{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:09:04Z","timestamp":1788588544936,"version":"build-2803163510"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006235","name":"Lawrence Berkeley National Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006235","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["CE230100015"],"award-info":[{"award-number":["CE230100015"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006132","name":"Office of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001786","name":"University of Adelaide","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006206","name":"Biological and Environmental Research","doi-asserted-by":"publisher","award":["DE-AC02-05CH11231"],"award-info":[{"award-number":["DE-AC02-05CH11231"]}],"id":[{"id":"10.13039\/100006206","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","bmn.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Biotechnology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.copbio.2024.103069","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T23:41:43Z","timestamp":1707522103000},"page":"103069","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Green horizons: how plant synthetic biology can enable space exploration and drive on Earth sustainability"],"prefix":"10.1016","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5456-179X","authenticated-orcid":false,"given":"Matthew Fox","family":"Morgan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Diab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Gilliham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny C","family":"Mortimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.copbio.2024.103069_bib1","unstructured":"\u3008https:\/\/www.space.com\/india-chandrayaan-3-global-moon-race\u3009 [Accessed 28 December 2023]."},{"key":"10.1016\/j.copbio.2024.103069_bib2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.copbio.2021.08.018","article-title":"SpaceHort: redesigning plants to support space exploration and on-earth sustainability","volume":"73","author":"Mortimer","year":"2022","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.copbio.2024.103069_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/genes9070348","article-title":"The multiplanetary future of plant synthetic biology","volume":"9","author":"Llorente","year":"2018","journal-title":"Genes"},{"key":"10.1016\/j.copbio.2024.103069_sbref3","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1080\/07388551.2021.1888070","article-title":"Molecular pharming to support human life on the moon, mars, and beyond","volume":"41","author":"McNulty","year":"2021","journal-title":"Crit Rev Biotechnol"},{"key":"10.1016\/j.copbio.2024.103069_bib5","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.actaastro.2013.11.031","article-title":"Greenhouses and their humanizing synergies","volume":"96","author":"Haeuplik-Meusburger","year":"2014","journal-title":"Acta Astronaut"},{"key":"10.1016\/j.copbio.2024.103069_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines9090992","article-title":"Plant-based COVID-19 vaccines: current status, design, and development strategies of candidate vaccines","volume":"9","author":"Maharjan","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.copbio.2024.103069_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/biom11010093","article-title":"Research progress of a potential bioreactor: duckweed","volume":"11","author":"Yang","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.copbio.2024.103069_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2022.107946","article-title":"Cyanobacteria and microalgae in supporting human habitation on Mars","volume":"59","author":"Mapstone","year":"2022","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.copbio.2024.103069_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fspas.2021.700370","article-title":"Choice of microbial system for in-situ resource utilization on mars","volume":"8","author":"Averesch","year":"2021","journal-title":"Front Astron Space Sci"},{"key":"10.1016\/j.copbio.2024.103069_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.700010","article-title":"Production of PHB from CO2-derived acetate with minimal processing assessed for space biomanufacturing","volume":"12","author":"Cestellos-Blanco","year":"2021","journal-title":"Front Microbiol"},{"key":"10.1016\/j.copbio.2024.103069_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-37910-1","article-title":"Microbial biomanufacturing for space-exploration \u2014 what to take and when to make","volume":"14","author":"Averesch","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2024.103069_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fspas.2021.733944","article-title":"Large-scale crop production for the moon and mars: current gaps and future perspectives","volume":"8","author":"Poulet","year":"2022","journal-title":"Front Astron Space Sci"},{"key":"10.1016\/j.copbio.2024.103069_bib13","unstructured":"Biofuels Market Size, Share & Growth Analysis Report, 2030. [date unknown]."},{"key":"10.1016\/j.copbio.2024.103069_bib14","series-title":"Billion-Ton Report: Advancing Domestic Resources for a Thriving Bioeconomy","author":"Langholtz","year":"2016"},{"key":"10.1016\/j.copbio.2024.103069_bib15","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41579-021-00577-w","article-title":"Microbial production of advanced biofuels","volume":"19","author":"Keasling","year":"2021","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.copbio.2024.103069_bib16","doi-asserted-by":"crossref","first-page":"8639","DOI":"10.1073\/pnas.2000053117","article-title":"Accumulation of high-value bioproducts in planta can improve the economics of advanced biofuels","volume":"117","author":"Yang","year":"2020","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.copbio.2024.103069_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/s13068-017-1007-6","article-title":"Gene stacking of multiple traits for high yield of fermentable sugars in plant biomass","volume":"11","author":"Aznar","year":"2018","journal-title":"Biotechnol Biofuels"},{"key":"10.1016\/j.copbio.2024.103069_bib18","unstructured":"Cost for Space Launch to Low Earth Orbit-Aerospace Security Project. Aerosp Secur; 2022."},{"key":"10.1016\/j.copbio.2024.103069_bib19","unstructured":"Orbex: World\u2019s Most Environmentally friendly space rocket | Orbex. [date unknown]."},{"key":"10.1016\/j.copbio.2024.103069_sbref16","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.joule.2022.05.011","article-title":"Biosynthesis of polycyclopropanated high energy biofuels","volume":"6","author":"Cruz-Morales","year":"2022","journal-title":"Joule"},{"key":"10.1016\/j.copbio.2024.103069_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-26393-7","article-title":"Designing the bioproduction of Martian rocket propellant via a biotechnology-enabled in situ resource utilization strategy","volume":"12","author":"Kruyer","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2024.103069_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.pss.2020.104850","article-title":"Mining moon & mars with microbes: biological approaches to extract iron from Lunar and Martian regolith","volume":"184","author":"Volger","year":"2020","journal-title":"Planet Space Sci"},{"key":"10.1016\/j.copbio.2024.103069_bib23","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1126\/science.aaz5819","article-title":"Plastic rain in protected areas of the United States","volume":"368","author":"Brahney","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.copbio.2024.103069_sbref20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41578-021-00407-8","article-title":"Bioplastics for a circular economy","volume":"7","author":"Rosenboom","year":"2022","journal-title":"Nat Rev Mater"},{"key":"10.1016\/j.copbio.2024.103069_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/polym12081641","article-title":"Bio-Polyethylene (Bio-PE), Bio-Polypropylene (Bio-PP) and Bio-Poly(ethylene terephthalate) (Bio-PET): recent developments in bio-based polymers analogous to petroleum-derived ones for packaging and engineering applications","volume":"12","author":"Siracusa","year":"2020","journal-title":"Polymers"},{"key":"10.1016\/j.copbio.2024.103069_bib26","series-title":"In-Space Manufacturing","author":"Litkenhous","year":"2019"},{"key":"10.1016\/j.copbio.2024.103069_bib27","first-page":"60","article-title":"The development and challenges of poly (lactic acid) and poly (glycolic acid)","volume":"3","author":"Jem","year":"2020","journal-title":"Adv Ind Eng Polym Res"},{"key":"10.1016\/j.copbio.2024.103069_bib28","unstructured":"PHA: A Biopolymer Whose Time Has Finally Come. Chem Eng News [date unknown]."},{"key":"10.1016\/j.copbio.2024.103069_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2022.111044","article-title":"Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBH): synthesis, properties, and applications \u2014 a review","volume":"167","author":"Eraslan","year":"2022","journal-title":"Eur Polym J"},{"key":"10.1016\/j.copbio.2024.103069_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23020362","article-title":"Biodegradable and biocompatible Polyhydroxy-alkanoates (PHA): auspicious microbial macromolecules for pharmaceutical and therapeutic applications","volume":"23","author":"Koller","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.copbio.2024.103069_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.00257","article-title":"Poly(4-Hydroxybutyrate): current state and perspectives","volume":"8","author":"Utsunomia","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.copbio.2024.103069_bib32","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1104\/pp.110.169581","article-title":"High levels of bioplastic are produced in fertile transplastomic tobacco plants engineered with a synthetic operon for the production of Polyhydroxybutyrate1[C][OA]","volume":"155","author":"Bohmert-Tatarev","year":"2011","journal-title":"Plant Physiol"},{"key":"10.1016\/j.copbio.2024.103069_bib33","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1467-7652.2012.00686.x","article-title":"Enhanced polyhydroxybutyrate production in transgenic sugarcane","volume":"10","author":"Petrasovits","year":"2012","journal-title":"Plant Biotechnol J"},{"key":"10.1016\/j.copbio.2024.103069_bib34","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1467-7652.2008.00350.x","article-title":"Production of polyhydroxybutyrate in switchgrass, a value-added co-product in an important lignocellulosic biomass crop","volume":"6","author":"Somleva","year":"2008","journal-title":"Plant Biotechnol J"},{"key":"10.1016\/j.copbio.2024.103069_bib35","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s004250000350","article-title":"Transgenic Arabidopsis plants can accumulate polyhydroxybutyrate to up to 4% of their fresh weight","volume":"211","author":"Bohmert","year":"2000","journal-title":"Planta"},{"key":"10.1016\/j.copbio.2024.103069_bib36","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/j.1467-7652.2010.00585.x","article-title":"Trade-offs between biomass growth and inducible biosynthesis of polyhydroxybutyrate in transgenic poplar","volume":"9","author":"Dalton","year":"2011","journal-title":"Plant Biotechnol J"},{"key":"10.1016\/j.copbio.2024.103069_bib37","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41557-019-0249-2","article-title":"Closed-loop recycling of plastics enabled by dynamic covalent diketoenamine bonds","volume":"11","author":"Christensen","year":"2019","journal-title":"Nat Chem"},{"key":"10.1016\/j.copbio.2024.103069_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abf0187","article-title":"Leveling the cost and carbon footprint of circular polymers that are chemically recycled to monomer","volume":"7","author":"Vora","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.copbio.2024.103069_sbref34","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1038\/s41893-023-01160-2","article-title":"Biorenewable and circular polydiketoenamine plastics","volume":"6","author":"Demarteau","year":"2023","journal-title":"Nat Sustain"},{"key":"10.1016\/j.copbio.2024.103069_sbref35","article-title":"Comparing in planta accumulation with microbial routes to set targets for a cost-competitive bioeconomy","volume":"119","author":"Yang","year":"2022","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.copbio.2024.103069_bib41","doi-asserted-by":"crossref","first-page":"8639","DOI":"10.1073\/pnas.2000053117","article-title":"Accumulation of high-value bioproducts in planta can improve the economics of advanced biofuels","volume":"117","author":"None.Yang","year":"2020","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.copbio.2024.103069_bib42","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10529-022-03247-w","article-title":"Current advances and future prospects in production of recombinant insulin and other proteins to treat diabetes mellitus","volume":"44","author":"Bhoria","year":"2022","journal-title":"Biotechnol Lett"},{"key":"10.1016\/j.copbio.2024.103069_bib43","unstructured":"Accelerating the Biomanufacturing Revolution. World Econ Forum [date unknown]."},{"key":"10.1016\/j.copbio.2024.103069_sbref38","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ymben.2021.09.001","article-title":"Design and construction of an artificial pathway for biosynthesis of acetaminophen in Escherichia coli","volume":"68","author":"Shen","year":"2021","journal-title":"Metab Eng"},{"key":"10.1016\/j.copbio.2024.103069_sbref39","first-page":"53","article-title":"Plant-made pharmaceuticals: exploring studies for the production of recombinant protein in plants and assessing challenges ahead","volume":"17","author":"Lee","year":"2023","journal-title":"Plant Biotechnol Rep"},{"key":"10.1016\/j.copbio.2024.103069_bib46","article-title":"Plant molecular farming for the production of valuable proteins \u2014 critical evaluation of achievements and future challenges","volume":"258\u2013259","author":"Schillberg","year":"2021","journal-title":"J Plant Physiol"},{"key":"10.1016\/j.copbio.2024.103069_bib47","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature13777","article-title":"Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp","volume":"514","author":"Qiu","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.copbio.2024.103069_bib48","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1056\/NEJMoa2201300","article-title":"Efficacy and safety of a recombinant plant-based adjuvanted Covid-19 vaccine","volume":"386","author":"Hager","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.copbio.2024.103069_bib49","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3357\/AMHP.5392.2020","article-title":"Dose tracker application for collecting medication use data from International Space Station Crew","volume":"91","author":"Wotring Virginia","year":"2020","journal-title":"Aerosp Med Hum Perform"},{"key":"10.1016\/j.copbio.2024.103069_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/s41526-019-0075-2","article-title":"Supplying a pharmacy for NASA exploration spaceflight: challenges and current understanding","volume":"5","author":"Blue","year":"2019","journal-title":"NPJ Microgravity"},{"key":"10.1016\/j.copbio.2024.103069_bib51","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1208\/s12248-011-9270-0","article-title":"Evaluation of physical and chemical changes in pharmaceuticals flown on space missions","volume":"13","author":"Du","year":"2011","journal-title":"AAPS J"},{"key":"10.1016\/j.copbio.2024.103069_bib52","unstructured":"NASA: National Aeronautics and Space Administration (NASA) Emergency Medical Procedures Manual for the International Space Station (ISS) [partial], 2016; 2016."},{"key":"10.1016\/j.copbio.2024.103069_bib53","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41591-021-01637-7","article-title":"Hemolysis contributes to anemia during long-duration space flight","volume":"28","author":"Trudel","year":"2022","journal-title":"Nat Med"},{"key":"10.1016\/j.copbio.2024.103069_bib54","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1136\/bjsports-2020-103602","article-title":"Pre-flight exercise and bone metabolism predict unloading-induced bone loss due to spaceflight","volume":"56","author":"Gabel","year":"2022","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.copbio.2024.103069_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41526-022-00194-8","article-title":"The effects of microgravity on bone structure and function","volume":"8","author":"Man","year":"2022","journal-title":"Npj Microgravity"},{"key":"10.1016\/j.copbio.2024.103069_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24044095","article-title":"Space omics and tissue response in astronaut skeletal muscle after short and long duration missions","volume":"24","author":"Blottner","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.copbio.2024.103069_bib57","doi-asserted-by":"crossref","DOI":"10.1097\/BRS.0000000000002959","article-title":"Negative effects of long-duration spaceflight on paraspinal muscle morphology","volume":"44","author":"Burkhart","year":"2019","journal-title":"Spine"},{"key":"10.1016\/j.copbio.2024.103069_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032328","article-title":"A mission to mars: prediction of GCR doses and comparison with astronaut dose limits","volume":"24","author":"Ramos","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.copbio.2024.103069_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096099","article-title":"Space radiation risks for astronauts on multiple international space station missions","volume":"9","author":"Cucinotta","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.copbio.2024.103069_bib60","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.lssr.2021.07.005","article-title":"A proposed change to astronaut exposures limits is a giant leap backwards for radiation protection","volume":"31","author":"Cucinotta","year":"2021","journal-title":"Life Sci Space Res"},{"key":"10.1016\/j.copbio.2024.103069_bib61","article-title":"Effects of intermittent administration of parathyroid hormone and parathyroid hormone-related protein on fracture healing: a narrative review of animal and human studies","volume":"3","author":"Yamashita","year":"2019","journal-title":"JBMR"},{"key":"10.1016\/j.copbio.2024.103069_bib62","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1007\/s00198-023-06809-4","article-title":"The effect of intermittent parathyroid hormone on bone lengthening: current evidence to inform future effective interventions","volume":"34","author":"Kitcharanant","year":"2023","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.copbio.2024.103069_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160034","article-title":"The role of Parathyroid Hormone-Related Protein (PTHrP) in osteoblast response to microgravity: mechanistic implications for osteoporosis development","volume":"11","author":"Camirand","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.copbio.2024.103069_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14740\/jem849","article-title":"The effect of microgravity on parathyroid hormone secretion: a meta-analysis","volume":"13","author":"Blue","year":"2023","journal-title":"J Endocrinol Metab"},{"key":"10.1016\/j.copbio.2024.103069_bib65","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.962292","article-title":"Plant-based production and characterization of a promising Fc-fusion protein against microgravity-induced bone density loss","volume":"10","author":"Xiong","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.copbio.2024.103069_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124125","article-title":"The role of insulin-like growth factor-1 in bone remodeling: a review","volume":"238","author":"Fang","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.copbio.2024.103069_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/app10134433","article-title":"Microgravity, bone homeostasis, and insulin-like growth factor-1","volume":"10","author":"Smith","year":"2020","journal-title":"Appl Sci"},{"key":"10.1016\/j.copbio.2024.103069_bib68","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.actaastro.2012.08.007","article-title":"Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading","volume":"92","author":"Kubota","year":"2013","journal-title":"Acta Astronaut"},{"key":"10.1016\/j.copbio.2024.103069_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ghir.2017.07.003","article-title":"Recombinant human IGF-1 produced by transgenic plant cell suspension culture enhances new bone formation in calvarial defects","volume":"36","author":"Poudel","year":"2017","journal-title":"Growth Horm IGF Res"},{"key":"10.1016\/j.copbio.2024.103069_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119591","article-title":"Oral delivery of novel human IGF-1 bioencapsulated in lettuce cells promotes musculoskeletal cell proliferation, differentiation and diabetic fracture healing","volume":"233","author":"Park","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.copbio.2024.103069_bib71","first-page":"53","article-title":"Plant-made pharmaceuticals: exploring studies for the production of recombinant protein in plants and assessing challenges ahead","volume":"17","author":"Lee","year":"2023","journal-title":"Plant Biotechnol Rep"},{"key":"10.1016\/j.copbio.2024.103069_bib72","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.plantsci.2018.03.012","article-title":"Towards a sustainable bio-based economy: redirecting primary metabolism to new products with plant synthetic biology","volume":"273","author":"Shih","year":"2018","journal-title":"Plant Sci"},{"key":"10.1016\/j.copbio.2024.103069_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.plantsci.2023.111815","article-title":"Running the numbers on plant synthetic biology solutions to global problems","volume":"335","author":"Van Gelder","year":"2023","journal-title":"Plant Sci"},{"key":"10.1016\/j.copbio.2024.103069_bib74","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1038\/s41587-022-01383-2","article-title":"Synthetic memory circuits for stable cell reprogramming in plants","volume":"40","author":"Lloyd","year":"2022","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.copbio.2024.103069_bib75","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1021\/acssynbio.0c00637","article-title":"Construction of DNA tools for hyperexpression in Marchantia chloroplasts","volume":"10","author":"Frangedakis","year":"2021","journal-title":"ACS Synth Biol"},{"key":"10.1016\/j.copbio.2024.103069_bib76","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s00299-018-2293-6","article-title":"Physcomitrella patens, a versatile synthetic biology chassis","volume":"37","author":"Reski","year":"2018","journal-title":"Plant Cell Rep"},{"key":"10.1016\/j.copbio.2024.103069_bib77","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.tplants.2021.11.014","article-title":"Wolffia, a minimalist plant and synthetic biology chassis","volume":"27","author":"Lam","year":"2022","journal-title":"Trends Plant Sci"}],"container-title":["Current Opinion in Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958166924000053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958166924000053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T17:50:58Z","timestamp":1724435458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0958166924000053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":77,"alternative-id":["S0958166924000053"],"URL":"https:\/\/doi.org\/10.1016\/j.copbio.2024.103069","relation":{},"ISSN":["0958-1669"],"issn-type":[{"value":"0958-1669","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Green horizons: how plant synthetic biology can enable space exploration and drive on Earth sustainability","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.copbio.2024.103069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103069"}}