{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:29:23Z","timestamp":1792819763154,"version":"4.5.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,3,31]],"date-time":"2027-03-31T00:00:00Z","timestamp":1806451200000},"content-version":"am","delay-in-days":303,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000104","name":"NASA","doi-asserted-by":"publisher","award":["80NSSC25M7144"],"award-info":[{"award-number":["80NSSC25M7144"]}],"id":[{"id":"10.13039\/100000104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Biotechnology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.copbio.2026.103491","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:16:29Z","timestamp":1775002589000},"page":"103491","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Microbial and synthetic biology solutions for waste management and biomanufacturing off Earth"],"prefix":"10.1016","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5556-4263","authenticated-orcid":false,"given":"Richa","family":"Guleria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"Blenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.copbio.2026.103491_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.patter.2020.100172","article-title":"International Space Station Open-Source Data","volume":"1","author":"Warren","year":"2020","journal-title":"Patterns"},{"key":"10.1016\/j.copbio.2026.103491_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/su17094088","article-title":"AI-driven waste management in innovating space exploration","volume":"17","author":"Olawade","year":"2025","journal-title":"Sustainability"},{"key":"10.1016\/j.copbio.2026.103491_bib3","first-page":"204","article-title":"The application of waste management systems for long duration spaceflight","volume":"41","author":"Oglesby","year":"2012","journal-title":"Work: J Prev Assess Rehabil"},{"key":"10.1016\/j.copbio.2026.103491_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/frspt.2024.1391200","article-title":"Enhanced astronaut hygiene and mission efficiency: a novel approach to in-suit waste management and water recovery in spacewalks","volume":"5","author":"Etlin","year":"2024","journal-title":"Front Space Technol"},{"key":"10.1016\/j.copbio.2026.103491_bib5","series-title":"How Solid Waste Management Works on the International Space Station","author":"Nash","year":"2024"},{"key":"10.1016\/j.copbio.2026.103491_bib6","first-page":"33","article-title":"Sustainability, sanitation and recycling for long duration space missions","volume":"13","author":"Mane","year":"2024","journal-title":"Int J Enhanc Res Sci Technol Eng"},{"key":"10.1016\/j.copbio.2026.103491_bib7","series-title":"Recycling in Space: Waste Handling in a Microgravity Environment Challenge","author":"Douglas","year":"2018"},{"key":"10.1016\/j.copbio.2026.103491_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2025.179145","article-title":"Toward net-zero in space exploration: a review of technological and policy pathways for sustainable space activities","volume":"972","author":"Olawade","year":"2025","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.copbio.2026.103491_bib9","series-title":"7th Symposium on Space Resource Utilization","first-page":"9","article-title":"Waste management options for long-duration space missions: when to reject, reuse, or recycle [dataset]","author":"Linne","year":"2014"},{"key":"10.1016\/j.copbio.2026.103491_bib10","doi-asserted-by":"crossref","DOI":"10.34133\/space.0154","article-title":"The production of solid wastes in CELSS and the difficulties in recycling by composting: a review","volume":"4","author":"Zhou","year":"2024","journal-title":"Space Sci Technol"},{"key":"10.1016\/j.copbio.2026.103491_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-37070-2","article-title":"Toward sustainable space exploration: a roadmap for harnessing the power of microorganisms","volume":"14","author":"Santomartino","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2026.103491_bib12","series-title":"53rd International Conference on Environmental Systems (ICES)","article-title":"The Trash Compaction Processing System (TCPS) technology demonstration and risk reduction [dataset]","author":"Richardson","year":"2024"},{"key":"10.1016\/j.copbio.2026.103491_bib13","unstructured":"Thompson J: ISS Dumps Waste Container of Junk into Outer Space; 2022. \u3008https:\/\/www.newsweek.com\/iss-waste-disposal-new-method-1723390\u3009."},{"key":"10.1016\/j.copbio.2026.103491_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/membranes14060127","article-title":"Integration of full-size graywater membrane-aerated biological reactor with reverse osmosis system for space-based wastewater treatment","volume":"14","author":"Hooshyari","year":"2024","journal-title":"Membranes"},{"key":"10.1016\/j.copbio.2026.103491_bib15","series-title":"45th International Conference on Environmental Systems","first-page":"16","article-title":"International Space Station environmental control and life support system mass and crewtime utilization in comparison to a long duration human space exploration mission [dataset]","author":"Bagdigian","year":"2015"},{"key":"10.1016\/j.copbio.2026.103491_sbref15","series-title":"51st International Conference on Environmental Systems","first-page":"11","article-title":"Trash compaction and processing system development and testing [dataset]","author":"Klopotic","year":"2022"},{"key":"10.1016\/j.copbio.2026.103491_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41526-023-00317-9","article-title":"Plant and microbial science and technology as cornerstones to bioregenerative life support systems in space","volume":"9","author":"De Micco","year":"2023","journal-title":"Npj Microgravity"},{"key":"10.1016\/j.copbio.2026.103491_bib18","series-title":"NASA Seeks Innovators for Lunar Waste Competition","author":"Bullard","year":"2024"},{"key":"10.1016\/j.copbio.2026.103491_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.mineng.2021.107288","article-title":"In situ resource utilization: the potential for space biomining","volume":"176","author":"Gumulya","year":"2022","journal-title":"Miner Eng"},{"key":"10.1016\/j.copbio.2026.103491_bib20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev-chembioeng-100522-115850","article-title":"Biological upcycling of plastic waste","volume":"15","author":"Klauer","year":"2024","journal-title":"Annu Rev Chem Biomol Eng"},{"key":"10.1016\/j.copbio.2026.103491_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2024.120638","article-title":"Development of functional consortia for the pretreatment of compostable lignocellulosic waste: a simple and effective solution to a large-scale problem","volume":"356","author":"L\u00f3pez-Gonz\u00e1lez","year":"2024","journal-title":"J Environ Manag"},{"key":"10.1016\/j.copbio.2026.103491_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-37910-1","article-title":"Microbial biomanufacturing for space-exploration\u2014what to take and when to make","volume":"14","author":"Averesch","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2026.103491_bib23","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.futures.2019.02.017","article-title":"Biodiversity requirements for self-sustaining space colonies","volume":"110","author":"Johnson","year":"2019","journal-title":"Futures"},{"key":"10.1016\/j.copbio.2026.103491_bib24","doi-asserted-by":"crossref","DOI":"10.1007\/s00792-021-01253-w","article-title":"The smallest space miners: principles of space biomining","volume":"26","author":"Santomartino","year":"2022","journal-title":"Extremophiles"},{"key":"10.1016\/j.copbio.2026.103491_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/life12060774","article-title":"The impacts of microgravity on bacterial metabolism","volume":"12","author":"Sharma","year":"2022","journal-title":"Life"},{"key":"10.1016\/j.copbio.2026.103491_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1487165","article-title":"Enhancing aerobic composting of food waste by adding hydrolytically active microorganisms","volume":"15","author":"Mironov","year":"2024","journal-title":"Front Microbiol"},{"key":"10.1016\/j.copbio.2026.103491_bib27","doi-asserted-by":"crossref","DOI":"10.1093\/ismejo\/wrae228","article-title":"Microbiome science of human excrement composting","volume":"18","author":"Meilander","year":"2024","journal-title":"ISME J"},{"key":"10.1016\/j.copbio.2026.103491_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2025.1556537","article-title":"Effect of different bulking agents on the quality, microbial community structure and metabolic functions during human feces composting in foam composting device","volume":"16","author":"Ning","year":"2025","journal-title":"Front Microbiol"},{"key":"10.1016\/j.copbio.2026.103491_bib29","unstructured":"Behnke N., Diamond S., Gallerno J., Nguyen M., Windbigler R.: NASA X-Hab Renewal of Used Substrate FABE 4910 2018:44, \u3008https:\/\/ntrs.nasa.gov\/api\/citations\/20230009742\/downloads\/2018%20Ohio.pdf\u3009."},{"key":"10.1016\/j.copbio.2026.103491_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02466-24","article-title":"Simulated microgravity confines and fragments the straw-based lignocellulose degrading microbial community","volume":"13","author":"Liao","year":"2025","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.copbio.2026.103491_bib31","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1080\/10643389.2018.1558889","article-title":"Recycling nutrients contained in human excreta to agriculture: pathways, processes, and products","volume":"49","author":"Harder","year":"2019","journal-title":"Crit Rev Environ Sci Technol"},{"key":"10.1016\/j.copbio.2026.103491_bib32","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/j.wasman.2011.03.021","article-title":"The anaerobic digestion of solid organic waste","volume":"31","author":"Khalid","year":"2011","journal-title":"Waste Manag"},{"key":"10.1016\/j.copbio.2026.103491_bib33","series-title":"The Role of Anaerobic Digestion and Biogas in the Circular Economy (IEA Bioenergy Task 37)","first-page":"44","author":"Fagerstr\u00f6m","year":"2018"},{"key":"10.1016\/j.copbio.2026.103491_bib34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.biotno.2024.02.001","article-title":"A comprehensive study on anaerobic digestion of organic solid waste: a review on configurations, operating parameters, techno-economic analysis and current trends","volume":"5","author":"Prasanna Kumar","year":"2024","journal-title":"Biotechnol Notes"},{"key":"10.1016\/j.copbio.2026.103491_sbref33","series-title":"50th International Conference on Environmental Systems","first-page":"9","article-title":"A prototype early planetary Organic Processor Assembly (OPA) based on dual-stage Anaerobic Membrane Bioreactor (AnMBR) for fecal and food waste treatment and resource recovery","author":"Bullard","year":"2021"},{"key":"10.1016\/j.copbio.2026.103491_bib36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.seppur.2017.08.017","article-title":"Development of a passive phase separator for space and earth applications","volume":"189","author":"Wu","year":"2017","journal-title":"Sep Purif Technol"},{"key":"10.1016\/j.copbio.2026.103491_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering10091084","article-title":"Mass transfer enhancement in high-solids anaerobic digestion of organic fraction of municipal solid wastes: a review","volume":"10","author":"Gao","year":"2023","journal-title":"Bioengineering"},{"key":"10.1016\/j.copbio.2026.103491_bib38","first-page":"32","article-title":"Coupling of anaerobic waste treatment to produce protein- and lipid-rich bacterial biomass","volume":"15","author":"Steinberg","year":"2017","journal-title":"Life Sci Space Res"},{"key":"10.1016\/j.copbio.2026.103491_sbref37","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.700810","article-title":"Development of nitrogen recycling strategies for bioregenerative life support systems in space","volume":"12","author":"Verbeelen","year":"2021","journal-title":"Front Microbiol"},{"key":"10.1016\/j.copbio.2026.103491_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-52778-2","article-title":"A new approach to biomining: bioengineering surfaces for metal recovery from aqueous solutions","volume":"9","author":"Urbina","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.copbio.2026.103491_sbref39","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-19276-w","article-title":"Space station biomining experiment demonstrates rare earth element extraction in microgravity and Mars gravity","volume":"11","author":"Cockell","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2026.103491_sbref40","doi-asserted-by":"crossref","DOI":"10.1186\/s40694-025-00201-z","article-title":"Biomining of lunar regolith simulant EAC-1 A with the fungus Penicillium simplicissimum","volume":"12","author":"Figueira","year":"2025","journal-title":"Fungal Biol Biotechnol"},{"key":"10.1016\/j.copbio.2026.103491_bib43","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.proenv.2016.02.107","article-title":"Bioleaching of Al from coarse-grained waste printed circuit boards in a stirred tank reactor","volume":"31","author":"Fu","year":"2016","journal-title":"Procedia Environ Sci"},{"key":"10.1016\/j.copbio.2026.103491_bib44","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jenvman.2018.05.056","article-title":"Recovery of Al, Cr and V from steel slag by bioleaching: batch and column experiments","volume":"222","author":"Gomes","year":"2018","journal-title":"J Environ Manag"},{"key":"10.1016\/j.copbio.2026.103491_bib45","article-title":"Bioleaching of Al from spent fluid catalytic cracking catalyst using Aspergillus species","volume":"23","author":"Das","year":"2019","journal-title":"Biotechnol Rep"},{"key":"10.1016\/j.copbio.2026.103491_bib46","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1007\/s00449-019-02178-7","article-title":"Bioleaching of silicon in electrolytic manganese residue using single and mixed silicate bacteria","volume":"42","author":"Lv","year":"2019","journal-title":"Bioprocess Biosyst Eng"},{"key":"10.1016\/j.copbio.2026.103491_bib47","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.pss.2013.09.009","article-title":"Growth of the acidophilic iron\u2013sulfur bacterium Acidithiobacillus ferrooxidans under Mars-like geochemical conditions","volume":"98","author":"Bauermeister","year":"2014","journal-title":"Planet Space Sci"},{"key":"10.1016\/j.copbio.2026.103491_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25214916","article-title":"Extremophilic microorganisms for the treatment of toxic pollutants in the environment","volume":"25","author":"Jeong","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.copbio.2026.103491_bib49","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/s12088-024-01297-4","article-title":"Extremophiles in space exploration","volume":"64","author":"Kaur","year":"2024","journal-title":"Indian J Microbiol"},{"key":"10.1016\/j.copbio.2026.103491_bib50","doi-asserted-by":"crossref","DOI":"10.1093\/jimb\/kuab015","article-title":"Potential applications of halophilic microorganisms for biological treatment of industrial process brines contaminated with aromatics","volume":"48","author":"Mainka","year":"2021","journal-title":"J Ind Microbiol Biotechnol"},{"key":"10.1016\/j.copbio.2026.103491_bib51","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00792-009-0264-0","article-title":"Selection of a cold-adapted bacterium for bioremediation of wastewater at low temperatures","volume":"13","author":"Gratia","year":"2009","journal-title":"Extremophiles"},{"key":"10.1016\/j.copbio.2026.103491_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.01490","article-title":"Diversity manipulation of psychrophilic bacterial consortia for improved biological treatment of medium-strength wastewater at low temperature","volume":"11","author":"Augelletti","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.copbio.2026.103491_bib53","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-024-01916-8","article-title":"Adaptation to space conditions of novel bacterial species isolated from the International Space Station revealed by functional gene annotations and comparative genome analysis","volume":"12","author":"Szydlowski","year":"2024","journal-title":"Microbiome"},{"key":"10.1016\/j.copbio.2026.103491_bib54","series-title":"New Frontiers in Astrobiology","first-page":"135","article-title":"Microbial life in space","author":"Vaishampayan","year":"2022"},{"key":"10.1016\/j.copbio.2026.103491_bib55","doi-asserted-by":"crossref","first-page":"14964","DOI":"10.33263\/BRIAC116.1496414973","article-title":"Bovine manure as a rich source for isolation of halo-tolerant bacterial strains capable of PAHs biodegradation in slurry bioreactor","volume":"11","author":"Jaafarzadeh","year":"2021","journal-title":"Biointerface Res Appl Chem"},{"key":"10.1016\/j.copbio.2026.103491_bib56","doi-asserted-by":"crossref","DOI":"10.1186\/s12934-016-0603-7","article-title":"Current knowledge and perspectives of Paenibacillus: a review","volume":"15","author":"Grady","year":"2016","journal-title":"Micro Cell Factor"},{"key":"10.1016\/j.copbio.2026.103491_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/biology11050727","article-title":"Paenibacillus sp strain OL15 immobilized in Agar as a potential bioremediator for waste lubricating oil-contaminated soils and insights into soil bacterial communities affected by inoculations of the strain and environmental factors","volume":"11","author":"Pongsilp","year":"2022","journal-title":"Biology"},{"key":"10.1016\/j.copbio.2026.103491_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/s41526-023-00285-0","article-title":"Microbial applications for sustainable space exploration beyond low Earth orbit","volume":"9","author":"Koehle","year":"2023","journal-title":"Npj Microgravity"},{"key":"10.1016\/j.copbio.2026.103491_bib59","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.actaastro.2017.08.026","article-title":"The water treatment and recycling in 105-day bioregenerative life support experiment in the Lunar Palace 1","volume":"140","author":"Xie","year":"2017","journal-title":"Acta Astronaut"},{"key":"10.1016\/j.copbio.2026.103491_bib60","first-page":"121","article-title":"Design and establishment of a large-scale controlled ecological life-support system integrated experimental platform","volume":"31","author":"Tang","year":"2021","journal-title":"Life Sci Space Res"},{"key":"10.1016\/j.copbio.2026.103491_bib61","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/71986","article-title":"Engineering Deinococcus radiodurans for metal remediation in radioactive mixed waste environments","volume":"18","author":"Brim","year":"2000","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.copbio.2026.103491_bib62","doi-asserted-by":"crossref","DOI":"10.1111\/1758-2229.13231","article-title":"Genome-scale metabolic modelling of extremophiles and its applications in astrobiological environments","volume":"16","author":"Noirungsee","year":"2024","journal-title":"Environ Microbiol Rep"},{"key":"10.1016\/j.copbio.2026.103491_bib63","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.actaastro.2025.01.007","article-title":"Factory in space: a review of material and manufacturing technologies","volume":"229","author":"Abdulhamid","year":"2025","journal-title":"Acta Astronaut"},{"key":"10.1016\/j.copbio.2026.103491_bib64","doi-asserted-by":"crossref","DOI":"10.1186\/s42055-021-00042-9","article-title":"From space back to Earth: supporting sustainable development with spaceflight technologies","volume":"4","author":"Maiwald","year":"2021","journal-title":"Sustain Earth"},{"key":"10.1016\/j.copbio.2026.103491_sbref63","doi-asserted-by":"crossref","DOI":"10.1038\/s41526-025-00463-2","article-title":"Development and flight-testing of modular autonomous cultivation systems for biological plastics upcycling aboard the ISS","volume":"11","author":"Liu","year":"2025","journal-title":"NPJ Microgravity"},{"key":"10.1016\/j.copbio.2026.103491_bib66","series-title":"DARPA Program Aims to Develop Fundamentals of Biomanufacturing in Space","year":"2021"},{"key":"10.1016\/j.copbio.2026.103491_bib67","series-title":"DARPA to Launch DoD\u2019s First In-space Manufacturing Research Program","author":"Erwin","year":"2021"},{"key":"10.1016\/j.copbio.2026.103491_sbref66","article-title":"Developing an alternative medium for in-space biomanufacturing","volume":"16","author":"Lee","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2026.103491_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ymben.2019.08.004","article-title":"The emergence of adaptive laboratory evolution as an efficient tool for biological discovery and industrial biotechnology","volume":"56","author":"Sandberg","year":"2019","journal-title":"Metab Eng"},{"key":"10.1016\/j.copbio.2026.103491_bib70","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mib.2018.02.009","article-title":"Rational engineering of synthetic microbial systems: from single cells to consortia","volume":"45","author":"Bittihn","year":"2018","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.copbio.2026.103491_bib71","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.tibtech.2018.11.002","article-title":"Synthetic biology tools to engineer microbial communities for biotechnology","volume":"37","author":"McCarty","year":"2019","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.copbio.2026.103491_bib72","article-title":"Adaptive laboratory evolution of Micrococcus luteus and identification of genes associated with radioresistance through genome-wide association study","volume":"15","author":"Tang","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.copbio.2026.103491_bib73","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-40777-x","article-title":"Engineering microbial division of labor for plastic upcycling","volume":"14","author":"Bao","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2026.103491_bib74","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ymben.2021.03.011","article-title":"Towards bio-upcycling of polyethylene terephthalate","volume":"66","author":"Tiso","year":"2021","journal-title":"Metab Eng"},{"key":"10.1016\/j.copbio.2026.103491_bib75","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.renene.2022.12.012","article-title":"Integrated bioprocess of microbial lipids production in Yarrowia lipolytica using food-waste derived volatile fatty acids","volume":"202","author":"Pereira","year":"2023","journal-title":"Renew Energy"},{"key":"10.1016\/j.copbio.2026.103491_sbref74","article-title":"Engineering microbial consortia for mixed plastic upcycling","volume":"17","author":"Diao","year":"2026","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2026.103491_bib77","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-14371-4","article-title":"Compartmentalized microbes and co-cultures in hydrogels for on-demand bioproduction and preservation","volume":"11","author":"Johnston","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2026.103491_bib78","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-28163-5","article-title":"Genetically stable CRISPR-based kill switches for engineered microbes","volume":"13","author":"Rottinghaus","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2026.103491_bib79","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/nchembio.1979","article-title":"\u201cDeadman\u201d and \u201cPasscode\u201d microbial kill switches for bacterial containment","volume":"12","author":"Chan","year":"2016","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.copbio.2026.103491_bib80","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-42358-4","article-title":"A robust yeast biocontainment system with two-layered regulation switch dependent on unnatural amino acid","volume":"14","author":"Chang","year":"2023","journal-title":"Nat Commun"}],"container-title":["Current Opinion in Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095816692600056X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095816692600056X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T16:14:26Z","timestamp":1779984866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095816692600056X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":80,"alternative-id":["S095816692600056X"],"URL":"https:\/\/doi.org\/10.1016\/j.copbio.2026.103491","relation":{},"ISSN":["0958-1669"],"issn-type":[{"value":"0958-1669","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microbial and synthetic biology solutions for waste management and biomanufacturing off Earth","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.copbio.2026.103491","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103491"}}