{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:20:26Z","timestamp":1792189226199,"version":"4.4.0"},"reference-count":12,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Opinion in Pharmacology"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.coph.2013.08.012","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T15:17:04Z","timestamp":1378394224000},"page":"673-677","source":"Crossref","is-referenced-by-count":25,"title":["Disruptive innovations: new anti-infectives in the age of resistance"],"prefix":"10.1016","volume":"13","author":[{"given":"George P","family":"Tegos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Hamblin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coph.2013.08.012_bib0005","series-title":"Antimicrobial Drug Discovery: Emerging Strategies.","article-title":"The antibiotic crisis","author":"Demain","year":"2012"},{"key":"10.1016\/j.coph.2013.08.012_bib0010","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/01.ASW.0000383221.79771.48","article-title":"Super bugs: survival of the fittest","volume":"23","author":"Salcido","year":"2010","journal-title":"Adv Skin Wound Care"},{"key":"10.1016\/j.coph.2013.08.012_bib0015","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1586\/eri.12.120","article-title":"Global antimicrobial resistance: from surveillance to stewardship, Part 1: surveillance and risk factors for resistance","volume":"10","author":"Canton","year":"2012","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.coph.2013.08.012_bib0020","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1586\/eri.13.12","article-title":"Clinical relevance of the ESKAPE pathogens","volume":"11","author":"Pendleton","year":"2013","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.coph.2013.08.012_bib0025","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.diagmicrobio.2008.02.012","article-title":"Antimicrobial stewardship: concepts and strategies in the 21st century","volume":"61","author":"Owens","year":"2008","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.coph.2013.08.012_bib0030","doi-asserted-by":"crossref","first-page":"S226","DOI":"10.1046\/j.1532-5415.50.7s.2.x","article-title":"Antimicrobial resistance and aging: beginning of the end of the antibiotic era?","volume":"50","author":"Yoshikawa","year":"2002","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.coph.2013.08.012_bib0035","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nrd3975","article-title":"Platforms for antibiotic discovery","volume":"12","author":"Lewis","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.coph.2013.08.012_bib0040","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1096\/fj.12-221127","article-title":"Bacterial resistance mechanism: what proteomics can elucidate","volume":"27","author":"Lima","year":"2013","journal-title":"FASEB J"},{"key":"10.1016\/j.coph.2013.08.012_bib0045","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2174\/1874285801307010034","article-title":"Microbial efflux systems and inhibitors: approaches to drug discovery and the challenge of clinical implementation","volume":"7","author":"Kourtesi","year":"2013","journal-title":"Open Microbiol J"},{"key":"10.1016\/j.coph.2013.08.012_bib0050","doi-asserted-by":"crossref","first-page":"e1002121","DOI":"10.1371\/journal.ppat.1002121","article-title":"\u201cPersisters\u201d: survival at the cellular level","volume":"7","author":"Dawson","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coph.2013.08.012_bib0055","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1021\/np200906s","article-title":"Natural products as sources of new drugs over the 30 years from 1981 to 2010","volume":"75","author":"Newman","year":"2012","journal-title":"J Nat Prod"},{"key":"10.1016\/j.coph.2013.08.012_bib0060","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2174\/1574891X11308010012","article-title":"Bacterial quorum sensing inhibitors: attractive alternatives for control of infectious pathogens showing multiple drug resistance","volume":"8","author":"Bhardwaj","year":"2013","journal-title":"Recent Pat Antiinfect Drug Discov"}],"container-title":["Current Opinion in Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489213001586?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489213001586?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T11:20:22Z","timestamp":1539429622000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471489213001586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S1471489213001586"],"URL":"https:\/\/doi.org\/10.1016\/j.coph.2013.08.012","relation":{},"ISSN":["1471-4892"],"issn-type":[{"value":"1471-4892","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}