{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T01:04:51Z","timestamp":1769389491532,"version":"3.49.0"},"reference-count":92,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Opinion in Pharmacology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.coph.2012.10.007","type":"journal-article","created":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T20:02:49Z","timestamp":1352404969000},"page":"98-107","source":"Crossref","is-referenced-by-count":57,"title":["Evaluation of presumptive biomarkers of oxidative stress, immune response and apoptosis in primary open-angle glaucoma"],"prefix":"10.1016","volume":"13","author":[{"given":"Maria D","family":"Pinazo-Dur\u00e1n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Zan\u00f3n-Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose J","family":"Garc\u00eda-Medina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Gallego-Pinazo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.coph.2012.10.007_bib0005","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","article-title":"Primary open-angle glaucoma","volume":"363","author":"Weinreb","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.coph.2012.10.007_bib0010_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1753-4887.2012.00476.x","article-title":"Free radicals and antioxidants: updating a personal view","volume":"70","author":"Halliwell","year":"2012","journal-title":"Nutr Rev"},{"key":"10.1016\/j.coph.2012.10.007_bib0015","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1056\/NEJM200008033430506","article-title":"Innate immunity","volume":"343","author":"Medzhitov","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.coph.2012.10.007_bib0020","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrm2312","article-title":"Apoptosis: controlled demolition at the cellular level","volume":"9","author":"Taylor","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.coph.2012.10.007_bib0025","series-title":"Biomarkers and Surrogate Endpoints in Clinical Research: Definitions and Conceptual Model","article-title":"Biomarkers and surrogate endpoints","author":"NIH Definitions Working Group","year":"2000"},{"key":"10.1016\/j.coph.2012.10.007_bib0030","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1365-2125.2005.02435.x","article-title":"Biomarkers and surrogate endpoints","volume":"59","author":"Aronson","year":"2005","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.coph.2012.10.007_bib0035","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0002-9394(03)00788-8","article-title":"Oxidative stress markers in aqueous humor of glaucoma patients","volume":"137","author":"Ferreira","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.coph.2012.10.007_bib0040","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/IJG.0b013e31815c3a7f","article-title":"Oxidative stress in primary open-angle glaucoma","volume":"17","author":"Zanon-Moreno","year":"2008","journal-title":"J Glaucoma"},{"key":"10.1016\/j.coph.2012.10.007_bib0045_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1472-8206.2011.00969.x","volume":"26","author":"Babizhayev","year":"2012","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.coph.2012.10.007_bib0050_1","first-page":"1182","article-title":"Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors","volume":"17","author":"McElnea","year":"2011","journal-title":"Mol Vis"},{"key":"10.1016\/j.coph.2012.10.007_bib0055","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1177\/112067210701700408","article-title":"Clinical evaluation of the neuroprotective effect of alpha-tocopherol against glaucomatous damage","volume":"17","author":"Engin","year":"2007","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.coph.2012.10.007_bib0060","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3109\/02713683.2011.584370","article-title":"Antioxidant status and oxidative stress in primary open angle glaucoma and pseudoexfoliative glaucoma","volume":"36","author":"Erdurmu\u015f","year":"2011","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0065_1","first-page":"2997","article-title":"Association between a SLC23A2 gene variation, plasma vitamin C levels, and risk of glaucoma in a Mediterranean population","volume":"17","author":"Zanon-Moreno","year":"2011","journal-title":"Mol Vis"},{"key":"10.1016\/j.coph.2012.10.007_bib0070","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.1167\/iovs.07-0170","article-title":"Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage","volume":"48","author":"Liu","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.coph.2012.10.007_bib0075","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3109\/02713680903548970","article-title":"Oxidative stress markers in patients with primary open-angle glaucoma","volume":"35","author":"Ghanem","year":"2010","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0080","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.preteyeres.2006.07.003","article-title":"Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences","volume":"25","author":"Tezel","year":"2006","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0085","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.freeradbiomed.2008.04.026","article-title":"Oxidative and nitrative stress markers in glaucoma","volume":"45","author":"Aslan","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.coph.2012.10.007_bib0090","first-page":"365","article-title":"Involvement of nitric oxide and other molecules with redox potential in primary open angle glaucoma","volume":"83","author":"Zan\u00f3n-Moreno","year":"2008","journal-title":"Arch Soc Esp Oftalmol"},{"key":"10.1016\/j.coph.2012.10.007_bib0095","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1167\/iovs.07-1363","article-title":"Expression of nitrotyrosine and oxidative consequences in the trabecular meshwork of patients with primary open-angle glaucoma","volume":"49","author":"Fern\u00e1ndez-Durango","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.coph.2012.10.007_bib0100","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3109\/02713681003778780","article-title":"Erythropoietin is increased in aqueous humor of glaucomatous eyes","volume":"35","author":"Wang","year":"2010","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0105","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1001\/archopht.123.4.458","article-title":"Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma","volume":"123","author":"Sacc\u00e0","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.coph.2012.10.007_bib0110_1","first-page":"41","article-title":"Oxidative DNA damage and total antioxidant status in glaucoma patients","volume":"17","author":"Sorkhabi","year":"2011","journal-title":"Mol Vis"},{"key":"10.1016\/j.coph.2012.10.007_bib0115","first-page":"2282","article-title":"Sustained stress response after oxidative stress in trabecular meshwork cells","volume":"13","author":"Li","year":"2007","journal-title":"Mol Vis"},{"key":"10.1016\/j.coph.2012.10.007_bib0120","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1001\/archophthalmol.2010.87","article-title":"Mitochondrial damage in the trabecular meshwork of patients with glaucoma","volume":"128","author":"Izzotti","year":"2010","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.coph.2012.10.007_bib0125_1","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1167\/iovs.12-7938","article-title":"Altered stability of mRNAs associated with glaucoma progression in human trabecular meshwork cells following oxidative stress","volume":"53","author":"Mochizuki","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.coph.2012.10.007_bib0130_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.exer.2010.08.016","article-title":"The case for autoimmunity in glaucoma","volume":"93","author":"Wax","year":"2011","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0135","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/IJG.0b013e318166f00b","article-title":"Helicobacter pylori IgG antibodies in aqueous humor and serum of subjects with primary open angle and pseudo-exfoliation glaucoma in a South Indian population","volume":"17","author":"Deshpande","year":"2008","journal-title":"J Glaucoma"},{"key":"10.1016\/j.coph.2012.10.007_bib0140","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/IJG.0b013e3181ca7868","article-title":"Elevated serum immunoglobulin G titers against Chlamydia pneumonia in primary open-angle glaucoma patients without systemic disease","volume":"19","author":"Yuki","year":"2010","journal-title":"J Glaucoma"},{"key":"10.1016\/j.coph.2012.10.007_bib0145","doi-asserted-by":"crossref","first-page":"5697","DOI":"10.1167\/iovs.10-5407","article-title":"Glaucomatous tissue stress and the regulation of immune response through glial toll-like receptor signaling","volume":"51","author":"Luo","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.coph.2012.10.007_bib0150","first-page":"132","article-title":"Complex autoantibody repertoires in patients with glaucoma","volume":"10","author":"Grus","year":"2004","journal-title":"Mol Vis"},{"key":"10.1016\/j.coph.2012.10.007_bib0155","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/02713680701871157","article-title":"Autoantibodies against human retinal antigens in sera of patients with glaucoma and ocular hypertension","volume":"33","author":"Reichelt","year":"2008","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0160_1","first-page":"1","article-title":"Biomarkers in primary open angle glaucoma","volume":"29","author":"Kokotas","year":"2012","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.coph.2012.10.007_bib0165","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0021-5155(01)00455-5","article-title":"Clinical significance of serum antibody against neuron-specific enolase in glaucoma patients","volume":"46","author":"Ikeda","year":"2002","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.coph.2012.10.007_bib0170","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00417-004-1094-5","article-title":"Autoantibodies in patients with glaucoma: a comparison of IgG serum antibodies against retinal, optic nerve, and optic nerve head antigens","volume":"243","author":"Joachim","year":"2005","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.coph.2012.10.007_bib0175","doi-asserted-by":"crossref","first-page":"7446","DOI":"10.1073\/pnas.97.13.7446","article-title":"T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathies","volume":"97","author":"Kipnis","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coph.2012.10.007_bib0180_1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbi.2011.07.241","article-title":"New insights into autoantibody profiles from immune privileged sites in the eye: a glaucoma study","volume":"26","author":"Boehm","year":"2012","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.coph.2012.10.007_bib0185","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s12177-009-9026-6","article-title":"The two sides of cytokine signaling and glaucomatous optic neuropathy","volume":"2","author":"Huang","year":"2009","journal-title":"J Ocul Biol Dis Infor"},{"key":"10.1016\/j.coph.2012.10.007_bib0190","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/IJG.0b013e3181b4cac7","article-title":"Serum cytokine alteration is associated with optic neuropathy in human primary open angle glaucoma","volume":"19","author":"Huang","year":"2010","journal-title":"J Glaucoma"},{"key":"10.1016\/j.coph.2012.10.007_bib0195_1","first-page":"431","article-title":"Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes","volume":"18","author":"Chua","year":"2012","journal-title":"Mol Vis"},{"key":"10.1016\/j.coph.2012.10.007_bib0200_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1167\/iovs.11-8434","article-title":"Multiplex cytokine analysis of aqueous humor in eyes with primary open-angle glaucoma, exfoliation glaucoma, and cataract","volume":"53","author":"Takai","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.coph.2012.10.007_bib0205_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00441-011-1274-7","article-title":"The role of TGF-\u03b2 in the pathogenesis of primary open-angle glaucoma","volume":"347","author":"Fuchshofer","year":"2012","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0210","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0079-6123(08)01128-X","article-title":"TNF-alpha signaling in glaucomatous neurodegeneration","volume":"173","author":"Tezel","year":"2008","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0215_1","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1167\/iovs.11-8902","article-title":"New proteins as vascular biomarkers in primary open angle glaucomatous aqueous humor","volume":"53","author":"Sacc\u00e0","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.coph.2012.10.007_bib0220","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.bbrc.2005.09.182","article-title":"Induction of IL-6 by mechanical stress in the trabecular meshwork","volume":"337","author":"Liton","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.coph.2012.10.007_bib0225","first-page":"2953","article-title":"Smoking, an additional risk factor in elder women with primary open-angle glaucoma","volume":"15","author":"Zanon-Moreno","year":"2009","journal-title":"Mol Vis"},{"key":"10.1016\/j.coph.2012.10.007_bib0230","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1167\/iovs.10-5289","article-title":"Oxidative stress and the regulation of complement activation in human glaucoma","volume":"51","author":"Tezel","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.coph.2012.10.007_bib0235","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1742-4933-2-8","article-title":"Innate immunity and inflammation in ageing: a key for understanding age-related diseases","volume":"2","author":"Licastro","year":"2005","journal-title":"Immun Ageing"},{"key":"10.1016\/j.coph.2012.10.007_bib0240","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1136\/bjo.83.8.980","article-title":"Ganglion cell death in glaucoma: what do we really know?","volume":"83","author":"Osborne","year":"1999","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.coph.2012.10.007_bib0245","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0002-9440(10)62042-1","article-title":"Transcriptional up-regulation and activation of initiating caspases in experimental glaucoma","volume":"167","author":"Huang","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.coph.2012.10.007_bib0250","series-title":"Glaucoma. Basic and Clinical Concepts","first-page":"207","article-title":"Glaucoma genetics. Regulation of cell surviving and death in the retina","author":"Pinazo-Dur\u00e1n","year":"2011"},{"key":"10.1016\/j.coph.2012.10.007_bib0255","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1371\/journal.pgen.0010004","article-title":"Susceptibility to neurodegeneration in a glaucoma is modified by bax gene dosage","volume":"1","author":"Libby","year":"2005","journal-title":"PLoS Genet"},{"key":"10.1016\/j.coph.2012.10.007_bib0260","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.brainres.2006.02.051","article-title":"Calpeptin provides functional neuroprotection to rat retinal ganglion cells following Ca2+ influx","volume":"1084","author":"Das","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0265","doi-asserted-by":"crossref","first-page":"712","DOI":"10.3109\/02713683.2012.669512","article-title":"Homocysteine and hydroxyproline levels in patients with primary open-angleglaucoma","volume":"37","author":"Ghanem","year":"2012","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0270","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.exer.2010.12.004","article-title":"Glaucoma patients present increased levels of diadenosine tetraphosphate, Ap(4)A, in the aqueous humour","volume":"92","author":"Castany","year":"2011","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0275","first-page":"2839","article-title":"Proteomic analysis of aqueous humor from patients with primary open angle glaucoma","volume":"16","author":"Duan","year":"2010","journal-title":"Mol Vis"},{"key":"10.1016\/j.coph.2012.10.007_bib0280","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/OPX.0b013e3181fc329f","article-title":"Brain-derived neurotrophic factor as a biomarker in primary open-angle glaucoma","volume":"88","author":"Ghaffariyeh","year":"2011","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.coph.2012.10.007_bib0285","first-page":"215","article-title":"Aqueous humor levels of soluble Fas and Fas-ligand in patients with primary open angle and pseudoexfoliation glaucoma","volume":"4","author":"Razeghinejad","year":"2007","journal-title":"Iran J Immunol"},{"key":"10.1016\/j.coph.2012.10.007_bib0290","first-page":"1513","article-title":"Apoptosis in the trabecular meshwork of glaucomatous patients","volume":"14","author":"Baleriola","year":"2008","journal-title":"Mol Vis"},{"key":"10.1016\/j.coph.2012.10.007_bib0295","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1167\/iovs.04-1472","article-title":"Hypophosphorylation of aqueous humor sCD44 and primary open-angle glaucoma","volume":"46","author":"Knepper","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.coph.2012.10.007_bib0300","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/1756-0500-2-224","article-title":"Aqueous humor level of sCD44 in patients with degenerative myopia and primary open-angle glaucoma","volume":"2","author":"Budak","year":"2009","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.coph.2012.10.007_bib0305","first-page":"1122","article-title":"Down-regulation of GRP78 in human glaucomatous trabecular meshwork cells","volume":"16","author":"Chai","year":"2010","journal-title":"Mol Vis"},{"key":"10.1016\/j.coph.2012.10.007_bib0310","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.preteyeres.2009.06.001","article-title":"Para-inflammation in the aging retina","volume":"28","author":"Xu","year":"2009","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0315","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1167\/iovs.06-0737","article-title":"Accelerated aging in glaucoma immuno-histochemical assessment of advanced glycation end products in the human retina and optic nerve head","volume":"48","author":"Tezel","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.coph.2012.10.007_bib0320","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1242\/jcs.00739","article-title":"Apoptosis \u2013 the p53 network","volume":"116","author":"Haupt","year":"2003","journal-title":"J Cell Sci"},{"key":"10.1016\/j.coph.2012.10.007_bib0325","doi-asserted-by":"crossref","first-page":"a000919","DOI":"10.1101\/cshperspect.a000919","article-title":"The tumor suppressor p53: from structures to drug discovery","volume":"2","author":"Joerger","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.coph.2012.10.007_bib0330","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1126\/science.1081274","article-title":"Life and death decisions","volume":"299","author":"Nicholson","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.coph.2012.10.007_bib0335","first-page":"105","article-title":"Biochemical characterization of the optic nerve in mice overexpressing the p53 gen. Oxidative stress assays","volume":"83","author":"Gallego-Pinazo","year":"2008","journal-title":"Arch Soc Esp Oftalmol"},{"key":"10.1016\/j.coph.2012.10.007_bib0340","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.exer.2010.03.008","article-title":"Mitochondria: their role in ganglion cell death and survival in primary open angle glaucoma","volume":"90","author":"Osborne","year":"2010","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0345","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1093\/nar\/gki759","article-title":"Oxidative stress-induced apoptosis in neurons correlates with mitochondrial DNA base excision repair pathway imbalance","volume":"22","author":"Harrison","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0350","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1136\/jmg.2003.016089","article-title":"Primary open angle glaucoma is associated with a specific p53 gene haplotype","volume":"41","author":"Ressiniotis","year":"2004","journal-title":"J Med Genet"},{"key":"10.1016\/j.coph.2012.10.007_bib0355","first-page":"1939","article-title":"Primary open angle glaucoma in a Caucasian population is associated with the p53 codon 72 polymorphism","volume":"15","author":"Daugherty","year":"2009","journal-title":"Mol Vis"},{"key":"10.1016\/j.coph.2012.10.007_bib0360","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1002\/pmic.200500358","article-title":"Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database","volume":"5","author":"Omenn","year":"2005","journal-title":"Proteomics"},{"key":"10.1016\/j.coph.2012.10.007_bib0365","doi-asserted-by":"crossref","first-page":"D603","DOI":"10.1093\/nar\/gkn810","article-title":"HMDB: a knowledgebase for the human metabolome","volume":"37","author":"Wishart","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0370","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/prca.200700105","article-title":"Proteomics in ocular fluids","volume":"1","author":"Grus","year":"2007","journal-title":"Proteomics Clin Appl"},{"key":"10.1016\/j.coph.2012.10.007_bib0375","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1167\/iovs.10-5531","article-title":"Proteome analysis of human aqueous humor","volume":"51","author":"Chowdhury","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.coph.2012.10.007_bib0380","first-page":"1891","article-title":"Alterations in the aqueous humor proteome in patients with a glaucoma shunt device","volume":"17","author":"Anshu","year":"2011","journal-title":"Mol Vis"},{"key":"10.1016\/j.coph.2012.10.007_bib0385","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1021\/pr1005372","article-title":"Proteome alterations in primary open angle glaucoma aqueous humor","volume":"9","author":"Izzotti","year":"2010","journal-title":"J Proteome Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0390","first-page":"2740","article-title":"Proteomic analysis of human aqueous humor using multidimensional protein identification technology","volume":"15","author":"Richardson","year":"2009","journal-title":"Mol Vis"},{"key":"10.1016\/j.coph.2012.10.007_bib0395","series-title":"ARVO Poster. 6411\/D699B","article-title":"Racial differences of oxygen levels in the human ocular anterior segment in vivo","author":"Siegfried","year":"2012"},{"key":"10.1016\/j.coph.2012.10.007_bib0400","series-title":"ARVO Poster 3863\/A563","article-title":"Global biochemical profile of aqueous humor from POAG patients and matched controls","author":"Luna","year":"2012"},{"key":"10.1016\/j.coph.2012.10.007_bib0405","doi-asserted-by":"crossref","first-page":"9391","DOI":"10.1073\/pnas.0812884106","article-title":"Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in vivo glaucoma model","volume":"106","author":"Barnett","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coph.2012.10.007_bib0410","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nrm2153","article-title":"The apoptosome: signalling platform of cell death","volume":"8","author":"Riedl","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.coph.2012.10.007_bib0415_1","doi-asserted-by":"crossref","first-page":"e173","DOI":"10.1038\/cddis.2011.54","article-title":"Ocular neuroprotection by siRNA targeting caspase-2","volume":"2","author":"Ahmed","year":"2011","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.coph.2012.10.007_bib0420","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/978-1-60761-987-1_15","article-title":"Data management and data integration in the HUPO plasma proteome project","volume":"696","author":"Omenn","year":"2011","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.coph.2012.10.007_bib0425","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1017\/S0266462308080343","article-title":"Key principles for the improved conduct of health technology assessments for resource allocation decisions","volume":"24","author":"Drummond","year":"2008","journal-title":"Int J Technol Assess Health Care"},{"key":"10.1016\/j.coph.2012.10.007_bib0430_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1586\/eop.09.6","article-title":"Progress toward personalized medicine for glaucoma: genetic testing privacy and legislation","volume":"4","author":"Moroi","year":"2009","journal-title":"Expert Rev Ophthalmol"},{"key":"10.1016\/j.coph.2012.10.007_bib0435","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0079-6123(08)01112-6","article-title":"Advances in neuroimaging of the visual pathways and their use in glaucoma","volume":"173","author":"Garaci","year":"2008","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0440_1","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1136\/bjophthalmol-2011-301280","article-title":"3-T Diffusion tensor imaging of the optic nerve in subjects with glaucoma: correlation with GDx-VCC, HRT-III and Stratus optical coherence tomography findings","volume":"96","author":"Nucci","year":"2012","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.coph.2012.10.007_bib0445","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1167\/iovs.10-5682","article-title":"Automated morphometry of the visual pathway in primary open-angle glaucoma","volume":"52","author":"Hernowo","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.coph.2012.10.007_bib0450_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1055\/s-0031-1299262","article-title":"Integrity\/demyelination of the optic radiation, morphology of the papilla, and contrast sensitivity in glaucoma patients","volume":"229","author":"Michelson","year":"2012","journal-title":"Klin Monbl Augenheilkd"},{"key":"10.1016\/j.coph.2012.10.007_bib0455_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2011.08.001","article-title":"Understanding glaucomatous damage: anatomical and functional data from ocular hypertensive rodent retinas","volume":"31","author":"Vidal-Sanz","year":"2012","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.coph.2012.10.007_bib0460_1","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1039\/C1MB05357D","article-title":"Differential protein expression in tears of patients with primary open angle and pseudoexfoliative glaucoma","volume":"8","author":"Pieragostino","year":"2012","journal-title":"Mol Biosyst"}],"container-title":["Current Opinion in Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489212002032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489212002032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T01:50:44Z","timestamp":1643593844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471489212002032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":92,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S1471489212002032"],"URL":"https:\/\/doi.org\/10.1016\/j.coph.2012.10.007","relation":{},"ISSN":["1471-4892"],"issn-type":[{"value":"1471-4892","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}