal-title":"Plant Cell"},{"key":"10.1016\/j.copbio.2018.12.008_bib0175","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1105\/tpc.108.063321","article-title":"MYB58 and MYB63 are transcriptional activators of the lignin biosynthetic pathway during secondary cell wall formation in Arabidopsis","volume":"21","author":"Zhou","year":"2009","journal-title":"Plant Cell"},{"key":"10.1016\/j.copbio.2018.12.008_bib0180","first-page":"1","article-title":"Arabidopsis NAC domain proteins, VND1 to VND5, are transcriptional regulators of secondary wall biosynthesis in vessels","volume":"9","author":"Zhou","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.copbio.2018.12.008_bib0185","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1105\/tpc.106.049320","article-title":"Arabidopsis irregular xylem8 and irregular xylem9: implications for the complexity of glucuronoxylan biosynthesis","volume":"19","author":"Pe\u00f1a","year":"2007","journal-title":"Plant Cell"},{"key":"10.1016\/j.copbio.2018.12.008_bib0190","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/j.1365-313X.2007.03307.x","article-title":"Comparison of five xylan synthesis mutants reveals new insight into the mechanisms of xylan synthesis","volume":"52","author":"Brown","year":"2007","journal-title":"Plant J"},{"key":"10.1016\/j.copbio.2018.12.008_bib0195","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1007\/s00425-007-0498-y","article-title":"Two NAC domain transcription factors, SND1 and NST1, function redundantly in regulation of secondary wall synthesis in fibers of Arabidopsis","volume":"225","author":"Zhong","year":"2007","journal-title":"Planta"},{"key":"10.1016\/j.copbio.2018.12.008_bib0200","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/pbi.12016","article-title":"Engineering secondary cell wall deposition in plants","volume":"11","author":"Yang","year":"2013","journal-title":"Plant Biotechnol J"},{"key":"10.1016\/j.copbio.2018.12.008_bib0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13068-016-0551-9","article-title":"Improving total saccharification yield of Arabidopsis plants by vessel-specific complementation of caffeoyl shikimate esterase (cse) mutants","volume":"9","author":"Vargas","year":"2016","journal-title":"Biotechnol Biofuels"},{"key":"10.1016\/j.copbio.2018.12.008_sbref0210","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1104\/pp.17.00434","article-title":"Defining the diverse cell populations contributing to lignification in Arabidopsis stems","volume":"174","author":"Smith","year":"2017","journal-title":"Plant Physiol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0215","first-page":"589","article-title":"Trans-cinnamic acid as an anti-auxin","volume":"38","author":"Van Overbeek","year":"1951","journal-title":"Am J Bot"},{"key":"10.1016\/j.copbio.2018.12.008_bib0220","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.plaphy.2005.08.008","article-title":"Study of cis-cinnamic acid in Arabidopsis thaliana","volume":"43","author":"Wong","year":"2005","journal-title":"Plant Physiol Biochem"},{"key":"10.1016\/j.copbio.2018.12.008_bib0225","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2307\/3869805","article-title":"Auxin polar transport is essential for the establishment of bilateral symmetry during early plant embryogenesis","volume":"5","author":"Liu","year":"1993","journal-title":"Plant Cell"},{"key":"10.1016\/j.copbio.2018.12.008_bib0230","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1104\/pp.16.00943","article-title":"cis-Cinnamic acid is a novel, natural auxin efflux inhibitor that promotes lateral root formation","volume":"173","author":"Steenackers","year":"2017","journal-title":"Plant Physiol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0235","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/bies.950160209","article-title":"The flavonoid biosynthetic pathway in plants: function and evolution","volume":"16","author":"Koes","year":"1994","journal-title":"BioEssays"},{"key":"10.1016\/j.copbio.2018.12.008_bib0240","first-page":"1013","article-title":"A null mutation in the first enzyme of flavonoid biosynthesis does not affect male fertility in Arabidopsis","volume":"8","author":"Burbulis","year":"1996","journal-title":"Plant Cell"},{"key":"10.1016\/j.copbio.2018.12.008_bib0245","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1105\/tpc.106.044495","article-title":"Flavonoid accumulation in Arabidopsis repressed in lignin synthesis affects auxin transport and plant growth","volume":"19","author":"Besseau","year":"2007","journal-title":"Plant Cell"},{"key":"10.1016\/j.copbio.2018.12.008_bib0250","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1105\/tpc.110.074161","article-title":"The growth reduction associated with repressed lignin biosynthesis in Arabidopsis thaliana is independent of flavonoids","volume":"22","author":"Li","year":"2010","journal-title":"Plant Cell"},{"key":"10.1016\/j.copbio.2018.12.008_bib0255","doi-asserted-by":"crossref","first-page":"20814","DOI":"10.1073\/pnas.1117873108","article-title":"Salicylic acid mediates the reduced growth of lignin down-regulated plants","volume":"108","author":"Gallego-Giraldo","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.copbio.2018.12.008_bib0260","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature13084","article-title":"Disruption of mediator rescues the stunted growth of a lignin-deficient Arabidopsis mutant","volume":"509","author":"Bonawitz","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.copbio.2018.12.008_bib0265","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/tpj.12902","article-title":"CCR1, an enzyme required for lignin biosynthesis in Arabidopsis, mediates cell proliferation exit for leaf development","volume":"83","author":"Xue","year":"2015","journal-title":"Plant J"},{"key":"10.1016\/j.copbio.2018.12.008_bib0270","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1073\/pnas.84.4.980","article-title":"Cell division promoting activity of naturally occurring dehydrodiconiferyl glucosides: do cell wall components control cell division?","volume":"84","author":"Binns","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.copbio.2018.12.008_bib0275","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1104\/pp.97.1.288","article-title":"Activity and accumulation of cell division-promoting phenolics in tobacco tissue cultures","volume":"97","author":"Teutonico","year":"1991","journal-title":"Plant Physiol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0280","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1104\/pp.18.00178","article-title":"Scopoletin 8-hydroxylase-mediated fraxetin production is crucial for iron mobilization","volume":"177","author":"Tsai","year":"2018","journal-title":"Plant Physiol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0285","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41589-018-0019-2","article-title":"Biosynthesis of redox-active metabolites in response to iron deficiency in plants","volume":"14","author":"Rajniak","year":"2018","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0290","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.phytochem.2014.09.019","article-title":"The plant cell wall integrity maintenance mechanism\u2014a case study of a cell wall plasma membrane signaling network","volume":"112","author":"Hamann","year":"2015","journal-title":"Phytochemistry"},{"key":"10.1016\/j.copbio.2018.12.008_bib0295","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1534\/genetics.111.128264","article-title":"Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway","volume":"189","author":"Levin","year":"2011","journal-title":"Genetics"},{"key":"10.1016\/j.copbio.2018.12.008_bib0300","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1086\/367580","article-title":"Out of the quagmire of plant defense hypotheses","volume":"78","author":"Stamp","year":"2003","journal-title":"Q Rev Biol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0305","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/pcp\/pci026","article-title":"Wall-associated kinase WAK1 interacts with cell wall pectins in a calcium-induced conformation","volume":"46","author":"Decreux","year":"2005","journal-title":"Plant Cell Physiol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0310","doi-asserted-by":"crossref","first-page":"9452","DOI":"10.1073\/pnas.1000675107","article-title":"A domain swap approach reveals a role of the plant wall-associated kinase 1 (WAK1) as a receptor of oligogalacturonides","volume":"107","author":"Brutus","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.copbio.2018.12.008_bib0315","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.cub.2007.05.018","article-title":"A receptor-like kinase mediates the response of Arabidopsis cells to the inhibition of cellulose synthesis","volume":"17","author":"H\u00e9maty","year":"2007","journal-title":"Curr Biol"},{"key":"10.1016\/j.copbio.2018.12.008_sbref0320","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/nph.15258","article-title":"Elicitors and defense gene induction in plants with altered lignin compositions","volume":"219","author":"Gallego-Giraldo","year":"2018","journal-title":"New Phytol"},{"key":"10.1016\/j.copbio.2018.12.008_bib0325","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.1073\/pnas.95.12.6619","article-title":"Lignin monomer composition is determined by the expression of a cytochrome P450-dependent monooxygenase in Arabidopsis","volume":"95","author":"Meyer","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.copbio.2018.12.008_bib0330","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.1074\/jbc.M111.312298","article-title":"REF4 and RFR1, subunits of the transcriptional coregulatory complex Mediator, are required for phenylpropanoid homeostasis in Arabidopsis","volume":"287","author":"Bonawitz","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.copbio.2018.12.008_sbref0335","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1105\/tpc.17.00282","article-title":"Mediator complex subunits MED2, MED5, MED16, and MED23 genetically interact in the regulation of phenylpropanoid biosynthesis","volume":"29","author":"Dolan","year":"2017","journal-title":"Plant Cell"},{"key":"10.1016\/j.copbio.2018.12.008_bib0340","doi-asserted-by":"crossref","first-page":"16048","DOI":"10.1073\/pnas.1521675112","article-title":"Identification of MEDIATOR16 as the Arabidopsis COBRA suppressor MONGOOSE1","volume":"112","author":"Sorek","year":"2015","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Current Opinion in Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958166918301332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958166918301332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T09:05:59Z","timestamp":1760691959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0958166918301332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":68,"alternative-id":["S0958166918301332"],"URL":"https:\/\/doi.org\/10.1016\/j.copbio.2018.12.008","relation":{},"ISSN":["0958-1669"],"issn-type":[{"value":"0958-1669","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Linking phenylpropanoid metabolism, lignin deposition, and plant growth inhibition","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.copbio.2018.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}