{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:10:16Z","timestamp":1793473816398,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","bmn.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Biotechnology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.copbio.2024.103167","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:49Z","timestamp":1718755249000},"page":"103167","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Industrializing methanotrophs and other methylotrophic bacteria: from bioengineering to product recovery"],"prefix":"10.1016","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1995-5523","authenticated-orcid":false,"given":"Dominic","family":"Sauvageau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Y","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Arenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4812-1947","authenticated-orcid":false,"given":"Shibashis","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4326-9275","authenticated-orcid":false,"given":"Maryssa","family":"Iacobelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9919-8208","authenticated-orcid":false,"given":"Mark","family":"Lawley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Lazic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabi\u00e1n L","family":"Rond\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6539-9572","authenticated-orcid":false,"given":"Cerrise","family":"Weiblen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.copbio.2024.103167_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.137769","article-title":"Outlook on engineering methylotrophs for one-carbon-based industrial biotechnology","volume":"449","author":"Pham","year":"2022","journal-title":"Chem Eng J"},{"key":"10.1016\/j.copbio.2024.103167_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.1050740","article-title":"Developing methylotrophic microbial platforms for a methanol-based bioindustry","volume":"10","author":"Singh","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.copbio.2024.103167_sbref3","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1007\/s12257-022-0154-1","article-title":"Pan-genome analysis reveals comparative genomic features of central metabolic pathways in Methylorubrum extorquens","volume":"28","author":"Lee","year":"2023","journal-title":"Biotechnol Bioproc Eng"},{"key":"10.1016\/j.copbio.2024.103167_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-43610-7","article-title":"The oxygen-tolerant reductive glycine pathway assimilates methanol, formate and CO2 in the yeast Komagataella phaffii","volume":"14","author":"Mitic","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2024.103167_bib5","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.jenvman.2018.11.017","article-title":"Novel haloalkaliphilic methanotrophic bacteria: an attempt for enhancing methane bio-refinery","volume":"231","author":"Cantera","year":"2019","journal-title":"J Environ Manag"},{"key":"10.1016\/j.copbio.2024.103167_bib6","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00253-014-6240-3","article-title":"Methylobacterium extorquens: methylotrophy and biotechnological applications","volume":"99","author":"Ochsner","year":"2015","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.copbio.2024.103167_bib7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1574-6976.2000.tb00532.x","article-title":"Heterologous protein expression in the methylotrophic yeast Pichia pastoris","volume":"24","author":"Cereghino","year":"2000","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.copbio.2024.103167_bib8","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.tibtech.2020.07.007","article-title":"Engineered methanotrophy: a sustainable solution for methane-based industrial biomanufacturing","volume":"39","author":"Nguyen","year":"2021","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.copbio.2024.103167_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.636486","article-title":"Biotransformation of methane and carbon dioxide into high-value products by methanotrophs: current state of art and future prospects","volume":"12","author":"Sahoo","year":"2021","journal-title":"Front Microbiol"},{"key":"10.1016\/j.copbio.2024.103167_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ymben.2021.01.009","article-title":"Rewiring the native methanol assimilation metabolism by incorporating the heterologous ribulose monophosphate cycle into Methylorubrum extorquens","volume":"64","author":"Yuan","year":"2021","journal-title":"Metab Eng"},{"key":"10.1016\/j.copbio.2024.103167_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2021.107700","article-title":"Type II methanotrophs: a promising microbial cell-factory platform for bioconversion of methane to chemicals","volume":"47","author":"Nguyen","year":"2021","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.copbio.2024.103167_bib12","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.ijbiomac.2021.10.066","article-title":"A shortcut to carbon-neutral bioplastic production: recent advances in microbial production of polyhydroxyalkanoates from C1 resources","volume":"192","author":"Jo","year":"2021","journal-title":"Int J Biol Macromolec"},{"key":"10.1016\/j.copbio.2024.103167_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ese.2020.100029","article-title":"Biological conversion of methane to polyhydroxyalkanoates: current advances, challenges, and perspectives","volume":"2","author":"Liu","year":"2020","journal-title":"Environ Sci Ecotechnol"},{"key":"10.1016\/j.copbio.2024.103167_sbref14","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.synbio.2024.02.003","article-title":"Construction of a broad-host-range Anderson promoter series and particulate methane monooxygenase promoter variants expand the methanotroph genetic toolbox","volume":"9","author":"Bhat","year":"2024","journal-title":"Syn Syst Biotechno"},{"key":"10.1016\/j.copbio.2024.103167_bib15","doi-asserted-by":"crossref","DOI":"10.1128\/aem.01883-22","article-title":"Cre\/lox-mediated CRISPRi library reveals core genome of a type I methanotroph Methylotuvimicrobium buryatense 5GB1C","volume":"89","author":"Cheng","year":"2023","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.copbio.2024.103167_bib16","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1128\/AEM.03724-15","article-title":"Electroporation-based genetic manipulation in type I methanotrophs","volume":"82","author":"Yan","year":"2016","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.copbio.2024.103167_bib17","first-page":"91","article-title":"Systems metabolic engineering of methanotrophic bacteria for biological conversion of methane to value-added compounds","volume":"180","author":"Guo","year":"2022"},{"key":"10.1016\/j.copbio.2024.103167_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11122987","article-title":"State-of the-art constraint-based modeling of microbial metabolism: from basics to context-specific models with a focus on methanotrophs","volume":"11","author":"Kulyashov","year":"2023","journal-title":"Microorg"},{"key":"10.1016\/j.copbio.2024.103167_bib19","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00073-22","article-title":"Integrative genome-scale metabolic modeling reveals versatile metabolic strategies for methane itilization in Methylomicrobium album BG8","volume":"7","author":"Villada","year":"2022","journal-title":"mSystems"},{"key":"10.1016\/j.copbio.2024.103167_bib20","doi-asserted-by":"crossref","DOI":"10.1186\/1752-0509-5-189","article-title":"Genome-scale reconstruction and system level investigation of the metabolic network of Methylobacterium extorquens AM1","volume":"5","author":"Peyraud","year":"2011","journal-title":"BMC Syst Biol"},{"key":"10.1016\/j.copbio.2024.103167_bib21","article-title":"Methane utilization in Methylomicrobium alcaliphilum 20Z R: a systems approach","volume":"8","author":"Akberdin","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.copbio.2024.103167_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1137749","article-title":"P3HB from CH4 using methanotrophs: aspects of bioreactor, fermentation process and modelling for cost-effective biopolymer production","volume":"11","author":"Safaeian","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.copbio.2024.103167_bib23","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41589-021-00836-0","article-title":"Metabolic engineering strategies to enable microbial utilization of C1 feedstocks","volume":"17","author":"Jiang","year":"2021","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.copbio.2024.103167_sbref24","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41587-021-01195-w","article-title":"Carbon-negative production of acetone and isopropanol by gas fermentation at industrial pilot scale","volume":"40","author":"Liew","year":"2022","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.copbio.2024.103167_bib25","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cherd.2018.03.039","article-title":"An innovative bioprocess for methane conversion to methanol using an efficient methane transfer chamber coupled with an airlift bioreactor","volume":"134","author":"Ghaz-Jahanian","year":"2018","journal-title":"Chem Engin Res Des"},{"key":"10.1016\/j.copbio.2024.103167_sbref26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.nbt.2022.04.004","article-title":"Poly(3-hydroxybutyrate) production from methane in bubble column bioreactors: process simulation and design optimization","volume":"70","author":"Amabile","year":"2022","journal-title":"N Biotechnol"},{"key":"10.1016\/j.copbio.2024.103167_bib27","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3182\/20100705-3-BE-2011.00083","article-title":"Optimal operating points for SCP production in the U-loop reactor","volume":"43","author":"Olsen","year":"2010","journal-title":"IFAC Proceed Vol"},{"key":"10.1016\/j.copbio.2024.103167_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2020.123388","article-title":"Cultivation of methanotrophic bacteria in a novel bubble-free membrane bioreactor for microbial protein production","volume":"310","author":"Valverde-P\u00e9rez","year":"2020","journal-title":"Biores Technol"},{"key":"10.1016\/j.copbio.2024.103167_bib29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bej.2017.03.006","article-title":"Development and evaluation of a trickle bed bioreactor for enhanced mass transfer and methanol production from biogas","volume":"122","author":"Sheets","year":"2017","journal-title":"Biochem Engin J"},{"key":"10.1016\/j.copbio.2024.103167_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2020.123791","article-title":"Conversion of biogas to methanol by methanotrophs immobilized on chemically modified chitosan","volume":"315","author":"Patel","year":"2020","journal-title":"Biores Technol"},{"key":"10.1016\/j.copbio.2024.103167_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.bej.2019.107441","article-title":"Evaluation of methane degradation performance in microbial gas-phase reactions using effectively immobilized methanotrophs","volume":"154","author":"Chen","year":"2020","journal-title":"Biochem Engin J"},{"key":"10.1016\/j.copbio.2024.103167_bib32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ymben.2021.09.005","article-title":"Recent advances toward the bioconversion of methane and methanol in synthetic methylotrophs","volume":"71","author":"Gregory","year":"2022","journal-title":"Metab Eng"},{"key":"10.1016\/j.copbio.2024.103167_sbref33","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1021\/acssynbio.2c00366","article-title":"Cell-free protein synthesis of particulate methane monooxygenase into nanodiscs","volume":"11","author":"Koo","year":"2022","journal-title":"ACS Syn Biol"},{"key":"10.1016\/j.copbio.2024.103167_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11900","article-title":"Printable enzyme-embedded materials for methane to methanol conversion","volume":"7","author":"Blanchette","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2024.103167_bib35","doi-asserted-by":"crossref","first-page":"00342-19","DOI":"10.1128\/mSystems.00342-19","article-title":"Genomic evidence for simultaneous optimization of transcription and translation through codon variants in the pmoCAB operon of type Ia methanotrophs","volume":"4","author":"Villada","year":"2019","journal-title":"mSystems"},{"key":"10.1016\/j.copbio.2024.103167_bib36","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3390\/methane1040026","article-title":"Optimization of methane feed and N:C ratio for biomass and polyhydroxybutyrate production by the alphaproteobacterial methanotroph Methylocystis sp. Rockwell","volume":"1","author":"Sharma","year":"2022","journal-title":"Methane"},{"key":"10.1016\/j.copbio.2024.103167_bib37","doi-asserted-by":"crossref","DOI":"10.1186\/s13068-014-0156-0","article-title":"Metabolic engineering of Methylobacterium extorquens AM1 for 1-butanol production","volume":"7","author":"Hu","year":"2014","journal-title":"Biotechnol Biofuel"},{"key":"10.1016\/j.copbio.2024.103167_bib38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bej.2018.03.010","article-title":"Nutrient recovery from industrial wastewater as single cell protein by a co-culture of green microalgae and methanotrophs","volume":"134","author":"Rasouli","year":"2018","journal-title":"Biochem Engin J"},{"key":"10.1016\/j.copbio.2024.103167_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.168844","article-title":"Enrichment of mixed methanotrophic cultures producing polyhydroxyalkanoates (PHAs) from various environmental sources","volume":"912","author":"G\u0119sicka","year":"2024","journal-title":"Sci Tot Environ"},{"key":"10.1016\/j.copbio.2024.103167_bib40","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/cppb.20024","article-title":"Extraction and analysis of terpenes\/terpenoids","volume":"1","author":"Jiang","year":"2016","journal-title":"Curr Prot Plant Biol"},{"key":"10.1016\/j.copbio.2024.103167_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.624021","article-title":"Recovery of polyhydroxyalkanoates from single and mixed microbial cultures: a review","volume":"9","author":"Pagliano","year":"2021","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.copbio.2024.103167_bib42","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ijbiomac.2022.07.072","article-title":"Polyhydroxybutyrate (PHB) produced from red grape pomace: effect of purification processes on structural, thermal and antioxidant properties","volume":"217","author":"Etxabide","year":"2022","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.copbio.2024.103167_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2020.116694","article-title":"In situ recovery of carboxylic acids from fermentation broths through membrane supported reactive extraction using membrane modules with improved stability","volume":"241","author":"G\u00f6ssi","year":"2020","journal-title":"Sep Purif Technol"},{"key":"10.1016\/j.copbio.2024.103167_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.bej.2023.108902","article-title":"Efficient extraction of lipids from microalgal biomass for the production of biofuels using low-cost protic ionic solvents","volume":"194","author":"Talhami","year":"2023","journal-title":"Biochem Engin J"},{"key":"10.1016\/j.copbio.2024.103167_sbref45","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2021.126087","article-title":"Synergistic effect of ultrasound and switchable hydrophilicity solvent promotes microalgal cell disruption and lipid extraction for biodiesel production","volume":"343","author":"Guo","year":"2022","journal-title":"Biores Technol"},{"key":"10.1016\/j.copbio.2024.103167_bib46","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1002\/bit.27862","article-title":"Strategies and challenges with the microbial conversion of methanol to high-value chemicals","volume":"118","author":"Zhan","year":"2021","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.copbio.2024.103167_bib47","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1007\/s13399-021-01872-5","article-title":"Conversion of methane to methanol: technologies and future challenges","volume":"12","author":"Srivastava","year":"2022","journal-title":"Biomass Convers Biorefine"},{"key":"10.1016\/j.copbio.2024.103167_bib48","article-title":"Methanotrophs: metabolic versatility from utilization of methane to multi-carbon sources and perspectives on current and future applications","volume":"384","author":"Le","year":"2023","journal-title":"Biores Technol"},{"key":"10.1016\/j.copbio.2024.103167_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.copbio.2023.102953","article-title":"The cofactor challenge in synthetic methylotrophy: bioengineering and industrial applications","volume":"82","author":"Kr\u00fcsemann","year":"2023","journal-title":"Curr Op Biotechnol"},{"key":"10.1016\/j.copbio.2024.103167_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.907500","article-title":"Recent trends of biotechnological production of polyhydroxyalkanoates from C1 carbon sources","volume":"10","author":"Ray","year":"2023","journal-title":"Front Bioeng Biotechnol"}],"container-title":["Current Opinion in Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958166924001034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958166924001034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T23:07:42Z","timestamp":1723072062000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0958166924001034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":50,"alternative-id":["S0958166924001034"],"URL":"https:\/\/doi.org\/10.1016\/j.copbio.2024.103167","relation":{},"ISSN":["0958-1669"],"issn-type":[{"value":"0958-1669","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Industrializing methanotrophs and other methylotrophic bacteria: from bioengineering to product recovery","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.copbio.2024.103167","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103167"}}