{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:37:59Z","timestamp":1785893879778,"version":"3.56.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013846","name":"Francqui Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013846","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","bmn.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Biotechnology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.copbio.2024.103132","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T03:09:54Z","timestamp":1714100994000},"page":"103132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["\u2018From metabolism to metabolism\u2019: holistic considerations on B-vitamin interactions, biofortification, and deficiencies"],"prefix":"10.1016","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0051-1703","authenticated-orcid":false,"given":"Lisa","family":"De Zanetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7755-1420","authenticated-orcid":false,"given":"Dominique","family":"Van Der Straeten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.copbio.2024.103132_bib1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0140-6736(20)31647-0","article-title":"Impacts of COVID-19 on childhood malnutrition and nutrition-related mortality","volume":"396","author":"Headey","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.copbio.2024.103132_bib2","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1177\/15648265110321S105","article-title":"Biofortification: a new tool to reduce micronutrient malnutrition","volume":"32","author":"Bouis","year":"2011","journal-title":"Food Nutr Bull"},{"key":"10.1016\/j.copbio.2024.103132_bib3","unstructured":"United Nations Environment Programme (UNEP). How to Feed 10 Billion People; 2020."},{"key":"10.1016\/j.copbio.2024.103132_bib4","unstructured":"FAO, IFAD, UNICEF, WFP and WHO. The State of Food Security and Nutrition in the World; 2020."},{"key":"10.1016\/j.copbio.2024.103132_bib5","doi-asserted-by":"crossref","first-page":"e1590","DOI":"10.1016\/S2214-109X(22)00367-9","article-title":"Micronutrient deficiencies among preschool-aged children and women of reproductive age worldwide: a pooled analysis of individual-level data from population-representative surveys","volume":"10","author":"Stevens","year":"2022","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.copbio.2024.103132_bib6","doi-asserted-by":"crossref","first-page":"e482","DOI":"10.1016\/S2214-109X(21)00594-5","article-title":"Global inequalities in the double burden of malnutrition and associations with globalisation: a multilevel analysis of Demographic and Health Surveys from 55 low-income and middle-income countries, 1992\u20132018","volume":"10","author":"Seferidi","year":"2022","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.copbio.2024.103132_bib7","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1177\/0379572120930123","article-title":"Diet quality and urbanization in Mozambique","volume":"41","author":"Smart","year":"2020","journal-title":"Food Nutr Bull"},{"key":"10.1016\/j.copbio.2024.103132_bib8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0140-6736(19)32497-3","article-title":"Dynamics of the double burden of malnutrition and the changing nutrition reality","volume":"395","author":"Popkin","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.copbio.2024.103132_bib9","unstructured":"World Obesity Atlas 2023. World Obesity Federation; 2023."},{"key":"10.1016\/j.copbio.2024.103132_bib10","unstructured":"UNICEF, WHO, World Bank Group. Levels and Trends in Child Malnutrition; 2023."},{"key":"10.1016\/j.copbio.2024.103132_sbref7","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/s43016-023-00851-5","article-title":"Global food nutrients analysis reveals alarming gaps and daunting challenges","volume":"4","author":"Wang","year":"2023","journal-title":"Nat Food"},{"key":"10.1016\/j.copbio.2024.103132_bib12","article-title":"Micronutrient status in obese patients: a narrative review","volume":"18","author":"Lapik","year":"2020","journal-title":"Obes Med"},{"key":"10.1016\/j.copbio.2024.103132_bib13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/ecam\/nek009","article-title":"A review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives","volume":"3","author":"Lonsdale","year":"2006","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.copbio.2024.103132_sbref10","doi-asserted-by":"crossref","DOI":"10.1038\/s43016-023-00905-8","article-title":"Biofortification\u2019s contribution to mitigating micronutrient deficiencies","volume":"5","author":"Li","year":"2024","journal-title":"Nat Food"},{"key":"10.1016\/j.copbio.2024.103132_bib15","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0140-6736(18)31788-4","article-title":"Food in the Anthropocene: the EAT\u2013Lancet Commission on healthy diets from sustainable food systems","volume":"393","author":"Willett","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.copbio.2024.103132_bib16","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s00394-022-03025-4","article-title":"The importance of vitamin B12 for individuals choosing plant-based diets","volume":"62","author":"Niklewicz","year":"2023","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.copbio.2024.103132_sbref13","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaq1012","article-title":"Carbon dioxide (CO 2 ) levels this century will alter the protein, micronutrients, and vitamin content of rice grains with potential health consequences for the poorest rice-dependent countries","volume":"4","author":"Zhu","year":"2018","journal-title":"Sci Adv"},{"key":"10.1016\/j.copbio.2024.103132_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fclim.2022.941842","article-title":"The impact of climate change on food systems, diet quality, nutrition, and health outcomes: a narrative review","volume":"4","author":"Owino","year":"2022","journal-title":"Front Clim"},{"key":"10.1016\/j.copbio.2024.103132_bib19","unstructured":"Intergovernmental Panel on Climate Change (IPCC). Climate Change 2023: Synthesis Report; 2023."},{"key":"10.1016\/j.copbio.2024.103132_bib20","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1177\/156482650002100409","article-title":"Breeding for trace minerals in wheat","volume":"21","author":"Monasterio","year":"2000","journal-title":"Food Nutr Bull"},{"key":"10.1016\/j.copbio.2024.103132_bib21","unstructured":"U.S. Department of Agriculture (USDA): Vitamin and Mineral Supplement Fact Sheets. [date unknown]."},{"key":"10.1016\/j.copbio.2024.103132_bib22","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1105\/tpc.111.093120","article-title":"Vitamin deficiencies in humans: can plant science help?","volume":"24","author":"Fitzpatrick","year":"2012","journal-title":"Plant Cell"},{"key":"10.1016\/j.copbio.2024.103132_bib23","series-title":"Diet, nutrition, and the prevention of chronic diseases: report of a Joint WHO\/FAO Expert Consultation, 2002","author":"WHO","year":"2003"},{"key":"10.1016\/j.copbio.2024.103132_bib24","unstructured":"HarvestPlus. Biofortification: The Evidence; 2021."},{"key":"10.1016\/j.copbio.2024.103132_bib25","unstructured":"World Health Organization (WHO) and Food and Agriculture Organization of the United Nations (FAO). Vitamin and Mineral Requirements in Human Nutrition; 2004."},{"key":"10.1016\/j.copbio.2024.103132_bib26","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.pbi.2007.04.009","article-title":"Plants need their vitamins too","volume":"10","author":"Smith","year":"2007","journal-title":"Curr Opin Plant Biol"},{"key":"10.1016\/j.copbio.2024.103132_bib27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1126\/science.287.5451.303","article-title":"Engineering the provitamin A (\u03b2-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm","volume":"287","author":"Ye","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.copbio.2024.103132_sbref20","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-19020-4","article-title":"Multiplying the efficiency and impact of biofortification through metabolic engineering","volume":"11","author":"Van Der Straeten","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2024.103132_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1029119","article-title":"Variation of vitamin B contents in maize inbred lines: potential genetic resources for biofortification","volume":"9","author":"Safiul Azam","year":"2022","journal-title":"Front Nutr"},{"key":"10.1016\/j.copbio.2024.103132_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2018.00443","article-title":"Toward eradication of B-vitamin deficiencies: considerations for crop biofortification","volume":"9","author":"Strobbe","year":"2018","journal-title":"Front Plant Sci"},{"key":"10.1016\/j.copbio.2024.103132_bib31","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1111\/1541-4337.12491","article-title":"Global concerns with B vitamin statuses: biofortification, fortification, hidden hunger, interactions, and toxicity","volume":"18","author":"Titcomb","year":"2019","journal-title":"Comp Rev Food Sci Food Saf"},{"key":"10.1016\/j.copbio.2024.103132_bib32","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1111\/pbi.13545","article-title":"Metabolic engineering of rice endosperm towards higher vitamin B1 accumulation","volume":"19","author":"Strobbe","year":"2021","journal-title":"Plant Biotechnol J"},{"key":"10.1016\/j.copbio.2024.103132_bib33","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1111\/pbi.13615","article-title":"Riboflavin fortification of rice endosperm by metabolic engineering","volume":"19","author":"Tian","year":"2021","journal-title":"Plant Biotechnol J"},{"key":"10.1016\/j.copbio.2024.103132_bib34","first-page":"1029","article-title":"Increased bioavailable vitamin B6 in field-grown transgenic cassava for dietary sufficiency","volume":"33","author":"Li","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.copbio.2024.103132_bib35","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/nbt.3358","article-title":"Improving folate (vitamin B9) stability in biofortified rice through metabolic engineering","volume":"33","author":"Blancquaert","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.copbio.2024.103132_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.721728","article-title":"Biofortification of cereals and pulses using new breeding techniques: current and future perspectives","volume":"8","author":"Shahzad","year":"2021","journal-title":"Front Nutr"},{"key":"10.1016\/j.copbio.2024.103132_sbref29","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodpol.2020.101976","article-title":"Viewpoint: agri-nutrition research: revisiting the contribution of maize and wheat to human nutrition and health","volume":"100","author":"Poole","year":"2021","journal-title":"Food Policy"},{"key":"10.1016\/j.copbio.2024.103132_bib38","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1093\/plphys\/kiab198","article-title":"Metabolic engineering provides insight into the regulation of thiamin biosynthesis in plants","volume":"186","author":"Strobbe","year":"2021","journal-title":"Plant Physiol"},{"key":"10.1016\/j.copbio.2024.103132_bib39","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1093\/plcell\/koab198","article-title":"The 5-formyl-tetrahydrofolate proteome links folates with C\/N metabolism and reveals feedback regulation of folate biosynthesis","volume":"33","author":"Li","year":"2021","journal-title":"Plant Cell"},{"key":"10.1016\/j.copbio.2024.103132_bib40","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1093\/jxb\/ers208","article-title":"Plant B vitamin pathways and their compartmentation: a guide for the perplexed","volume":"63","author":"Gerdes","year":"2012","journal-title":"J Exp Bot"},{"key":"10.1016\/j.copbio.2024.103132_bib41","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/plphys\/kiad500","article-title":"Single-cell RNA-sequencing profiles reveal the developmental landscape of the Manihot esculenta Crantz leaves","volume":"194","author":"Zang","year":"2023","journal-title":"Plant Physiol"},{"key":"10.1016\/j.copbio.2024.103132_bib42","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev-arplant-050213-035825","article-title":"Engineering complex metabolic pathways in plants","volume":"65","author":"Farr\u00e9","year":"2014","journal-title":"Annu Rev Plant Biol"},{"key":"10.1016\/j.copbio.2024.103132_sbref35","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.molp.2017.05.008","article-title":"Development of \u201cpurple endosperm rice\u201d by engineering anthocyanin biosynthesis in the endosperm with a high-efficiency transgene stacking system","volume":"10","author":"Zhu","year":"2017","journal-title":"Mol Plant"},{"key":"10.1016\/j.copbio.2024.103132_bib44","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1039\/b108967f","article-title":"The biosynthesis of adenosylcobalamin (vitamin B12)","volume":"19","author":"Warren","year":"2002","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.copbio.2024.103132_bib45","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.14936","article-title":"Breeding and adoption of biofortified crops and their nutritional impact on human health","volume":"1520","author":"Kumar","year":"2023","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.copbio.2024.103132_sbref38","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-14981-y","article-title":"Marker-free carotenoid-enriched rice generated through targeted gene insertion using CRISPR-Cas9","volume":"11","author":"Dong","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2024.103132_sbref39","series-title":"Genetically Engineered Crops: Experiences and Prospects","author":"National Academies of Sciences, Engineering, and Medicine","year":"2016"},{"key":"10.1016\/j.copbio.2024.103132_bib48","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.tibtech.2022.12.011","article-title":"Public acceptance and stakeholder views of gene edited foods: a global overview","volume":"41","author":"Strobbe","year":"2023","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.copbio.2024.103132_bib49","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/tpj.15859","article-title":"B vitamin supply in plants and humans: the importance of vitamer homeostasis","volume":"111","author":"Liu","year":"2022","journal-title":"Plant J"},{"key":"10.1016\/j.copbio.2024.103132_bib50","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/jipb.13047","article-title":"Benefiting others and self: production of vitamins in plants","volume":"63","author":"Li","year":"2021","journal-title":"J Integr Plant Biol"},{"key":"10.1016\/j.copbio.2024.103132_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/nu8020068","article-title":"B vitamins and the brain: mechanisms, dose and efficacy \u2014 a review","volume":"8","author":"Kennedy","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.copbio.2024.103132_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/nu12092867","article-title":"B vitamins and one-carbon metabolism: implications in human health and disease","volume":"12","author":"Lyon","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.copbio.2024.103132_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2021.112822","article-title":"The scope of flavin-dependent reactions and processes in the model plant Arabidopsis thaliana","volume":"189","author":"Eggers","year":"2021","journal-title":"Phytochemistry"},{"key":"10.1016\/j.copbio.2024.103132_bib54","series-title":"Advances in Botanical Research","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/B978-0-12-386479-6.00002-0","article-title":"Biosynthesis of NAD and its manipulation in plants\u2730","author":"Noctor","year":"2011"},{"key":"10.1016\/j.copbio.2024.103132_bib55","series-title":"Advances in Botanical Research","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/B978-0-12-386479-6.00001-9","article-title":"Pantothenate biosynthesis in higher plants","author":"Webb","year":"2011"},{"key":"10.1016\/j.copbio.2024.103132_bib56","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1016\/j.phytochem.2007.03.038","article-title":"Vitamin B biosynthesis in plants","volume":"68","author":"Roje","year":"2007","journal-title":"Phytochemistry"},{"key":"10.1016\/j.copbio.2024.103132_bib57","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.molp.2020.11.019","article-title":"Regulation of plant vitamin metabolism: backbone of biofortification for the alleviation of hidden hunger","volume":"14","author":"Jiang","year":"2021","journal-title":"Mol Plant"},{"key":"10.1016\/j.copbio.2024.103132_bib58","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.tplants.2010.07.003","article-title":"Vitamins in plants: occurrence, biosynthesis and antioxidant function","volume":"15","author":"Asensi-Fabado","year":"2010","journal-title":"Trends Plant Sci"},{"key":"10.1016\/j.copbio.2024.103132_bib59","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00726-013-1653-3","article-title":"Plant amino acid-derived vitamins: biosynthesis and function","volume":"46","author":"Miret","year":"2014","journal-title":"Amino Acids"},{"key":"10.1016\/j.copbio.2024.103132_bib60","doi-asserted-by":"crossref","first-page":"12002","DOI":"10.1074\/jbc.REV120.010918","article-title":"The importance of thiamine (vitamin B1) in plant health: from crop yield to biofortification","volume":"295","author":"Fitzpatrick","year":"2020","journal-title":"J Biol Chem"},{"key":"10.1016\/j.copbio.2024.103132_bib61","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.molp.2015.09.005","article-title":"Amino acid catabolism in plants","volume":"8","author":"Hildebrandt","year":"2015","journal-title":"Mol Plant"},{"key":"10.1016\/j.copbio.2024.103132_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067860","article-title":"The global hidden hunger indices and maps: an advocacy tool for action","volume":"8","author":"Muthayya","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.copbio.2024.103132_bib63","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/j.cropro.2007.02.012","article-title":"Ability of vitamins to induce downy mildew disease resistance and growth promotion in pearl millet","volume":"26","author":"Pushpalatha","year":"2007","journal-title":"Crop Prot"},{"key":"10.1016\/j.copbio.2024.103132_bib64","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.plantsci.2018.04.024","article-title":"Overexpression of PDX-II gene in potato (Solanum tuberosum L.) leads to the enhanced accumulation of vitamin B6 in tuber tissues and tolerance to abiotic stresses","volume":"272","author":"Bagri","year":"2018","journal-title":"Plant Sci"},{"key":"10.1016\/j.copbio.2024.103132_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.plantsci.2023.111929","article-title":"Exogenous riboflavin (vitamin B2) application enhances salinity tolerance through the activation of its biosynthesis in rice seedlings under salinity stress","volume":"339","author":"Jiadkong","year":"2024","journal-title":"Plant Sci"},{"key":"10.1016\/j.copbio.2024.103132_bib66","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1104\/pp.16.01371","article-title":"Does abiotic stress cause functional B vitamin deficiency in plants?","volume":"172","author":"Hanson","year":"2016","journal-title":"Plant Physiol"},{"key":"10.1016\/j.copbio.2024.103132_bib67","doi-asserted-by":"crossref","DOI":"10.1080\/15592324.2023.2186045","article-title":"Alleviation of drought stress through foliar application of thiamine in two varieties of pea (Pisum sativum L.)","volume":"18","author":"Kausar","year":"2023","journal-title":"Plant Signal Behav"},{"key":"10.1016\/j.copbio.2024.103132_sbref60","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2017.02265","article-title":"Alleviation of nitrogen and sulfur deficiency and enhancement of photosynthesis in Arabidopsis thaliana by overexpression of uroporphyrinogen III methyltransferase (UPM1)","volume":"8","author":"Garai","year":"2018","journal-title":"Front Plant Sci"},{"key":"10.1016\/j.copbio.2024.103132_bib69","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1007\/s10529-011-0684-7","article-title":"Transgenic potato overproducing l-ascorbic acid resisted an increase in methylglyoxal under salinity stress via maintaining higher reduced glutathione level and glyoxalase enzyme activity","volume":"33","author":"Upadhyaya","year":"2011","journal-title":"Biotechnol Lett"},{"key":"10.1016\/j.copbio.2024.103132_sbref62","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/s41893-020-00656-5","article-title":"Proactive conservation to prevent habitat losses to agricultural expansion","volume":"4","author":"Williams","year":"2020","journal-title":"Nat Sustain"},{"key":"10.1016\/j.copbio.2024.103132_sbref63","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2018.00012","article-title":"Biofortified crops generated by breeding, agronomy, and transgenic approaches are improving lives of millions of people around the world","volume":"5","author":"Garg","year":"2018","journal-title":"Front Nutr"},{"key":"10.1016\/j.copbio.2024.103132_bib72","article-title":"Application of CRISPR\/Cas9 in crop quality improvement","volume":"22","author":"Liu","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.copbio.2024.103132_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2023.108242","article-title":"The role of orphan crops in the transition to nutritional quality-oriented crop improvement","volume":"68","author":"Verbeecke","year":"2023","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.copbio.2024.103132_bib74","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1080\/03066150.2022.2072213","article-title":"Caporalato capitalism. Labour brokerage and agrarian change in a Mediterranean society","volume":"50","author":"Perrotta","year":"2023","journal-title":"J Peasant Stud"}],"container-title":["Current Opinion in Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958166924000685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958166924000685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T13:16:59Z","timestamp":1730899019000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0958166924000685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":74,"alternative-id":["S0958166924000685"],"URL":"https:\/\/doi.org\/10.1016\/j.copbio.2024.103132","relation":{},"ISSN":["0958-1669"],"issn-type":[{"value":"0958-1669","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u2018From metabolism to metabolism\u2019: holistic considerations on B-vitamin interactions, biofortification, and deficiencies","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.copbio.2024.103132","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103132"}}