{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:39:46Z","timestamp":1792805986854,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000901","name":"Juvenile Diabetes Research Foundation International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Pharmacology"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.coph.2009.07.003","type":"journal-article","created":{"date-parts":[[2009,8,7]],"date-time":"2009-08-07T06:02:02Z","timestamp":1249624922000},"page":"763-770","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":141,"title":["Endoplasmic reticulum stress in \u03b2-cells and development of diabetes"],"prefix":"10.1016","volume":"9","author":[{"given":"Sonya G","family":"Fonseca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Burcin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Gromada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Urano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coph.2009.07.003_bib1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.coph.2009.07.003_bib2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.tibs.2007.09.003","article-title":"That which does not kill me makes me stronger, adapting to chronic ER stress","volume":"32","author":"Rutkowski","year":"2007","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.coph.2009.07.003_bib3","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1242\/jcs.113.21.3697","article-title":"IRE1 and efferent signaling from the endoplasmic reticulum","volume":"113","author":"Urano","year":"2000","journal-title":"J Cell Sci"},{"key":"10.1016\/j.coph.2009.07.003_bib4","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0092-8674(01)00611-0","article-title":"XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor","volume":"107","author":"Yoshida","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.coph.2009.07.003_bib5","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0092-8674(01)00612-2","article-title":"Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development","volume":"107","author":"Shen","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.coph.2009.07.003_bib6","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/415092a","article-title":"IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA","volume":"415","author":"Calfon","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.coph.2009.07.003_bib7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1534-5807(03)00022-4","article-title":"A time-dependent phase shift in the mammalian unfolded protein response","volume":"4","author":"Yoshida","year":"2003","journal-title":"Dev Cell"},{"key":"10.1016\/j.coph.2009.07.003_bib8","doi-asserted-by":"crossref","first-page":"7448","DOI":"10.1128\/MCB.23.21.7448-7459.2003","article-title":"XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response","volume":"23","author":"Lee","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.coph.2009.07.003_bib9","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.287.5453.664","article-title":"Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1","volume":"287","author":"Urano","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.coph.2009.07.003_bib10","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1101\/gad.992302","article-title":"ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats","volume":"16","author":"Nishitoh","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.coph.2009.07.003_bib11","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S1097-2765(00)80283-X","article-title":"ASK1 is essential for JNK\/SAPK activation by TRAF2","volume":"2","author":"Nishitoh","year":"1998","journal-title":"Mol Cell"},{"key":"10.1016\/j.coph.2009.07.003_bib12","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/16729","article-title":"Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase","volume":"397","author":"Harding","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.coph.2009.07.003_bib13","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S1097-2765(00)80330-5","article-title":"Perk is essential for translational regulation and cell survival during the unfolded protein response","volume":"5","author":"Harding","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/j.coph.2009.07.003_bib14","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S1097-2765(00)00108-8","article-title":"Regulated translation initiation controls stress-induced gene expression in mammalian cells","volume":"6","author":"Harding","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/j.coph.2009.07.003_bib15","doi-asserted-by":"crossref","first-page":"33741","DOI":"10.1074\/jbc.273.50.33741","article-title":"Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors","volume":"273","author":"Yoshida","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coph.2009.07.003_bib16","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S1097-2765(00)00133-7","article-title":"ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs","volume":"6","author":"Ye","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/j.coph.2009.07.003_bib17","doi-asserted-by":"crossref","first-page":"6755","DOI":"10.1128\/MCB.20.18.6755-6767.2000","article-title":"ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response","volume":"20","author":"Yoshida","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.coph.2009.07.003_bib18","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1091\/mbc.10.11.3787","article-title":"Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress","volume":"10","author":"Haze","year":"1999","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.coph.2009.07.003_bib19_1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.devcel.2007.07.018","article-title":"Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1","volume":"13","author":"Yamamoto","year":"2007","journal-title":"Dev Cell"},{"key":"10.1016\/j.coph.2009.07.003_bib20","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/jcb.20118","article-title":"Endoplasmic reticulum stress triggers an acute proteasome-dependent degradation of ATF6","volume":"92","author":"Hong","year":"2004","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.coph.2009.07.003_bib21_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cmet.2006.07.007","article-title":"Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1","volume":"4","author":"Lipson","year":"2006","journal-title":"Cell Metab"},{"key":"10.1016\/j.coph.2009.07.003_bib22","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0022-3476(72)80596-1","article-title":"Infancy-onset diabetes mellitus and multiple epiphyseal dysplasia","volume":"80","author":"Wolcott","year":"1972","journal-title":"J Pediatr"},{"key":"10.1016\/j.coph.2009.07.003_bib23","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/78085","article-title":"EIF2AK3 encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott\u2013Rallison syndrome","volume":"25","author":"Delepine","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.coph.2009.07.003_bib24","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/S1097-2765(01)00264-7","article-title":"Diabetes mellitus and exocrine pancreatic dysfunction in PERK\u2212\/\u2212 mice reveals a role for translational control in secretory cell survival","volume":"7","author":"Harding","year":"2001","journal-title":"Mol Cell"},{"key":"10.1016\/j.coph.2009.07.003_bib25","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nm1259","article-title":"Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis","volume":"11","author":"Scheuner","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.coph.2009.07.003_bib26","doi-asserted-by":"crossref","first-page":"15920","DOI":"10.1073\/pnas.252341799","article-title":"Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK","volume":"99","author":"Yan","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coph.2009.07.003_bib27","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.2337\/diabetes.54.4.1074","article-title":"Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK","volume":"54","author":"Ladiges","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.coph.2009.07.003_bib28_1","doi-asserted-by":"crossref","first-page":"15040","DOI":"10.1073\/pnas.0707291104","article-title":"Insulin gene mutations as a cause of permanent neonatal diabetes","volume":"104","author":"Stoy","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coph.2009.07.003_bib29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1172\/JCI4431","article-title":"A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse","volume":"103","author":"Wang","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.coph.2009.07.003_bib30","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.2337\/db06-0658","article-title":"Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice","volume":"56","author":"Herbach","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.coph.2009.07.003_bib31","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1172\/JCI0214550","article-title":"Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes","volume":"109","author":"Oyadomari","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.coph.2009.07.003_bib32","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1084\/jem.182.6.1625","article-title":"DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis","volume":"182","author":"Casciola-Rosen","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.coph.2009.07.003_bib33","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/BF00403906","article-title":"The harmony of the spheres, inducible nitric oxide synthase and related genes in pancreatic beta cells","volume":"39","author":"Eizirik","year":"1996","journal-title":"Diabetologia"},{"key":"10.1016\/j.coph.2009.07.003_bib34","doi-asserted-by":"crossref","first-page":"10845","DOI":"10.1073\/pnas.191207498","article-title":"Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway","volume":"98","author":"Oyadomari","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coph.2009.07.003_bib35","doi-asserted-by":"crossref","first-page":"48879","DOI":"10.1074\/jbc.M108658200","article-title":"A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells","volume":"276","author":"Cardozo","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coph.2009.07.003_bib36_1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.2337\/diabetes.54.2.452","article-title":"Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells","volume":"54","author":"Cardozo","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.coph.2009.07.003_bib37","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1128\/MCB.24.13.5721-5732.2004","article-title":"Role for activating transcription factor 3 in stress-induced beta-cell apoptosis","volume":"24","author":"Hartman","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.coph.2009.07.003_bib38","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","article-title":"Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes","volume":"52","author":"Butler","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.coph.2009.07.003_bib39","series-title":"Diabetes Mellitus","first-page":"115","article-title":"Detrimental effects of chronic hyperglycemia on the pancreatic beta-cells","author":"Leahy","year":"2004"},{"key":"10.1016\/j.coph.2009.07.003_bib40","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/378785a0","article-title":"Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B","volume":"378","author":"Cross","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.coph.2009.07.003_bib41","doi-asserted-by":"crossref","first-page":"968","DOI":"10.2337\/diabetes.54.4.968","article-title":"Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase\/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells","volume":"54","author":"Srinivasan","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.coph.2009.07.003_bib42","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.2337\/diabetes.51.8.2496","article-title":"Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation","volume":"51","author":"Alarcon","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.coph.2009.07.003_bib43_1","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1210\/en.2005-1494","article-title":"Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis","volume":"147","author":"Karaskov","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.coph.2009.07.003_bib44","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1074\/jbc.M607627200","article-title":"Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis","volume":"282","author":"Cnop","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coph.2009.07.003_bib45","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1210\/en.2004-0478","article-title":"Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms, role of nuclear factor-kappaB and endoplasmic reticulum stress","volume":"145","author":"Kharroubi","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.coph.2009.07.003_bib46","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1126\/science.1103160","article-title":"Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes","volume":"306","author":"Ozcan","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.coph.2009.07.003_bib47","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1074\/jbc.M508510200","article-title":"The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation","volume":"281","author":"Kawamori","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coph.2009.07.003_bib48","first-page":"715","article-title":"Diabetes mellitus and simple optic atrophy among siblings, report of four cases","volume":"1","author":"Wolfram","year":"1938","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.coph.2009.07.003_bib49","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2337\/diacare.12.2.135","article-title":"Genetically programmed selective islet beta-cell loss in diabetic subjects with Wolfram's syndrome","volume":"12","author":"Karasik","year":"1989","journal-title":"Diabetes Care"},{"key":"10.1016\/j.coph.2009.07.003_bib50","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/2441","article-title":"A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)","volume":"20","author":"Inoue","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.coph.2009.07.003_bib51","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1093\/hmg\/7.13.2021","article-title":"Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein","volume":"7","author":"Strom","year":"1998","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.coph.2009.07.003_bib52","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/humu.1110","article-title":"WFS1\/wolframin mutations, Wolfram syndrome, and associated diseases","volume":"17","author":"Khanim","year":"2001","journal-title":"Hum Mutat"},{"key":"10.1016\/j.coph.2009.07.003_bib53","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1086\/302609","article-title":"Clinical and molecular genetic analysis of 19 Wolfram syndrome kindreds demonstrating a wide spectrum of mutations in WFS1","volume":"65","author":"Hardy","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.coph.2009.07.003_bib54","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/humu.10258","article-title":"Mutational spectrum of the WFS1 gene in Wolfram syndrome, nonsyndromic hearing impairment, diabetes mellitus, and psychiatric disease","volume":"22","author":"Cryns","year":"2003","journal-title":"Hum Mutat"},{"key":"10.1016\/j.coph.2009.07.003_bib55","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/hmg\/10.5.477","article-title":"WFS1 (Wolfram syndrome 1) gene product, predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain","volume":"10","author":"Takeda","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.coph.2009.07.003_bib56","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1093\/hmg\/ddg214","article-title":"Wolfram syndrome, structural and functional analyses of mutant and wild-type wolframin, the WFS1 gene product","volume":"12","author":"Hofmann","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.coph.2009.07.003_bib57_1","doi-asserted-by":"crossref","first-page":"39609","DOI":"10.1074\/jbc.M507426200","article-title":"WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic {beta}-cells","volume":"280","author":"Fonseca","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coph.2009.07.003_bib58_1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/ng2067","article-title":"Common variants in WFS1 confer risk of type 2 diabetes","volume":"39","author":"Sandhu","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.coph.2009.07.003_bib59","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s00125-007-0887-6","article-title":"Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations","volume":"51","author":"Franks","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.coph.2009.07.003_bib60","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.bbrc.2007.11.040","article-title":"A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress","volume":"365","author":"Han","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.coph.2009.07.003_bib61","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2006.01.004","article-title":"The biology of incretin hormones","volume":"3","author":"Drucker DJ","year":"2006","journal-title":"Cell Metab"},{"key":"10.1016\/j.coph.2009.07.003_bib62","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cmet.2006.10.001","article-title":"GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress","volume":"4","author":"Yusta","year":"2006","journal-title":"Cell Metab"}],"container-title":["Current Opinion in Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489209001180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489209001180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T06:47:20Z","timestamp":1761461240000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471489209001180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S1471489209001180"],"URL":"https:\/\/doi.org\/10.1016\/j.coph.2009.07.003","relation":{},"ISSN":["1471-4892"],"issn-type":[{"value":"1471-4892","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endoplasmic reticulum stress in \u03b2-cells and development of diabetes","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coph.2009.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}