{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T23:50:58Z","timestamp":1792281058916,"version":"4.4.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"CONACYT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","bmn.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Biotechnology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.copbio.2024.103106","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T05:47:45Z","timestamp":1710395265000},"page":"103106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Neutrophils, an emerging new therapeutic platform"],"prefix":"10.1016","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3557-5122","authenticated-orcid":false,"given":"Alejandra","family":"L\u00f3pez-Arredondo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A","family":"Cruz-Cardenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A","family":"C\u00e1zares-Preciado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas E","family":"Timmins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion EG","family":"Brunck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.copbio.2024.103106_bib1","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1182\/blood-2016-03-700336","article-title":"Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives","volume":"127","author":"Lahoz-Beneytez","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.copbio.2024.103106_bib2","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1182\/blood-2015-05-645986","article-title":"Efficacy of transfusion with granulocytes from G-CSF\/dexamethasone\u2013treated donors in neutropenic patients with infection","volume":"126","author":"Price","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.copbio.2024.103106_bib3","first-page":"152","article-title":"A randomized controlled trial to explore the safety and efficacy of irradiated buffy-coat granulocytes in pediatric patients with febrile neutropenia","volume":"13","author":"Ramachandran","year":"2023","journal-title":"Am J Blood Res"},{"key":"10.1016\/j.copbio.2024.103106_bib4","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1111\/j.1537-2995.2006.00996.x","article-title":"Safety and efficacy of therapeutic early onset granulocyte transfusions in pediatric patients with neutropenia and severe infections","volume":"46","author":"Sachs","year":"2006","journal-title":"Transfusion"},{"key":"10.1016\/j.copbio.2024.103106_bib5","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/bjh.18863","article-title":"Granulocyte transfusion during cord blood transplant for relapsed, refractory AML is associated with massive CD8+ T-cell expansion, significant cytokine release syndrome and induction of disease remission","volume":"202","author":"Borrill","year":"2023","journal-title":"Br J Haematol"},{"key":"10.1016\/j.copbio.2024.103106_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2017.00023","article-title":"Age-appropriate functions and dysfunctions of the neonatal neutrophil","volume":"5","author":"Lawrence","year":"2017","journal-title":"Front Pediatr"},{"key":"10.1016\/j.copbio.2024.103106_bib7","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3109\/08880018.2013.868562","article-title":"Granulocyte transfusions for children with infection and neutropenia or granulocyte dysfunction","volume":"31","author":"D\u00edaz","year":"2014","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/j.copbio.2024.103106_bib8","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1055\/s-0039-1694991","article-title":"Transfusion-associated acute lung injury following donor granulocyte transfusion in two pediatric patients","volume":"8","author":"Arslan","year":"2019","journal-title":"J Pediatr Intensive Care"},{"key":"10.1016\/j.copbio.2024.103106_bib9","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/sj.bmt.1705066","article-title":"Short- and long-term haematological surveillance of healthy donors of allogeneic peripheral haematopoietic progenitors mobilized with G-CSF: a single institution prospective study","volume":"36","author":"Tassi","year":"2005","journal-title":"Bone Marrow Transpl"},{"key":"10.1016\/j.copbio.2024.103106_bib10","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1053\/bbmt.2002.v8.pm12171483","article-title":"Transplantation of ex vivo expanded cord blood","volume":"8","author":"Shpall","year":"2002","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.copbio.2024.103106_bib11","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1182\/blood.V96.9.3001","article-title":"Ex vivo expanded peripheral blood progenitor cells provide rapid neutrophil recovery after high-dose chemotherapy in patients with breast cancer","volume":"96","author":"McNiece","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.copbio.2024.103106_bib12","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1200\/JCO.20.01739","article-title":"Open-label phase II prospective, randomized, controlled study of Romyelocel-L myeloid progenitor cells to reduce infection during induction chemotherapy for acute myeloid leukemia","volume":"39","author":"Desai","year":"2021","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.copbio.2024.103106_bib13","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/bit.22433","article-title":"Clinical scale ex vivo manufacture of neutrophils from hematopoietic progenitor cells","volume":"104","author":"Timmins","year":"2009","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.copbio.2024.103106_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2019.00021","article-title":"Ex vivo manufactured neutrophils for treatment of neutropenia \u2014 a process economic evaluation","volume":"6","author":"Torres-Acosta","year":"2019","journal-title":"Front Med"},{"key":"10.1016\/j.copbio.2024.103106_bib15","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/sctm.18-0255","article-title":"Neutrophils derived from genetically modified human induced pluripotent stem cells circulate and phagocytose bacteria in vivo","volume":"8","author":"Trump","year":"2019","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.copbio.2024.103106_bib16","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/oncolo\/oyac074","article-title":"Chemotherapy-induced neutropenia and febrile neutropenia in the US: a beast of burden that needs to be tamed?","volume":"27","author":"Boccia","year":"2022","journal-title":"Oncologist"},{"key":"10.1016\/j.copbio.2024.103106_bib17","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0140-6736(21)00933-8","article-title":"Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b\/2 open-label study","volume":"398","author":"Berdeja","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.copbio.2024.103106_bib18","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/jha2.350","article-title":"CAR-T-OPENIA: chimeric antigen receptor T-cell therapy-associated cytopenias","volume":"3","author":"Taneja","year":"2021","journal-title":"EJHaem"},{"key":"10.1016\/j.copbio.2024.103106_bib19","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.4049\/jimmunol.1601855","article-title":"Multicenter systems analysis of human blood reveals immature neutrophils in males and during pregnancy","volume":"198","author":"Blazkova","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.copbio.2024.103106_bib20","doi-asserted-by":"crossref","first-page":"16481","DOI":"10.1073\/pnas.2003603117","article-title":"Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism","volume":"117","author":"Gupta","year":"2020","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.copbio.2024.103106_bib21","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1111\/j.1537-2995.2012.03661.x","article-title":"Impact of the mobilization regimen and the harvesting technique on the granulocyte yield in healthy donors for granulocyte transfusion therapy","volume":"52","author":"Ikemoto","year":"2012","journal-title":"Transfusion"},{"key":"10.1016\/j.copbio.2024.103106_bib22","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1159\/000492629","article-title":"An international registry of granulocyte transfusions","volume":"45","author":"Pagano","year":"2018","journal-title":"Transfus Med Hemother"},{"key":"10.1016\/j.copbio.2024.103106_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.03130","article-title":"Mouse models and tools for the in vivo study of neutrophils","volume":"10","author":"Stackowicz","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.copbio.2024.103106_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1105103","article-title":"Humanized MISTRG as a preclinical in vivo model to study human neutrophil-mediated immune processes","volume":"14","author":"Martinez-Sanz","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.copbio.2024.103106_bib25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/voxs.12423","article-title":"How different animal models help us understand TRALI","volume":"13","author":"Fung","year":"2018","journal-title":"ISBT Sci Ser"},{"key":"10.1016\/j.copbio.2024.103106_bib26","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/imr.13154","article-title":"Human neutrophils \u2260 murine neutrophils: does it matter?","volume":"314","author":"Nauseef","year":"2023","journal-title":"Immunol Rev"},{"key":"10.1016\/j.copbio.2024.103106_bib27","series-title":"Pharmacology of Immunosuppression","first-page":"209","article-title":"Immune suppression in allogeneic hematopoietic stem cell transplantation","author":"Michniacki","year":"2022"},{"key":"10.1016\/j.copbio.2024.103106_bib28","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41587-019-0016-3","article-title":"Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients","volume":"37","author":"Deuse","year":"2019","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.copbio.2024.103106_bib29","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1056\/NEJMoa2113206","article-title":"Betibeglogene autotemcel gene therapy for non\u2013\u03b20\/\u03b20 genotype \u03b2-thalassemia","volume":"386","author":"Locatelli","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.copbio.2024.103106_bib30","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1056\/NEJMoa2117175","article-title":"Biologic and clinical efficacy of LentiGlobin for sickle cell disease","volume":"386","author":"Kanter","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.copbio.2024.103106_bib31","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2022019117","article-title":"Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich Syndrome","author":"Labrosse","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.copbio.2024.103106_bib32","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41591-019-0735-5","article-title":"Lentiviral gene therapy for X-linked chronic granulomatous disease","volume":"26","author":"Kohn","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.copbio.2024.103106_bib33","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41434-020-0127-y","article-title":"Lentiviral gene therapy and vitamin B3 treatment enable granulocytic differentiation of G6PC3-deficient induced pluripotent stem cells","volume":"27","author":"Hoffmann","year":"2020","journal-title":"Gene Ther"},{"key":"10.1016\/j.copbio.2024.103106_bib34","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.omtm.2022.07.015","article-title":"Preclinical safety and efficacy of lentiviral-mediated gene therapy for leukocyte adhesion deficiency type I","volume":"26","author":"Mesa-N\u00fa\u00f1ez","year":"2022","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1016\/j.copbio.2024.103106_bib35","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41573-019-0020-9","article-title":"Gene therapy targeting haematopoietic stem cells for inherited diseases: progress and challenges","volume":"18","author":"Cavazzana","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.copbio.2024.103106_bib36","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1182\/bloodadvances.2016003798","article-title":"Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells","volume":"1","author":"Pittermann","year":"2017","journal-title":"Blood Adv"},{"key":"10.1016\/j.copbio.2024.103106_bib37","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1182\/blood-2020-140260","article-title":"Efficient Correction of HAX1 Mutations in Primary HSPCs of Severe Congenital Neutropenia Patients Using CRISPR\/CAS9 GENE-Editing","volume":"136","author":"Ritter","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.copbio.2024.103106_bib38","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1016\/j.ymthe.2020.08.004","article-title":"CRISPR-Cas9-mediated ELANE mutation correction in hematopoietic stem and progenitor cells to treat severe congenital neutropenia","volume":"28","author":"Tran","year":"2020","journal-title":"Mol Ther"},{"key":"10.1016\/j.copbio.2024.103106_sbref39","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111128","article-title":"Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy","volume":"40","author":"Chang","year":"2022","journal-title":"Cell Rep"},{"key":"10.1016\/j.copbio.2024.103106_bib40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/ppul.24203","article-title":"Health outcomes in spinal muscular atrophy type 1 following AVXS-101 gene replacement therapy","volume":"54","author":"Al-Zaidy","year":"2019","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.copbio.2024.103106_bib41","first-page":"2016","article-title":"Gene therapy using haematopoietic stem and progenitor cells","volume":"22","author":"Ferrari","year":"2020","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.copbio.2024.103106_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111171","article-title":"During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodes","volume":"40","author":"Pylaeva","year":"2022","journal-title":"Cell Rep"},{"key":"10.1016\/j.copbio.2024.103106_sbref43","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-37872-4","article-title":"CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy","volume":"14","author":"Chang","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2024.103106_bib44","article-title":"Engineered anti-prostate cancer CAR-neutrophils from human pluripotent stem cells","volume":"20","author":"Harris","year":"2023","journal-title":"J Immunol Regen Med"},{"key":"10.1016\/j.copbio.2024.103106_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108387","article-title":"BCG vaccination induces long-term functional reprogramming of human neutrophils","volume":"33","author":"Moorlag","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.copbio.2024.103106_bib46","doi-asserted-by":"crossref","unstructured":"Lin CJ, Hwang TL, Wang RYL, Nain A, Shih RH, Chang L, Lin HJ, Harroun SG, Chang HT, Huang CC: Augmenting Neutrophil Extracellular Traps with Carbonized Polymer Dots: A Potential Treatment for Bacterial Sepsis; Small [date unknown]. \u3008doi:10.1002\/smll.202307210\u3009.","DOI":"10.1002\/smll.202307210"},{"key":"10.1016\/j.copbio.2024.103106_sbref46","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cell.2020.09.058","article-title":"Innate immune training of granulopoiesis promotes anti-tumor activity","volume":"183","author":"Kalafati","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.copbio.2024.103106_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101577","article-title":"Nanotechnology reinforced neutrophil-based therapeutic strategies for inflammatory diseases therapy","volume":"46","author":"Wu","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.copbio.2024.103106_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101946","article-title":"Apoptotic neutrophil-mediated inflammatory microenvironment regulation for the treatment of ARDS","volume":"52","author":"Liu","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.copbio.2024.103106_bib50","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/s41565-018-0254-4","article-title":"Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis","volume":"13","author":"Zhang","year":"2018","journal-title":"Nat Nanotech"},{"key":"10.1016\/j.copbio.2024.103106_bib51","doi-asserted-by":"crossref","first-page":"16461","DOI":"10.1021\/acsnano.3c00227","article-title":"Bioengineered neutrophil extinguisher targets cascade immune pathways of macrophages for alleviating cytokine storm in pneumonia","volume":"17","author":"Zhou","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.copbio.2024.103106_bib52","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1021\/acsnano.3c09848","article-title":"Engineered biomimetic nanovesicles based on neutrophils for hierarchical targeting therapy of acute respiratory distress syndrome","volume":"18","author":"Li","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.copbio.2024.103106_bib53","doi-asserted-by":"crossref","DOI":"10.1126\/scirobotics.aaz9519","article-title":"Dual-responsive biohybrid neutrobots for active target delivery","volume":"6","author":"Zhang","year":"2021","journal-title":"Sci Robot"},{"key":"10.1016\/j.copbio.2024.103106_bib54","article-title":"Artificial super neutrophils for inflammation targeting and HClO generation against tumors and infections","volume":"31","author":"Zhang","year":"2019","journal-title":"Adv Mater"},{"key":"10.1016\/j.copbio.2024.103106_sbref54","article-title":"Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy","volume":"8","author":"Zhang","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.copbio.2024.103106_bib56","doi-asserted-by":"crossref","first-page":"7663","DOI":"10.2147\/IJN.S328705","article-title":"The Advances of neutrophil-derived effective drug delivery systems: a key review of managing tumors and inflammation","volume":"16","author":"Wang","year":"2021","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.copbio.2024.103106_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120784","article-title":"Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy","volume":"273","author":"Wang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.copbio.2024.103106_bib58","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/JLB.3A0320-210R","article-title":"Neutrophils produce proinflammatory or anti-inflammatory extracellular vesicles depending on the environmental conditions","volume":"109","author":"Kolonics","year":"2021","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.copbio.2024.103106_bib59","article-title":"Granulocyte transfusions for preventing infections in people with neutropenia or neutrophil dysfunction","volume":"2015","author":"Estcourt","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.copbio.2024.103106_bib60","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1182\/blood-2015-11-680918","article-title":"Anoxia and glucose supplementation preserve neutrophil viability and function","volume":"128","author":"Monceaux","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.copbio.2024.103106_bib61","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-05978-7","article-title":"Preservative solution that stabilizes erythrocyte morphology and leukocyte viability under ambient conditions","volume":"7","author":"Sandlin","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.copbio.2024.103106_bib62","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb1069","article-title":"Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion","volume":"13","author":"Fan","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.copbio.2024.103106_bib63","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cryobiol.2016.05.004","article-title":"Investigating the potential for cryopreservation of human granulocytes with concentrated glycerol","volume":"72","author":"Moss","year":"2016","journal-title":"Cryobiology"},{"key":"10.1016\/j.copbio.2024.103106_bib64","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1182\/blood.V56.2.237.237","article-title":"Cryopreservation of human granulocytes: study of granulocyte function and ultrastructure","volume":"56","author":"Boonlayangoor","year":"1980","journal-title":"Blood"},{"key":"10.1016\/j.copbio.2024.103106_bib65","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1182\/blood.V66.2.267.267","article-title":"Liquid preservation of human neutrophils stored in synthetic media at 22 \u00b0C: controlled observations on storage variables","volume":"66","author":"Glasser","year":"1985","journal-title":"Blood"},{"key":"10.1016\/j.copbio.2024.103106_bib66","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/trf.16732","article-title":"Prolonged storage of purified granulocyte concentrates: introduction of a new purification method","volume":"62","author":"Klinkmann","year":"2022","journal-title":"Transfusion"},{"key":"10.1016\/j.copbio.2024.103106_bib67","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.839475","article-title":"Comparison of neutrophil function in granulocyte concentrates from prednisone- and G-CSF-treated donors: effect of stimulant, leukapheresis and storage","volume":"9","author":"Murru","year":"2022","journal-title":"Front Med"},{"key":"10.1016\/j.copbio.2024.103106_bib68","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aah3480","article-title":"CRISPR-Cas9 gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease","volume":"9","author":"De Ravin","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.copbio.2024.103106_bib69","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1182\/blood.2022016074","article-title":"Lentiviral gene therapy for X-linked chronic granulomatous disease recapitulates endogenous CYBB regulation and expression","volume":"141","author":"Wong","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.copbio.2024.103106_bib70","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41591-021-01641-x","article-title":"Long-term safety and efficacy of lentiviral hematopoietic stem\/progenitor cell gene therapy for Wiskott\u2013Aldrich syndrome","volume":"28","author":"Magnani","year":"2022","journal-title":"Nat Med"},{"key":"10.1016\/j.copbio.2024.103106_bib71","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1182\/blood-2017-04-777136","article-title":"Gene therapy for Wiskott-Aldrich syndrome in a severely affected adult","volume":"130","author":"Morris","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.copbio.2024.103106_bib72","doi-asserted-by":"crossref","first-page":"598","DOI":"10.3324\/haematol.2019.221804","article-title":"CRISPR\/Cas9-mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients","volume":"105","author":"Nasri","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.copbio.2024.103106_bib73","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.omtm.2022.06.002","article-title":"Mutant allele knockout with novel CRISPR nuclease promotes myelopoiesis in ELANE neutropenia","volume":"26","author":"Sabo","year":"2022","journal-title":"Mol Ther Methods Clin Dev"}],"container-title":["Current Opinion in Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958166924000429?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958166924000429?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T13:16:04Z","timestamp":1730898964000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0958166924000429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":73,"alternative-id":["S0958166924000429"],"URL":"https:\/\/doi.org\/10.1016\/j.copbio.2024.103106","relation":{},"ISSN":["0958-1669"],"issn-type":[{"value":"0958-1669","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophils, an emerging new therapeutic platform","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.copbio.2024.103106","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103106"}}