{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:32:13Z","timestamp":1787157133265,"version":"build-2736575974"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018694","name":"HORIZON EUROPE Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","award":["101120389"],"award-info":[{"award-number":["101120389"]}],"id":[{"id":"10.13039\/100018694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/X01911X\/1"],"award-info":[{"award-number":["BB\/X01911X\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/T011408\/1\\u201319-ERACoBioTech-33 SyCoLim"],"award-info":[{"award-number":["BB\/T011408\/1\\u201319-ERACoBioTech-33 SyCoLim"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/R01602X\/1"],"award-info":[{"award-number":["BB\/R01602X\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/T013176\/1"],"award-info":[{"award-number":["BB\/T013176\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/Y008510\/1"],"award-info":[{"award-number":["BB\/Y008510\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"HORIZON EUROPE Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["AI-4-EB BB\/W013770\/1"],"award-info":[{"award-number":["AI-4-EB BB\/W013770\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/Y014073\/1"],"award-info":[{"award-number":["EP\/Y014073\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["18229"],"award-info":[{"award-number":["18229"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["PERFECOAT-101022370"],"award-info":[{"award-number":["PERFECOAT-101022370"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["949080"],"award-info":[{"award-number":["949080"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018703","name":"HORIZON EUROPE European Innovation Council","doi-asserted-by":"publisher","award":["BB\/X511055\/1"],"award-info":[{"award-number":["BB\/X511055\/1"]}],"id":[{"id":"10.13039\/100018703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018703","name":"HORIZON EUROPE European Innovation Council","doi-asserted-by":"publisher","award":["EP\/X52556X\/1"],"award-info":[{"award-number":["EP\/X52556X\/1"]}],"id":[{"id":"10.13039\/100018703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018703","name":"HORIZON EUROPE European Innovation Council","doi-asserted-by":"publisher","award":["101098826"],"award-info":[{"award-number":["101098826"]}],"id":[{"id":"10.13039\/100018703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Biotechnology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.copbio.2026.103523","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:47:51Z","timestamp":1780508871000},"page":"103523","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Advances in metabolic engineering for the production of sustainable aviation fuels"],"prefix":"10.1016","volume":"100","author":[{"given":"Nicolas","family":"Fink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"de Freitas Naves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heber","family":"Gamboa-Mel\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2631-5898","authenticated-orcid":false,"given":"Rodrigo","family":"Ledesma-Amaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.copbio.2026.103523_bib1","article-title":"The contribution of global aviation to anthropogenic climate forcing for 2000 to 2018","volume":"244","author":"Lee","year":"2020","journal-title":"Atmos Environ"},{"key":"10.1016\/j.copbio.2026.103523_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.fuel.2020.120004","article-title":"Sustainable aviation fuel prescreening tools and procedures","volume":"290","author":"Heyne","year":"2021","journal-title":"Fuel"},{"key":"10.1016\/j.copbio.2026.103523_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.paerosci.2023.100922","article-title":"Hydrogen-powered aircraft: fundamental concepts, key technologies, and environmental impacts","volume":"141","author":"Adler","year":"2023","journal-title":"Prog Aerosp Sci"},{"key":"10.1016\/j.copbio.2026.103523_bib4","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.enpol.2017.12.007","article-title":"Aviation CO\u2082 emissions reductions from the use of alternative jet fuels","volume":"114","author":"Staples","year":"2018","journal-title":"Energy Policy"},{"key":"10.1016\/j.copbio.2026.103523_bib5","unstructured":"ASTM International. Standard specification for aviation turbine fuel containing synthesized hydrocarbons (ASTM D7566-24d). West Conshohocken (PA): ASTM International; 2024."},{"key":"10.1016\/j.copbio.2026.103523_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/en18205510","article-title":"Sustainable aviation fuels: a review of current techno economic viability and life cycle impacts","volume":"18","author":"Uddin","year":"2025","journal-title":"Energies"},{"key":"10.1016\/j.copbio.2026.103523_bib7","unstructured":"O\u2019Malley J., Pavlenko N., Kim Y.H. Meeting the SAF Grand Challenge: current and future measures to increase U.S. sustainable aviation fuel production capacity. Int Counc Clean Transp white paper; 2023 \u3008https:\/\/theicct.org\/wp-content\/uploads\/2023\/11\/ID-37-%E2%80%93-SAF-Grand-Challenge-white-paper-letter-40036-v3.pdf\u3009."},{"key":"10.1016\/j.copbio.2026.103523_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.enconman.2025.120344","article-title":"Techno-economic assessment of electrification options to produce sustainable aviation fuel via biomass gasification and Fischer\u2013Tropsch synthesis","volume":"345","author":"Dossow","year":"2025","journal-title":"Energy Convers Manag"},{"key":"10.1016\/j.copbio.2026.103523_bib9","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1002\/cssc.201801690","article-title":"The alcohol-to-jet conversion pathway for drop-in biofuels: techno-economic evaluation","volume":"11","author":"Geleynse","year":"2018","journal-title":"ChemSusChem"},{"key":"10.1016\/j.copbio.2026.103523_bib10","article-title":"Current outlook on sustainable feedstocks and processes for sustainable aviation fuel production","volume":"49","author":"Zahid","year":"2024","journal-title":"Curr Opin Green Sustain Chem"},{"key":"10.1016\/j.copbio.2026.103523_bib11","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41579-021-00577-w","article-title":"Microbial production of advanced biofuels","volume":"19","author":"Keasling","year":"2021","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.copbio.2026.103523_sbref10","article-title":"Sustainable aviation fuels: Key opportunities and challenges in lowering carbon emissions for aviation industry","volume":"13","author":"Wang","year":"2024","journal-title":"Carbon Capture Sci Technol"},{"key":"10.1016\/j.copbio.2026.103523_bib13","article-title":"Microbial production of fuels, commodity chemicals, and materials from sustainable sources of carbon and energy","volume":"36","author":"Cowan","year":"2023","journal-title":"Curr Opin Syst Biol"},{"key":"10.1016\/j.copbio.2026.103523_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106944","article-title":"Multi-criteria decision analysis for the evaluation and screening of sustainable aviation fuel production pathways","volume":"26","author":"Okolie","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.copbio.2026.103523_bib15","doi-asserted-by":"crossref","unstructured":"Rosales Calderon O., Tao L., Abdullah Z., Moriarty K., Smolinski S., Milbrandt A., et al. Sustainable Aviation Fuel (SAF) State-of-Industry Report: State of SAF Production Process. Golden, CO: National Renewable Energy Laboratory; 2024. NREL\/TP-5100-87802. \u3008https:\/\/www.nrel.gov\/docs\/fy24osti\/87802.pdf\u3009 [accessed 24 November 2025].","DOI":"10.2172\/2426562"},{"key":"10.1016\/j.copbio.2026.103523_bib16","unstructured":"Holladay J., Abdullah Z., Heyne J. Sustainable Aviation Fuel: Review of Technical Pathways [Internet]. DOE EERE; Pacific Northwest National Lab. (PNNL), Richland, WA (United States); National Renewable Energy Lab. (NREL), Golden, CO (United States); University of Dayton, OH (United States); 2020 Sept [cited 2024 Nov 25]. Report No.: DOE\/EE-2041. Available from: \u3008https:\/\/www.osti.gov\/biblio\/1660415\u3009."},{"key":"10.1016\/j.copbio.2026.103523_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2025.132039","article-title":"Sustainable aviation fuel (SAF) from lignin: pathways, catalysts, and challenges","volume":"419","author":"Lv","year":"2025","journal-title":"Bioresour Technol"},{"key":"10.1016\/j.copbio.2026.103523_bib18","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1039\/D4SC06164K","article-title":"Potential pathways for CO\u2082 utilization in sustainable aviation fuel synthesis","volume":"16","author":"Ramos-Fernandez","year":"2025","journal-title":"Chem Sci"},{"key":"10.1016\/j.copbio.2026.103523_sbref15","doi-asserted-by":"crossref","DOI":"10.1186\/s13036-024-00473-w","article-title":"Advanced metabolic engineering strategies for the sustainable production of free fatty acids and their derivatives using yeast","volume":"18","author":"Saha","year":"2024","journal-title":"J Biol Eng"},{"key":"10.1016\/j.copbio.2026.103523_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.599560","article-title":"Sustainable production of microbial isoprenoid-derived advanced biojet fuels using different generation feedstocks: a review","volume":"8","author":"Walls","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.copbio.2026.103523_sbref17","doi-asserted-by":"crossref","DOI":"10.1186\/s13068-024-02546-w","article-title":"Microbial conversion of ethanol to high-value products: progress and challenges","volume":"17","author":"Sun","year":"2024","journal-title":"Biotechnol Biofuels"},{"key":"10.1016\/j.copbio.2026.103523_sbref18","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2023.129993","article-title":"High titre (>100 g\/L) ethanol production from pretreated corn stover hydrolysate by modified yeast strains","volume":"391","author":"Zhao","year":"2024","journal-title":"Bioresour Technol"},{"key":"10.1016\/j.copbio.2026.103523_bib23","doi-asserted-by":"crossref","DOI":"10.1186\/s13068-019-1463-2","article-title":"Replacing water and nutrients for ethanol production by ARTP-derived biogas slurry tolerant Zymomonas mobilis strain","volume":"12","author":"Duan","year":"2019","journal-title":"Biotechnol Biofuels"},{"key":"10.1016\/j.copbio.2026.103523_bib24","article-title":"Perspectives and progress in bioethanol processing and socio-economic impacts","volume":"16","author":"Alberto","year":"2024","journal-title":"Sustainability"},{"key":"10.1016\/j.copbio.2026.103523_bib25","doi-asserted-by":"crossref","DOI":"10.1186\/s12934-024-02419-9","article-title":"A new Zymomonas mobilis platform strain for the efficient production of chemicals","volume":"23","author":"Frohwitter","year":"2024","journal-title":"Microb Cell Fact"},{"key":"10.1016\/j.copbio.2026.103523_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/jof9100984","article-title":"From Saccharomyces cerevisiae to ethanol: unlocking the power of evolutionary engineering in metabolic engineering applications","volume":"9","author":"Topalo\u011flu","year":"2023","journal-title":"J Fungi"},{"key":"10.1016\/j.copbio.2026.103523_bib27","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1002\/bit.24563","article-title":"High-titre-butanol production by Clostridium acetobutylicum JB200 in fed-batch fermentation with intermittent gas stripping","volume":"109","author":"Xue","year":"2012","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.copbio.2026.103523_bib28","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.02560-18","article-title":"Improved n-butanol production from Clostridium cellulovorans by integrated metabolic and evolutionary engineering","volume":"85","author":"Wen","year":"2019","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.copbio.2026.103523_bib29","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ymben.2017.10.014","article-title":"A systematically chromosomally engineered Escherichia coli efficiently produces butanol","volume":"44","author":"Dong","year":"2017","journal-title":"Metab Eng"},{"key":"10.1016\/j.copbio.2026.103523_bib30","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1007\/s00253-011-3173-y","article-title":"High-flux isobutanol production using engineered Escherichia coli: a bioreactor study with in situ product removal","volume":"90","author":"Baez","year":"2011","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.copbio.2026.103523_bib31","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.tibtech.2019.01.011","article-title":"Biological conversion of amino acids to higher alcohols","volume":"37","author":"El-Dalatony","year":"2019","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.copbio.2026.103523_bib32","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s00253-009-2401-1","article-title":"3-Methyl-1-butanol production in Escherichia coli: random mutagenesis and two-phase fermentation","volume":"86","author":"Connor","year":"2010","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.copbio.2026.103523_bib33","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ymben.2020.07.004","article-title":"Production of 1-octanol in Escherichia coli by a high-flux thioesterase route","volume":"61","author":"Hern\u00e1ndez Lozada","year":"2020","journal-title":"Metab Eng"},{"key":"10.1016\/j.copbio.2026.103523_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2025.108684","article-title":"Brews, fuels, and opioids: expanding the yeast Ehrlich pathway for chemical and pharmaceutical manufacturing","volume":"84","author":"Rumpl","year":"2025","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.copbio.2026.103523_bib35","doi-asserted-by":"crossref","first-page":"9498","DOI":"10.1021\/acs.jafc.1c03864","article-title":"Engineering plant sesquiterpene synthesis into yeasts: a review","volume":"69","author":"Mai","year":"2021","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.copbio.2026.103523_bib36","article-title":"Microbial platform for terpenoid production: Escherichia coli and yeast","volume":"9","author":"Wang","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.copbio.2026.103523_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25081881","article-title":"A gram-scale limonene production process with engineered Escherichia coli","volume":"25","author":"Rolf","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.copbio.2026.103523_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.fuel.2023.127872","article-title":"Efficient production of \u03b1-pinene through identifying the rate-limiting enzymes and tailoring inactive terminal of pinene synthase in Escherichia coli.","volume":"343","author":"Zhou","year":"2023","journal-title":"Fuel"},{"key":"10.1016\/j.copbio.2026.103523_sbref35","doi-asserted-by":"crossref","first-page":"19395","DOI":"10.1021\/acs.jafc.4c05046","article-title":"Systematic engineering to enhance \u03b2-myrcene production in yeast","volume":"72","author":"Shu","year":"2024","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.copbio.2026.103523_bib40","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/nature19769","article-title":"Rewriting yeast central carbon metabolism for industrial isoprenoid production","volume":"537","author":"Meadows","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.copbio.2026.103523_sbref37","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ymben.2025.02.014","article-title":"The oleaginous yeast Rhodosporidium toruloides engineered for biomass hydrolysate-derived (E)-\u03b1-bisabolene production","volume":"90","author":"Adamczyk","year":"2025","journal-title":"Metab Eng"},{"key":"10.1016\/j.copbio.2026.103523_bib42","doi-asserted-by":"crossref","first-page":"15157","DOI":"10.1021\/acs.jafc.2c05847","article-title":"Enhancing trans-nerolidol productivity in Yarrowia lipolytica by improving precursor supply and optimizing nerolidol synthase activity","volume":"70","author":"Liu","year":"2022","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.copbio.2026.103523_bib43","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.tibtech.2020.03.009","article-title":"Novel strategies and platforms for industrial isoprenoid engineering","volume":"38","author":"Daletos","year":"2020","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.copbio.2026.103523_bib44","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ymben.2016.06.004","article-title":"Combining metabolic engineering and process optimization to improve production and secretion of fatty acids","volume":"38","author":"Ledesma-Amaro","year":"2016","journal-title":"Metab Eng"},{"key":"10.1016\/j.copbio.2026.103523_bib45","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.tibtech.2012.09.006","article-title":"Engineering Escherichia coli to synthesize free fatty acids","volume":"30","author":"Lennen","year":"2012","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.copbio.2026.103523_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14650","article-title":"Engineering fungal de novo fatty acid synthesis for short chain fatty acid production","volume":"8","author":"Gajewski","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2026.103523_bib47","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nbt.3095","article-title":"Distributing a metabolic pathway among a microbial consortium enhances production of natural products","volume":"33","author":"Zhou","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.copbio.2026.103523_bib48","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1099\/mic.0.29028-0","article-title":"Microdiesel: Escherichia coli engineered for fuel production","volume":"152","author":"Kalscheuer","year":"2006","journal-title":"Microbiology"},{"key":"10.1016\/j.copbio.2026.103523_bib49","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1007\/s00253-023-12466-8","article-title":"Directed evolution of a wax ester synthase for production of fatty acid ethyl esters in Saccharomyces cerevisiae","volume":"107","author":"Valle-Rodr\u00edguez","year":"2023","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.copbio.2026.103523_bib50","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1021\/acssynbio.7b00453","article-title":"Overproduction of fatty acid ethyl esters by the oleaginous yeast Yarrowia lipolytica through metabolic engineering and process optimization","volume":"7","author":"Gao","year":"2018","journal-title":"ACS Synth Biol"},{"key":"10.1016\/j.copbio.2026.103523_bib51","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.apenergy.2013.10.003","article-title":"Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid ethyl esters, an advanced biofuel, by eliminating non-essential fatty acid utilization pathways","volume":"115","author":"Valle-Rodr\u00edguez","year":"2014","journal-title":"Appl Energy"},{"key":"10.1016\/j.copbio.2026.103523_bib52","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1021\/acs.jafc.7b00002","article-title":"Photosynthetic CO\u2082 conversion to fatty acid ethyl esters (FAEEs) using engineered cyanobacteria","volume":"65","author":"Lee","year":"2017","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.copbio.2026.103523_bib53","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1002\/cssc.201500002","article-title":"Highly selective condensation of biomass-derived methyl ketones as a source of aviation fuel","volume":"8","author":"Sacia","year":"2015","journal-title":"ChemSusChem"},{"key":"10.1016\/j.copbio.2026.103523_bib54","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1128\/AEM.06785-11","article-title":"Engineering of bacterial methyl ketone synthesis for biofuels","volume":"78","author":"Goh","year":"2012","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.copbio.2026.103523_bib55","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ymben.2014.09.003","article-title":"Substantial improvements in methyl ketone production in E. coli and insights on the pathway from in vitro studies","volume":"26","author":"Goh","year":"2014","journal-title":"Metab Eng"},{"key":"10.1016\/j.copbio.2026.103523_bib56","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ymben.2020.08.003","article-title":"High titre methyl ketone production with tailored Pseudomonas taiwanensis VLB120","volume":"62","author":"Nies","year":"2020","journal-title":"Metab Eng"},{"key":"10.1016\/j.copbio.2026.103523_bib57","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1002\/bit.26995","article-title":"Methyl ketone production by Pseudomonas putida is enhanced by plant-derived amino acids","volume":"116","author":"Dong","year":"2019","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.copbio.2026.103523_bib58","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1016\/j.ijbiomac.2020.08.162","article-title":"Cyanobacterial aldehyde deformylating oxygenase: structure, function, and potential in biofuels production","volume":"164","author":"Basri","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.copbio.2026.103523_bib59","doi-asserted-by":"crossref","DOI":"10.1186\/s12896-017-0351-8","article-title":"Identification of residues important for the activity of aldehyde-deformylating oxygenase through investigation into the structure-activity relationship","volume":"17","author":"Wang","year":"2017","journal-title":"BMC Biotechnol"},{"key":"10.1016\/j.copbio.2026.103523_bib60","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.tibtech.2021.01.001","article-title":"Metabolic engineering of Cupriavidus necator H16 for sustainable biofuels from CO\u2082","volume":"39","author":"Panich","year":"2021","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.copbio.2026.103523_bib61","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s10295-016-1814-y","article-title":"Biobased production of alkanes and alkenes through metabolic engineering of microorganisms","volume":"44","author":"Kang","year":"2017","journal-title":"J Ind Microbiol Biotechnol"},{"key":"10.1016\/j.copbio.2026.103523_bib62","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1093\/plphys\/kiab168","article-title":"Fatty acid photodecarboxylase is an ancient photoenzyme that forms hydrocarbons in the thylakoids of algae","volume":"186","author":"Moulin","year":"2021","journal-title":"Plant Physiol"},{"key":"10.1016\/j.copbio.2026.103523_bib63","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-19995-0","article-title":"Synthesis of high-titre alka(e)nes in Yarrowia lipolytica is enabled by a discovered mechanism","volume":"11","author":"Li","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2026.103523_sbref60","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ymben.2025.05.003","article-title":"Engineering oleaginous yeast Rhodotorula toruloides for production of alkanes and alkenes","volume":"91","author":"Yu","year":"2025","journal-title":"Metab Eng"},{"key":"10.1016\/j.copbio.2026.103523_sbref61","article-title":"Sustainable biolipids-to-alkane conversion: a cascade biocatalysis strategy with enhanced photobiocatalytic efficiency","volume":"7","author":"Liang","year":"2025","journal-title":"Energy"},{"key":"10.1016\/j.copbio.2026.103523_bib66","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adg3881","article-title":"Autocatalytic effect boosts the production of medium-chain hydrocarbons by fatty acid photodecarboxylase","volume":"9","author":"Samire","year":"2023","journal-title":"Sci Adv"},{"key":"10.1016\/j.copbio.2026.103523_bib67","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1016\/j.csbj.2023.03.045","article-title":"Machine learning for metabolic pathway optimization: a review","volume":"21","author":"Cheng","year":"2023","journal-title":"Comput Struct Biotechnol J"},{"key":"10.1016\/j.copbio.2026.103523_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2025.133286","article-title":"Leveraging artificial intelligence for efficient microbial production","volume":"439","author":"Gong","year":"2026","journal-title":"Bioresour Technol"},{"key":"10.1016\/j.copbio.2026.103523_bib69","doi-asserted-by":"crossref","DOI":"10.1093\/jimb\/kuac023","article-title":"Recent progress in adaptive laboratory evolution of industrial microorganisms","volume":"50","author":"Wang","year":"2023","journal-title":"J Ind Microbiol Biotechnol"},{"key":"10.1016\/j.copbio.2026.103523_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.engmic.2023.100103","article-title":"Advances in the dynamic control of metabolic pathways in Saccharomyces cerevisiae","volume":"3","author":"Xiao","year":"2023","journal-title":"Eng Microbiol"},{"key":"10.1016\/j.copbio.2026.103523_bib71","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-42790-6","article-title":"The potential of CO\u2082-based production cycles in biotechnology to fight the climate crisis","volume":"14","author":"Bachleitner","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.copbio.2026.103523_bib72","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-45011-w","article-title":"Compositional and temporal division of labor modulates mixed sugar fermentation by an engineered yeast consortium","volume":"15","author":"Shin","year":"2024","journal-title":"Nat Commun"}],"container-title":["Current Opinion in Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958166926000881?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958166926000881?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:05:58Z","timestamp":1787155558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0958166926000881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":72,"alternative-id":["S0958166926000881"],"URL":"https:\/\/doi.org\/10.1016\/j.copbio.2026.103523","relation":{},"ISSN":["0958-1669"],"issn-type":[{"value":"0958-1669","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advances in metabolic engineering for the production of sustainable aviation fuels","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.copbio.2026.103523","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103523"}}